Õÿ∫ —µ`°“√≥å· ≈–«`∏`√—°…“‡π ÈÕßÕ°Àπ—ßµ“ ÿπ

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121
√“¬ß“π —Èπ
Õÿ∫—µ‘°“√≥å·≈–«‘∏’√—°…“‡π◊ÈÕßÕ°Àπ—ßµ“ ÿπ—¢ : 69 µ—« (2543-2546)
π≈‘π’ µ—𵑫π‘™1* ª√“≥’ µ—𵑫π‘™1 —𵑠«ß§åÕ”π«¬°ÿ≈1 Õπÿ‡∑æ √—ß ’æ‘æ—≤πå2
Abstract
Nalinee Tuntivanich1* Pranee Tuntivanich1 Santi Wongaumnuaykul1 Anudep Rungsipipat2
THE PREVALENCE AND TREATMENT OF EYELID NEOPLASMS IN
DOGS : 69 CASES (2000-2003)
The prevalence and treatment of 69 eyelid masses in dogs at the Ophthalmology clinic, Department of
Surgery, Small Animal Hospital, Chulalongkorn University, between November 2000 and November 2003, in
relation to breed, sex, age, location, tumor size, histopathological diagnosis and surgical treatment is reported.
The average age of the affected dogs was 7.85 years. Mixed breeds, males and the upper eyelid were at a higher risk.
The average size of the mass was 6.49 mm. Benign tumors (88.41%) were more frequent than malignant ones
(11.59%). Sebaceous gland tumors were more frequently encounted (79.7%) than malignant tumors, malignant
melanomas, squamous cell carcinomas and mastocytomas. Amputation and liquid nitrogen spray cryotherapy
is the effective treatment for all eyelid masses with a 100% cure rate.
Keywords : eyelid, neoplasms, dog
1
Ophthalmology clinic, Small Animal Hospital, Department of Surgery, Faculty of Veterinary Science, Chulalongkorn University, Pathumwan
Bangkok, 10330
2
Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Pathumwan Bangkok, 10330
*
Corresponding author
1
Àπ૬®—°…ÿ§≈‘π‘° ‚√ß欓∫“≈ —µ«å‡≈Á° ¿“§«‘™“»—≈¬»“ µ√å §≥– —µ«·æ∑¬»“ µ√å ®ÿÓ≈ß°√≥å¡À“«‘∑¬“≈—¬ ª∑ÿ¡«—π °√ÿ߇∑æœ 10330
¿“§«‘™“欓∏‘«‘∑¬“ §≥– —µ«·æ∑¬»“ µ√å ®ÿÓ≈ß°√≥å¡À“«‘∑¬“≈—¬ ª∑ÿ¡«—π °√ÿ߇∑æœ 10330
*
ºŸâ√—∫º‘¥™Õ∫∫∑§«“¡
2
122
