annexes to the DHU FIRE project (19.10.11)
Transcription
annexes to the DHU FIRE project (19.10.11)
CV - Jamel EL BENNA Title and position: Ph.D., Research Director at CNRS. Laboratory Head: INSERM U773, Faculté de médecine Xavier Bichat, Université Paris7, 75018 Paris, France, Tél : 01 57 27 77 23. Email : [email protected] Diplomas: Master’s degree in Biochemistry and Biology (Paris XI-Orsay-University) (1988) Thesis and Ph.D degree in sciences (Paris XI-Orsay-University) (1992) HDR (Diplôme d’Habilitation à Diriger des Recherches) (University Paris-VII) (2003). Employment : 1992-1995: post-doctoral position in the Biochemistry department (Pr. Bernard Babior), The Scripps Research Institute-La Jolla -California, USA. 1995-1996: Research Scientist (CR1) at CNRS. 1996-present : Research Director (DR2) at CNRS. Scientific functions: -Supervisor of a research group in INSERM U479 unit (1998-2004) -Supervisor of a research group in INSERM U683/U773 unit (2005-2008) -Supervision of 8 thesis ; examiner of 10 thesis -Scientific Expertise for : ANR, INSERM, CNRS, Swiss Science Fondation et several associations. -Organisation of 2 meetings. -Member of the editorial Board: Biochem. Pharmacol, Open J. Inflammation, Am. J. Blood Research. -Referee for scientific reviews (JBC, Blood, J.Immunol, J.Leuk.Biol, EMBOJ, Biochem.Pharmacol….) -Member of the scientific committee of “bio-therapy.net“ site -Member of the faculté X.Bichat executive board (2000-2004). Teaching : in 3 Masters (University Paris 7-Saint Louis, University Paris 7-Bichat, University Paris 11-Orsay) and University of Tunis Tunisia. Grants and patents : grant from ANR (2008-2010), ARC (2 contrats), ARP (4 contrats), American Arthritis Foundation Award (USA), patent (US60/774,653 ; 60/774,653). Membership : American Society for Biochemistry and Molecular Biology (ASBMB), American Association for the Advancement of Science (AAAS), The Society for Free Radical Research International (SFRRI). Publications and communications: (For PubMed search please use “Benna J”): 91 publications, 8 book chapters, 85 abstracts, 25 invited speaker. BIBLIOGRAPHY – Jamel EL BENNA PRODUCTIONS SCIENTIFIQUES 1. Publications dans des revues avec comité de lecture : (pour voir toutes les publication sur PubMed utilisez ‘Benna J’) 1. Labro M.T., El Benna J. and Babin-Chevaye C . : Comparison of the in vitro effect of several macrolides on the oxidative burst of human neutrophils. J. Antimicrob. Chemother. 1989, 24, 561-572. 2. El Benna J. and Labro M.T. : Effect of quinine and cinchonine on human neutrophil functions in vitro. J. Antimicrob. Chemother. 1990, 25, 949-957. 3. Labro M.T. and El Benna J. : Synergistic bactericidal interaction of josamycin with human neutrophils in vitro. J. Antimicrob. Chemother. 1990, 26, 515-524. 4. Labro M.T. and El Benna J. : Comparison of cefodizime with various cephalosporins for their indirect effect on the human neutrophil oxidative burst in vitro. J. Antimicrob. Chemother. 1990, 26, suppl. C, 49-57. 5. Gaudry M., Combadière C., Marquetty C., Sheibani A., El Benna J. and Hakim J. : Dissimilarities in superoxide anion production by human neutrophils stimulated by phorbol myristate acetate or phorbol dibutyrate. Immunopharmacol. 1990, 19, 23-32. 6. Labro M.T. and El Benna J. : Synergie entre la josamycine et un stress oxydant pour la bactéricidie des staphylococcus aureus. Pathol. Biol. 1990, 38, 450-454. 7. Labro M.T. and El Benna J. : Effect of monodesethylamodiaquine on polymorphonuclear neutrophil functions in vitro. Antimicrob. Agents Chemother. 1991, 35 : 824-830. 8. El Benna J., Pasquier C. and Labro M.T. : Quinine uptake by human polymorphonuclear neutrophils. Antimicrob. Agents Chemother. 1991, 35, 1474-1478. 9. Labro M.T., El Benna J. : Effects of anti-infectious agents on polymorphonuclear Clinical Microbiol. Infect. Dis. 1991, 10, 124-131. neutrophils. Europ. J. 10. El Benna J., Hakim J. and Labro M.T. : Inhibition of human neutrophil protein kinase C activity antimalarial drug mefloquine. Biochem. Pharmacol. 1992, 43 : 527-532. by the 11. Labro M.T., El Benna J., Jemni A. : Bacterial alterations induced by subinhibitory concentrations of cefixime : consequences on bactericidal function of human polymorphonuclear neutrophils in vitro. (In French). Pathol. Biol. 1992, 40 : 427-432. 12. Labro M.T., El Benna J., Abdelghaffar H. : Modulation of human polymorphonuclear neutrophil by macrolides. Preliminary data concerning Dirithromycin. J. Antimicrob. Chemother. 1993, 31 : 51-64. 13. Combadière C., El Benna J., Pedruzzi E., Hakim J., Périanin A. : Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor staurosporine. Blood 1993, 82 : 28902898. 14. Labro M.T., El Benna J., Charlier N., Abdelghaffar H., Hakim J. : Cefdinir (CI-983) : a new oral amino-2thiazolyl cephalosporin inhibits human neutrophil myeloperoxidase in the extracellular medium but not the phagolysosome. J. Immunol. 1994, 152 : 2447-2455. 15. El Benna J., Ruedi J.M., Babior B.M. : The cytosolic guanine nucleotide-binding protein Rac2 operates in vivo as a component of the neutrophil respiratory burst oxidase. Transfer of Rac2 and the cytosolic oxidase components during oxidase activation. J. Biol. Chem. 1994, 269 : 6729-6734. 16. *Park J.W., *El Benna J., Scott K.E., Christensen B.L., Chanock S., Babior B.M. : Isolation of a complex of respiratory burst oxidase components from resting neutrophil cytosol. Biochemistry. 1994, 33 : 2907-2911. ( * Il est signalé dans cette publication que les 2 premiers auteurs ont contribué de manière équivalente à ce travail. ) 17. El Benna J., Faust L.P., Babior B.M. : The phosphorylation of the respiratory burst oxidase component p47 phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases. J. Biol. Chem 1994, 269 : 23431-23436. 18. El Benna J., Labro M.T., Hakim J. : Resolution of major protein kinase substrates in neutrophil cytosol in response to DAG/PS and arachidonic acid stimulation and the selective action of various protein kinase inhibitors. Cell. Signal. 1994 6 : 167-171. 19. Chanock S.J., El Benna J., Smith R.M., Babior B.M. : The respiratory burst oxidase. J. Biol. Chem. 1994, 269 : 24519-24522. 20. *Faust L. P., *El Benna J., Babior B.M., and Chanock S.J.: The phosphorylation targets of p47phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesis. J. Clin. Invest.1995,96:1499-1505. (* Il est signalé dans cette publication que les 2 premiers auteurs ont contribué de manière équivalente à ce travail. ) 21. El Benna J., Park J-W., Ruedi J.M., and Babior B.M.: Cell-free activation of the respiratry burst oxidase by protein kinase C. Blood. Cells. Mol. Dis. 1995, 21:201-206. 22. El Benna J. Faust L.P., Johnson J.L., and Babior B.M.: Phosphorylation of the respiratory burst oxidase subunit p47phox as determined by 2-dimensional phosphopeptide mapping. Phosphorylation by protein kinase C, protein kinase A and a mitogen-activated protein kinase. J. Biol. Chem. 1996,271:6374-6378. 23. El Benna J. , Han J., Park J.W., Schmid E., Ulevitch R. J., Babior B.M.: Activation of p38 in stimulated human neutrophils. Phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK. Arch. Biochem. Biophys. 1996, 334:395-400. 24. Park J-W., Hoyal C.R., El Benna J. and Babior B.M.: Kinase-dependent activation of the leukocyte NADPH oxidase in a cell-free system: phosphorylation of membranes and p47phox during oxidase activation. J. Biol. Chem. 1997, 272: 11035-11043. 