THURSDAY 15th JANUARY - SiRIC

THURSDAY 15th JANUARY
From chromosomes to genes
2:00pm
Introduction
Christian Bréchot (Institut Pasteur, Paris, France)
Agnès Buzyn (Inca, Paris, France)
2:05pm-2:20pm
Chairs:
Jessica Zucman Rossi (Inserm U1162, Paris, France)
Olivier Delattre (Inserm U830, Institut Curie, Paris, France)
2:20pm-3:00pm
Timothy Triche (Director, Center for Personalized Medicine, Children Hospital, Los Angeles,
USA)
Ewing Sarcoma: Genomic insights beyond EWS-FLI1
3:00pm-3:20pm
Philippe Grandval (Gastroenterology and oncogenetic, Inserm U910, Hôpital La Timone,
Marseille)
Inherited colorectal cancer predispositions: development of an integrated tool for interpretation
of germline variations
3:20pm-4:00pm
Pieter de Jong (Scientist, Children’s Hospital Oakland Research Institute & Director,
BACPAC Resources Center, UCSF Benioff Children’s Hospital Oakland)
The evolving karyotype of small apes: factors contributing to the relative instability of the
gibbon karyotype
4:00pm-4:30pm
Coffee break
Genetic predisposition
4:30pm-4:40pm
Chairs:
Stephen Chanock (NCI, Bethesda, USA)
Fabien Calvo (Hôpital St Louis, Paris, France)
4:40pm-5:25pm
Guy Rouleau (Director of the Montreal Neurological Institute and Hospital, Chair of the
Department of Neurology and Neurosurgery, Mc Gill Univ, Montreal, Canada)
Lessons learned from cancer applied to the Brain
5:25pm-5:45pm
Ziad Albahni (UMR1149, Hôpital Robert Debré, Paris, France)
Nod2 and the epithelial barrier function
5:45pm-6:25pm
Richard Houlston (Professor of population and Molecular genetics, Cancer Research
Institute, London, UK)
Polygenic susceptibility to cancer comes of age
Reception
7:00pm
Piano Récital, Jérôme Granjon
Jérôme Granjon was awarded 1st prize for piano and chamber music at the Paris National
Conservatoire and won the Città di Senigallia international piano competition. He is often
invited to play in recital and with orchestras (Orchestre Philharmonique de Radio-France,
Orchestre National de Lille, Moscow Soloists, etc.) in Europe, the USA, Japan and Brazil.
Beethoven: Sonate n°17 en ré mineur op.31 n°2 dite "Tempête" (23')
Largo - Allegro
Adagio
Allegretto
Janacek: Dans les Brouillards, pièces 1, 3 et 4 (10')
Debussy: Pagodes, extrait des Estampes (6')
Schumann: Humoresque op.20 (27')
8:10pm
Friendly dinner party
FRIDAY 16th JANUARY
Genes and cancer
9:00am
Introduction
Thierry Philip (Institut Curie, Paris, France)
9:00am-9:10am
Chairs:
Marco Giovannini (UCLA, Los Angeles, USA)
Pierre Laurent-Puig (HEGP, Paris, France)
9:10am-9:50am
Elias Campo (Chief, Hematopathology Unit Professor of Pathology, Hospital Clinic, University
of Barcelona, Barcelona, Spain)
Chronic lymphocytic leukemia, from genomes to clinics
9:50am-10:05am
Jean Charles Nault (Inserm U1162, Paris, France)
Viral and non viral mechanisms of malignant transformation in liver carcinogenesis
10:05am-10:45am Andrew Feinberg (Gilman Scholar and Professor, Johns Hopkins University, Baltimore, USA)
The Epigenetic Basis of Human Cancer
10:45am-11:15am
Coffee break
11:15am11:25am
Chairs:
Alain Puisieux (CRCL, Centre Léon Bérard, Lyon, France)
Anne Vincent-Salomon (Institut Curie, Paris, France)
11:25am-12:05am Stephen Chanock (Director, Division of Cancer Epidemiology & Genetics, NCI, Bethesda,
USA)
Discovery of cancer susceptibility loci the Gilles way
12:05am-12:45am Serge Jothy (Pathologist at St. Michael’s Hospital, Toronto, and Professor of Pathology at the
University of Toronto, Toronto, Canada)
A new era in anatomic pathology: lessons we are learning from the expression and function of
cancer molecules
12:45am-2:00pm
Lunch
From next generation sequencing to treatment
2:00pm-2:10pm
Chairs:
Christian Bréchot (Institut Pasteur, Paris, France)
Jean Pierre Hugot (UMR1149, Hôpital Robert Debré, France)
2:10pm-2:50pm
Peter Lichter (Head of the Molecular Genetics Division at the German Cancer Research
Center/DKFZ, Heidelberg, Germany)
Integrative OMICS Analyses of Brain Tumors: Impact on Elucidation of Pathomechanisms and
Clinical Translation
2:50pm-3:10pm
David Cox (Research Associate, Centre Léon Bérard, Lyon, France)
Genetic predisposition: from tumor initiation through disease progression
3:10pm-3:50pm
Michael Stratton (Director, Wellcome Trust Sanger Institute, Cambridge, UK)
Signatures of Mutational Processes in Human Cancer
3:50pm-4:10pm
Thomas Grunewald (Post-Doc, Inserm U830 "Genetics and Biology of Cancers", Institut
Curie Research Center, Paris)
Germline variation at a polymorphic GGAA-microsatellite predisposes to EWSR1-FLI1-driven
tumorigenesis of Ewing sarcoma
4:10pm-4:50pm
Thomas Hudson (President and Scientific Director Ontario Institute for Cancer Research,
Toronto, Canada)
Challenges in Translational Research
4:50pm-5:00pm
Concluding remarks
Sylviane Olschwang (Gastroenterology and oncogenetic, Inserm U910, Hôpital La Timone,
Marseille)