Thai J. Vet. Med. Vol. 34 No. 4, 31 December 2004
∫∑§—¥¬àÕ
π≈‘π’ µ—𵑫π‘™1* ª√“≥’ µ—𵑫π‘™1 —𵑠«ß§åÕ”π«¬°ÿ≈1 Õπÿ‡∑æ √—ß ’æ‘æ—≤πå2
Õÿ∫—µ‘°“√≥å·≈–«‘∏’√—°…“‡π◊ÈÕßÕ°Àπ—ßµ“ ÿπ—¢ : 69 µ—« (2543-2546)
√“¬ß“πÕÿ∫—µ‘°“√≥å¢Õ߇π◊ÈÕßÕ°Àπ—ßµ“ ÿπ—¢ ®”π«π 69 µ—« ∑’ˇ¢â“¡“√—∫°“√√—°…“∑’ËÀπ૬®—°…ÿ§≈‘π‘° ¿“§«‘™“»—≈¬»“ µ√å
‚√ß欓∫“≈ —µ«å‡≈Á° §≥– —µ«·æ∑¬»“ µ√å ®ÿÓ≈ß°√≥å¡À“«‘∑¬“≈—¬ √–À«à“߇¥◊Õπ惻®‘°“¬π 2543 ∂÷߇¥◊Õπ惻®‘°“¬π 2546
∑’ˇ°’ˬ«°—∫æ—π∏ÿå ‡æ» Õ“¬ÿ µ”·Àπàß∑’Ëæ∫ ™π‘¥ ¢π“¥ ·≈–«‘∏’°“√√—°…“ ‡π◊ËÕßÕ°∑’ËÀπ—ßµ“æ∫‰¥â¡“°∑’Ë ÿ¥∑’ËÀπ—ßµ“∫π„π ÿπ—¢æ—π∏ÿåº ¡
‡æ»ºŸâ Õ“¬ÿ‡©≈’ˬ 7.85 ªï ¢π“¥‡©≈’ˬ¢Õß°âÕπ‡π◊ÈÕ‡∑à“°—∫ 6.49 ¡¡. ‡ªìπ‡π◊ÈÕßÕ°™π‘¥‰¡à√⓬√âÕ¬≈– 84.41 ™π‘¥√⓬√âÕ¬≈– 11.59
‡π◊ÈÕßÕ°™π‘¥‰¡à√⓬¢ÕßµàÕ¡ sebaceous æ∫‰¥â¡“°∑’Ë ÿ¥√âÕ¬≈– 79.7 ‡π◊ÈÕßÕ°™π‘¥√⓬‰¥â·°à malignant melanoma, squamous
cell carcinoma ·≈– mastocytoma °“√√—°…“¥â«¬«‘∏’µ—¥ÕÕ°·≈â«æàπ¥â«¬‰π‚µ√‡®π‡À≈« ‰¥âª√– ‘∑∏‘º≈√âÕ¬≈– 100 ∑—Èß™π‘¥√⓬
·≈–‰¡à√⓬
§” ”§—≠ : Àπ—ßµ“ ‡π◊ÈÕßÕ° ÿπ—¢
∫∑π”
Àπ—ßµ“‡ªìπ à«πª√–°Õ∫¢Õßµ“∑’Ë¡’ à«π¢Õߺ‘«Àπ—ß
‡¬◊ËÕ‡¡◊Õ° µàÕ¡µà“ßÊ ·≈–°≈â“¡‡π◊ÈÕ ∑”Àπâ“∑’˪ÑÕß°—π≈Ÿ°µ“
Àπ—ßµ“ª√–°Õ∫¥â«¬º‘«Àπ—ß 2 ™—Èπ ™—ÈππÕ°¡’≈—°…≥–‡ªìπº‘«
Àπ—ß∑—Ë«Ê ‰ª ·µà∫“ß°«à“ à«π™—Èπ„π‡ªìπ‡¬◊ËÕ‡¡◊Õ°∫“ß ’¢“«
‡√’¬°«à“ palpebral conjunctiva Àπ—ßµ“¡’µàÕ¡ meibomian
À√◊ÕµàÕ¡ tarsal Õ¬Ÿàµ≈Õ¥§«“¡¬“«¢Õß tarsal plate (Prince et
al., 1960) ∂Ⓡ°‘¥°“√Õ—°‡ ∫¢ÕßÀπ—ßµ“ µàÕ¡ meibomian
Õ“®®–¢¬“¬„À≠à·≈–¡’ÀπÕ߉À≈ÕÕ°¡“ ´÷Ëß “¡“√∂√—°…“‰¥â
‚¥¬∫’∫µàÕ¡‡Õ“ÀπÕß∑’ËÕ¬Ÿà¿“¬„πÕÕ°¡“ ·≈⫪ѓ¬µ“¥â«¬¬“
ªØ‘™’«π–º ¡§Õ√嵑‚§ ‡µ’¬√å√Õ¬¥å (ª√“≥’ ·≈–§≥–, 2002)
‡π◊ÕÈ ßÕ°∑’ÀË π—ßµ“ ÿπ¢— Õ“®®–æ∫™π‘¥ papilloma ∑’„Ë °≈âÊ
¢Õ∫µ“ hemangioma À√◊Õ meibomian adenoma ‡π◊ÈÕßÕ°∑’Ë
Àπ—ßµ“æ∫‰¥â∫Õà ¬∑’ Ë ¥ÿ „π —µ«åÕ“¬ÿ¡“° (Milton, 1986; Severin,
1995) —µ«å∑’ˇªìπ‚√§®–· ¥ßÕ“°“√√–§“¬‡§◊Õß∑”„Àâ°–æ√‘∫
µ“∫àÕ¬Ê πÈ”µ“‰À≈ (Robert et al., 1986) ∫“ߧ√—Èß°âÕπ‡π◊ÈÕ
‰ª —¡º— °—∫°√–®°µ“∑”„Àâ°√–®°µ“Õ—°‡ ∫À√◊Õ‡ªìπ·º≈‰¥â