25. El Benna J., Dang MCP, Gaudry M., Fay M., Morel F., Hakim J., Gougerot-Pocidalo M.: Phosphorylation of the respiratory burst oxidase subunit p67phox during human neutrophil activation: regulation by PKC-dependent and independent pathways. J. Biol. Chem. 1997, 272: 17204-17208. 26. Inanami O., Johnson J.L, McAdera J.K., El Benna J., Faust L.P., ., Newburger P.E. and B.M. Babior. Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47phox on serine S303 or S304. J. Biol. Chem. 1998 , 273: 9539-9543. 27. Cachia O, El Benna J, Pedruzzi E, Descomps B., Gougerot-Pocidalo M-A and Léger LC. æ-Tocophérol inhibits the respiratory burst in human monocytes. Attenuation of p47phox membrane translocation and phosphorylation. J. Biol. Chem. 1998,273:32801-32805. 28. Johnson J.L, Park JW, El Benna J., Faust L.P., Inanami O, and B.M. Babior. Activation of p47phox, a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser359 or 370 precedes phosphorylation at other sites and is required for activity. J. Biol. Chem. 1998,273:35147-35152. 29. Gaudry M., Brégerie O., Andrieu V., El Benna J., Pocidalo M-A., and Hakim J.: Intracellular pool of vascular endothelial growth factor in human neutrophils. Blood. 1997, 90: 4153-4161. 30. Schmid E., El Benna J., Galter D., Klein G. and W. Droge. Redox priming of the insulin receptor beta-chain associated with altered tyrosine kinase activity and insulin responsiveness in the abence of tyrosine phosphorylationby. FASEB Journal. 1998, 12: 863-870. 31. Dang MCP, Dewas, C., Gaudry M., Fay M., Pedruzzi, E., Gougerot-Pocidalo M., and El Benna, J.: Priming of human neutrophil respiratory burst by GM-CSF involves partial Phosphorylation of p47phox. J. Biol. Chem. 1999, 274: 20704-20708. 32. El Benna J., Dang PMC., Andrieu V., Vergnaud S., Dewas C., Cachia O., Fay M., Morel F., Chollet-Martin S., Hakim J. and Gougerot-Pocidalo M-A.: P40phox associates with the neutrophil Triton X-100-insoluble cytoskeletal fraction and PMA-activated membrane skeleton, a comparative study with p67phox and p47phox. J. Leukocyte Biology. 1999, 66, 1014-1020. 33. Vergnaud S., Paclet M.H., El Benna J., Pocidalo M-A., Morel F. Complementation of NADPH oxidase in p67phox-deficient CGD patients p67-phox/p40-phox interaction. Eur. J. Biochem. 2000, 267, 1059-1067. 34. Dewas C., Fay M., Gougerot-Pocidalo M-A and El Benna J. The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils. J. Immunology. 2000, 165,5238-5244. 35. Ogier-Denis E., Pattingre S., El Benna J., and Codogno P. ERK1/2-dependent phosphorylation of GAIP stimulates its GTPase accelarating capacities and autophagy in human colon cancer cells. J. Biol. Chem. 2000. 275, 39090-39095. 36. Dang P-M., Fontayne A., Hakim J., El Benna J., and A. Périanin. Protein kinase C z (zeta) phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and regulates the respiratory burst of f-MetLeu-Phe-stimulated human neutrophils. J. Immunology. 2001, 166, 1206-1213. 37. ElBim C., Réglier H., Fay M., Delarche C., Andrieu V., El Benna J., and Gougerot-Pocidalo M-A. Intracellular pool of IL-10 receptors in specific granules of human neutrophils. Differential mobilization by proinflammatory mediators. J. Immunology. 2001, 166, 5201-5207. 38. Gérard B., El Benna J., Alcain F., Gougerot-Pocidalo M-A., Grandchamps B., and Chollet-Martin S. Characterization of 11 novel mutations in the X-linked chronic granulomatous disease (CYBB gene). Human Mutations. 2001, 18, 163. 39. Grenier A., Chollet-Martin S., Crestani B., Delarche C., El Benna J., Boutten A., Andrieu V., Durand G., Gougerot-Pocidalo M-A., Aubier M. and Dehoux M. Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophils. Blood. 2002, 99, 2997-3004. 40. El Benna J., Hayem G, Dang PMC, Fay M., Elbim C., Chollet-Martin S., Meyer O., and Gougerot-Pocidalo MA. Polymorphonuclear neutrophil NADPH oxidase priming and p47phox phosphorylation in rheumatoid joints. Inflammation, 2002, 26, 273-278. 41. Fontayne A., Dang P-M., Gougerot-Pocidalo M-A., El Benna J. Phosphorylation of p47phox sites by PKC alpha, beta, delta and zeta : effect on binding to p22phox and NADPH oxidase activation. Biochemistry. 2002, 41, 7743-7750. 42. Thabut G., El Benna J., Samb A., Corda S., Megret J., Leseche G., Vicaut E., Aubier M., Boczkowski J. Tumor necrosis factor-a increases airway smooth muscle oxidants production through a NADPH oxidase-like system to enhance myosin light chain phosphorylation and contractility. J. Biol. Chem. 2002, 277, 22814-22821. 43. Gougerot-Pocidalo M-A, El Benna J., Elbim C., Chollet-Martin S., Dang MC. Regulation of human neutrophil oxidative burst by pro- and anti-inflammatory cytokines. J. Soc. Biol. 2002, 196, 37-46. 44. Dang PMC., Morel, F., Gougerot-Pocidalo M-A., El Benna J. Phosphorylation of the NADPH oxidase PHOX component p67 by ERK2 and p38MAPK : Selectivity of the phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich region. Biochemistry. 2003, 42, 4520-4526. 45. Dewas C., Dang PMC., Gougerot-Pocidalo M-A and El Benna J. Tumor necrosis factor (TNF-a)lpha) induces phosphorylation of p47phox in human neutrophils: partial phosphorylation of p47phox is a common event of the priming of human neutrophils by TNF-alpha and granulocyte-macrophage colony-stimulating factor (GM-CSF). J. Immunol. 2003, 171, 4392-4398. 46. Marie J.C., Rouyer-Fessard C., Couvineau A., Nicole P., El Benna J., and Laburthe M. Serine 447 in the carboxy tail of human VPAC1 receptor is crucial for agonist-induced desensitization but not internalization of the receptor. Molecular Pharmacology 2003, 64, 1565-1574. 47. O’Dowd YM., El-Benna J., Perianin A., and Newsholme P. Inhibition of formyl-methionyl-leucyl-phenylalaninestimulated respiratory burst in human neutrophils by adrenaline: Inhibition of Phospholipase A2 activity but not p47phox phosphorylation and translocation. Biochem. Pharmacology, 2004, 67, 183-190. 48. Ancelin M., Chollet-Martin S., Hervé M.A., Legrand C., El Benna J., and Perrot-Applanat M. Vascular endothelial growth factor VEGF189 induces human neutrophil chemotaxis in extravascular tissue via an autocrine amplification mechanism. Laboratory Investigation , 2004,84, 502-512. 49. Taillé C., El-Benna J., Dang PMC., Ogier-Denis E., Aubier M., and J. Boczkowski. Induction of Heme phox Oxygenase-1 inhibits NADPH oxidase activity in murine macrophages by limiting heme availability for gp91 expression. J. Biol. Chem. 2004, 279, 28681-28688. 50. Ethuin F., Gérard B., El Benna J., Boutten A., Gougerot-Pocidalo M-A., Jacob L. et Chollet-Martin S. Human neutrophils produce interferon gamma upon stimulation by interleukin-12. Laboratory Investigation, 2004, 84, 1363--1371. 51.O’Dowd Y., Driss F., Dang PMC, Elbim C., Gougerot-Pocidalo MA., Pasquier C., and El-Benna J. Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil : scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils. Biochemical Pharmacology, 2004, 68, 2003-2008. 52. Gillibert M., Dehry Z, Terrier M, El Benna J, and Lederer F. Another biological effect of Tosyl phenylalanine phox chloromethyl ketone: it prevents p47 phosphorylation and translocation upon neutrophil stimulation Biochem. J. 2005, 386, 549-556. 