10 Congress of the French Society of Cell and Gene Therapy

10th Congress of the French Society of Cell
and Gene Therapy
Nantes, 6-8 June 2011
MONDAY 6 JUNE
10:30 –12:45
Vectors and tools “10 years on”
Chairpersons: François-Loïc Cosset et Karim Benihoud
Hildegard Büning, Department I of Internal Medicine and Center for Inv1
Molecular Medicine Cologne (ZMMK), University of Cologne, Germany
Tailoring adeno-associated viral vectors for gene transfer and
gene therapy
Andrew Baker, Department of Molecular Medicine, University of
Inv2
Glasgow, United Kingdom
Adenovirus tropism: mechanisms and exploitation
François-Loïc Cosset , 1INSERM U758, Ecole Normale Supérieure de
Inv3
Lyon, France
Stealth lentiviral vectors targeted to hematopoietic cells
Selected Abstracts
Madeleine Zerbato, Genethon, Evry, France
Genomic targeting with group II introns: characterization of
Pl.LSU/2 intron protein and evidence for intron splicing
activity
Mattias Lindberg, INSERM U613, Université de Bretagne
Or1
Or2
Occidentale, Brest, France
Gene therapy of cystic fibrosis : plasmid DNA contribution on
in vivo lipid-based transfection efficacy
Vanessa Gauttier, INSERM UMR948 , Nantes, France
Evaluation of the tumorigenic potential of AAV transduction
in the newborn rat liver
12:45–14:00
Lunch
14:00 –16:15
Imaging and Gene Transfer
Chairpersons: G. Vassaux et Patrick Midoux
Georges Vassaux, Inserm U948, CHU Hotel Dieu, Nantes, France
Molecular imaging of genes expression using the Na/I,
symporter: applications in gene therapy
Andy Miller, Institute of Pharmaceutical Science,University College,
Or3
Inv4
Inv5
London, UK
Delivering on RNAi Therapeutics, Molecular Imaging and
Theranostics; what do we think that we know?
Veerle Baekelandt, Division of Molecular Medicine, University of
Inv6
Leuven, Belgium
In vivo gene transfer and non-invasive imaging in rodent
brain with viral vectors: progress and challenges
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10th Congress of the French Society of Cell
and Gene Therapy
Nantes, 6-8 June 2011
Selected Abstracts
Yuan Ping, Supramolecular Biomaterials Laboratory, National
Or4
Univeristy of Singapore, Republic of Singapore
PEG-detachable cationic polymer for FGFR-targeted delivery
of p53
Thomas Bucher, INSERM UMR649, Nantes, France
New AAV-based strategies for gene therapy of a feline SMA
model
Thi My Anh Neildez, Généthon, Evry, France
Physiologic oxygen levels improve in-vitro generation of
regulatory T Lymphocytes.
16:15 –16:45
Break
16:45 –18:45
Biotech Forum
Or5
Or6
Chairpersons: Sophie Gomez et Sophie Lebel-Binay
Introduction by Atlanpole Biotherapies - Olivier Boisteau, Clean Cells
Local Companies Testimonies:
In Cell Art, Bruno Pitard/Chloé Bellocq
Affilogic, Olivier Kitten
TcL Pharma, Maryvonne Hiance
From Research to the Production of Therapies :
-A new approach to Cell Therapy for the Heart, results of Bonami trials –
Patricia Lemarchand
-A production tool for Cells, the UTCG - Sylvain Bercegeay
Development of Cell and Gene Therapies: Issues and perspectives
Progress update « Cell therapy manufacturing: stem cells and
immunobiotherapies » – Christophe Iochem, Clean Cells
Presentation of the European Project TERM – Agnès Kammoun
18:45 –19:30
Opening Lecture
Thierry VandenDriessche, Free University of Brussels (VUB),
Brussels, Belgium.
Cell and Gene Therapy, 10 years on.
19:45 –21:00
Welcome Reception (co-sponsored by Atlanpole Biotherapie)
Brasserie Felix
TUESDAY 7 JUNE
9:00 -10:45
Cell therapy and transplantation
Chairpersons: Gilles Blancho et Michel Pucéat
Gilles Blancho, INSERM UMR 643, CHU de Nantes, France
Use of transgenic and cloned animals in xenotransplantation
José V. Castell, Dep.de Bioquímica, Hospital Universitario La
Fe, Valencia, Spain
HEPATIC CELL THERAPY: WHEN?, WITH WHICH CELLS?, WHICH CLINICAL
OUTCOME?. (THE EXPERIENCE OF VALENCIA).
Inv7
Inv8
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10th Congress of the French Society of Cell
and Gene Therapy
Nantes, 6-8 June 2011
Selected Abstracts
Elodie Fourquet, INSERM U1037 Toulouse, France
Using engineered stromal cells for the targeted therapy of
liver carinoma
Wenwei Zhang, Inserm U972, Kremlin-Bicêtre, France
Characterization at the clonal level of mesenchymal stem cells
from human fetal liver
Nicolas Petit, INSERM U95, Hôpital de la Pitié Salpêtrière, Paris,
Or7
Or8
Or9
France
Progress towards gene therapy of HIV infection in humanized
mice
10:45 -11:15
Break
11:15 -12:45
Muscular and neuromuscular therapies
Chairpersons: Luis Garcia et Anna Salvetti
Karl Rouger, UMR 703 INRA, Ecole Nationale Vétérinaire, Nantes Inv9
Atlantique, France
Long-term muscle repair and clinical efficacy in Duchenne
Muscular Dystrophy dogs after systemic delivery of allogenic
Muscle Stem (MuStem) cells
Luis Garcia, Biothéraphies des maladies du système neuromusculaire,
Inv10
UMRS 974/Institut de myologie, Paris, France
Antisense delivery for mRNA-based therapeutics for
neuromuscular diseases.