(ª√“≥’ ·≈–§≥– 1998; Gelatt and Gelatt, 2001)
®÷ßÕ“®®–√—°…“„ÀâÀ“¬‰¥â¥«â ¬°“√∑”»—≈¬°√√¡‡¬◊Õ°·¢Áß (ª√“≥’
·≈–§≥–, 1998) °“√√—°…“¥â«¬«‘∏’»—≈¬°√√¡µ—¥ÕÕ°À√◊Õ„™â
‰øøÑ“ ‰¡à‡ªìπ∑’Ëπ‘¬¡ ‡π◊ËÕß®“°¡’°“√∑”≈“¬‡π◊ÈÕ‡¬◊ËÕ¡“°‡°‘π‰ª
(Roberts et al., 1986)
«— µ ∂ÿ ª √– ß§å ¢ Õß°“√»÷ ° …“‡æ◊Ë Õ √“¬ß“πÕÿ ∫— µ‘ ° “√≥å
°“√‡°‘¥‚√§‡π◊ÈÕßÕ°∑’ËÀπ—ßµ“ ÿπ—¢®”π«π 69 µ—« ∑’Ëæ∫µ—Èß·µà
‡¥◊Õπ惻®‘°“¬π 2543 ∂÷߇¥◊Õπ惻®‘°“¬π 2546 ¥—ßπ’È Õ“¬ÿ
æ—π∏ÿå ·≈–‡æ»¢Õß ÿπ—¢∑’ˇªìπ‚√§ µ”·Àπàß∑’Ëæ∫‡π◊ÈÕßÕ°·≈–
¢π“¥¢Õ߇π◊ÈÕßÕ° ™π‘¥¢Õ߇π◊ÈÕßÕ° ·≈–«‘∏’°“√√—°…“·≈–º≈
¢Õß°“√√—°…“
«— ¥ÿ·≈–«‘∏’°“√
ÿπ—¢®”π«π 69 µ—« ‡ªìπ ÿπ—¢ªÉ«¬∑’ˇ¢â“¡“√—∫°“√
√—°…“∑’ËÀπ૬®—°…ÿ§≈‘π‘° ¿“§«‘™“»—≈¬»“ µ√å ‚√ß欓∫“≈
—µ«å‡≈Á° §≥– —µ«·æ∑¬»“ µ√å ®ÿÓ≈ß°√≥å¡À“«‘∑¬“≈—¬
µ—Èß·µà‡¥◊Õπ惻®‘°“¬π 2543 ∂÷߇¥◊Õπ惻®‘°“¬π 2546
¥â«¬Õ“°“√æ∫°âÕπ‡π◊ÈÕ∑’ËÀπ—ßµ“∫πÀ√◊ÕÀπ—ßµ“≈à“ß
∑”°“√‡°Á∫√«∫√«¡ª√–«—µ∑‘ “ߧ≈‘π°‘ ‰¥â·°à æ—π∏ÿå ‡æ»
Õ“¬ÿ µ”·Àπàß™π‘¥·≈–¢π“¥¢Õß°âÕπ‡π◊ÈÕßÕ° ‚¥¬®”·π°µ“¡
√–∫∫ Tumor Node Metastasis (TNM) (Owen, 1980)
„À⬓ atropine sulphate 0.04 ¡°./°°. √à«¡°—∫
acepromazine 0.2 ¡°./°°. ‡¢â“°≈â“¡‡π◊ÕÈ ·≈–À¬¥¬“™“ (0.5%
tetracaine hydrochloride) ∑’˵“ ¿“¬À≈—ß —µ«åßà«ß·≈–¬“™“
ÕÕ°ƒ∑∏‘Ï „™â¡¥’ À√◊Õ°√√‰°√µ—¥°âÕπ‡π◊ÕÈ ÕÕ° ¢Ÿ¥·º≈¥â«¬ curette
·≈â«æàπ¥â«¬‰π‚µ√‡®π‡À≈« 2 √Õ∫ (freeze thaw) „Àâ¡∫’ √‘‡«≥
°«â“ß°«à“√Õ¬‚√§ „™â¬“ªÑ“¬µ“™π‘¥∑’Ë¡’¬“ªØ‘™’«π–√à«¡°—∫
‡µ’¬√å√Õ¬¥å„ à·º≈∑ÿ°«—π®π°√–∑—Ëß·º≈À“¬
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123
°âÕπ™‘Èπ‡π◊ÈÕ∑’Ë∂Ÿ°µ—¥ÕÕ° ‰¥â√—∫°“√‡°Á∫√—°…“ ¿“æ„π
πÈ”¬“ 10% øÕ√å¡“≈’π ·≈⫺à“π¢—ÈπµÕπ°“√‡µ√’¬¡‡π◊ÈÕ‡¬◊ËÕ
∑“ߌ‘ ‚µ‡∑§π‘§ ‚¥¬Ωíß„πæ“√“øîπ·≈–¬âÕ¡ ’™‘Èπ‡π◊Èե⫬ ’
Œ’¡“∑ÁÕ°‰´≈‘π-Õ‘‚Õ´‘π À≈—ß®“°π—Èπ∑”°“√®”·π°≈—°…≥–
∑“ß®ÿ≈欓∏‘«‘∑¬“ µ“¡ WHO Histological classification
(Goldschmidt et al., 1998)
Strafuss (1976) √“¬ß“π°“√æ∫‡π◊ÈÕßÕ°∑’ËÀπ—ßµ“ ÿπ—¢∑’Ë¡’
¢π“¥µË”°«à“ 10 ¡¡. ‰¥â¡“°°«à“¢π“¥∑’Ë„À≠à°«à“ 10 ¡¡.