53. Kustermans G, El-Benna J, Piette J, and Legrand-Poels S. Perturbation of actin dynamics induces NF-kB activation in myelomonocytic cells via NADPH oxidase-dependent pathway. Biochem. J. 2005, 387, 531-540. 54. ElBim C., Guichard C., Dang PMC., Fay M., Demur H., Pouzet C., El Benna J., and Gougerot-Pocidalo M-A. Interleukin-18 primes the oxydative burst of neutrophils in response to formyl-peptides : rôle of cytochrome b558 translocation and fMLP receptor endocytosis. Clin. Diagnost. Lab. immunol. 2005, 12, 436-446. 55. François S., El-Benna J, Dang PMC, Gougerot-Pocidalo MA., and Elbim C. Inhibition of neutrophil apoptosis by toll-like receptor (TLR) agonists in whole blood : implication of the phosphoinositide 3-kinase/Akt and NF-kB signaling pathways, leading to increased levels of Mcl-1, A1 and phosphorylated Bad. J. Immunology. 2005, 174, 3633-3642. 56. Taillé C., El-Benna J., Lanone S., Mann B.E., Boczkowski J., and R. Motterlini. Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle. J. Biol. Chem. 2005, 280, 25350-25360. 57. Lanone S., Bloc S., Foresti R., Almolki A., Taillé C., Callebert J., Conti M., Goven D., Aubier M., Dureuil B., ElBenna J., Motterlini R., Boczkowski J. Bilirubin decreases NOS2 expression via inhibition of NAD(P)H oxidase: Implication for protection against endotoxic shock in rats. The FASEB Journal. 2005, 19,1890-1892. 58. El-Benna J, Dang PMC, Gougerot-Pocidalo MA., and Elbim C. The phagocyte NADPH oxidase: a multicomponent enzyme essentiel for host defense. Archivum Immunologie et Therapie Experimentalis (AITE), 2005, 53, 199-206. 59. Paruch S, El-Benna J, Djerdjouri B, Marullo S, and Périanin A. The p44/42 Mitogen-activated protein kinases mediates phospholipase D activation by the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine in Neutrophil-like HL-60 cells. The FASEB Journal. 2006, 20, 142-144. 60. Dang PMC, Elbim C., Marie J.C., Chiandotto M., Gougerot-Pocidalo MA, and El-Benna J. The antiinflammatory effect of IL10 on human neutrophil respiratory burst invoves inhibition of GM-CSF-induced p47phox phosphorylation through a decrease in ERK1/2 activity. The FASEB Journal. 2006, 20, 1504-1506. 61. Dang PMC, Stensballe A, Boussetta T, Raad H, Dewas C, Kroviarsky Y, Hayem G., Jensen ON, GougerotPocidalo MA, and El-Benna J. A specific p47phox-serine phosphorylated by convergent MAPKinases mediates neutrophil NADPH oxidase priming at inflammatory sites. The Journal of Clinical Investigation. 2006, 116, 20332043. 62. Gougerot-Pocidalo MA., and Elbim C, Dang PMC, El-Benna J. Polynucleaires neutrophiles humains et deficits immunitaires primitifs. La presse Médicale, 2006, 35, 871-878. 63. Chollet-Martin S, Lopez A, Gaud C, Henry D, Stos B, El Benna J, Chedevile G, Gendrel D, Gougerot-Pocidalo MA, Grandchamp B, Gerard B. Severe X-linked chronic granulomatous disease in two unrelated females. Eur. J. Pediatr. 2007, 166:153-159. 64. Cazenave S, Berson A, Haoizi D, Vadrot N, Fau D, Grodet A, Lettéron P, Feldman G, El-Benna J, Fromenty B, Robin MA, Pessayre D. High hepathic glutathione stores alleviate Fas-induced apoptosis in mice. J. Hepathology 2007, 46(5):858-868. 65. Yang CS, Lee DS, Song CH, Ahn SJ, Li S, Kim JM, Kim KS, Yu DG, Jeon BH, Lee TH, Lee ZW, El-Benna J, Yu DY, and Jo EK. Role of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. The Journal of Experimental Medecine, 2007, 204: 583-594. 66. Jancic C, Savina A, Wasmeier C, Tolmachova T, El-Benna J, Dang PMC, Pascolo P, Gougerot-Pocidalo MA, Raposo G, Seabra MC and Amigorena S. Rab27a regulates phagosomal pH and NADPH-oxidase activity in dendritic cell phagosomes. Nature Cell Biology, 2007, 9:367-378. 67. Hoarau C, Gérard B, Lescanne E, Henry D, François S, Lacapère JJ, El-Benna J, Dang PMC, Grandchamp B, Lebranchu Y, Gougerot-Pocidalo MA. and Elbim C. TLR9 activation induces neutrophil responses in a child with IRAK4 deficiency: Involvement of the direct PI3K pathway. J. Immunology. 2007, 179:4754-4765. 68.Yang CS, Lee HM, Lee JY, Kim JA, Lee SJ, Shin DM, Lee YH, Lee DS, El-Benna J, Jo EK. Reactive oxygen species and p47phox activation are essential for the Mycobacterium tubercolisis-induced pro-inflammatory response in murine microglia. J. Neuroinflammation, 2007, 4 :27. 69. Gougerot-Pocidalo MA, El Benna J, Dang PM, Elbim C. Pathogens trapped in neutrophil nets. Med Sci (Paris). 2007, 23: 464-465. 70. El-Benna J, Dang PMC, Gougerot-Pocidalo MA. The role of the NADPH oxidase systems Nox and Duox in host defense and inflammation. Expert Review of Clinical Immunology, 2007,3 :111-115. 71. Yang CS, Shin DM, Lee HM, Son JW, Lee SJ, Akira S, Gougerot-Pocidalo MA, El-Benna J, Ichijo H, and Jo EK. ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signaling. Cellular Microbiology, 2008,10:741-754. 72. Qian L, Wei SJ, Zhang D, Wilson B, El-Benna J, Hong JS, and Flood PM. TGFb1 mediates an antiinflammatory and neuroprotective effect on the microglial cell respiratory burst through the inhibition of ERKphox mediated p47 -Ser345 phosphorylation and translocation. J. Immunol. 2008, 181, 660-668. 73. Almolki A, Guenegou A, Golda S, Boyer L, Benallaoua M, Amara N, Bachoual R, Martin C, Rannou F, Lanone S, Dulak J, Burgel PR, El-Benna J, Leynaert AB, Aubier M, Boczkowski J. Heme Oxygenase-1 Prevents Airway Mucus Hypersecretion Induced by Cigarette Smoke in Rodents and Humans. Am J Pathol. 2008, 173, 981-992. 74. Kannengiesser C, Gérard B, El Benna J, Dominique Henri, Sylvie Chollet-Martin, Marie-Anne GougerotPocidalo , Carole Elbim and Bernard Grandchamp . Molecular epidemiology of chronic granulomatous disease in a series of 80 kindred, France, identification of 31 novel mutations. Human Mutation 2008, 29(9):E132-E149. 75. El-Benna J, Dang PM, Gougerot-Pocidalo MA. Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane. Semin Immunopathol. 2008 Jul;30(3):279-89. Review. 76. Pongnimitprasert N, El-Benna J, Foglietti MJ, Gougerot-Pocidalo MA, Bernard M, Braut-Boucher F. Potential role of the "NADPH oxidases" (NOX/DUOX) family in cystic fibrosis. Ann Biol Clin (Paris). 2008 NovDec;66(6):621-629. Review. 77. Raad H, Paclet MH, Boussetta T, Kroviarski Y, Morel F, Quinn MT, Gougerot-Pocidalo MA, Dang PM, ElBenna J. Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox. FASEB J. 2009;23(4):1011-1022. 78. Roux D, Gaudry S, Dreyfuss D, El-Benna J, de Prost N, Denamur E, Saumon G, Ricard JD. Candida albicans impairs macrophage function and facilitates Pseudomonas aeruginosa pneumonia in rat. Crit Care Med. 2009;37(3):1062-1067. 79. Khaldi H, Marchand-Adam S, Kannengiesser C, Fabre A, Debray MP, Danel C, Gougerot-Pocidalo MA, El Benna J, Humbert M, Aubier M, Crestani B. Diffuse interstitial pneumonia and pulmonary hypertension: a novel manifestation of chronic granulomatous disease. Eur Respir J. 2009 Jun;33(6):1498-502. 80. Boussetta T, Raad H, Lettéron P, Gougerot-Pocidalo MA, Marie JC, Driss F, El-Benna J. Punicic acid a conjugated linolenic acid inhibits TNFalpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats. PLoS One. 2009 Jul 31;4(7):e6458. PubMed PMID: 19649246 81. Hájková V, Svobodová A, Krejčová D, Cíž M, Velebný V, Lojek A, El-Benna J, Kubala L. Soluble glucomannan isolated from Candida utilis primes blood phagocytes. Carbohydr Res. 2009;344:2036-2041. 82. El-Benna J, Dang PM, Gougerot-Pocidalo MA, Marie JC, Braut-Boucher F. p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases. Exp Mol Med. 2009 Apr 30;41(4):217-225. Review. 