LES PUBLICATIONS Philippe LEFEBVRE

LES PUBLICATIONS
MOLECULAR ANALYSIS OF GENE REGULATION IN CARDIO-METABOLIC DISEASES
U 1011 Inserm
Institut Pasteur de Lille
Université de Lille 2
affiliated to IFR 114 & IFR 142
Responsable
Philippe LEFEBVRE
00 33 3 20 97 42 20
2010
Carmona MC, Lefebvre P, Lefebvre B, Galinier A, Benani A, Jeanson Y, Louche K, Flajollet S, Ktorza A,
Dacquet C, Pénicaud L,
Casteilla L From The Consortium Of The French Ministry Of Research And Technology : Molecules And New
Therapeutic Targets
Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice.
Int J Obes, 2009, 33:204-211.
Lefebvre B, Benomar Y, Guedin A, Langlois A, Hennuyer N, Dumont J, Bouchaert E, Dacquet C, Penicaud L,
Casteilla L, Pattou F, Ktorza A, Staels B, Lefebvre P.
Proteasomal degradation of Retinoid X Receptorα reprograms transcriptional activity of PPARγ in obese mice and
humans.
J Clin Invest, 2010, 120:1454-1468.
Lefebvre P, Benomar Y, Staels B.
Retinoid X receptors : common heterodimerization partners with distinct functions.
Trends Endocrinol Metab, 2010, in press.
Pourcet B, Pineda-Torra I, Derudas B, Staels B, Glineur C.
SUMOylation of the human peroxisome proliferator-activated receptorα inhibits trans-activity through the recruitment of
the nuclear corepressor NCoR.
J Biol Chem, 2010, 285:5983-5992.
Ristea Popescu I, Helleboid-Chapman A, Lucas A, Vandewalle B, Dumont J, Bouchaert E, Derudas B, KerrConte J, Caron S, Pattou F, Staels B.
The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity.
FEBS Letters, 2010, 584:2845-2851.
2009
Bougarne N, Paumelle R, Caron S, Hennuyer N, Mansouri R, Gervois P, Staels B, Haegeman G, De Bosscher K.
PPARα blocks glucocorticoid receptor α-mediated transactivation but cooperates with the activated glucocorticoid
receptor α for
transrepression on NF-κB.
Proc Natl Acad Sci USA, 2009, 106:7397-7402.
Carmona MC, Lefebvre P, Lefebvre B, Galinier A, Benani A, Jeanson Y, Louche K, Flajollet S, Ktorza A,
Dacquet C, Pénicaud L, Casteilla L.
From The Consortium Of The French Ministry Of Research And Technology : Molecules And New Therapeutic Targets
Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice.
Int J Obes, 2009, 33:204-211.
Helleboid-Chapman A, Nowak M, Helleboid S, Moitrot E, Rommens C, Dehondt H, Heliot L, Drobecq H,
Fruchart-Najib J, Fruchart JC.
Apolipoprotein AV modulates insulin secretion in pancreatic β-cells through its interaction with Midkine.
Cell Physiol Biochem, 2009, 24:451-460.
Lalloyer F, Pedersen TA, Gross B, Lestavel S, Yous S, Vallez E, Gustafsson JA, Mandrup S, Fievet C, Staels B,
Tailleux A.
Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR
heterodimer in the liver.
Arterioscler Thromb Vasc Biol, 2009, 29:1488-1495.
Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B.
Role of bile acids and bile acid receptors in metabolic regulation.
Physiol Rev, 2009, 89:147-191.
2008
Carpentier R, Sacchetti P, Segard P, Staels B, Lefebvre P.
The glucocorticoid receptor is a co-regulator of the orphan nuclear receptor Nurr1.
J Neurochem, 2008, 104:777-789.
Duez H, Van Der Veen J, Duhem C, Pourcet B, Touvier T, Fontaine C, Derudas B, Bauge E, Havinga R, Bloks
VW, Wolters H, Van Der Sluijs FH, Vennstrom B, Kuipers F, Staels B.
