Measure of dermis density

Clinical study on
The improvement of stretch
marks with a treatment of
meso-needling + LED
MESO-NEEDLING AND LED
INSTRUMENTAL STUDY ON STRETCH MARKS
Instrumental study realized by an independant clinical research center in dermatology
(GREDECO, Paris, France) on 15 subjects.

Objective : To measure the improvement of stretch marks
(abdomen, hips, buttocks), 1 recent and 14 old, with the association Mesoneedling NCTF 135HA + LED.

Protocol: 12 sessions , 1 session per week during 12 weeks
 Meso-needling NCFT135HA, (1mm needles)
 LED : Continuous red and pulsed near IR (294Hz) in the same time
during 12 minutes (8,64 Joules/cm2 for continuous red and 7,2 Joules /cm2 for pulsed NIR

Evaluation at D10 and D90 after the end of the treatment
 Dermatologic scoring on wrinkled aspect, depth of the stretch marks
 Profilometric study (Skin Station®, unit: Volume/ mm2)
 Chromatic analysis between stretch marks and normal skin
(Chromameter Konica Minolta CR/DP-400®)
 Standardized photography
 Measure of dermis density with a high-frequency ultransound
 Global efficiency score (0 to 10) done by the subjects.
MESO-NEEDLING AND LED
CLINICAL STUDY
RESULTS OF AN INSTRUMENTAL STUDY ON STRETCH MARKS
Dermatologic scoring on wrinkled aspect, and depth of the stretch marks
Stretch marks depth
Score 0 to 4 (deepest)
Wrinkled aspect
Score 0 to 4 (worse aspect)
2,50
3,00
- 61 %
2,50
P=0,00568 x 10
- 59 %
2,00
-5
P=0,00128 x 10 -7
2,00
1,50
1,50
2,33
2,63
1,00
1,00
1,37
0,50
1,40
1,05
0,00
D0
N=15
J0
10 jours après la fin
After 8dusessions
traitement
N=15
3 mois après la fin
D90
12 sessions
du after
traitement
N=15
0,95
0,50
0,00
D0 J0
N=15
Jours après la D90
3 mois
après
fin
After 810sessions
after
12lasessions
fin du traitement
du traitement
N=15
N=14
MESO-NEEDLING AND LED
INSTRUMENTAL MEASURES
 Profilometric study (Skin Station®, unit: Volume/ mm2)
 Chromatic analysis between stretch marks and normal skin (Chromameter Konica Minolta
CR/DP-400®)
Chromatic analysis (L parameter)
Profilometric study (V/mm2)
between stretch marks and normal skin
- 29 %
40,00
P=0,000035
- 47 %
2,50
35,00
P=0,026
2,00
30,00
25,00
1,50
37,48
20,00
29,69
15,00
26,71
1,00
2,04
1,58
10,00
1,09
0,50
5,00
0,00
0,00
D0
N=15
J0
10 jours après la fin 3 mois après la fin
8 sessions
after
12 sessions
du traitement D90du
traitement
After
N=15
N=15
D0J0
N=15
après la D90
3 mois
après12
la fin
After108jours
sessions
after
sessions
fin du traitement
du traitement
N=15
N=14
MESO-NEEDLING AND LED
INSTRUMENTAL MEASURES
Measure of dermis density with a high-frequency ultransound
Reflect of the collagen density increased
Dermis density
+ 25 %
P=0,00228 x 10 -4
80,00
70,00
60,00
50,00
75,11
40,00
30,00
65,83
58,22
20,00
10,00
0,00
J0
D0
N=15
10 jours après la fin du traitement
After 8 sessions
N=15
3 mois après la fin du traitement
D90 after 12 sessions
N=14
MESO-NEEDLING AND LED
PICTURES WITH ECHOGRAPHY
Visible increased of the dermis density (reflect of collagen density)
DermscanC-2D USB (20 probe, 20MHz)
Subject 4
D0
D90 after 12 sessions
MESO-NEEDLING AND LED
VISIBLE IMPROVEMENT
Very good global efficiency score done by the subjects on a 0 to 10 scale:
7,47 / 10 at 10 days after the end treatment
8,07/ 10 at 90 days after the end treatment
Subject 7
D0
D90 after end treatment
MESO-NEEDLING AND LED
VISIBLE IMPROVEMENT
Subject 4
D0
D90 after end treatment
Subject 6
D0
D10 after end treatment