83. Kroviarski Y., Debbabi M., Bachoual R., Périanin A., Gougerot-Pocidalo M.A., El-Benna J. and Dang P.M. Phosphorylation of NADPH oxidase activator 1 on serine 282 by MAP Kinases and on serine 172 by Protein Kinase C and Protein Kinase A prevents NOX1 hyperactivation. FASEB. J. 2010 Jun;24(6):2077-92. Epu 2010 Jan 28. PubMed PMID: 20110267. 84. Mohapatra NP, Soni S, Rajaram MV, Dang PM, Reilly TJ, El-Benna J, Clay CD, Schlesinger LS, Gunn JS. Francisella Acid Phosphatases Inactivate the NADPH Oxidase in Human Phagocytes. J Immunol. 2010 May 1;184(9):5141-50. 85. El-Benna J, Dang PM, Périanin A. Peptide-based inhibitors of the phagocyte NADPH oxidase. Biochem Pharmacol. 2010 Sep 15;80(6):778-85. Epub 2010 May 25. Review. PubMed PMID: 20510204. 86. Patel S, Franyal AM, Dang PMC, El-Benna J and Périanin A. Formylpeptides-mediated stimulation of protein kinase B (AKT) in neutrophilic HL-60 cells is essential for the activation of p44/42 MAP kinases and phospholipase D, and promotes superoxide production. J Biol Chem. 2010; 285(42):32055-63. Epub 2010 Aug 6. 87. Boussetta T, Gougerot-Pocidalo MA, Hayem G, Ciappelloni S, Raad H, Arabi-Derkawi R, Bournier O, Kroviarski Y, Zhou XZ, Malter JS, Lu PK, Bartegi A, Dang PMC and El-Benna J. The prolyl isomerase Pin1 acts as a novel molecular switch for TNFa-induced NADPH oxidase priming in human neutrophils. Blood 2010, 116(26):5795-802. Epub 2010 Oct 18. PubMed PMID: 20956805. 88. Klimchenko O, Di Stefano A, Geoerger B, Hamidi S, Opolon P, Robert T, Routhier M, El-Benna J, Delezoide AL, Boukour S, Lescure B, Solary E, Vainchenker W, Norol F. Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions. Blood. 2011, 117: 30653075. PubMed PMID: 21149635. 89. Bachoual R, Talmoudi W, Boussetta T, Braut F, El-Benna J. An aqueous pomegranate peel extract inhibits neutrophil myeloperoxidase in vitro and attenuates lung inflammation in mice. Food Chem Toxicol. 2011, 49: 1224-1228. PubMed PMID: 21376769. 90. Dang PM, Raad H, Derkawi RA, Boussetta T, Paclet MH, Belambri SA, Makni-Maalej K, Kroviarski Y, Morel F, Gougerot-Pocidalo MA, El-Benna J. The NADPH oxidase cytosolic component p67phox is constitutively phosphorylated in human neutrophils: Regulation by a protein tyrosine kinase, MEK1/2 and phosphatases1/2A. Biochem Pharmacol. 2011. [Epub ahead of print] PubMed PMID: 21784060 (sous presse). 2. Publications dans des actes de colloque avec comité de lecture : 1. Labro M.T., Bryskier A., Babin-Chevaye C., El Benna J. : Interaction of antimalarial drugs with human neutrophil functions. International Congress for Infectious Diseases. Rio de Janeiro 17-21 Avril 1988. 2. Labro M.T., El Benna J., Bryskier A : Interaction of antimalarial agents with human neutrophils in vitro. Biennal Conference on Chemotherapy of Infectious Diseases and Malignancies. Montreux, (Suisse) 5-8 Mars 1989. 3. El Benna J., Labro M.T., Babin-Chevaye C. : Effects of quinine on human neutrophil functions in vitro. The Proceedings of the 16th International Congress of Chemotherapy, Jérusalem, June 1989. 4. Labro M.T., El Benna J. : Synergie entre la Josamycine et un stress oxydant pour la bactéricidie de S. aureus. Réunion Interdisciplinaire de Chimiothérapie Antiinfectieuse, Paris, 7 Décembre 1989. 5. Labro M.T., El Benna J., Babin-Chevaye C. : Effects of Fleroxacin (RO-236240) on human neutrophils bactericidal function. 29th ICAAC, Houston (Texas) 17-20 Septembre 1989. 6. El Benna J. : Interaction des antipaludéens avec le polynucléaire neutrophile humain. Colloque de la Société de Biologie Cellulaire de France, Société de Chimie Biologique. Orsay, 27-29 Septembre 1989. 7. Labro M.T., El Benna J. : Comparison of Cefodizime with various cephalosporins for their indirect effect on neutrophils oxidative burst. International Congress for Infectious Diseases. Montréal, Canada, 15-19 Juillet 1990. 8. El Benna J., Labro M.T. : Quinine (Qn) uptake by human neutrophils (PMN). International Congress for Infectious Diseases. Montréal, Canada, 15-19 Juillet 1990. 9. El Benna J., Labro M.T. : Quinine uptake by human neutrophils (PMN) 31st Interscience Conference on Antimicrobial Agents and Chemotherapy. ICAAC, Chicago, 29 Septembre-2 Octobre 1991. 10. El Benna J., Jemni A., Labro M.T. : Modification des bactéries induites par le Cefixime (CFX) à concentrations sub-inhibitrices. Réunion Interdisciplinaire de Chimiothérapie anti-infectieuse. Paris, 5-6 Décembre 1991. 11. Labro M.T., El Benna J. : Interaction of macrolides and quinolones with the host defence system. 2nd International Conference on Progress in Pathogen-Antibiotic Interactions, Turin, 24-28 Septembre 1991. 12. Labro M.T., El Benna J. : Interaction of antibiotics with the phagocyte oxidative burst. 2nd International Congress of the Immune Consequences of Trauma, Shock and Sepsis. Munich, 6-9 Mars 1991. 13. Labro M.T., El Benna J. : CI-983 (Cefdinir) has different effect on PMN oxidative burst triggered by soluble and particulate stimuli. ASM General Meeting. New Orleans USA, 26-30 Mai 1992. 14. Labro M.T., El Benna J. Barre J. : Effect of roxithromycine (ROX) and erythromycin (ERY) on human neutrophil (PMN) functions ex vivo. In Program and Abstracts of the First International Conference on Macrolides, Azalides and Streptomycines. Santa Fe, NM, 1992, Abstract 175. 15. El Benna J., Babior B.M. : Participation of the subplasmallemmal actin cytoskeleton in the activation of the respiratory burst oxidase of human neutrophils. FASEB J. 1993, 7 : A1079. 16. El Benna J., Chanock S.J., Christensen B, Faust LP., Babior B.M. : The phosphorylation of P47phox, a cytosolic component of the respiratory burst oxidase. The American Society of Hematology Meeting. Décembre 1993. Blood 1993, 82 Abstr. 733. 17. Faust L.P., El Benna J., Christensen B., Chanock S.J. and Babior B.M. : The study of p47 phox phosphorylation by site-directed mutagenesis in B-lymphocytes. FASEB J. 1994, 8 Abstract 523. 18. Faust LP, El Benna J, Christensen B, Babior BM, Chanock SJ. Inactivation of the respiratory burst oxidase by the elimination of phosphorylation targets in p47phox. Blood, 1994, vol 84, Abst. 1474. 19. Faust LP, El Benna J., and Babior BM. Evidence for the existence of multiple pathways for the activation of the respiratory burst oxidase in B lymphocytes. FASEB J,1995, vol 9, Abst. 190. 20.Johnson JL, Park JW, El Benna J, Inanami O, and Babior BM. Phosphorylation-dependent activation of the respiratory burst oxidase. Blood, 1996, vol 88, Abst. 2476. 21. El Benna J., Dang MCP, Gaudry M., Fay M., Morel F., Hakim J., Gougerot-Pocidalo M.: Phosphorylation de la p67phox du polynucléaire neutrophile humain. VIème colloque "de la recherche à la découverte". Réunion de la section 22 du CNRS: thérapeutique et médicaments,concepts et moyens. Mars 1997, Reims, France. 22. Hoyal C., Park, J-W, El Benna J., and Babior B.M. Protein kinase-mediated activation of the NADPH oxidase in a cell-free system. FASEB J. 1997, 11:3085. 23.Cachia O, El Benna J, Pedruzzi E, Gougerot-Pocidalo and Léger LC. alpha-tocophérol inhibits the respiratory burst in human monocytes. Attenuation of p47phox membrane translocation and phosphorylation. The third congress of the international society for the study of fatty acids and lipids (ISSFAL), Fatty acids and lipids, from cell biology to human disease. Juin 1998, Lyon, France. 