Auto-assemblage d`ADN – polymère π
Transcription
Auto-assemblage d`ADN – polymère π
Séminaires & Conférences Chimie École Doctorale 459 Jeudi 22 Octobre 2015, 13h45 Salle de Cours SC-16.01 – UM Faculté des Sciences (campus Triolet) Auto-assemblage d’ADN – polymère π-conjugué Dr. Mathieu SURIN Laboratory for Chemistry of Novel Materials, Université de Mons, Belgique Professeur invité Chaire Total Fondation Balard π-Conjugated polyelectrolytes (CPEs) constitute an emerging class of (nano)materials, as these combine solubility in water and the unique optoelectronic properties of the π-conjugated polymer backbone, with prospective applications in biosensing and medical diagnosis. During this seminar, we will particularly emphasize the binding and self-assembly mechanisms of DNA with CPEs, which have been overlooked in the design of CPEbased biosensors. Importantly, we will show that DNA sequence-specific interactions are at play upon the self-assembly with CPE, related to conformational chirality of the polymer backbone within the complexes. Moreover, we establish the mechanisms of DNA-DNA hybridization in complexes, which strongly depend on the DNA sequences. This constitutes a step forward towards a rational design of DNA-CPE materials for biosensing applications. References J. Rubio-Magnieto, et al., Chem. Commun. 2013, 49, 5483. J. Rubio-Magnieto, et al., Soft Matter 2015, 11, 6460.