Selected Abstracts
Alberto Epstein, CGphiMC - UMR5534 CNRS - Université Lyon 1,
Or10
France
Silencing of NMDA receptor NR1 subunit using HSV-1-derived
amplicon vectors impairs cognitive functions in rats and
reduces amyloid-beta oligomers binding and toxicity in
cultured neurons.
Caroline Sevin , INSERM U745, Paris, France
Brain gene therapy for Metachromatic Leukodystrophy using
AAVrh10 vector : optimized clinical protocol
12:45 -14:30
Lunch Sponsored by THERMOFISHER
Thermo Prize Awards Ceremony
14:30 -15:15
SFTCG ASSEMBLEE GENERALE DES MEMBRES
Or11
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10th Congress of the French Society of Cell
and Gene Therapy
Nantes, 6-8 June 2011
15:15 -17:30
Vectors and immune response
Chairpersons: François Lemoine et Anne Galy
Bernhard Ryffel, Labo d'immunologie et embryologie moléculaire,
Inv11
UMR 6218 CNRS, Université d'Orléans, France
Innate immune response: Mechanisms and pathways
Anne Galy, Genethon, Evry, France
Mechanisms of immunization by gene transfer
Jennifer Richardson, UMR 1161 Virologie Inra, Anses, ENVA,
Inv12
Inv13
Maisons-Alfort, France
Antigen encoded by vaccine vectors derived from human
adenovirus serotype 5 is preferentially presented to CD8+ T
lymphocytes by the CD8alpha+ dendritic cell subset
Selected Abstracts
Aurelie Ploquin, INSERM U758, ENS Lyon, France
Recombinant AAV vectors as genetic vaccines to induce a
neutralising humoral response against nipah virus
Geraldine Lescaille, UPMC Paris 06 & UMR CNRS 7211/INSERM
Or12
Or13
U959,Paris, France
Vaccine strategy based on DNA vaccines forming E7
recombinant retrovirus-like particles for the treatment of
HPV-induced head and neck cancers
Christine Chauveau, INSERM U649, Nantes, France
Impact of the immune system on rAAV2/4.hRPE65 mediated
gene delivery in retina: Efficacy of sequential subretinal
readministration of rAAV2/4.hRPE65 in RPE65-/- dogs.
17:30 -19:00
POSTERS
19:30 -22:00
Gala Dinner (Invitations or Pre-booking only)
Or14
MERCREDI 8 JUIN
8:30-10:45
Innovative cell and gene therapies in cancer
Chairpersons: Daniel Scherman et Pierre Cordelier
Inv14
Daniel Scherman, Laboratory of Chemical and Genetic Pharmacology
Inv15
and of Imaging - UMR 8151 CNRS - U1022 Inserm - Paris
Recent progress in non viral gene delivery and therapy
Jean Rommelaere, DKFZ Dept. F010 and INSERM Unit 701,
Inv16
Deutsches Krebsforschungszentrum, Heidelberg, Germany
Virotherapy of glioblastoma
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10th Congress of the French Society of Cell
and Gene Therapy
Nantes, 6-8 June 2011
Selected Abstracts
Joe-Marc Chauvin, INSERM U892 F-44093, Nantes, France
The cross-priming of tumor reactive cytotoxic T cells by
synthetic long peptides depends on a sufficient HLA binding
of the CD8 epitope.
Valerie Trichet, INSERM UMR957 Faculté de médecine, Nantes,
Or15
Or16
France
Therapeutic interest of RNA interference molecules in two
rare bone diseases
Flavie Sicard, INSERM UMR1037, Toulouse, France
In vivo targeting of microRNA 21 using lentiviral vectors for
the gene therapy of pancreatic cancer
10:45-11:15
Break
11:15-13:00
POSTERS
13:00-14:00
LUNCH
14:00-16:30
Clinical trials « 10 years on »
Chairpersons: Odile Cohen Hagenhauer et Nathalie Cartier
Salima Hacein-Bey, Département de biothérapies, Hôpital Necker
Or17
Inv17
Enfants-Malades, Paris, France
Ten years of gene therapy for SCID-X1
Amit Nathwani, Departmentof Haematology, University College
Inv18
London ,KD Haemophilia Centre and Thrombosis Unit, Royal Free NHS
Trust, NHS Blood and Transplant, U.K
A phase I/II clinical trial entailing peripheral vein administration of
a novel self complementary adeno-associated viral vector
encoding human FIX for haemophilia B gene therapy
Graziella Pellegrini, Centre for Regenerative Medicine "Stefano
Inv19
Ferrari", Modena, Italy
Limbal stem-cell therapy and long-term corneal regeneration
Selected Abstracts
Marie-Anne Burlot, U745 INSERM, Faculté de Pharmacie, Paris,
Or18
France
Evaluation of cholesterol 24S-hydroxylase overexpression by
AAV-gene transfer as a potential therapeutic target for
Alzheimer’s Disease-Like Tau Neuropathology
Caroline Le Guiner, GENETHON, Evry, France
Effective limb transduction and phenotypic correction after
injection of rAAV8-U7snRNA in GRMD dogs
Or19
Closing
David Klatzmann, UPMC CNRS UMR 7211 / INSERM U959,Groupe
Hospitalier Pitié Salpêtrière, Paris, France
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