24. Vergnaud S, Paclet MH, El Benna J, Stasia MJ, Martel C, Pocidalo MA and Morel F. Reconstitution of NADPH oxidase activity in p67phox (-) chronic granulomatous disease. Down regulation by p40phox complementation. European society for clinical investigation, 33 rd annual Scientific meeting, 7-10th April 1999, Milan, Italy. 25. Pasquier C., and El Benna J. Vitamin E inhibits tha activation of protein kinase C involved in monocyte activation and cell proliferation. Dietary factors and cardiovascular diseases. 20-23 June 1999, Viterbo, Italy. 26. El Benna J, Dang PM-C, Dewas, C, et M-A Gougerot-Pocidalo. Phosphorylation de la p47phox dans les polynucleaires neutrophiles humains: Phosphorylation différentielle suivant l’agoniste utilisé. VIIème colloque “ De la recherche à la découverte ” Réunion de la section 22. 13 et 14 Avril 2000, Paris,France. 27. El Benna J, Dang PM-C, Dewas, C, et M-A Gougerot-Pocidalo. Pro-inflammatory cytokines induce p47phox phosphorylation in human neutrophils. The european society for clinical investigation, 34th annual scientific meeting. 17-20 May 2000, Aarhus, Denmark. 28. Hayem G., El Benna J., Fay M., Chollet-Martin S., Meyer O., and Gougerot-Pocidalo M-A. Polymorphonuclear neutrophil NADPH oxidase priming and activation in rheumatoid joints: correlation with disease activity and synovial concentrations of TNF, IL-8 and GM-CSF. Am. Soc. Rheumatol. 2000. 29. Dewas C., Dang PM-C., Gougerot-Pocidalo M-A., et El Benna J. Les cytokines proinflammatoires induisent la Phosphorylation de la p47phox dans les polynucleaires neutrophiles humains - Etude comparative et analyse des voies transductionnelles. Réunion annuelle de la SFI (société française d’immunologie), 23-25 mai 2000, Paris, France. 30. Fontayne A., Dang PM-C., Gougerot-Pocidalo M-A., et El Benna J. Le composant de la NADPH oxydase p47phox est un bon substrat pour les PKC conventionnelles, nouvelles et atypiques. 9ème journée de la recherche de l’UFR de medecine Xavier Bichat. 27 septembre 2000, Paris, France. 31. Dewas C., Dang PM-C., Gougerot-Pocidalo M-A., et El Benna J. Les cytokines proinflammatoires induisent la Phosphorylation d’un composant de la NADPH oxydase (p47phox) dans les polynucleaires neutrophiles humains. 9ème journée de la recherche de l’UFR de medecine Xavier Bichat. 27 septembre 2000, Paris, France. 32. ElBim C., Réglier H., Fay M., Delarche C., Andrieu V., El Benna J., and Gougerot-Pocidalo M-A. Mise en évidence d’un pool Intracellular de recepteur à IL-10 dans les granules spécifiques des neutrophiles humains. Mobilisation differentielle par les médiateurs proinflammatoires. 9ème journée de la recherche de l’UFR de medecine Xavier Bichat. 27 septembre 2000, Paris, France. 33. Dewas C., Dang PM-C., Gougerot-Pocidalo M-A., et El Benna J. Cytokines proinflammatoires et priming de la production des formes reactives de l’oxygène dans les neutrophiles humains. Analyse des voies transductionnelles conduisant à la Phosphorylation de la p47phox. 3ème colloque du groupe thematique :Phosphorylation des proteines. Société Française de Biochimie et Biologie Moléculaire., 2-4 octobre 2000, Saint-Malo, France. 34. Fontayne A., Dang PM-C., Gougerot-Pocidalo M-A., et El Benna J. La p47phox, un composant de la NADPH oxydase est un bon substrat pour les PKC conventionnelles, nouvelles et atypiques. 3ème colloque du groupe thematique :Phosphorylation des proteines. Société Française de Biochimie et Biologie Moléculaire., 2-4 octobre 2000, Saint-Malo, France. 35. Thabut G., El-Benna J., Samb A., Corda S., Megret J., Vicaut E., Aubier M., Boczkowski J. TNFa induces airway hyperreactivity via activation of a NADPH oxidase in airway smooth muscle. American Thoracic Society (ATS), 18-23 May 2001, San Francisco, CA, USA. 36. Samb A., Taillé C., Motterlini R., El-Benna J.,, Aubier M., Boczkowski J. Heme oxygenase decreases contractile responses of guinea pig airway smooth muscle in vitro. American Thoracic Society (ATS), 18-23 May 2001, San Francisco, CA, USA. 37. Thabut G., El-Benna J., Samb A., Corda S., Megret J., Vicaut E., Aubier M., Boczkowski J. Le TNFa induit la production d’oxydants par le muscle lisse des voies aeriennes via l’activation d’une NADPH oxidase . Society for free radical research. Réunion annuelle de la SFRR France. Le 16 Janvier 2001. Paris, France. 38. Dewas C., Gougerot-Pocidalo M-A and El Benna J. Activation of NADPH oxidase and p47phox phosphorylation: Role of ERK1/2 and p38 mitogen-activated protein kinases. European Journal of Clinical th Investigation. Abst.154. 35 Annual Meeting of the European Society for Clinical Investigation. Phagocyte Workshop. Barcelonne, Spain (2-5 May 2001). 39. Dang P-M., Fontayne A., Hakim J., El Benna J., and A. Périanin. Protein kinase C z (zeta) phosphorylates the NADPH oxidase component p47phox, on selective sites and participates in formyl-peptide-mediated-neutrophil th respiratory burst. European Journal of Clinical Investigation. Abst.152. 35 Annual Meeting of the European Society for Clinical Investigation. Phagocyte Workshop. Barcelonne, Spain (2-5 May 2001). 40. ElBim C., Réglier H., Fay M., Delarche C., Andrieu V., El Benna J., and Gougerot-Pocidalo M-A. Intracellular pool of IL-10 receptors in specific granules of human neutrophils: Differential mobilization by proinflammatory th mediators. European Journal of Clinical Investigation. Abst.149. 35 Annual Meeting of the European Society for Clinical Investigation. Phagocyte Workshop. Barcelonne, Spain (2-5 May 2001). 41. Chollet-Martin S. El Benna J., Gougerot-Pocidalo M-A., Grandchamps B., and Gerard B. Characterization of 10 novel mutations in the X-linked chronic granulomatous disease (CYBB gene). European Journal of Clinical th Investigation. Abst.182. 35 Annual Meeting of the European Society for Clinical Investigation. Phagocyte Workshop. Barcelonne, Spain (2-5 May 2001). 42. Ogier-Denis E., Pattingre S., El Benna J., and Codogno P. Autophagic degradation is regulated by MAP kinase pathway in human colon cancer cells HT-29. Biology of the cell 2001, 93, Abstract C19. PHOX 43. Dang P-M., Morel, F., Gougerot-Pocidalo M-A., El Benna J. Phosphorylation of p67 in resting and stimulated neutrophils : regulation by a tyrosine kinase dependent pathway and Extracellular Signal-Regulated Kinase 1/2. The XIth Biennial Meeting of the Society for Free Radical Research International (SFFR), Paris, July 16-20, 2002. 44. Chan S., Fontayne A., Junquiera V., EL Benna J., Pasquier C. Effect of nitrites on neutrophils superoxide production. The XIth Biennial Meeting of the Society for Free Radical Research International (SFFR), Paris, July 16-20, 2002. 45. Fontayne A., Dang P-M., Gougerot-Pocidalo M-A., El Benna J. Phosphorylation of p47phox sites by PKC a, b, d and z : effect on binding to p22phox and NADPH oxidase activation. The XIth Biennial Meeting of the Society for Free Radical Research International (SFFR), Paris, July 16-20, 2002. 46. EL Benna J. The phagocyte NADPH oxidase: structure and activation. The XIth Biennial Meeting of the Society for Free Radical Research International (SFFR), Paris, July 16-20, 2002. Abstract in Free Radical in Biology and Medecine . 