A time for metabolism and hormones_flyer (pdf

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colloques médecine et recherche
Colloques Médecine et Recherche
hormone metabolism igf
adipocyte leptine neuropeptide ghrelin obesity
diabetes steroid receptors peptide hormone
LTP metabolism endocrine regulation insulin
androgen igf pituitary corticosteroid neuropeptide
androgen estrogen growth hormone
diabetes hormone
leptine metabolism
peptide
steroid receptors ghrelin igf neuropeptide pituitary
insulin diabetes adipocyte peptide obesity
hormone metabolism igf steroid receptors
endocrine regulation neuropeptide insulin
pituitary diabetes growth hormone corticosteroid androgen
estrogen
To be returned to the Fondation IPSEN with the registration fee
À retourner avec les droits d’inscription à la Fondation IPSEN
endocrinology
cancer science
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
2015
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2002 Brain somatic cross-talk and the central control of metabolism
2002 Endocrine aspects of successful aging: Of genes, hormones and lifestyles
2003 Hormones and the brain
2004 Deciphering growth
2005 Insights into receptor function and new drug development
targets
2006 Hormonal control of cell cycle
2007 Hormones and social behavior
2008 IGFs: Local repair and survival factors throughout life-span
2009 Novel insights in adipose cell functions
2010 Multi-system endocrine disruption
2011 Multiple origins of sex differences in brain.
Neuroendocrine functions and their pathologies
2012 Hormones, intrauterine health and programming
2013 Brain crosstalk in puberty and adolescence
2014 A time for metabolism and hormones (in preparation)
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neurosciences
Paris - December 5, 2014
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Registration Fee / Frais d’inscription
100 € before November 1, 2014
130 € after November 1, 2014
Including lunch, coffee-breaks, congress bag, proceedings.
Comprenant déjeuner, pauses-café, kit congrès, compte-rendu.
Free for students but :
- Registration is compulsory and should be completed
on October 15th at the latest. Registration will be
confirmed according to avaibility on November 1st.
- Due to space restrictions, lunch for students is
sujected to avaibility.
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- Cheque should be made out to ‘Fondation IPSEN/
Fondation de France’
- For foreigners, payment on site will be accepted
(cash only, no credit card please).
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FONDATION
IPSEN
65, quai Georges Gorse - 92650 Boulogne-Billancourt cedex - France
Tél. : +33 (0)1 58 33 50 00 – Fax : +33 (0)1 58 33 50 01
www.fondation-ipsen.org
1990 Glutamate, cell death and memory
1991 Gene transfer and therapy in the nervous system
1992 Motor and cognitive functions of the prefrontal cortex
1993 Temporal coding
1994 Neurobiology of decision-making
1995 Isolation, characterization and utilization of CNS stem cells
1996 Normal and abnormal development of the cortex
1997 Neuroplasticity: Building a bridge from the laboratory to the clinic
1998 Neuroimmune interactions and neuropsychiatric diseases
2000 Neuronal death: By accident or by design
2001 Neurosciences at the post-genomic era
2003 Stem cells in the nervous system: Function and clinical implications
2005 Neurobiology of human values
2006 Memories: Molecules and circuits
2007 Retrotransposition, diversity & the brain
2008 Neurobiology of «Umwelt»: How living beings perceive
the world
2009 Macro-roles for micrornas in the life and death of neurons
2010 Characterizing consciousness: From cognition to the clinic?
2011 Epigenetics, brain and behavior
2012 Programmed cells : From basic neuroscience to therapy
2013 New frontiers in social neuroscience
2014 Micro-, meso- and macro-connectomics of the brain
2015 Micro-, meso- and macro-dynamics of the brain
(in preparation)
vascular SYSTEM
2004
2005
2006
2007
2008
Origins and regenation of the vascular tree
Life and death of the vascular tree
The vascular tree aflame!
Angiogenesis and neurogenesis
Oxygen sensing in the vascular tree
Can cancer be treated as a chronic disease?
Are inflammation and cancer linked?
Metastasis and invasion
Metabolism and cancer
Molecular targets of cancer therapy
Stem cells and cancer
Epigenetics and cancer
Mouse models of human cancer: Are they relevant?