Õ¥§≈âÕß°—∫°“√»÷°…“§√—ßÈ π’∑È æ’Ë ∫‡π◊ÕÈ ßÕ°∑’ÀË π—ßµ“¢π“¥‡≈Á°°«à“
10 ¡¡. ®”π«π√âÕ¬≈– 65.22 (45/69) ¢π“¥„À≠à°«à“ 10
¡¡. ®”π«π√âÕ¬≈– 34.78 (24/69) (µ“√“ß∑’Ë 2) ¢π“¥¢Õß
°âÕπ‡π◊ÈÕßÕ°∑’ËÀπ—ßµ“¢÷ÈπÕ¬Ÿà°—∫°“√‡Õ“„®„ à¢Õ߇®â“¢Õß —µ«å
¡“°°«à“‡ÀµÿÕ◊Ëπ ∂Ⓡ®â“¢Õß —µ«å‡ªìπ§π™à“ß —߇°µ‡¡◊ËÕæ∫¡’ ‘Ëß
º‘¥ª°µ‘∑’˵“°Áπ”¡“æ∫®—°…ÿ —µ«·æ∑¬å∑—π∑’ °âÕπ‡π◊ÈÕßÕ°°Á®–
¬—ß¡’¢π“¥‡≈Á°Õ¬Ÿà ·µà∂Ⓡ®â“¢Õß≈–‡≈¬∑‘È߉«âπ“π°âÕπ‡π◊ÈÕ°Á®–¡’
¢π“¥„À≠à¢÷Èπ‡√◊ËÕ¬Ê À√◊Õ·µ°ÕÕ° °âÕπ‡π◊ÈÕßÕ°¬‘Ëß¡’¢π“¥
„À≠à°Á®–¬‘Ëß∑”„À⇰‘¥°“√√–§“¬‡§◊Õß∑’˵“‡æ‘Ë¡¡“°¢÷Èπ ‡¡◊ËÕ
∑”°“√æ‘®“√≥“µ“¡·∫∫ TNM æ∫°âÕπ‡π◊ÈÕ¡’¢π“¥‡ âπºà“π
»Ÿπ¬å°≈“߇©≈’ˬ 6.9 ¡¡. ‚¥¬‰¡àæ∫°“√·æ√à°√–®“¬‰ª¬—ß
µàÕ¡πÈ”‡À≈◊ÕßÀ√◊Õ·æ√à°√–®“¬‰ª¬—ßÕ«—¬«–¿“¬„πÀ√◊Õ¿“¬„π
≈Ÿ°µ“
‡¡◊Ë Õ ®”·π°™π‘ ¥ ∑“ß®ÿ ≈ 欓∏‘ «‘ ∑ ¬“æ∫‡π◊È Õ ßÕ°™π‘ ¥
‰¡à√⓬√âÕ¬≈– 88.41 (61/69) ·≈–™π‘¥√⓬√âÕ¬≈– 11.59
(8/69) ‡π◊ÈÕßÕ°∑’Ëæ∫¡“°∑’Ë ÿ¥‰¥â·°à sebaceous adenoma 20
µ—« (20/61, 32.79%) ÿπ—¢¡’Õ“¬ÿ‡©≈’ˬ 6.67 ªï ¢π“¥¢Õß
°âÕπ‡π◊ÈÕ‡©≈’ˬ 5.11 ¡¡. æ∫∑’ËÀπ—ßµ“∫π 10 µ—« ·≈–Àπ—ß
µ“≈à“ß 10 µ—« √Õß≈ß¡“‰¥â·°à sebaceous epithelioma À√◊Õ
meibomian epithelioma 18 µ—« (18/61, 29.5%) Õ“¬ÿ ÿπ—¢
‡©≈’ˬ 9.22 ªï ¢π“¥¢Õß°âÕπ‡π◊ÈÕ‡©≈’ˬ 8.33 ¡¡. æ∫∑’ËÀπ—ß
µ“∫π 14 µ—« ·≈–Àπ—ßµ“≈à“ß 4 µ—« ™π‘¥ sebaceous hyperplasia
17 µ—« (17/61, 27.87%) Õ“¬ÿ ÿπ—¢‡©≈’ˬ 7.29 ªï ¢π“¥¢Õß
°âÕπ‡π◊ÈÕ‡©≈’ˬ 5.82 ¡¡. æ∫∑’ËÀπ—ßµ“∫π 11 µ—« ·≈–Àπ—ß
µ“≈à“ß 6 µ—« Õ¥§≈âÕß°—∫√“¬ß“π¢Õß Rungsipipat ·≈–§≥–
(2003) ∑’Ëæ∫Õÿ∫—µ‘°“√≥å‡π◊ÈÕßÕ°¢Õß sebaceous gland ∑’Ë
∫√‘‡«≥‡¬◊ËÕ∫ÿÀπ—ßµ“¢Õß ÿπ—¢√âÕ¬≈– 37.8 (48/127) ‡π◊ÈÕßÕ°
™π‘¥ papilloma æ∫‰¥âπâÕ¬∑’Ë ÿ¥∑’ËÀπ—ßµ“ æ∫‰¥â 6 µ—« (6/61,
9.84%) Õ“¬ÿ µ— «å‡©≈’¬Ë 6.83 ªï ¢π“¥¢Õß°âÕπ‡π◊ÕÈ ‡©≈’¬Ë 5.67
¡¡. æ∫∑’ËÀπ—ßµ“∫π 4 µ—« ·≈–Àπ—ßµ“≈à“ß 2 µ—« (µ“√“ß∑’Ë 3)
à«π malignant melanoma, squamous cell carcinoma ·≈–
malignant mastocytoma ∑’Ëæ∫‰¥â 5 µ—« (5/8 62.5%), 2 µ—«
(2/8 25%) ·≈– 1 µ—« (1/8 12.5%) µ“¡≈”¥—∫ malignant
melanoma æ∫„π ÿπ—¢Õ“¬ÿ‡©≈’ˬ 7.4 ªï ¡’¢π“¥¢Õß°âÕπ‡π◊ÈÕ
‡©≈’ˬ 9.4 ¡¡. æ∫∑’ËÀπ—ßµ“∫π 2 µ—« ·≈–Àπ—ßµ“≈à“ß 3 µ—«
™π‘¥ squamous cell carcinoma æ∫„π ÿπ—¢Õ“¬ÿ‡©≈’ˬ 8 ªï
