Registration Form A time for metabolism and
Transcription
Registration Form A time for metabolism and
Registration Form Colloques Médecine et Recherche To be returned to the Fondation IPSEN with the registration fee À retourner avec les droits d’inscription à la Fondation IPSEN endocrinology cancer science 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 Street and N° / N° et Rue............................................................................ 2002 Brain somatic cross-talk and the central control of metabolism 2002 Endocrine aspects of successful aging: Of genes, hormones and lifestyles 2003 Hormones and the brain 2004 Deciphering growth 2005 Insights into receptor function and new drug development targets 2006 Hormonal control of cell cycle 2007 Hormones and social behavior 2008 IGFs: Local repair and survival factors throughout life-span 2009 Novel insights in adipose cell functions 2010 Multi-system endocrine disruption 2011 Multiple origins of sex differences in brain. Neuroendocrine functions and their pathologies 2012 Hormones, intrauterine health and programming 2013 Brain crosstalk in puberty and adolescence 2014 A time for metabolism and hormones (in preparation) Area code / Code postal............................................................................... neurosciences Paris - December 5, 2014 Family name / Nom ...................................................................................... First name / Prénom....................................................................................... Speciality / Spécialité...................................................................................... Department or Unit / Service ou Laboratoire.................................... .................................................................................................................................... .................................................................................................................................... Affiliation / Affiliation (Hôpital, Inserm, CNRS, etc).............................. .................................................................................................................................... .................................................................................................................................... City / Ville.............................................................................................................. Country / Pays.................................................................................................... Telephone / Téléphone ................................................................................. E-mail..................................................................................................................... .................................................................................................................................... Registration Fee / Frais d’inscription 100 € before November 1, 2014 130 € after November 1, 2014 Including lunch, coffee-breaks, congress bag, proceedings. Comprenant déjeuner, pauses-café, kit congrès, compte-rendu. Free for students but : - Registration is compulsory and should be completed on October 15th at the latest. Registration will be confirmed according to avaibility on November 1st. - Due to space restrictions, lunch for students is sujected to avaibility. Student / Étudiant Payment / Mode de règlement - Cheque should be made out to ‘Fondation IPSEN/ Fondation de France’ - For foreigners, payment on site will be accepted (cash only, no credit card please). 1990 1991 1992 1993 1994 1995 1996 1997 1998 2000 2001 2003 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 Glutamate, cell death and memory Gene transfer and therapy in the nervous system Motor and cognitive functions of the prefrontal cortex Temporal coding Neurobiology of decision-making Isolation, characterization and utilization of CNS stem cells Normal and abnormal development of the cortex Neuroplasticity: Building a bridge from the laboratory to the clinic Neuroimmune interactions and neuropsychiatric diseases Neuronal death: By accident or by design Neurosciences at the post-genomic era Stem cells in the nervous system: Function and clinical implications Neurobiology of human values Memories: Molecules and circuits Retrotransposition, diversity & the brain Neurobiology of «Umwelt»: How living beings perceive the world Macro-roles for micrornas in the life and death of neurons Characterizing consciousness: From cognition to the clinic? Epigenetics, brain and behavior Programmed cells : From basic neuroscience to therapy New frontiers in social neuroscience Micro-, meso- and macro-connectomics of the brain Dynamics of the brain vascular tree Date......................................................................................................................... Signature : 65, quai Georges Gorse - 92650 Boulogne-Billancourt cedex - France Tél. : +33 (0)1 58 33 50 00 – Fax : +33 (0)1 58 33 50 01 www.fondation-ipsen.org 2004 2005 2006 2007 2008 Origins and regenation of the vascular tree Life and death of the vascular tree The vascular tree aflame! Angiogenesis and neurogenesis Oxygen sensing in the vascular tree Can cancer be treated as a chronic disease? Are inflammation and cancer linked? Metastasis and invasion Metabolism and cancer Molecular targets of cancer therapy Stem cells and cancer Epigenetics and cancer Mouse models of human cancer: Are they relevant? Cancer immunotherapy Cancer genomics alzheimer’s disease 1987 Immunological aspects of Alzheimer’s disease and brain amyloidosis 1988 Genetics and Alzheimer’s disease 1988 Neuronal grafting and Alzheimer’s disease: Future perspectives 1989 Biological markers of Alzheimer’s disease 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2006 Imaging, cerebral topography and Alzheimer’s disease Growth factors and Alzheimer’s disease Neurophilosophy and Alzheimer’s disease Heterogeneity of Alzheimer’s disease The ß-amyloid protein precursors in development, aging and Alzheimer’s disease Alzheimer’s disease: Lessons from cell biology Apolipoprotein E and Alzheimer’s disease Connections, cognition and Alzheimer’s disease Presenilins and Alzheimer’s disease Epidemiology of Alzheimer’s disease: From gene to prevention Fatal attractions within neurons: Intracytoplasmic protein aggregates in Alzheimer’s disease and reated neurodegenerative disorders Neurodegenerative diseases: Loss of function through gain of function Notch from neurodevelopment to neurodegeneration: keeping the fate Immunization against Alzheimer’s and other neurodegenerative diseases The living brain and Alzheimer’s disease Genotype – proteotype – phenotype correlations in dementia Alzheimer: 100 years and beyond (in collaboration with Tübingen University) 2007 2008 2009 2010 2011 2012 Synaptic plasticity and the mechanism of Alzheimer’s disease Intracellular traffic and neurodegenerative disorders Diabetes, insulin and Alzheimer’s disease Two faces of evil: Cancer and neurodegeneration Protein quality control in neurodegenerative diseases Proteopathic seeds and neurodegenerative diseases A time for metabolism and hormones Traduction Paris - December 5, 2014 longevity 1996 Longevity: To the limits and beyond 1998 The paradoxes of longevity 1999 Sex and longevity: sexuality, gender, reproduction, parenthood 2001 Brain and longevity 2004 Frailty and longevity 2FI0192 A time for metabolism and hormones Program A time for metabolism and hormones Scientific Committee: Paolo Sassone-Corsi (University of California, Irvine, USA) Yves Christen (Fondation IPSEN, Paris, France) Paris - December 5, 2014 Life on Earth has evolved by coping, adapting and because of the light-dark cycle due to the rotation of our planet on its axis. Circadian rhythms are widespread among all life forms and govern a remarkable array of physiological and metabolic functions. Rhythms are based on the circadian clock, is an extensive molecular network of timing mechanisms that converge to maintain organismal physiological state. In mammals, biological rhythms are established and maintained by a central clock consisting of around 20,000 pacemaker neurons found in the suprachiasmatic nucleus (SCN). SCN neurons are entrained by light, the most powerful zeitgeber (time-giver), via the retinohypothalamic tract. The central SCN clock directs rhythms in a number of peripheral tissues using several, still illdefined, output cues. These include numerous secreted paracrine signals, transduction pathways and endocrine control systems whose deciphering is biomecally and pharmacologically critical. Indeed, disruption of the synchrony within clock system leads to a number of metabolic and physiological disorders. Moreover, peripheral clocks are also entrained by extrinsic cues, specifically food intake, which operates as a powerful zeitgeber. In addition, it has been shown that various ‘nutrient sensors’ are linked to circadian rhythms, reinforcing the notion that there is a tightly coupled relationship between metabolic state and the clock. Finally, as a considerable fraction of the genome is functionally regulated by the clock, a further layer of this complex timing mechanism lies in the emerging link between cellular metabolic state and epigenetics. This Symposium is centered on the emerging links between the circadian clock system, endocrinology and cellular metabolism. egistration: R Centre de Conferences et de Réceptions Etoile St-Honoré 21-25 rue Balzac - 75008 Paris, France Organization / Organisation Fondation IPSEN Astrid de Gérard 65, quai Georges Gorse 92650 Boulogne-Billancourt Cedex France Tél. : +33 (0)1 58 33 50 