47. Thabut G., El-Benna J., Samb A., Corda S., Megret J., Vicaut E., Aubier M., Boczkowski J. Tumor Necrosis Factor-alpha increases airway smooth muscle oxydants production through a NADPH oxidase-like system to enhance myosin light chain phosphorylation and contractility. Society for free radical research. The XIth Biennial Meeting of the Society for Free Radical Research International (SFFR), Paris, July 16-20, 2002. Source: FREE RADICAL BIOLOGY AND MEDICINE Volume: 33 Supplement: 1 Pages: S31-S31 Meeting Abstract: 74 Published: 2002. 48. Taillé C., El-Benna J., Dang PMC., Ogier-Denis E., Aubier M., and J. Boczkowski. Antioxidant effect of Heme phox Oxygenase-1 is mediated by inhibition of NADPH oxidase: role of heme content on gp91 expression. Meeting on: Heme Oxygenase : Regulation, Functions and clinical application. Uppsala, Sweden, September 28-October 3, 2003. 49. Gillibert M., Derhy Z., Terrier M. El Benna J., and F. Lederer. Tosyl-Phenylalanine Chloromethyl Ketone inhibits NADPH oxidase activation by preventing p47phox phosphorylation and translocation. European Journal of Clinical th Investigation. Abst. 37 Annual Meeting of the European Society for Clinical Investigation. Phagocyte Workshop. Verona, Italy (2-5 April 2003). 50. Guichart C., Dang PMC., Gougerot-Pocidalo MA., El Benna J. and C. Elbim. IL-8 primes neutrophil NADPH oxidase via different mechanisms. Réunion de la Société Française d’Immunologie, J. les Bains-Nice, Novembre 2003, France. PHOX 51. Dang PMC., Gougerot-Pocidalo MA., and El-Benna J. Constitutive phosphorylation of p67 in human neutrophils: regulation by a tyrosine kinase-dependent pathway and extracellular signal-regulated kinase 1/2. th European Journal of Clinical Investigation. Abst. 38 Annual Meeting of the European Society for Clinical Investigation. Phagocyte Workshop. Utrecht, Hollande (14-17 April 2004). 52. Dang PMC., Morel F., Gougerot-Pocidalo M-A., and El-Benna J. Phosphorylation of the NADPH oxidase PHOX component p67 by ERK2 and p38MAPK : Selectivity of the phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich region. European Journal of Clinical Investigation. th Abst. 38 Annual Meeting of the European Society for Clinical Investigation. Phagocyte Workshop. Utrecht, Hollande (14-17 April 2004). 53. Dang PMC., Gougerot-Pocidalo MA., and El-Benna J. Mécanismes moléculaires intervenant dans l’inhibition de la production des formes réactives de l’oxygène par l’interleukine 10 dans les polynucléaires neutrophils. Quinzième journée de l’A.R.P (Association de Recherche sur la Polyarthrite). Paris, le 5 novembre 2004. 54. Elbim C; Guichard C; Demur H; El Benna J et al. Title: Interleukin-18 primes the oxidative burst of polymorphonuclear neutrophils in response to formyl-peptides: Role of fMLP receptor endocytosis and PMN degranulation. Conference: 22nd Congress of the International-Society-for-Analytical-Cytology Location: Montpellier, FRANCE Date: MAY 22-27, 2004. Source: CYTOMETRY PART A Volume: 59A Issue: 1 Pages: 3636 Published: MAY 2004 55. Guichard C; Dang MC; Adam F; El Benna et al. Title: Desensitization of polymorphonuclear neutrophils oxidative burst by interleukin-8. Involvement of reduced extracellular signal-regulated kinases (ERK1/2) activation. Conference: 22nd Congress of the International-Society-for-Analytical-Cytology Location: Montpellier, FRANCE Date: MAY 22-27, 2004. Source: CYTOMETRY PART A Volume: 59A Issue: 1 Pages: 36-36 Published: MAY 2004 56. Dang PMC., Paclet MH, Morel F., Gougerot-Pocidalo M-A., and El-Benna J. La p67phox est constitutivement phosphorylée dans les polynucléaires neutrophiles humains au repos : Régulation par une protéine tyrosine kinase et les phosphatases 1/2A. Club Oxydase Grenoble (Pr. F. Morel), 17 et 18 Mars 2005. 57. Pham My-Chan Dang, Mélanie Chiandotto, Carole ElBim, Marie-Anne Gougerot-Pocidalo et Jamel El-Benna. L’interleukine-10 (IL-10) inhibe l’activation de la NADPH oxydase des neutrophiles en inhibant la phosphorylation de la p47phox médiée par ERK1/2 : Mise en évidence d’une protéine inhibant la forme active de ERK1/2. Club Oxydase Grenoble (Pr. F. Morel), 17 et 18 Mars 2005. 58. François S., El-Benna J, Dang PMC, Gougerot-Pocidalo MA., and Elbim C. Inhibition of neutrophil apoptosis by toll-like receptor (TLR) agonists in whole blood : implication of the phosphoinositide 3-kinase/Akt and NF-kB signaling pathways, leading to increased levels of Mcl-1, A1 and phosphorylated Bad. European Journal of Clinical th Investigation. Abst. 39 Annual Meeting of the European Society for Clinical Investigation. Phagocyte Workshop. Athenes, Grece (7-9 April 2005). 59. Dang PMC, Stensballe A, Raad H, Dewas C, Hayem G., Jensen ON, Gougerot-Pocidalo MA, and El-Benna J. Régulation de la NADPH oxydase phagocytaire : rôle de la phosphorylation d’une sous unité de l’enzyme, la p47phox, lors du priming par le GM-CSF et le TNFalpha. 16ème journée de l’A.R.P (Association de Recherche sur la Polyarthrite). Paris, le 25 novembre 2005. 60. Gougerot-Pocidalo MA., Dang PMC, Elbim C., Kroviarski Y and EL-Benna J. Nouvel inhibiteur de l’inflammation. 2ème edition de tremplin recherche organisé par le Sénat. Paris le 21 Février 2006. 61. Raad H., Paclet M-H., Morel F., Quinn MT., Gougerot-Pocidalo M-A., Dang PM., and El-Benna J. Phosphorylation of gp91phox/Nox2 in human neutrophils. Gordon Conference, les diablerets, Suisse, 2006. 62. François S., El-Benna J, Dang PMC, Gougerot-Pocidalo MA., and Elbim C. Inhibition of neutrophil apoptosis by toll-like receptor (TLR) agonists in whole blood : implication of the phosphoinositide 3-kinase/Akt and NF-kB signaling pathways, leading to increased levels of Mcl-1, A1 and phosphorylated Bad. European Congress of Immunology, Septembre 2006 Paris, France. 63. Dang PMC, Stensballe A, Raad H, Dewas C, Hayem G., Jensen ON, Gougerot-Pocidalo MA, and El-Benna J. Régulation de la NADPH oxydase phagocytaire : rôle de la phosphorylation d’une sous unité de l’enzyme, la p47phox, lors du priming par le GM-CSF et le TNFalpha. 17ème journée de l’A.R.P (Association de Recherche sur la Polyarthrite). Paris, le 25 novembre 2006. 64. Arnaud B, Ollivier V, El Benna J, Jandrot-Perrus M, Ajzenberg N. Monocytes Down-Regulate Platelet Activation Induced by a Collagen Surface. 48th Annual Meeting of the American Society of Hematology, December 2006, Orlando, Florida, USA. Source: BLOOD Volume: 108 Issue: 11 Pages: 507A-508A Part: Part 1 Meeting Abstract: 1788 Published: NOV 65. Raad H., Paclet M-H., Morel F., Quinn MT., Gougerot-Pocidalo M-A., Dang PM., and El-Benna J. Phosphorylation of gp91phox/Nox2 in human neutrophils. GREMI 2007, Institut Pasteur, Paris. 66. Arnaud B, Ollivier V, El Benna J, Jandrot-Perrus M, Ajzenberg N. Monocytes Down-Regulate Platelet Activation Induced by a Collagen Surface. GREMI 2007, Institut Pasteur, Paris. 67. Arnaud B, Ollivier V, El Benna J, Jandrot-Perrus M, Ajzenberg N. Monocytes Down-regulate Platelet Activation Induced by a Collagen Surface. Société Française d’Hématologie (SFH), Paris 2007. 68. Raad H., Paclet M-H., Morel F., Quinn MT., Gougerot-Pocidalo M-A., Dang PM., and El-Benna J. Phosphorylation de la gp91phox/Nox2 dans les neutrophiles humains. 5ème club oxydase, Grenoble 2007. 69. Kroviarski Y, Debbabi M, Gougerot-Pocidalo M-A., El-Benna J. and Dang PM.C. Phosphorylation de NOXO et NOXA et activation de NOX1. 