Fiche UE BMC-NV508-CVB

Intitulé de l’UE STRUCTURAL METHODS FOR BIOLOGICAL
MACROMOLECULES IDENTIFICATION OF NEW THERAPEUTIC TARGETS
Code de l’UE : NV508
Responsable de l’UE :
Secrétariat :
Catherine VENIEN-BRYAN, Professeur UPMC
Mel : [email protected]
Frank SOBOTT, Professeur Antwerp University (Belgium)
Mel : [email protected]
Carine JOSEPH
Tél. : 01 44 27 35 35
Mel : [email protected]
1. Descriptif de l’UE
Volumes horaires globaux (CM, TD, TP, stage autre…) : 30 h (20 h CM + 10 h travail
personnel)
Nombre de crédits de l’UE : 3 ECTS
Mention et spécialité de Master où l’UE est proposée : Mention "Biologie Moléculaire &
Cellulaire", spécialités "Biochimie & Biologie moléculaire" et "Biophysique"
Semestre où l’enseignement est proposé : Semestre 3 du Master
Effectifs prévus : 20 dont 10 de l'UPMC
2. Présentation pédagogique de l’UE
a) Objectifs de l'Unité d'Enseignement
This course is suitable for students interested in learning more about state of the art
biophysical methods and their application to crucial biological problems and to drug design.
Biophysical methods are widely used in both industrial and academic research to study
biological macromolecules. The course aims at a compréhensive coverage of the field,
including all major structural and biophysical techniques employed for the characterization of
high and low resolution structure, structural transition, macromolecular assemblies and
interactions with small molecules. The students will study a wide range of problems from a
structural and mechanistic perspective using a range of structural biology methods including
x-ray crystallography, modeling and drug design, cryo-electron microscopy and mass
spectrometry.
b) Thèmes abordés
The course will provide innovative and ambitious teaching programs.
It will be delivered and monitored simultaneously at the Antwerp University, Belgium and at
the UPMC, Paris and will include lectures on :
• X-ray crystallography and drug design (Dr David Banner Hoffmann-La Roche, Basel)
• Mass spectrometry (Prof. Frank Sobott, Antwerp University)
• Cryo-electron microscopy combined with image analysis analysis (Prof. Catherine VénienBryan,UPMC, Paris)
• Modeling and Drug design (Dr Paul Emsley, University of Oxford)
These biophysical foundations will be applied to biological topics medically important, with
the view to developing new drugs.
c) Organisation pédagogique
The course will be mostly lecture based with some demonstrations.
Language: English
Reference material: English-posted on the course web site
Teaching schedule: classes will be given in February or March over two weeks.
The course will be delivered in real time in Paris with a video conference link to Antwerp.
All the course notes and material will be in English, the course and reference materials will be
available well in advance and posted on the course website.
.
Mode of assessment: students will be assessed on a written essay. In addition, each student
will present a recent publication (15 minutes talk) selected from a list of articles provided by
the lecturers.
d) Pré-requis
-This international course is aimed at postgraduate students (level Master 2 or PhD).
-Basic knowledge of structural biology and/or protein biochemistry and/or of physical
chemistry.
3. Equipe pédagogique
Cours magistraux par vidéoconférence : Catherine Vénien-Bryan (UPMC), Frank Sobott
(Antwerp University, Belgium), David Banner (Hoffman La Roche, Basel, Switzerland) and
Paul Emsley (University of Oxford, UK).