Cancer immunotherapy
Cancer genomics
Tumor heterogeneity and tumor microenvironment
alzheimer’s disease
1987 Immunological aspects of Alzheimer’s disease and brain
amyloidosis
1988 Genetics and Alzheimer’s disease
1988 Neuronal grafting and Alzheimer’s disease: Future perspectives
1989 Biological markers of Alzheimer’s disease
1989
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1995
1996
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1998
1999
2000
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2002
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(in collaboration with Tübingen University)
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Synaptic plasticity and the mechanism of Alzheimer’s disease
Intracellular traffic and neurodegenerative disorders
Diabetes, insulin and Alzheimer’s disease
Two faces of evil: Cancer and neurodegeneration
Protein quality control in neurodegenerative diseases
Proteopathic seeds and neurodegenerative diseases
longevity
1996
1998
1999
2001
2004
endocrinology
Imaging, cerebral topography and Alzheimer’s disease
Growth factors and Alzheimer’s disease
Neurophilosophy and Alzheimer’s disease
Heterogeneity of Alzheimer’s disease
The ß-amyloid protein precursors in development, aging
and Alzheimer’s disease
Alzheimer’s disease: Lessons from cell biology
Apolipoprotein E and Alzheimer’s disease
Connections, cognition and Alzheimer’s disease
Presenilins and Alzheimer’s disease
Epidemiology of Alzheimer’s disease: From gene
to prevention
Fatal attractions within neurons: Intracytoplasmic protein aggregates in Alzheimer’s disease and reated neurodegenerative disorders
Neurodegenerative diseases: Loss of function through gain
of function
Notch from neurodevelopment to neurodegeneration:
keeping the fate
Immunization against Alzheimer’s and other neurodegenerative diseases
The living brain and Alzheimer’s disease
Genotype – proteotype – phenotype correlations in dementia
Alzheimer: 100 years and beyond
Longevity: To the limits and beyond
The paradoxes of longevity
Sex and longevity: sexuality, gender, reproduction, parenthood
Brain and longevity
Frailty and longevity
A time for metabolism and
hormones
Temps, métabolisme et hormones
Paris - December 5, 2014
2FI0196 - Design: Alain Compans
A time for metabolism and hormones
FONDATION
IPSEN
Program
A time for metabolism and hormones
Scientific Committee:
Paolo Sassone-Corsi (University of California, Irvine, USA)
Yves Christen (Fondation IPSEN, Paris, France)
Paris - December 5, 2014
Life on Earth has evolved by coping, adapting and because of the light-dark cycle due to the
rotation of our planet on its axis. Circadian rhythms are widespread among all life forms and govern
a remarkable array of physiological and metabolic functions. Rhythms are based on the circadian
clock, is an extensive molecular network of timing mechanisms that converge to maintain organismal
physiological state. In mammals, biological rhythms are established and maintained by a central clock
consisting of around 20,000 pacemaker neurons found in the suprachiasmatic nucleus (SCN). SCN
neurons are entrained by light, the most powerful zeitgeber (time-giver), via the retinohypothalamic
tract. The central SCN clock directs rhythms in a number of peripheral tissues using several, still illdefined, output cues. These include numerous secreted paracrine signals, transduction pathways
and endocrine control systems whose deciphering is biomecally and pharmacologically critical.
Indeed, disruption of the synchrony within clock system leads to a number of metabolic and
physiological disorders. Moreover, peripheral clocks are also entrained by extrinsic cues, specifically
food intake, which operates as a powerful zeitgeber. In addition, it has been shown that various
‘nutrient sensors’ are linked to circadian rhythms, reinforcing the notion that there is a tightly
coupled relationship between metabolic state and the clock. Finally, as a considerable fraction of the
genome is functionally regulated by the clock, a further layer of this complex timing mechanism lies
in the emerging link between cellular metabolic state and epigenetics. This Symposium is centered
on the emerging links between the circadian clock system, endocrinology and cellular metabolism.
Au cours de l’évolution, la vie sur Terre s’est adaptée à l’influence du cycle jour-nuit, dû à la rotation de
notre planète sur son axe. Les rythmes circadiens sont répandus parmi toutes les formes de vie, et ils
guident un remarquable éventail de fonctions physiologiques et métaboliques. Les rythmes reposent
sur l’horloge circadienne, un réseau moléculaire étendu de mécanismes temporels harmonisés pour
maintenir l’état physiologique de l’organisme. Chez les mammifères, les rythmes biologiques sont définis et
maintenus par une horloge centrale composée d’environ 20 000 neurones régulateurs situés dans le noyau
suprachiasmatique (NSC). Les neurones du NSC sont sous l’influence de la lumière, qui est l’horloge – ou
Zeitgeber – la plus puissante, via la voie rétinohypothalamique. L’horloge centrale du NSC guide les rythmes
d’un certain nombre de tissus périphériques à l’aide de plusieurs signaux de sortie encore mal définis. Ceuxci comprennent de nombreux signaux paracrines sécrétés, des voies de transduction et des systèmes de
contrôle endocrinien dont le décodage est essentiel du point de vue biomédical et pharmacologique. En
effet, la perturbation du synchronisme du système d’horloge se traduit par un certain nombre de troubles
métaboliques et physiologiques. Par ailleurs, les horloges périphériques sont également sensibles à des
signaux extrinsèques, en particulier la consommation alimentaire, qui agit comme un puissant Zeitgeber. En
outre, on a montré que divers capteurs de la présence du nutriment sont associés aux rythmes circadiens,
ce qui renforce la notion d’une relation étroite entre l’état métabolique et l’horloge. Enfin, comme l’horloge
régule une partie considérable du génome du point de vue fonctionnel, une couche supplémentaire
décomplexé de ce mécanisme temporel complexe provient des relations entre l’état métabolique
cellulaire et l’épigénétique. Ce symposium est principalement consacré aux approches émergentes
étudiant les liens entre le système d’horloge circadienne, l’endocrinologie et le métabolisme cellulaire.