¢π“¥¢Õß°âÕπ‡π◊ÈÕ‡©≈’ˬ 8.5 ¡¡. ∑’ËÀπ—ßµ“≈à“ß∑—Èß 2 µ—« à«π
malignant mastocytoma ‡ªìπ‡π◊ÕÈ ßÕ°√⓬∑’æË ∫‰¥âπÕâ ¬∑’ Ë ¥ÿ ‡æ’¬ß
º≈·≈–«‘®“√≥å
„π°“√»÷°…“‡π◊ÈÕßÕ°∑’ËÀπ—ßµ“∫π·≈–Àπ—ßµ“≈à“ß ÿπ—¢
®”π«π 69 µ—« æ∫«à“ ÿπ—¢æ—π∏ÿåº ¡ ¡’Õÿ∫—µ‘°“√≥å Ÿß ÿ¥√âÕ¬≈–
27.54 (19/69) ´÷Ëß Õ¥§≈âÕß°—∫ Roberts ·≈–§≥– (1986)
‰¥â√“¬ß“π‰«â √Õß≈ß¡“‰¥â·°àæ—π∏ÿå Shihtzu ·≈–æ—π∏ÿå Cocker
Spaniel æ∫‰¥â √âÕ¬≈– 15.94 (11/69) ·≈–√âÕ¬≈– 8.69
(6/69) µ“¡≈”¥—∫ æ—π∏ÿå Poodle ·≈– Pekingese æ∫‰¥âæ—π∏ÿå
≈– 5 µ—« (7.24%) Great Dane ·≈– Datchshund æ∫‰¥â
æ—π∏ÿå≈– 3 µ—« (4.35%) æ—π∏ÿå Doberman Pinscher Rottweiler
Golden Retreiver St. Bernard ·≈– Bassette Hound æ∫‰¥â
æ—π∏ÿå≈– 2 µ—« (2.90%) æ—π∏ÿå Masstiff Miniature Pinscher
Pug Yorkshire Terrier Chow-chow Char-Pei ·≈– Springle
spaniel æ∫‰¥âæ—π∏ÿå≈– 1 µ—« (1.45%) (µ“√“ß∑’Ë 1) ´÷Ëß·µ°
µà“ß®“°√“¬ß“π¢Õß Strafuss (1976) ∑’Ëæ∫‡π◊ÈÕßÕ°∑’ËÀπ—ßµ“
¡“°∑’Ë ÿ¥„π ÿπ—¢æ—π∏ÿå Poodle √Õß≈ß¡“‰¥â·°àæ—π∏ÿåº ¡
°“√∑’Ë æ ∫°â Õ π‡π◊È Õ ßÕ°∑’Ë À π— ß µ“ ÿ π— ¢ æ— π ∏ÿå º ¡·≈–
æ—π∏ÿå Shihtzu ¡“°°«à“æ—π∏ÿåÕ◊Ëπ Õ“®®–‡π◊ËÕß®“°¡’ºŸâπ‘¬¡‡≈’Ȭß
ÿπ—¢∑—Èß Õßæ—π∏ÿåπ’È¡“°°«à“æ—π∏ÿåÕ◊ËπÊ ·≈–æ∫„π‡æ»ºŸâ√âÕ¬≈–
63.77(44/69) ‡æ»‡¡’¬√âÕ¬≈– 36.23(25/69) (µ“√“ß∑’Ë 1)
µà“ß®“°∑’Ë Robert ·≈–§≥– (1986) ‰¥â√“¬ß“π‰«â«à“æ∫‡π◊ÈÕ
ßÕ°∑’ËÀπ—ßµ“ „π ÿπ—¢‡æ»‡¡’¬¡“°°«à“‡æ»ºŸâ ®“°°“√»÷°…“§√—Èß
π’Èæ∫°âÕπ‡π◊ÈÕßÕ°∑’ËÀπ—ßµ“∫π√âÕ¬≈– 60.87(42/69) ·≈–
Àπ—ßµ“≈à“ß√âÕ¬≈– 39.13(27/69) (µ“√“ß∑’Ë 1) µ√ß°—∫
√“¬ß“π¢Õß Krehbiel ·≈– Langtiam (1975) ∑’Ëæ∫°âÕπ‡π◊ÈÕ
ßÕ°∑’ËÀπ—ßµ“∫π¡“°°«à“Àπ—ßµ“≈à“ß
¢π“¥‡ âπºà“π»Ÿπ¬å°≈“ߢÕß°âÕπ‡π◊ÈÕßÕ°¡’¢π“¥µ—Èß·µà
2 ¡¡. ®π∂÷ß 20 ¡¡. ¢π“¥∑’ËπâÕ¬°«à“ 20 ¡¡. ®”π«π 65 µ—«
·≈–¢π“¥ 20 ¡¡. ®”π«π 4 µ—« ‰¡àæ∫¢π“¥∑’Ë„À≠à°«à“ 20
¡¡. ‚¥¬æ∫¢π“¥∑’ËÕ¬Ÿà√–À«à“ß 2-5 ¡¡. ·≈–¢π“¥µ—Èß·µà 610 ¡¡. ®”π«π 39 µ—« (56.52%) ·≈– 21 µ—« (30.43%)
µ“¡≈”¥—∫ ¢π“¥ 11-15 ¡¡. ·≈– 16-20 ¡¡. æ∫‰¥â 5 µ—«
(7.25%) ·≈– 4 µ—« (5.80%) µ“¡≈”¥—∫ (µ“√“ß∑’Ë 2)
Õ¥§≈âÕß°—∫∑’Ë Robert ·≈–§≥– (1986) ‰¥â√“¬ß“π‰«â
124
1 µ—«‡∑à“π—Èπ „π ÿπ—¢Õ“¬ÿ 6 ªï ¢π“¥¢Õß°âÕπ‡π◊ÈÕ 20 ¡¡.
