International Chair of Therapeutic Innovation - CNRS
Transcription
International Chair of Therapeutic Innovation - CNRS
International Chair of Therapeutic Innovation Prof. Jonathan W. LEDERER Prof. Lederer graduated from Yale University (PhD with Prof. Richard W. Tsien in 1975, MD in 1976) and did his postdoctoral training in Oxford with Prof. Denis Noble (1977-1979). He has been a principle investigator for about 30 years, receiving his first NIH R01 in 1980 and has been continuously funded since then. In 1998 he received an NIH Merit award for work on Ca2+ signaling in heart and has published extensively on this and related topics. He has carried out novel work on cardiac Ca2+ signaling since 1976 and has been particularly focused on the details of cardiac molecular signaling and on the role of Ca2+ signaling on many scales (molecular, subcellular, cellular and tissue). He discovered the Ca2+-activated arrhythmogenic "transient inward current" (ITI) in cells and Purkinje fibers, characterized Ca2+ overload in these cells and tissues, discovered Ca2+ sparks (with Mark Cannell and Heping Cheng) and has investigated critical features in cardiac molecular physiology and pathophysiology. His work is marked by advanced cellular techniques (imaging while doing photolysis and electrophysiology) and much use of state-of-the-art imaging. Recently he and his colleagues discovered "X-ROS" signaling and developed novel instrumentation that has made it possible to stretch single ventricular myocytes while measuring force, doing imaging and patch clamping the cells. Prof. Lederer has been a consultant or collaborator on numerous grants. International Chair of Therapeutic Innovation PLENARY LECTURE Member Laboratories: Cea iBiTec-S SCBM Cea iBiTec-S SIMOPRO Cnrs UMR 8076 Cnrs UMR 8113 Cnrs UMR 8122 Cnrs UMR 8182 Cnrs UMR 8612 Cnrs UPR 2301 Inserm UMR-S 769 Inserm UMR-S 914 Inserm UMR-S 981 Inserm UMR-S 996 Inserm UMR-S 999 Inserm UMR-S 1012 Inserm UMR-S 1030 X-ROS in the heart: a novel nanoscopic signaling pathway by Coordinating Partner: Partner Institutions: Prof. W. Jonathan LEDERER Professor & Director Center for Biomedical Engineering and Technology University of Maryland, Baltimore, USA & Professor of Physiology School of Medicine, University of Baltimore, USA Date : vendredi 20 Avril 2012 à 15h30 Lieu : Contact: Dr. Rodolphe Fischmeister Coordinator LabEx LERMIT Inserm UMR-S 769 Faculté de Pharmacie Université Paris-Sud 5, Rue Jean-Baptiste Clément 92296 Châtenay-Malabry Cedex France Tel.: +33-1-46.83.57.71 Fax: +33-1-46.83.54.75 [email protected] Centre Chirurgical Marie Lannelongue Amphithéâtre René Sauvage 133 avenue de la résistance Le Plessis Robinson http://www.u999.u-psud.fr/fr/plan-dacces.html Contact : [email protected]