5ème club oxydase, Grenoble 2007. 70. Hajkova Veronika; Moravcova Aneta; Ciz Milan; El Benna J. Title: Glucomannan isolated from Candida utilis induces activation of NADPH oxidase in human blood phagocytes. Conference: 14th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine Location: Washington, DC Date: NOV 14-18, 2007. Source: FREE RADICAL BIOLOGY AND MEDICINE 2007,Volume: 43 Supplement: 1 Pages: S139-S140. 71. Kannengiesser C, Gérard B, El Benna J, Dominique Henri, Sylvie Chollet-Martin, Marie-Anne GougerotPocidalo , Carole Elbim and Bernard Grandchamp. Caractérisation de 25 nouvelles mutations chez 94 probands de granulomatose septique chronique. Les 4ème assises de Génétique Humaine et Médicale , Lille du 17 au 19 janvier 2008. 72. Raad H., Paclet M-H., Morel F., Quinn MT., Gougerot-Pocidalo M-A., Dang PM., and El-Benna J. Phosphorylation of gp91phox/Nox2 in human neutrophils: a novel mechanism for the regulation of ROS production. nd European Journal of Clinical Investigation. Abst. 42 Annual Meeting of the European Society for Clinical Investigation. Phagocyte Workshop. ESCI 2009, Frankfor, Allemagne (7-9 April 2009). 73. Boussetta T, Raad H, Lettéron P, Gougerot-Pocidalo MA, Marie JC, Driss F, El-Benna J. L’acide punicique inhibe l’hyperactivation de la NADPH oxydase des neutrophiles induite par le TNFa et protège contre l’inflammation du colon chez le rat. 6 ème club oxydase (Les NADPH oxidases NOX/DUOX : rôles physiologiques et physiopathologiques), le 28 et 29 Mai 2009, Paris.(Présentation orale). 74. Patel S, Fraynal AM., Paruch S., Djerdjouri B., Dang PM, El-Benna J, et Périanin A. L’activation de la NADPH oxydase induite par le facteur chimiotactique f-Met-Leu-Phe dans les HL-60 différenciées en neutrophiles met en jeu l’activation séquentielle de la Protéine kinase B, des ERK1/2 et de la phospholipase D. 6 ème club oxydase (Les NADPH oxidases NOX/DUOX : rôles physiologiques et physiopathologiques), le 28 et 29 Mai 2009, Paris.(Présentation orale). 75. Debbabi M., Kroviarski Y., Bachoual R., Périanin A., Gougerot-Pocidalo M.A., El-Benna J. and Dang P.M. La phosphorylation de NOXA1 sur les sérines 282 et 172 inhibe l’activité de NOX1. 6 ème club oxydase (Les NADPH oxidases NOX/DUOX : rôles physiologiques et physiopathologiques), le 28 et 29 Mai 2009, Paris.(Présentation orale). 76. Chedid P, El Benna J, Marie JC. L’adiponectine, médiateur emergent de l’inflammation: Régulation de la NADPH oxydase des phagocytes. 6 ème club oxydase (Les NADPH oxidases NOX/DUOX : rôles physiologiques et physiopathologiques), le 28 et 29 Mai 2009, Paris. 77. Djerdjouri B, Boussetta T, Hurtado-Nedelec M, Bounaama A, Tounsi N, Dang PM, Gougerot-Pocidalo MA and El Benna J. L’indométacine, un anti inflammatoire non stéroïdien, inhibe le priming des polynucléaires neutrophiles induit par le TNFa. 6 ème club oxydase (Les NADPH oxidases NOX/DUOX : rôles physiologiques et physiopathologiques), le 28 et 29 Mai 2009, Paris. 78. Mouzaoui S, Djerdjouri B, Rebah N, Gougerot-Pocidalo MA, El-Benna J, Debbabi M, Kroviarski Y, and Dang PM. L’inflammation intestinale induite par le TNFa augmente l’expression du complexe NOX1 (NADPH oxidase 1) et de KC, et entraîne le recrutement des polynucléaires neutrophiles : effet protecteur de l’apocynine. 6 ème club oxydase (Les NADPH oxidases NOX/DUOX : rôles physiologiques et physiopathologiques), le 28 et 29 Mai 2009, Paris. 79. Pongnimitprasert N, Bernard M, Babin-Chevaye C, Fay M, Dupuy C, El Benna J, Gougerot-Pocidalo MA, BrautBoucher F. Role potentiel des Dual oxydases (DUOX1-2) comme source des formes réactives de l’oxygène dans un modèle cellulaire de la mucoviscidose. 6 ème club oxydase (Les NADPH oxidases NOX/DUOX : rôles physiologiques et physiopathologiques), le 28 et 29 Mai 2009, Paris. 80. Boussetta T.; Raad H.; Bartegi A., Driss F and El Benna J. Punicic acid a conjugated linolenic acid from pomegranate seed oil inhibits TNF alpha-induced neutrophil hyperactivation. ESCI meeting, Bari, Italy. European J. Clinical Investigation, 2010, Vol: 40 Supplement: 1 Pages: 46-46. 81. Chedid P.; Hurtado-Nedelec M.; El Benna J.; et al. Adiponectin, an emerging immune modulator, regulates phagocytic NADPH oxidase. ESCI meeting, Bari, Italy. Source: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Volume: 40 Supplement: 1 Pages: 34-34 Published: MAR 2010. 82. Chedid P., Hurtado-Nedelec M., Bournier O., Hayem G., Gougerot-Pocidalo, M.A., Frystyk J., Flyvbjerg A., El Benna J., Marie J.C. L’adiponectine, médiateur émergent de l’inflammation : Régulation de la NADPH oxydase des phagocytes. 7ème club oxydase, Grenoble, le 26 et 27 Mai 2011. 83. Riad Arabi Derkawi, Yvonne O’Dowd, Tarek Boussetta, Houssam Raad, Yolande Kroviarski, Ni Cheng, Richard . Ye, Gougerot-Pocidalo MA, Jamel El-Benna Régulation de la NADPH oxydase phagocytaire NOX2 par PAT1. 7ème club oxydase, Grenoble, le 26 et 27 Mai 2011. 84. Maya DEBBABI, Yolande KROVIARSKI, Odile BOURNIER, Marie-Anne GOUGEROT-POCIDALO, Jamel ElBENNA and Pham My-Chan DANG. La phosphorylation de NOXO1 par la protéine kinase c potentialise l’activité de la NADPH oxydase 1. 7ème club oxydase, Grenoble, le 26 et 27 Mai 2011. 85. Sahra Amel Belambri, Karama Makni-Maalej, Silvia Ciappelloni, Marie-Anne Gougerot-Pocidalo, Pham MyChan Dang, Jamel El-Benna. Etude des sites de phosphorylation de la p47phox dans les neutrophiles humains en utilisant des anticorps spécifiques. 7ème club oxydase, Grenoble, le 26 et 27 Mai 2011. 86 . Tarek Boussetta, Marie-Anne Gougerot-Pocidalo, Gilles Hayem, Silvia Ciappelloni, Houssam Raad, Riad Arabi 5 Derkawi, Odile Bournier, Yolande Kroviarski, Xiao Zhen Zhou , James S. Malter, Ping K Lu, Aghleb Bartegi, Pham My-Chan Dang and Jamel El-Benna. Le mécanisme moléculaire du priming de la NOX2 par le TNFα : Rôle de la proline isomérase Pin1. 7ème club oxydase, Grenoble, le 26 et 27 Mai 2011. 87. Karama Makni-Maalej, Sahra Amel Belambri, Tarek Boussetta, Margarita Hurtado-Nedelec, Marie-Anne . Gougerot-Pocidalo, Jamel El-Benna Le CL097, un agoniste des TLR 7 et 8 induit le priming de la NADPH oxydase et la phosphorylation de la p47phox dans les neutrophiles humains. 7ème club oxydase, Grenoble, le 26 et 27 Mai 2011. 88. Souad Mouzaoui, Bahia Djerdjouri, Nessrine Rebah, Marie-Anne Gougerot-Pocidalo, Jamel El-Benna, Maya Debbabi, Yolande Kroviarski and Pham My-Chan Dang. L’inflammation intestinale induite par le TNFα augmente l’expression du complexe NOX1 (NADPH oxidase 1) : effet protecteur de l’apocynine. 7ème club oxydase, Grenoble, le 26 et 27 Mai 2011. 89. Loïc Rolas, Nesrine Makhezer*, Souméya Hadjoudj* Jamel El Benna, Bahia Djerdjouri* et Axel Périanin. L’activation de la NOX2 induite par le peptide pro-inflammatoire f-Met-Leu-Phe dans le neutrophile humain met en jeu la protéine kinase mTOR, en amont des voies MAP kinases et PKB (AKT). 7ème club oxydase, Grenoble, le 26 et 27 Mai 2011. 3. Brevets: 1-El-Benna J, Dang PMC, Gougerot-Pocidalo MA: Brevet déposé pour un peptide qui inhibe l’activation de la NADPH oxydase et un anticorps qui détecte son préactivation: (Brevet T983 US): El-Benna J « Polypeptides, pharmaceutical compositions and methods for the prevention and the therapeutic treatment of inflammatory disorders ». 