HUBERT Pierre born 8th June 1952, in Nancy, France Diplomas


HUBERT Pierre born 8th June 1952, in Nancy, France Diplomas
born 8th June 1952, in Nancy, France
Diplomas :
HDR (Habilitation à diriger des recherches), Louis Pasteur University,
Strasbourg, France (ULP), 2000;
PhD in Cell Biology (Doctorat d'Université en Sciences), Louis Pasteur
University, Strasbourg, 1992;
MD (Doctorat d’Etat en Médecine), Louis Pasteur University, Strasbourg, 1979.
Position :
Scientist (Chargé de recherche) within INSERM (Institut National de la Santé et de la
Recherche Médicale) since 1981.
Current lab :
Laboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM, UPR 9027 du
Prof. James Sturgis, Dr. Alain Filloux
31 Chemin Joseph Aiguier, 13402 Marseille cedex 20, France
Previous labs :
• INSERM unit 575 (Physiopathology of the nervous system)
Dr. Dominique Aunis
5 rue Blaise Pascal, 67000 Strasbourg, France
• Center for Neurochemistry (CNRS)
Prof. Guy Vincendon
5 rue Blaise Pascal, 67000 Strasbourg, France
• post-doc : 1979 – 1980 : Départment of Biological Chemistry (Pr. Itzakh Ohad),
Hebrew University, Jerusalem, Israël.
Main publications :
Bennasroune, A., A. Gardin, D. Aunis, G. Cremel, and P. Hubert, Tyrosine kinase
receptors as attractive targets of cancer therapy. Crit Rev Oncol Hematol, 2004. 50(1): p.
Bennasroune, A., M. Fickova, A. Gardin, S. Dirrig-Grosch, D. Aunis, G. Cremel, and
P. Hubert, Transmembrane peptides as inhibitors of ErbB receptor signaling. Mol Biol Cell,
2004. 15(7): p. 3464-74.
Gardin, A., C. Auzan, E. Clauser, T. Malherbe, D. Aunis, G. Crémel, and P. Hubert,
Substitution of the insulin receptor transmembrane domain with that of glycophorin A inhibits
insulin action. Faseb J, 1999. 13(11): p. 1347-1357.
Fickova, M., P. Hubert, G. Crémel, and C. Leray, Dietary (n-3) and (n-6) polyunsaturated
fatty acids rapidly modify fatty acid composition and insulin effects in rat adipocytes. J Nutr,
1998. 128(3): p. 512-9.
Roques, M., G. Cremel, D. Aunis, and P. Hubert, Biological effects of encapsulated insulin
on transfected chinese hamster ovary cells. Diabetologia, 1995. 38(2): p. 180-186.
Leray, V., P. Hubert, C. Burgun, C. Staedel, and G. Crémel, Reconstitution studies of
lipid effects on insulin-receptor kinase activation. Eur J Biochem, 1993. 213(1): p. 277284.
Crémel, G., M. Fickova, C. Leray, V. Leray, E. Meuillet, J. Klimes, C. Staedel, and P.
Hubert, Lipid modulation of insulin receptor tyrosine kinase activity in cultured cells, animals, and
reconstituted systems. Ann. N.Y. Acad. Sci., 1993. 683: p. 164-171.
Roques, M., C. Damge, C. Michel, C. Staedel, G. Crémel, and P. Hubert,
Encapsulation of insulin for oral administration preserves interaction of the hormone with its
receptor in vitro. Diabetes, 1992. 41: p. 451-456.
Leray, V., P. Hubert, G. Crémel, and C. Staedel, Detergents affect insulin binding,
tyrosine kinase activity and oligomeric structure of partially purified insulin receptors. Arch.
Biochem. Biophys., 1992. 294: p. 22-29.
Hubert, P., C. Bruneau-Wack, G. Crémel, Y. Le Marchand-Brustel, and C. Staedel,
Lipid induced insulin resistance in cultured hepatoma cells is associated with a decreased
insulin receptor tyrosine kinase activity. Cell Regul. (Mol. Biol. Cell), 1991. 2: p. 66-75.
Languages :
• French, fluent
• English, fluent