vlL=_o.4o7[_lo2a]. 500c=p_riso_ofeff.ots
Transcription
vlL=_o.4o7[_lo2a]. 500c=p_riso_ofeff.ots
_vlL=_o.4o7[_lo2a] . 500 c=p_riso_ ofeff.ots _ LSM(_I02m) J.M. _I_0GERTY, J.H., DILL£, _ For a preliminary report on the pharmacological _ffects of LSM see Gogerty and Dille, Fed.Proc./.% 428 @_1956). LSM is made available by $andoz and also by _li Lilly. The present study was made on material "[_/'upp]ledby the latter firm. (EK 12'610) T/Dr.Bs/Dr.Spi/pz 558 Comparaison de la morpholide de l'acide d-lysergique et du TSn GOGERTY_ J.H., DILLE, J.M. (Dept.of Pharmacol., School. of Med._ Univ.ofWashington_Seattle) , Pharmacolo_ , (Pharmacologie de la morpholide de l'acide d-lysergique ' of d-lys_rg_c acid morpholid_ (LSM). J.Pharmacol.Exper.Therap. j _2Q, 340 (1957). Les effets pharmagologiques de la morpholide de l'acide d-lysergique (LSM) ressemblent _ ceux du LSD. " La dose d_ LSM n_cessaire pour _lever la t@mp_ratu+_,, du corps du lapin est 3 x plus forte que celle du LSD_ • et la dur6e de l'effet est plus courte. _--; , , "'_" Sur Itut6z_ASisol_ d_ ia ratt_ _ l'efficacit_ du LSM est _ peu pros 1/12 de celle de LSD quant _ _onisme vis-a-vis de la 5-hvdroxvtrv_+_O. . Les effets du LSM sur le comDortem_$ _'anlm_nv " ressemblent _ ceux du LSD, mais les doses n@cessaires. sont _ peu pros 1/3 plus fortes et l'effet dure molns;_ Iongtemps. _'_-. i (2 sujets)_ les effets du LSM sont qualitativement similaires a ceux du LSD_ mais les doses n_cessaires sont au moins 1/3 plus fortes et l'effet dure molns longtemps. e_ ° J ' F 105 11/13 <? / G@vl[_afl_0n of _-ly_r_ic acid merpholide and LSD GOGERTY, J.H., DIL_.P, J.M. (Dept.of Pharmacol., of Med., Univ.of Washington, Seattle) Pha._macolo_v of d-lys_r_ic acid moroholide J.Pharmacol.Exper.Therap. School (LSM). 120, 340 (1957). The pharmacological effects of d-lysergic acid _orpholide (LSM) are similar to those of LSD. The dose of LSM required to raise body temperature _n the rabbit is three times as great as that of LSD _md the effect is of shorter duration. On the isolated rat uterus LSM is approximately 1/12 as effective as LSD in anta_onisin_ 5-hvdroxvtrvoThe behavioural $_fects o_ LSM in animals are similar to those of LSD but the doses required are approximately 1/3 greater and the effects are of shorter duration. In _t_an beings (2 volunteers) the effects of LSM were qualitatively similar to those of LSD but the dose required was at least 1/3 larger and the duration of action was shorter. L_ !o5 z!/13 r _ effects .ovl LsD .o. _o7 t_102aJ M5oo oo_p_ri.o_ of LSM(§io_) _ GOGERTY, J.H., DILLE, J.M. i For a prellmina_j report on the pharmacological effects of LSM see Gogerty and Dille, Fed.Proc..l_ 428 (1956). LSM is made available by $andoz and also by Eli Lilly. The present study was made on material supplied by the latter firm. , I b w5 (EK 12'610) NKT/Dr.Bs/Dr.Spl/pz 558 J Vcrgleioh yon D-Lysergs_uremorpholid und L_D , , i ._, GOGERTYp J.H., DIT.TR_ J.M. (Dept.of Pharmacol., School of _'-_ Mecl., Unlv.of Washington, Seattle) PharmacoloKy of d-lyser_ic acid morpholide (Pharmakologie von D-Lysergs_uremorpholid J.Pharmacol.Exper.Therap. Die pharmakologischen (LSM) sind Rhnlich wie (LSM). (LS_I). 120, 340 (1957). Wirkungen yon D-LysergsRuremorpholid die yon LSD. Die zur Erh_hun_ der KSrpertemperatur forderliche LSM-Dosis ist 3 x hSher als Wirkungsdauer ist kUrzer. des beim Kaninchens erLSD, ,M die Hi'nsichtlich des 5-Hydroxytryptami_anta_onismus am isol. Rattenuterus besitzt LSD ann_hernd 1/12 der Wirksamkeit yon LSD. Die LSD-Wirkung auf das Verhalten yon Tieren entspricht der des LSD, doch sind die erforderlichen Dosen um an_hernd 1/3 grSsser und die Wirkuns von kttrzerer Dauer. Beim Menschen (2 Versuchspersonen) wirkt LSM qualitativ Rhnlich wie LSD, doch ist die erforderliche Dosis mindestens um 1/3 grosset und die Wirkur_ yon k_rzerer l_uer. D 105 II/13 _vl LSDNo. 4o7 j_lo2_lM 5oooo_pari_o_of effects (D_E) LSM (§ 102m) GOGERTY, J.H., DILL_, J.M. For a preliminary/ report on the pharmacological effects of LSM see Gogerty and Dille, Fed.Proc. ,I_ 428 (1956). LSM is made available by $andoz and also by Eli Lilly. The present study was made on material supplied by the latter firm. w5 (EK 12'61o) NKT/Dr .Bs/Dr , .Spi/pz 558