Fondation IPSEN
sous l’égide de la Fondation de France
Information
egistration: R
Centre de Conferences et de Réceptions Etoile St-Honoré
21-25 rue Balzac - 75008 Paris, France
Organization / Organisation
Fondation IPSEN
Astrid de Gérard
65, quai Georges Gorse
92650 Boulogne-Billancourt Cedex
France
Tél. : +33 (0)1 58 33 50 00
[email protected]
Venue / Lieu
8:30 am
Yves Christen: Welcoming remarks
8:45 am
Paolo Sassone-Corsi (University of California, Irvine, USA)
The epigenetic language of the circadian clock
9:15 am
Joseph Takahashi (University of Texas Southwestern Medical Center, Dallas, USA)
Molecular architecture of the circadian clock in mammals
9:45 am
Joseph Bass (Northwestern University, Chicago, USA)
Circadian mechanisms in bioenergetics and cell physiology
10:15 am
Posters and coffee break
10:45 am
Amita Sehgal (University of Pennsylvania, Philadelphia, USA)
Control of metabolism by central and peripheral clocks in Drosophila
11:15 am
Carla Green (University of Texas Southwestern Medical Center, Dallas, USA)
Circadian post-transcriptional control of metabolism
11:45 am
Akhilesh B. Reddy (University of Cambridge, Cambridge, UK)
Redox and metabolic oscillations in the clockwork
12:15 pm
Mitchell Lazar (University of Pennsylvania, Philadelphia, USA)
Integrating metabolism around the clock
12:45 pm Lunch and posters
2:00 pm
François Rouyer (CNRS UPR 3294, Gif-sur-Yvette, France)
Molecular control sleep-wake cycles in Drosophila
2:30 pm
Michael H. Hastings (Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, UK)
Circadian pacemaking in the suprachiasmatic nucleus, the co-ordinator of endocrine rhythms
3:00 pm
Steven Brown (University of Zurich, Zurich, Switzerland)
Circadian metabolomics from mice and men: Insights for mechanism and medicine
3:30 pm
Posters and coffee break
4:00 pm
Stafford Lightman (University of Bristol, Bristol, UK)
Rhythms within rhythms: the importance of oscillations for glucocorticoid hormones
4:30 pm
Louis J. Ptácek (Howard Hughes Medical Institute, San Francisco, USA)
Human genetics studies to probe the molecular basis of human sleep
5:00 pm
Thomas Bourgeron (Institut Pasteur, Paris, France)
Genes, clocks, and synapses in AutismS
5:30 pm
Conclusion
Centre de Conférences
et de Réceptions Etoile St-Honoré
21-25 rue Balzac
75008 Paris
France
Parking public Etoile Friedland à 150 mètres
Métro : Charles de Gaulle Etoile (lignes 1, 2 et 6) et RER A
Official language / Langue officielle
English / Anglais
Posters / Communications affichées
Abstracts for posters should be submitted before
November 1, 2014
[email protected]
Les abstracts des posters doivent être soumis d’ici le
1er Novembre 2014
[email protected]
Lunch / Déjeuner
Served on site / Servi sur place
Accommodation / Hôtel
You will receive, along with your registration
receipt, a list of hotels located close to the venue
of the meeting.
Vous recevrez, avec votre accusé d’inscription, une liste d’hôtels
proches du lieu de la réunion.
FONDATION
IPSEN
65, quai Georges Gorse - 92650 Boulogne-Billancourt cedex - France
Tél. : +33 (0)1 58 33 50 00 – Fax : +33 (0)1 58 33 50 01
www.fondation-ipsen.org