·≈–æ∫∑’ÀË π—ßµ“∫π (µ“√“ß∑’Ë 3) ÿπ¢— æ—π∏ÿºå ¡æ∫‡ªìπ‡π◊ÕÈ ßÕ°
∑’ÀË π—ßµ“‰¥â¡“°∑’ Ë ¥ÿ à«π„À≠à‡ªìπ sebaceous gland adenoma
·≈– sebaceous gland hyperplasia (µ“√“ß∑’Ë 4)
Robert ·≈–§≥– (1986) ‰¥â√“¬ß“π°“√æ∫‡π◊ÕÈ ßÕ°™π‘¥
sebaceous gland adenoma ´÷Ë߇ªìπ‡π◊ÈÕßÕ°™π‘¥‰¡à√⓬∑’ËÀπ—ß
µ“∫π ÿπ—¢¡“°∑’Ë ÿ¥ ´÷Ëßµ√ß°—∫√“¬ß“π°“√»÷°…“§√—Èßπ’È √Õß≈ß
¡“‰¥â·°à hyperplasia ·≈– epithelioma ‡π◊ÈÕßÕ°™π‘¥√⓬æ∫
‰¥â§àÕπ¢â“ßπâÕ¬ ·≈–¡—°®–‡ªìπ™π‘¥ melanoma, mast cell
tumor, squamous cell carcinoma ·≈– hemangiosarcoma (Gelatt
and Gelatt, 2001) ®“°°“√»÷°…“§√—Èßπ’Èæ∫«à“ ‡π◊ÈÕßÕ°™π‘¥
papilloma ‡ªìπ‡π◊ÈÕßÕ°∑’ËÀπ—ßµ“™π‘¥‰¡à√⓬∑’Ëæ∫‰¥âπâÕ¬∑’Ë ÿ¥
¡—°®–æ∫Àà“ß®“°¢Õ∫µ“ÕÕ°¡“‡≈Á°πâÕ¬ ·≈–®–¡’≈—°…≥–
§≈⓬¥Õ°°–À≈Ë” ∑”„Àâ “¡“√∂·¬°‡π◊ÈÕßÕ°™π‘¥π’ÈÕÕ°®“°
™π‘¥Õ◊Ëπ‰¥âßà“¬ (Milton, 1986)
ÿπ—¢∑’Ë¡’°âÕπ‡π◊ÈÕ∑’ËÀπ—ßµ“¡’Õ“¬ÿ‡©≈’ˬ 7.85 ªï æ∫¡“°
∑’Ë ÿ¥ 40 µ—« (40/69 57.97%) ÿπ—¢∑’Ë¡’Õ“¬ÿ√–À«à“ß 4-9 ªï
24 µ—« (24/49 34.78%) ‡ªìπ ÿπ—¢∑’Ë¡’Õ“¬ÿ 10 ªï¢÷Èπ‰ª
·≈–∑’Ëæ∫πâÕ¬∑’Ë ÿ¥ 5 µ—« (5/49 7.25%) Õ¬Ÿà„π™à«ßÕ“¬ÿ‰¡à
‡°‘π 3 ªï (µ“√“ß∑’Ë 3) „°≈⇧’¬ß°—∫∑’Ë Krehbiel ·≈–§≥– (1975)
‰¥â√“¬ß“π‰«â
Thai J. Vet. Med. Vol. 34 No. 4, 31 December 2004
°“√√— ° …“‡π◊È Õ ßÕ°∑’Ë À π— ß µ“Õ“®®–∑”‰¥â ∑—È ß «‘ ∏’ ∑ “ß
»—≈¬°√√¡·≈–°“√„™â§«“¡‡¬Áπ ·µà “¡“√∂æ∫°≈—∫‡ªìπ¢÷Èπ¡“
„À¡à‰¥âÕ’° (Robert et al., 1986) Strafuss (1976) √“¬ß“π
°“√°≈—∫‡ªìπ¢÷Èπ¡“„À¡à„π‡«≈“ 30 ‡¥◊Õπ À≈—ß®“°√—°…“‡π◊ÈÕ
ßÕ°∑’ËÀπ—ßµ“¥â«¬«‘∏’∑“ß»—≈¬°√√¡ ·≈– 8 ‡¥◊ÕπÀ≈—ß®“°
√—°…“¥â«¬°“√„™â§«“¡‡¬Áπ ´÷Ëߢ÷ÈπÕ¬Ÿà°—∫™π‘¥¢Õ߇π◊ÈÕßÕ° °“√
√—°…“¥â«¬«‘∏’°“√„™â§«“¡‡¬Áπ®–∑”„Àâ¡’‚√§·∑√°´âÕππâÕ¬