3. Conférencier invité dans des congrès internationnaux: 1-El Benna J., Babior B.M. : The neutrophil 47kDa cytosolic oxidase component is phosphorylated in the carboxy terminal region. The Oxygen Society Meeting. Novembre 1993. Free Radical Biology and Medicine 1993, 15 Abstr. 12:6. 2-El Benna J, Faust LP, and Babior BM. The analysis of p47phox phosphorylation sites by site-directed mutagenesis in B lymphocytes: identification of new phosphorylation sites S315, S359 and S370.:BLOOD, 1995, vol 86, Abst. 1030. 3-El Benna J, and Labro MT. New horizons in macrolide use: effect on the oxidative burst.Glasgow1996 J. Neurogastroenterology and Motility. 1996. 4-El Benna J, Faust LP, and Babior BM. The analysis of p47phox phosphorylation sites by site-directd mutagenesis in B lymphocytes. Oxidative stress and redox regulation: cellular signaling, aids, cancer and other diseases. Mai 1996. Institut Pasteur, Paris. 5-El Benna J. Etude de la phosphorylation de la p47phox du polynucleaire neutrophile humain. Société française de biochimie et de biologie moléculaire. Colloque du groupe thématique "Phosphorylation des proteines" Dourdan, Juin 1996. 6-El Benna J. Rôle of the phosphorylation of p47phox as assessed by site-directed mutagenesis in B lymphocytes. International symposium on the NADPH oxidase, June 1996. The Scripps Research Institute, La Jolla CA ,USA 7-El Benna J.:NADPH oxydase:role des phosphorylations de la p47phox et de la p67phox dans la production d'anions superoxyde par les polynucléaires neutrophiles humains. Reunion de la SFRR(société française de recherches sur les radicaux libres), Juillet 1997, Paris,France. 8-El Benna J, Dang PM-C, Dewas, C, et M-A Gougerot-Pocidalo. Phosphorylation de la p47phox dans les polynucleaires neutrophiles humains. Reunion de la SFRR (société française de recherches sur les radicaux libres), 17 Janvier, 2000, Paris,France. 9-El Benna J, Dang PM-C, Dewas, C, et M-A Gougerot-Pocidalo. Pro-inflammatory cytokines induce p47phox phosphorylation in human neutrophils. The european society for clinical investigation, 34th annual scientific meeting. 17-20 May 2000, Aarhus, Denmark. 10-El Benna J. Pro-inflammatory cytokines induce p47phox phosphorylation in human neutrophils. Innate th Immunity : the 5 european winter conference in immunity. Saint Sorlin Workshop, (16-19 January 2001), Saint Sorlin, France. 11-El Benna J. P47phox phosphorylation and NADPH oxidase activation. Oxygen Club of California. Santa Barbara CA, USA. (7-11 Mars 2001). 12-EL Benna J. The phagocyte NADPH oxidase: structure and activation. The XIth Biennial Meeting of the Society for Free Radical Research International (SFRR), Paris, July 16-20, 2002. 13-El Benna J. The NADPH oxidase and signal transduction. Club Oxydase, Grenoble (Pr. F. Morel), 23 Mai 2003. 14. El Benna J. Regulation of neutrophil NADPH oxidase activity by pro-inflammatory and anti-inflammatory cytokines. Oxidative stress and inflammation, GREMI, Pasteur Institute, January 26, Paris 2007. Conférence plénière. 15. El Benna J. Hyperactivation ou “priming “ de la NADPH oxydase phagocytaire: mécanismes et rôle dans l’inflammation. Les NADPH oxydases NOX dans l’inflammation et le viellissement- 5ème club Oxydase-31 Mai et er 1 Juin 2007. Conférence plénière. 16. El-Benna J. ROS production by the phagocyte NADPH oxidase in innate immunity and inflammation. 2008 Annual International Conference of the Korean Society of Molecular Biology and Medical Biochemistry. 29-31 October 2008, Seoul, South Korea. (Conférencier invité). 17. El-Benna J. ROS production by the phagocyte NADPH oxidase in innate immunity and inflammation. Innate immunity workshop, 28 October 2008, University of Deajon, South Korea. (Conférencier invité). 18-El-Benna J. ROS production by the phagocyte NADPH oxidase in innate immunity and inflammation. Innate immunity workshop, 17 Mars 2009, GIGA Center, University of Liège, Belgique. (Conférencier invité). 19. El Benna J. Hyperactivation ou “priming “ de la NADPH oxydase phagocytaire: rôle dans l’mmunité innée et l’inflammation. Mini-symposium sur l’immunité innée, Université de l’ile de la réunion, 22-24 Octobre 2009. (Conférence plénière). 20. EL Benna J. Inhibition of NADPH oxidase (NOX2) by peptides. Ernst Klenk Symposium in Molecular Medicine. NOX Family NADPH oxidases as Therapeutic Targets. November 4-6, 2010, Cologne, Allemagne. 4-Chapitres de livres et d’ouvrages: 1. Labro M.T., El Benna J. : Interaction of antibiotics with the phagocyte oxidative burst. Host Defense Dysfunction in Trauma, Shock and Sepsis. Faist P.D., Meakins Shildberg (eds) Spring-Verlag. 1993, 953-964. 2. Babior B.M., El Benna J.,Chanock S.J., and Smith R.M. The NADPH oxidase of leukocytes: The respiratory burst oxidase. Oxidative stress and the molecular biology of antioxidant defenses. Edited by John G. Scandalios, Cold Spring Harbor Laboratory Press. 1997, p737-783. 3. El Benna J., Gougerot-Pocidalo M-A and Dang PMC. The phagocyte NADPH oxidase: structure and activation. Proceedings of XI Biennial Meeting of the Society for Free Radical Research International. 2002. p75-78. C. Pasquier Editor, Monduzzi Editore, Bologna-Italy. 4. El-Benna J., and Dang PMC. Analysis of protein phosphorylation in human neutrophils: Methods in Molecular Medecine, Neutrophil Methods and Protocols, Humana press Inc. Quinn, DeLeo and Bokoch Editors. 2007, 412:85-96. 5. Dang PM, El Benna J, Gougerot-Pocidalo MA. NOXO1 protein target data base. 2007. 6. El Benna J, Dang PM, Gougerot-Pocidalo MA. P47phox target data base. 2007. 7. Gougerot-Pocidalo MA, El Benna J, Dang PM, Elbim C. Pathogens trapped in neutrophil nets. Med Sci (Paris). 2007, 23: 464-465. 8. Driss F and El Benna J. Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil by scavenging reactive oxygen species produced by human neutrophils. Olives and Olive Oil in Health and Disease Prevention, edited by Victor R. Preedy and Ronald Ross Watson. Oxford Academic Press, 2010, pp1289-1294. 5-Conférencier invité dans des laboratoires et centres de recherches: Ces conférences ont portés sur la structure et la régulation de l’activation de la NADPH oxydase par la phosphorylation de la p47phox et de la p67phox: 1-Juin1996, Conférence dans le département de Biochimie, The Scripps Research Institute, La Jolla CA ,USA 2-Janvier1997, Conférence à l’unité U294-CHU X. Bichat (Pr. J. Hakim). 3-Fevrier 1998, Conférence à l’université de Reims (Pr. J.C. Monboisse et Pr. F.X. Macquart). 4-Avril 1999: Conférence à l’unité Inserm U507-Hopital Necker (directeur: P. Lesavre). 5-Fevrier 2000: Conférence à l’unité Inserm U504-Villejuif (directeur: P. Codogno). 6-Mars 2000: Conférence à l’unité Inserm U410-CHU. X. Bichat (directeur: M. Laburthe). 7-Fevrier 2001, Conférence à l’unité inserm U408-CHU.X Bichat (directeur Pr. M. Aubier). 8-Juin 2002 : Conférence dans le laboratoire de Biochimie de l’hopital Bichat (Pr. Grandchamp). 9-Octobre 2002, Conférence à l’IFR02-CHU-Xavier Bichat (invité par N. Farman, directrice de L’IFR02). 10-Juin 2003 :Inserm E9907 (Pr. MC. Guillin), CHU. X. Bichat. 11. Juin 2004 : Séminaire à la faculté de Bobigny (Université Paris 13) (Pr. Fagard R). 12-Decembre 2004 : Séminaire au centre de recherche Bichat-Beaujon (Directeur Marc Laburthe). 13. Novembre 2005 : Séminaire à la faculté des sciences de Gabès (Tunisie). 14. Mars 2009: Conférence Laburthe). dans le centre de recherche CRB3/ Inserm U773-CHU. X. Bichat (directeur: M.