Regulation of bile acid synthesis by the orphan nuclear receptor Reverbalpha.
Gastroenterology, 2008, 135:689-698.
Fontaine C, Rigamonti E, Pourcet B, Duez H, Fruchart JC, Chinetti-Gbaguidi G, Staels B.
The orphan nuclear receptor Rev-erbalpha is a novel Liver X Receptor (LXR) target gene driving a negative feedback
loop on select LXR-induced pathways in human macrophages.
Mol Endocrinology, 2008, 22:1797-1811.
Mansouri RM, Bauge E, Gervois P, Fruchart-Najib J, Fievet C, Staels B, Fruchart JC.
Atheroprotective effect of human apolipoprotein A5 in a mouse model of mixed dyslipidemia.
Circ Res, 2008, 103:450-453.
Mansouri R, Bauge E, Staels B, Gervois P.
Systemic and distal repercussions of liver-specific PPARa control of the acute phase response.
Endocrinology, 2008, 149:3215-3223.
Nowak M, Helleboid-Chapman A, Jakel H, Moitrot E, Rommens C, Pennachio LA, Fruchar-Najib J, Fruchart JC.
Glucose regulates the expression of the apolipoprotein A5 gene.
J Mol Biol, 2008, 380:789-798.
Rigamonti E, Fontaine C, Lefebvre B, Duhem C, Lefebvre P, Marx N, Staels B, Chinetti-Gbaguidi G.
Induction of CXCR2 receptor by PPARg in human macrophages.
Arterioscler Thromb Vasc Biol, 2008, 28:932-939.
2007
Ahituv N, Akiyama J, Chapman-Helleboid A, Fruchart J, Pennacchio LA.
In vivo characterization of human apo A5 haplotypes.
Genomics, 2007, 90:674-679
Carmona MC, Louche K, Lefebvre B, Pilon A, Hennuyer N, Audinot- Bouchez V, Fievet C, Torpier G,
Formstecher P, Renard P, Lefebvre P, Dacquet C, Staels B, Casteilla L, Penicaud L on behalf of the
Consortium of the French Ministry of Research and Technology.
S 26948 : a new specific PPARg modulator with potent antidiabetes and antiatherogenic effects.
Diabetes, 2007, 56 : 2797-2808.
Flajollet S, Lefebvre B, Cudejko C, Staels B, Lefebvre P.
The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid
receptor.
Mol Cell Endocrinol, 2007, 270:3-32.
Fontaine C, Rigamonti E, Nohara A, Gervois P, Teissier E, Fruchart JC, Staels B, Chinetti-Gbaguidi G.
Liver X receptor activation potentiates the lipopolysaccharide response in human macrophages.
Circ Res, 2007, 101:40-49.
Gervois P, Fruchart JC, Staels B.
Drug insight : mechanisms of action and therapeutic applications for agonists of PPAR.
Nat Clin Pract Endocrinol Metab, 2007, 3:145-156.
Gross B, Staels B.
PPAR agonists : multimodal drugs for the treatment of type-2 diabetes.
Best Pract Res Clin Endoc Met, 2007, 21:687-710.
PhD
Benoît POURCET
Directeur de thèse : Corine Glineur
"Mécanismes moléculaires de la régulation de l’activité du récepteur nucléaire humain PPARα : un rôle-clef des
modifications post-traductionnelles"
Université de Lille 2
30 Mars 2009
Roxane MANSOURI
Directeur de thèse : Philippe Gervois
"PPARα : contribution globale dans le contrôle de l’inflammation liée aux risques cardiovasculaires"
Université de Lille 2
17 Décembre 2007
Rodolphe CARPENTIER
Directeur de thèse : Philippe Lefebvre
"Partenaires d’interactions, gènes cibles et rôles potentiels du récepteur nucléaire orphelin Nurr1"
Université de Lille 2
26 Novembre 2007