√“§“∂Ÿ° ·≈–‰¡à∑”„À⇠’¬√Ÿª√à“ߢÕßÀπ—ßµ“ (Fraunfelder et al.,
1984)
„π°“√»÷°…“§√—Èßπ’ȉ¥â„Àâ°“√√—°…“°âÕπ‡π◊ÈÕßÕ°∑’ËÀπ—ß
µ“ ÿπ—¢∑—Èß™π‘¥‰¡à√⓬·≈–™π‘¥√⓬¥â«¬°“√µ—¥ÕÕ°·≈–æàπ¥â«¬
‰π‚µ√‡®π‡À≈«„Àâ§√Õ∫§≈ÿ¡ à«π∑’Ëæ∫√Õ¬‚√§ 2 §√—Èß ·≈â«
ªÑ“¬·º≈¥â«¬¬“ªÑ“¬µ“∑’¡Ë ¬’ “ªØ‘™«’ π–º ¡ ‡µ’¬√å√Õ¬¥å®π·º≈À“¬
‰¥âº≈„π°“√√—°…“‚¥¬‰¡à¡’‚√§·∑√°´âÕπ ‰¡àæ∫°âÕπ‡π◊ÈÕ‡°‘¥
¢÷Èπ¡“„À¡à ‚¥¬æ‘®“√≥“®“°°“√°≈—∫¡“√—∫°“√√—°…“´È” ·µà
º‘«Àπ—ßµ√ß∫√‘‡«≥¥—ß°≈à“«®–¡’ ’¢“«‡π◊ËÕß®“°¢“¥‡´≈≈å∑’Ë √â“ß
‡¡Á¥ ’ ®÷ß·π–π”„Àâ√—°…“‚√§‡π◊ÈÕßÕ°∑—Èß™π‘¥√⓬·≈–‰¡à√⓬∑’Ë
Àπ—ßµ“ ÿπ¢— ¥â«¬«‘∏„’ ™â§«“¡‡¬Áπ ‚¥¬°“√µ—¥°âÕπ‡π◊ÕÈ ÕÕ°°àÕπ „™â
curette ¢Ÿ¥·º≈„Àâ –Õ“¥ ·≈â«æàπ¥â«¬‰π‚µ√‡®π‡À≈«„Àâ
§√Õ∫§≈ÿ¡ à«π∑’Ëæ∫√Õ¬‚√§ 2 §√—Èß °“√√—°…“¥â«¬«‘∏’π’ȉ¥âº≈
√âÕ¬≈–√âÕ¬ √“§“‰¡à·æß Àπ—ßµ“‰¡àº‘¥√Ÿª√à“ß πÕ°®“° ’¢Õß
º‘«Àπ—ß®–‡ª≈’ˬπ‡ªìπ ’¢“«‡∑à“π—Èπ
‡«™™ “√ —µ«·æ∑¬å ªï∑’Ë 34 ©∫—∫∑’Ë 4, 31 ∏—𫓧¡ 2547
125
µ“√“ß∑’Ë 1 · ¥ßæ—π∏ÿå ‡æ» ·≈–∫√‘‡«≥∑’Ëæ∫‡ªìπ‡π◊ÈÕßÕ°∑’ËÀπ—ßµ“ ÿπ—¢
æ—π∏ÿå
®”π«π
(µ—«)
Mixed
19
Shihtzu
11
Cocker Spaniel
6
Poodle
5
Pekingese
5
Great Dane
3
Datchshund
3
Doberman Pinscher
2
Rottweiler
2
Golden Retreiver
2
St. Bernard
2
Bassette Hound
2
Masstiff
1
Miniature Pinscher
1
Pug
1
Yorkshire Terrier
1
Chow-chow
1
Char Pei
1
Springle Spaniel
1
√âÕ¬≈–
27.54
15.94
8.69
7.24
7.24
4.35
4.35
2.90
2.90
2.90
2.90
2.90
1.45
1.45
1.45
1.45
1.45
1.45
1.45
√«¡
√âÕ¬≈–
‡æ»
ºŸâ
12
6
4
5
4
1
1
2
2
1
2
1
1
1
1
44
63.77%
Àπ—ßµ“
‡¡’¬
7
5
2
1
2
2
1
2
1
1
1
25
36.23%
∫π
8
9
2
5
2
2
2
1
2
2
1
1
1
1
1
1
1
42
60.87%
µ“√“ß∑’Ë 2 ¢π“¥‡ âπºà“π»Ÿπ¬å°≈“ߢÕ߇π◊ÈÕßÕ°∑’Ëæ∫∑’ËÀπ—ßµ“ ÿπ—¢
¢π“¥‡ âπºà“π»Ÿπ¬å°≈“ߢÕß°âÕπ‡π◊ÈÕ (¡¡.)
