DNA structure, nucleosome positioning and chromatin remodelling

Vendredi 3 décembre 2010 à 11h
Auditorium Chemla, Bâtiment IDA
DNA structure, nucleosome positioning and
chromatin remodelling
- how is chromatin organised?
Pr. Andrew. A. Travers
Professeur Emérite LMB Cambridge. Chaire d'excellence ANR, LBPA,
Fondation Pierre Gilles de Gennes. ENS Cachan.
DNA is packaged in the eukaryotic nucleus and in the bacterial nucleoid by DNAbinding proteins that stabilise different superhelical structures. The formation of these
DNA-protein complexes in both organisms is facilitated by the physiochemical
properties conferred by the sequence organisation of DNA. The seminar will describe
how such sequence characteristics determine histone octamer binding and how these
sequence preferences can be modified by chromatin remodelling complexes to
facilitate transcriptional regulation as well as to aid chromatin compaction or
activation.
Invité par Malcolm Buckle (7673)