Fiche UE BMC-NV508-CVB
Transcription
Fiche UE BMC-NV508-CVB
Intitulé de l’UE STRUCTURAL METHODS FOR BIOLOGICAL MACROMOLECULES IDENTIFICATION OF NEW THERAPEUTIC TARGETS Code de l’UE : NV508 Responsable de l’UE : Secrétariat : Catherine VENIEN-BRYAN, Professeur UPMC Mel : [email protected] Frank SOBOTT, Professeur Antwerp University (Belgium) Mel : [email protected] Carine JOSEPH Tél. : 01 44 27 35 35 Mel : [email protected] 1. Descriptif de l’UE Volumes horaires globaux (CM, TD, TP, stage autre…) : 30 h (20 h CM + 10 h travail personnel) Nombre de crédits de l’UE : 3 ECTS Mention et spécialité de Master où l’UE est proposée : Mention "Biologie Moléculaire & Cellulaire", spécialités "Biochimie & Biologie moléculaire" et "Biophysique" Semestre où l’enseignement est proposé : Semestre 3 du Master Effectifs prévus : 20 dont 10 de l'UPMC 2. Présentation pédagogique de l’UE a) Objectifs de l'Unité d'Enseignement This course is suitable for students interested in learning more about state of the art biophysical methods and their application to crucial biological problems and to drug design. Biophysical methods are widely used in both industrial and academic research to study biological macromolecules. The course aims at a compréhensive coverage of the field, including all major structural and biophysical techniques employed for the characterization of high and low resolution structure, structural transition, macromolecular assemblies and interactions with small molecules. The students will study a wide range of problems from a structural and mechanistic perspective using a range of structural biology methods including x-ray crystallography, modeling and drug design, cryo-electron microscopy and mass spectrometry. b) Thèmes abordés The course will provide innovative and ambitious teaching programs. It will be delivered and monitored simultaneously at the Antwerp University, Belgium and at the UPMC, Paris and will include lectures on : • X-ray crystallography and drug design (Dr David Banner Hoffmann-La Roche, Basel) • Mass spectrometry (Prof. Frank Sobott, Antwerp University) • Cryo-electron microscopy combined with image analysis analysis (Prof. Catherine VénienBryan,UPMC, Paris) • Modeling and Drug design (Dr Paul Emsley, University of Oxford) These biophysical foundations will be applied to biological topics medically important, with the view to developing new drugs. c) Organisation pédagogique The course will be mostly lecture based with some demonstrations. Language: English Reference material: English-posted on the course web site Teaching schedule: classes will be given in February or March over two weeks. The course will be delivered in real time in Paris with a video conference link to Antwerp. All the course notes and material will be in English, the course and reference materials will be available well in advance and posted on the course website. . Mode of assessment: students will be assessed on a written essay. In addition, each student will present a recent publication (15 minutes talk) selected from a list of articles provided by the lecturers. d) Pré-requis -This international course is aimed at postgraduate students (level Master 2 or PhD). -Basic knowledge of structural biology and/or protein biochemistry and/or of physical chemistry. 3. Equipe pédagogique Cours magistraux par vidéoconférence : Catherine Vénien-Bryan (UPMC), Frank Sobott (Antwerp University, Belgium), David Banner (Hoffman La Roche, Basel, Switzerland) and Paul Emsley (University of Oxford, UK).