®”π«π∑’Ëæ∫ (%)
πâÕ¬°«à“ 2
2-5
6 - 10
11 - 15
16 - 20
39 (56.52%)
21 (30.43%)
5 (7.25%)
4 (5.80%)
ňҧ
11
2
4
3
1
1
1
1
1
1
1
27
39.13%
18
Sebaceous epithelioma
√«¡
1
Malignant Mastocytoma
8
2
Squamous cell carcinoma
√«¡
5
61
Malignant melanoma
‡π◊ÈÕßÕ°™π‘¥√⓬ (malignant tumors)
Papilloma
6
20
Sebaceous adenoma
(Meibomian epithelioma)
17
∑’æË ∫
®”π«π
Sebaceous hyperplasia
‡π◊ÈÕßÕ°™π‘¥‰¡à√⓬ (benign tumors)
™π‘¥¢Õ߇π◊ÕÈ ßÕ°
100
12.5
25
62.5
100
9.84
29.5
32.79
27.87
√âÕ¬≈–
1
-
-
1
4
1
-
3
-
0-3
2
1
-
1
17
2
4
6
5
4-6
4
-
2
2
17
2
5
6
4
7-9
Õ“¬ÿ (ªï)
-
-
-
-
17
1
9
4
3
10-12
µ“√“ß∑’Ë 3 ‡π◊ÈÕßÕ°™π‘¥‰¡à√⓬·≈–™π‘¥√⓬∑’Ëæ∫∑’ËÀπ—ßµ“ ÿπ—¢ Õ“¬ÿ Õ“¬ÿ‡©≈’ˬ ¢π“¥‡©≈’ˬ ·≈–µ”·Àπàß∑’Ëæ∫
1
-
-
1
6
-
-
1
5
13-15
7.13
6.0
8.0
7.4
7.5
6.83
9.22
6.67
7.29
Õ“¬ÿ
‡©≈’ˬ
(ªï)
12.63
20
8.5
9.4
6.23
5.67
8.33
5.11
5.82
¢π“¥φ
‡©≈’ˬ
(¡¡.)
3
1
-
2
39
4
14
10
11
5
-
2
3
22
2
4
10
6
∫√‘‡«≥∑’Ëæ∫
Àπ—ßµ“ Àπ—ßµ“
∫π
ňҧ
126
Thai J. Vet. Med. Vol. 34 No. 4, 31 December 2004
Mixed
Shihtzu
Cocker Spaniel
Poodle
Pekingese
Great Dane
Datchshund
Doberman Pinscher
Rottweiler
Golden Retriever
St. Bernard
Bassette Hound
Masstiff
Miniature Pinscher
Pug
Yorkshire Terrier
Chow Chow
Char Pei
Springle Spaniel
æ—π∏ÿå
Sebaceous
Hyperplasia
5
6
1
2
1
1
1
-
µ“√“ß∑’Ë 4 ™π‘¥¢Õ߇π◊ÈÕßÕ°∑’ËÀπ—ßµ“∑’Ëæ∫„π ÿπ—¢æ—π∏ÿåµà“ß Ê
Sebaceous
Adenoma
6
3
4
1
2
1
1
2
-
™π‘¥¢Õ߇π◊ÈÕßÕ°∑’Ëæ∫∑’ËÀπ—ßµ“ ÿπ—¢
Sebaceous
Papilloma
Malignant
Epithelioma
Melanoma
3
2
1
1
1
3
2
1
2
1
2
1
1
2
1
1
1
1
1
1
Squamous
cell carcinoma
1
1
Malignant
Mastocytoma
1
-
‡«™™ “√ —µ«·æ∑¬å ªï∑’Ë 34 ©∫—∫∑’Ë 4, 31 ∏—𫓧¡ 2547
127
128
Thai J. Vet. Med. Vol. 34 No. 4, 31 December 2004
‡Õ° “√Õâ“ßÕ‘ß
ª√“≥’ µ—𵑫𑙠°—¡ªπ“∑ ÿπ∑√«‘¿“µ ·≈– π≈‘π’ µ—𵑫π‘™.
2002 (2545). ‚√§¢ÕßÀπ—ßµ“. „π : ‚√§¢Õßπ—¬π嵓
—µ«å. ∫∑∑’Ë 6 æ‘¡æå∑’Ë‚√ßæ‘¡æå®ÿÓ≈ß°√≥å¡À“«‘∑¬“≈—¬.
°√ÿ߇∑æ¡À“π§√ Àπâ“ 67-98.
ª√“≥’ µ—𵑫𑙠∑—»√‘π »‘«‡«™™ °—¡ªπ“∑ ÿπ∑√«‘¿“µ
·≈–π‘≈‘π’ µ—𵑫π‘™. 1998 (2541). °“√∑”»—≈¬°√√¡
‡¬◊Õ°·¢Áß√—°…“‡π◊ÈÕßÕ°¢Õß Meibomian gland „π ÿπ—¢ :
√“¬ß“π —µ«åªÉ«¬ ‡«™™ “√ —µ«·æ∑¬å 28(1): 81-88.
Fraunfelder, P.T., Zacarian, S.A., Wingfield, J.L. and
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Owen, L.N. 1980. World Health Organization TNM
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Mac Ewen (eds). Philadelphia. J.B. Lippincott Co.
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Prince, J.H., Diesem, C.D., Eglitis, I. and Ruskell, G.L.
1960. Anatomy and Histology of the Eye and Orbit in
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Roberts, S.M., Severin, G.A. and Lavach, J.D. 1986.
Goldschmidt, M.M., Dunstan, R.W. Stannard, A.A., von
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Gelatt, K.N. and Gelatt, J.P. 2001. Surgery of the
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