HUBERT Pierre born 8th June 1952, in Nancy, France Diplomas
Transcription
HUBERT Pierre born 8th June 1952, in Nancy, France Diplomas
HUBERT Pierre born 8th June 1952, in Nancy, France Diplomas : • HDR (Habilitation à diriger des recherches), Louis Pasteur University, Strasbourg, France (ULP), 2000; • PhD in Cell Biology (Doctorat d'Université en Sciences), Louis Pasteur University, Strasbourg, 1992; • MD (Doctorat d’Etat en Médecine), Louis Pasteur University, Strasbourg, 1979. Position : Scientist (Chargé de recherche) within INSERM (Institut National de la Santé et de la Recherche Médicale) since 1981. Current lab : Laboratoire d'Ingénierie des Systèmes Macromoléculaires (LISM, UPR 9027 du CNRS) Prof. James Sturgis, Dr. Alain Filloux 31 Chemin Joseph Aiguier, 13402 Marseille cedex 20, France • Previous labs : • INSERM unit 575 (Physiopathology of the nervous system) Dr. Dominique Aunis 5 rue Blaise Pascal, 67000 Strasbourg, France 1991-2004 • Center for Neurochemistry (CNRS) Prof. Guy Vincendon 5 rue Blaise Pascal, 67000 Strasbourg, France 1981-2000 • post-doc : 1979 – 1980 : Départment of Biological Chemistry (Pr. Itzakh Ohad), Hebrew University, Jerusalem, Israël. Main publications : • • • Bennasroune, A., A. Gardin, D. Aunis, G. Cremel, and P. Hubert, Tyrosine kinase receptors as attractive targets of cancer therapy. Crit Rev Oncol Hematol, 2004. 50(1): p. 23-38. Bennasroune, A., M. Fickova, A. Gardin, S. Dirrig-Grosch, D. Aunis, G. Cremel, and P. Hubert, Transmembrane peptides as inhibitors of ErbB receptor signaling. Mol Biol Cell, 2004. 15(7): p. 3464-74. Gardin, A., C. Auzan, E. Clauser, T. Malherbe, D. Aunis, G. Crémel, and P. Hubert, Substitution of the insulin receptor transmembrane domain with that of glycophorin A inhibits • • • • • • • insulin action. Faseb J, 1999. 13(11): p. 1347-1357. Fickova, M., P. Hubert, G. Crémel, and C. Leray, Dietary (n-3) and (n-6) polyunsaturated fatty acids rapidly modify fatty acid composition and insulin effects in rat adipocytes. J Nutr, 1998. 128(3): p. 512-9. Roques, M., G. Cremel, D. Aunis, and P. Hubert, Biological effects of encapsulated insulin on transfected chinese hamster ovary cells. Diabetologia, 1995. 38(2): p. 180-186. Leray, V., P. Hubert, C. Burgun, C. Staedel, and G. Crémel, Reconstitution studies of lipid effects on insulin-receptor kinase activation. Eur J Biochem, 1993. 213(1): p. 277284. Crémel, G., M. Fickova, C. Leray, V. Leray, E. Meuillet, J. Klimes, C. Staedel, and P. Hubert, Lipid modulation of insulin receptor tyrosine kinase activity in cultured cells, animals, and reconstituted systems. Ann. N.Y. Acad. Sci., 1993. 683: p. 164-171. Roques, M., C. Damge, C. Michel, C. Staedel, G. Crémel, and P. Hubert, Encapsulation of insulin for oral administration preserves interaction of the hormone with its receptor in vitro. Diabetes, 1992. 41: p. 451-456. Leray, V., P. Hubert, G. Crémel, and C. Staedel, Detergents affect insulin binding, tyrosine kinase activity and oligomeric structure of partially purified insulin receptors. Arch. Biochem. Biophys., 1992. 294: p. 22-29. Hubert, P., C. Bruneau-Wack, G. Crémel, Y. Le Marchand-Brustel, and C. Staedel, Lipid induced insulin resistance in cultured hepatoma cells is associated with a decreased insulin receptor tyrosine kinase activity. Cell Regul. (Mol. Biol. Cell), 1991. 2: p. 66-75. Languages : • French, fluent • English, fluent