docalzheimer - Massachusetts Alzheimer`s Disease Research Center
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alzheimer - Massachusetts Alzheimer`s Disease Research Center
To be returned to the Fondation IPSEN with the registration fee À retourner avec les droits d’inscription à la Fondation IPSEN Proteopathic seeds and neurodegenerative diseases alzheimer’s disease Immunological Aspects of Alzheimer’s Disease and Brain Amyloidosis Angers, September 14, 1987 Genetics and Alzheimer’s Disease Paris, March 25, 1988 Neuronal Grafting and Alzheimer’s Disease: Future Perspectives Montpellier, September 19, 1988 Biological Markers of Alzheimer’s Disease Paris - February 27, 2012 Toulouse, April 24, 1989 Family name / Nom ...................................................................................... Lille, October 16, 1989 First name / Prénom....................................................................................... Strasbourg, April 25, 1990 Speciality / Spécialité...................................................................................... San Diego, January 11, 1991 Department or Unit / Service ou Laboratoire.................................... Marseille, April 6, 1992 .................................................................................................................................... .................................................................................................................................... Affiliation / Affiliation (Hôpital, Inserm, CNRS, etc).............................. .................................................................................................................................... .................................................................................................................................... Street and N° / N° et Rue............................................................................ Area code / Code postal............................................................................... City / Ville.............................................................................................................. Country / Pays.................................................................................................... Telephone / Téléphone ................................................................................. Fax ........................................................................................................................... Imaging, Cerebral Topography and Alzheimer’s Disease Growth Factors and Alzheimer’s Disease Neurophilosophy and Alzheimer’s Disease Heterogeneity of Alzheimer’s Disease The ß-Amyloid Protein Precursors in Development, Aging and Alzheimer’s Disease Lyon, June 21, 1993 Alzheimer’s Disease: Lessons from Cell Biology Paris, April 25, 1994 Apolipoprotein E and Alzheimer’s Disease Paris, May 29, 1995 Connections, Cognition and Alzheimer’s Disease Paris, May 20, 1996 Presenilins and Alzheimer’s Disease Paris, April 28, 1997 Epidemiology of Alzheimer’s Disease: from Gene to Prevention Paris, May 11, 1998 Fatal Attractions within Neurons: Intracytoplasmic Protein Aggregates in Alzheimer’s Disease and Reated Neurodegenerative Disorders - Paris, April 12, 1999 Neurodegenerative Diseases: Loss of Function through Gain of Function - Paris, February 28, 2000 Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate - Paris, March 19, 2001 Immunization Against Alzheimer’s and other Neurodegenerative Diseases - Paris, March 13, 2002 The Living Brain and Alzheimer’s Disease E-mail..................................................................................................................... Paris, March 17 , 2003 .................................................................................................................................... Paris, September 13, 2004 Genotype – Proteotype – Phenotype correlations in Dementia Alzheimer: 100 Years and Beyond (in collaboration with Tübingen University) Registration Fee / Frais d’inscription Tübingen, November 2-5, 2006 90 € before January 1, 2012 130 € after January 1, 2012 Paris, April 16, 2007 Including lunch, coffee-breaks, congress bag, proceedings Comprenant déjeuner, pauses-café, kit congrès , compte-rendu. Free for students but registration is compulsory and should be completed before January 15, 2012. Due to space restrictions, lunch for students will be allocated according to availability on a first registered, first served basis. Student / Étudiant Payment / Mode de règlement Cheque should be made out to the Fondation IPSEN/ Fondation de France. For foreigners, payment on site will be accepted (cash only). Chèque à l’ordre de la Fondation IPSEN/ Fondation de France. Signature : Metabolism and Cancer Costa Rica, March 9-12, 2008 Molecular Targets of Cancer Therapy Jaipur, February 14-18, 2009 Stem Cells and Cancer Bariloche, March 6-10, 2010 Epigenetics and Cancer Swakopmund, March 19-23, 2011 Mouse Models of