00 [email protected] Venue / Lieu 2FI096 - Design: Alain Compans La vie sur Terre a évolué en faisant face, en s’adaptant, et en raison du cycle jour-nuit dû à la rotation de notre planète sur son axe. Les rythmes circadiens sont répandus parmi toutes les formes de vie, et ils guident un remarquable éventail de fonctions physiologiques et métaboliques. Les rythmes reposent sur l’horloge circadienne, un réseau moléculaire étendu de mécanismes temporels harmonisés pour maintenir l’état physiologique de l’organisme. Chez les mammifères, les rythmes biologiques sont définis et maintenus par une horloge centrale composée d’environ 20 000 neurones régulateurs situés dans le noyau suprachiasmatique (NSC). Les neurones du NSC sont sensibles à la lumière, l’horloge – ou Zeitgeber – la plus puissante, via la voie rétinohypothalamique. L’horloge centrale du NSC guide les rythmes d’un certain nombre de tissus périphériques à l’aide de plusieurs signaux de sortie encore mal définis. Ceux-ci comprennent de nombreux signaux paracrines sécrétés, des voies de transduction et des systèmes de contrôle endocrinien dont le décodage est essentiel du point de vue biomédical et pharmacologique. En effet, si le synchronisme du système d’horloge est perturbé, un certain nombre de troubles métaboliques et physiologiques apparaissent. Par ailleurs, les horloges périphériques sont également sensibles à des signaux extrinsèques, en particulier la consommation alimentaire, qui agit comme un puissant Zeitgeber. En outre, on a montré que divers « capteurs de nutriment » sont associés aux rythmes circadiens, ce qui renforce la notion d’une relation étroite entre l’état métabolique et l’horloge. Enfin, comme l’horloge régule une partie considérable du génome du point de vue fonctionnel, une couche supplémentaire de ce mécanisme temporel complexe repose sur le lien émergent entre l’état métabolique cellulaire et l’épigénétique. Ce symposium est axé sur les liens émergents entre le système d’horloge circadienne, l’endocrinologie et le métabolisme cellulaire. Fondation IPSEN sous l’égide de la Fondation de France Information 8:30 am Yves Christen: Welcoming remarks 8:45 am Paolo Sassone-Corsi (University of California, Irvine, USA) The epigenetic language of the circadian clock 9:15 am Joseph Takahashi (University of Texas Southwestern Medical Center, Dallas, USA) Molecular architecture of the circadian clock in mammals 9:45 am Joseph Bass (Northwestern University, Chicago, USA) Circadian mechanisms in bioenergetics and cell physiology 10:15 am Posters and coffee break 10:45 am Amita Sehgal (University of Pennsylvania, Philadelphia, USA) Control of metabolism by central and peripheral clocks in Drosophila 11:15 am Carla Green (University of Texas Southwestern Medical Center, Dallas, USA) Circadian post-transcriptional control of metabolism 11:45 am Akhilesh B. Reddy (University of Cambridge, Cambridge, UK) Redox and metabolic oscillations in the clockwork 12:15 pm Mitchell Lazar (University of Pennsylvania, Philadelphia, USA) Integrating metabolism around the clock 12:45 pm Lunch and posters 2:00 pm François Rouyer (CNRS UPR 3294, Gif-sur-Yvette, France) Molecular control sleep-wake cycles in Drosophila 2:30 pm Michael H. Hastings (Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, UK) Circadian pacemaking in the suprachiasmatic nucleus, the co-ordinator of endocrine rhythms 3:00 pm Steven Brown (University of Zurich, Zurich, Switzerland) Circadian metabolomics from mice and men: Insights for mechanism and medicine 3:30 pm Posters and coffee break 4:00 pm Stafford Lightman (University of Bristol, Bristol, UK) Rhythms within rhythms: the importance of oscillations for glucocorticoid hormones 4:30 pm Louis J. Ptácek (Howard Hughes Medical Institute, San Francisco, USA) Human genetics studies to probe the molecular basis of human sleep 5:00 pm Thomas Bourgeron (Institut Pasteur, Paris, France) Genes, clocks, and synapses in AutismS 5:30 pm Conclusion Centre de Conférences et de Réceptions Etoile St-Honoré 21-25 rue Balzac 75008 Paris France Parking public Etoile Friedland à 150 mètres Métro : Charles de Gaulle Etoile (lignes 1, 2 et 6) et RER A Official language / Langue officielle English / Anglais Posters / Communications affichées Abstracts for posters should be submitted before November 1, 2014 [email protected] Les abstracts des posters doivent être soumis d’ici le 1er Novembre 2014 [email protected] Lunch / Déjeuner Served on site / Servi sur place Accommodation / Hôtel You will receive, along with your registration receipt, a list of hotels located close to the venue of the meeting. Vous recevrez, avec votre accusé d’inscription, une liste d’hôtels proches du lieu de la réunion. 65, quai Georges Gorse - 92650 Boulogne-Billancourt cedex - France Tél. : +33 (0)1 58 33 50 00 – Fax : +33 (0)1 58 33 50 01 www.fondation-ipsen.org