Plan de Cochin
Transcription
Plan de Cochin
Pr. John D. Scott Howard Hughes Medical Institute. Department of Pharmacology. University of Washington. School of Medicine, Seattle, WA Guiding signals through anchored enzyme complexes Lundi 29 Septembre 2014 à 14h – Hôpital Cochin - Amphithéâtre Jean Dausset, Rez-de-Jardin du bâtiment Jean Dausset (27 Rue du Faubourg St-Jacques) - 75014 PARIS. (RER B station Port-Royal, Metro ligne 6 (Saint Jacques) ou Bus 38, 83,91) John Scott is interested in the specificity of signal transduction events that are controlled by anchoring proteins, which facilitate rapid signal transduction by optimally positioning protein kinases and phosphatases in the vicinity of their activating signals and close to their substrates. His research program focuses on defining the intracellular communication networks that promote specificity in signal transduction events. His laboratory identified a family of A-kinase–anchoring proteins (AKAPs) that target the cAMP-dependent protein kinase (PKA) and other signaling enzymes to specific subcellular sites. AKAPs influence the regulation of physiological processes by bringing enzymes close to their appropriate effectors and substrates at precisely the right moment. His group made progress on establishing the AKAP model, the functional consequences of PKA anchoring, and the bigger role of AKAP signaling networks in the coordinate regulation of cellular signaling. Rue MÉTRO t4BJOUJBDRVFTMJHOF BUS t-JHOFT PASTEUR PÉPINIÈRE Blaise PASCAL SICARD ENTREPRISE PHARMACIE ACHARD LOGE Accès Piétons Véhicules GUSTAVE ROUSSY HARDY ALBARRAN FLORENT COSTE SERVICES GÉNÉRAUX UCR HIN CORNILBRISSAUD Entrée T COC PORTE RICORD OLLIER Sortie Rue du Faubourg Saint-Jacques SAINT-JACQUES Accès Piétons Rue du Faubourg Saint-Jacques échain Jean DAUSSET Rue M Boulevard de Port-Royal MAISON DE SOLENN LAVOISIER U INSTIT Amphithéâtre Jean Dausset Rez-de-Jardin Bâtiment Jean Dausset 27 Rue du Faubourg St-Jacques 75014 PARIS é Sant CRÈCHE COCHIN RER B tPPSU3PyBM BUS de la échain MOYENS D’ACCÈS : Rue M Plan de Cochin