Human Cancer: are they Relevant? Ouro Preto, March 10 - 14, 2012 (in preparation) neurosciences Glutamate, Cell Death and Memory Paris, September 24, 1990 Gene Transfer and Therapy in the Nervous System Paris, September 23, 1991 Motor and Cognitive Functions of the Prefrontal Cortex Paris, November 23, 1992 Temporal Coding Paris, October 11, 1993 Neurobiology of Decision-Making Paris, October 24, 1994 Isolation, Characterization and Utilization of CNS Stem Cells Paris, September 18,1995 Normal and Abnormal Development of the Cortex Neuroplasticity: Building a Bridge from the Laboratory to the Clinic Paris, October 6, 1997 Neuroimmune Interactions and Neuropsychiatric Diseases Paris, October 5, 1998 Neuronal Death: by Accident or by Design Paris, October 9, 2000 Neurosciences at the Post-Genomic Era Stem Cells in the Nervous System: Function and Clinical Implications Paris, January 20, 2003 Neurobiology of Human Values Paris, January 24 , 2005 Memories: Molecules and Circuits Paris, February 18, 2008 Paris, April 26, 2010 Protein Quality Control in Neurodegenerative Diseases Paris, May 9, 2011 Proteopathic Seeds and Neurodegenerative Diseases Paris, February 27, 2012 (in preparation) endocrinology Brain Somatic Cross-Talk and the Central Control of Metabolism Paris, January 28, 2002 Endocrine Aspects of Successful Aging: of Genes, Hormones and Lifestyles Paris, December 2, 2002 Hormones and the Brain Paris, December 8, 2003 Deciphering Growth Paris, December 6,2004 Paris, December 5, 2005 Hormonal Control of Cell Cycle Paris, December 4, 2006 Hormones and Social Behavior Neurobiology of «Umwelt»: How Living Beings Perceive the World Macro-Roles for microRNAs in the Life and Death of Neurons Paris, April 20, 2009 Epigenetics, Brain and Behavior Paris, April 18, 2011 Programmed Cells : from Basic Neuroscience to Therapy Paris, April 2, 2012 (in preparation) longevity Longevity: to the Limits and Beyond Paris, April 19, 1996 The Paradoxes of Longevity Paris, March 23, 1998 Sex and Longevity: Sexuality, Gender, Reproduction, Parenthood Paris, October 18 ,1999 Brain and Longevity Paris, October 8, 2001 Frailty and Longevity Paris, October 11, 2004 vascular tree Origins and Regenation of the Vascular Tree Paris, October 18, 2004 Life and Death of the Vascular Tree Novel Insights in Adipose Cell Functions Paris, October 9, 2006 Multi-System Endocrine Disruption Paris, October 22, 2007 Multiple Origins of Sex Differences in Brain. Neuroendocrine Functions and their Pathologies Paris, October 27, 2008 Paris, November 29, 2010 Paris, November 28, 2011 (in preparation) Paris -- February 27, 2012 Paris May 9, 2011 Characterizing Consciousness: from Cognition to the Clinic? Paris, May 3, 2010 Paris, October 17, 2005 Paris, December 4, 2009 Propagation protéinopathique Le contrôle qualité des protéines et maladies neurodégénératives dans les maladies neurodégénératives Retrotransposition, Diversity & the Brain IGFs: Local Repair and Survival Factors Throughout Life-Span Paris, December 1, 2008 Protein Quality Control Proteopathic seeds andin Neurodegenerative Diseases neurodegenerative diseases Paris, December 3, 2001 Diabetes, Insulin and Alzheimer’s Disease Two Faces of Evil: Cancer and Neurodegeneration alzheimer Paris, October 16, 1996 Paris, March 12, 2007 Paris, December 3, 2007 65, quai Georges Gorse - 92650 Boulogne-Billancourt cedex - France Tél. : +33 (0)1 58 33 50 00 – Fax : +33 (0)1 58 33 50 01 www.fondation-ipsen.org Metastasis and Invasion Spineto, May 20-23, 2007 Intracellular Traffic and Neurodegenerative Disorders Insights into Receptor Function and New Drug Development Targets Date......................................................................................................................... Are Inflammation and Cancer Linked? Cape Town, February 12-15, 2006 Paris, April 24, 2006 Paris, April 6, 2009 neurodegeneration ApoE secretase apoptosis MMS memory alpha-synuclein atrophy dementia entorhinal cortex prion neurodegeneration presenilin cortex bêta-amyloïde entorhinal cortex alpha-synuclein atrophy entorhinal cortex secretase transgenic mouse cortex atrophy alpha-synuclein BACE 1 dementia entorhinalmemory secretase prion MMS atrophy MMS epidemiology alpha-synuclein aggregation apoptosis memory notch biological markers transgenic mouse presenilin ApoE neurodegeneration prion dementia entorhinal cortex BACE 1 transgenic mouse secretase Agra, Februray 14-15, 2005 Synaptic Plasticity and the Mechanism of Alzheimer’s Disease Paris, April 28, 2008 COLLOQUES MÉDECINE ET RECHERCHE cancer science Can Cancer be treated as a Chronic Disease? The Vascular Tree Aflame! Angiogenesis and Neurogenesis Oxygen Sensing in the Vascular Tree 2FI0146 - Design : Alain Compans Registration Form colloques médecine et recherche Information Proteopathic seeds and neurodegenerative diseases Scientific Committee Mathias Jucker (Hertie-Institute Clinical Brain Research, Tübingen, Germany) Yves Christen (Fondation IPSEN, Paris, France) Paris - February 27, 2012 The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans, and appears to occur many years before the onset of clinical symptoms. The initial cause of this pathogenic cascade, and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates corruptive protein templating, or seeding, as a prime mover of the neurodegenerative process. The prion-like corruption of proteins also characterizes such clinically and etiologically diverse neurological disorders as Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of affected proteins thus could reveal universal principles and common therapeutic targets for some of the most devastating and intractable human brain disorders. Le mauvais repliement et l’agrégation de protéines spécifiques constitue un événement précoce et obligatoire pour un grand nombre de maladies neurodégénératives humaines liées à l’âge. Cet évènement semble se produire plusieurs années avant l’apparition des symptômes cliniques. La cause initiale de cette cascade pathogène et les moyens par lesquels la maladie se dissémine dans le système nerveux restent mal connus. Les recherches récentes suscitées par la découverte d’analogies pathologiques entre les maladies à prion et la maladie d’Alzheimer, conduit de plus en plus à voir dans un processus de corruption d’une protéine à une autre à partir d’un élément pathologique capable de se propager l’origine du mécanisme neurodégénératif. La corruption protéiques de type prion caractérise des troubles neurologiques aussi divers d’un point de vue clinique et neurologique que la maladie de Parkinson, la maladie de Huntington, la sclérose latérale amyotrophique et la dégénérescence lobaire frontotemporale. La compréhension du mauvais repliement, de l’agrégation, de la circulation et de la pathogénicité des protéines touchées pourrait donc aboutir à la découverte des principes universels et des cibles thérapeutiques communes à certains des troubles les plus dévastateurs et les plus incurables du cerveau humain. egistration: R Centre de Conférences et de Réceptions Etoile St-Honoré 21-25 rue Balzac - 75008 Paris, France 8:20 am Mathias Jucker and Yves Christen: Welcoming remarks SESSION 1 8:30 am Stanley Prusiner (University of California San Francisco, San Francisco, USA) The widening spectrum of prion diseases 9:00 am Robert Tycko (National Institutes of Health, NIDDK, Bethesda, USA) Beta-amyloid fibril structures, in vitro and in vivo 9:30 am Mathias Jucker (University of Tübingen, Tübingen, Germany) Prion-like properties of cerebral β-amyloidosis 10:00 am Coffee break and posters 10:30 am Claudio Soto (University of Texas Houston Medical School, Houston, USA) Induction of β-amyloid deposition by relevant routes of exposure 11:00 am Michel Gœdert (MRC Laboratory of Molecular Biology, Cambridge, UK) Prion-like properties of assembled tau 11:30 am Patrik Brundin (Lund University, Lund, Sweden) Is Parkinson’s disease a prion-like disorder? 12:00 am Virginia Lee (University of Pennsylvania School of Medicine, Philadelphia, USA) Alpha-synuclein transmission in synucleinopathies 12:30 pm Lunch and posters Fondation IPSEN Sonia Le Cornec 65, quai Georges Gorse 92650 Boulogne-Billancourt Cedex France Tél. : 33 (0)1 55 30 50 00 Fax : 33 (0)1 55 30 50 01 [email protected] Venue / Lieu Centre de Conférences et de Réceptions Etoile St-Honoré 21-25, rue Balzac 75008 Paris France Parking public Etoile Friedland à 150 mètres Métro : Charles de Gaulle Etoile (lignes 1, 2 et 6) et RER A Official language / Langue officielle English / Anglais Posters / Communications affichées Abstracts for posters should be submitted before January 15, 2012. [email protected] Les abstracts des posters doivent être soumis avant le 15 janvier 2012 [email protected] Lunch / Déjeuner SESSION 2 Fondation IPSEN sous l’égide de la Fondation de France Organization / Organisation Served on site / Servi sur place 2:00 pm Anne Bertolotti (MRC Laboratory of Molecular Biology, Cambridge, UK) Prion-like propagation of mutant SOD1 misfolding 2:30 pm Ron Kopito (Stanford University, Stanford, USA) Mechanisms of cytoplasmic penetration by polyglutamine aggregates 3:00 pm Per Westermark (Uppsala University, Uppsala, Sweden) Cross-seeding in amyloidosis 3:30 pm Coffee break and posters 4:00 pm Roland Riek (ETH Zürich, Zürich, Switzerland) Structure - activity relationship of amyloids in disease and health 4:30 pm Peter Lansbury (Brigham and Women´s Hospital, Boston, USA) Developing therapeutics for proteopathic seeds 5:00 pm Eric Kandel (Columbia University, New York, USA) Prion-like mechanisms and learning 5:30 pm Conclusion Accommodation / Hôtel You will receive, along with your registration confirmation, a list of hotels located close to the venue. Vous recevrez, avec votre confirmation d’inscription, une liste d’hôtels proches du lieu de la réunion. 65, quai Georges Gorse - 92650 Boulogne-Billancourt cedex - France Tél. : +33 (0)1 58 33 50 00 – Fax : +33 (0)1 58 33 50 01 www.fondation-ipsen.org
