Toxicology From a Different Point of View

Toxicology From a Different Point of View
La toxicologie d’un point de vue différent
Marc Baril
Professeur associé
Département de santé environnementale et santé au travail
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TOXICOLOGY
A World of Abbreviations
ALARA, Ceiling, EDI, GLP, im, inhl, ip, Kow, Koc,LC, LD,
MAC, MAK, MCL, MSDS, NOAEL, NOEL, OEL, ’’omics’’,
PBBK, PEL, PPE, QSAR, SAR, sc, STEL, TDI, TLV, TWA, UF
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History
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Toxicology Societies
American society since 1972
European society since 1975
Canadian society since 1979
IUTOX founded in 1980
52 member societies
8 Instutional members
20, 000 toxicologists
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Where We Come From
Early part of the twentieth century is generally considered to
mark the beginning of the development of the modern
science of toxicology.
However, the most rapid growth of the discipline occured
after World War II as the production of organic molecules
began to increase at an expotential rate.
(Gallo 1988, cited by Watson KD and Wexler P in Information
sources in toxicology 4 ed 2009)
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Where We Come
From
Biochemistry
Pharmacy
Medecine
Chemistry
Physiology
And even …engineering.
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How We Have Evolved
Toxline originally called Toxicon
First available in september 1972.
Covers biochemical, pharmacological, physiological and
Toxicological effect of drugs and other chemicals
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How We Have Evolved (2)
1972 : 170,000 bibliographic records
1980 (12) : more than 1.1 million records
1997 : 2 million records
2013: 4 million records
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How We Have Evolved (3)
Originally records from :
Index Medicus
Biological abstract,
Chemical abstract
International pharmaceutical abstract
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How We Have Evolved (4)
In 2015
Records composed from 18 subfiles
Records are not significally altered or enhanced before
being imported
As a results there is no single control vocabulary
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How We Have Evolved (5)
Toxiline is updated monthly
140,000 records added each year
File is rebuilt each year to provide updated MeSH indexing
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World Impact of Toxicology Evolution
Data 2005-2011
By Gransalke K. Labtimes 01/2015
Countries
Europe
USA
China
Canada
Japan
India
South
Korea
Citations
401,111
416,080
60,623
58,635
57,815
37,012
Articles
22,090
27,436
4,883
3,689
5,425
3,120
Cit/Art
18.2
15,2
12,4
15.9
10.7
11.9
28,913
3,003
9.8
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Impact of Toxicology Evolution
in Europe
Countries
England
Germany
France
Italy
Netherlands
Spain
Sweden
Switzerland
Denmark
Belgium
Citations
73,096
71,043
49,162
45,708
34,247
32,569
29,152
25,085
21,583
18,740
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Articles
3,038
3,401
2,541
2,542
1,627
1,862
1,370
964
882
890
Cit/Art
24.1
20.9
19.4
18
21.1
17.5
21.3
26
24.5
21.1
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Impact of time on Toxicology
LD50 from 200 animals to 3
Irritation from hundreds of rabbits during in vitro tests
Corrosion from animals to Ph
OECD Guidelines
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Impact of Time on Toxicology
More and more of cellular, molecular and biochemical toxicology
Establishment of models
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Impact of Time on Toxicology
Approaches of testing and assessment of human
and
environmental risks are undergoing rapid
developpment
I.e: Nanotoxicology associated with
Nonatechnology
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Toxicology Output
Enormous amount of data
Research increasingly devoted to quantitative assessments
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Toxicology Output
Database
HSDB
ICSC CARDS WHO
Toxicological index CSST
NIOSH pocket guide NIOSH
Fiche INRS
Gestis IFA
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Toxicology Output
Documentation
TLV documentation ACGIH
MAK documentation MAK committee
SCOEL documentation
DECOS documentation
ANSES documentation
AEGL documentation
Fiche INERISiue chimique (Calcul du RM)
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Toxicology Output - Tools
INRS
Mixie - France
Mu risque chimique (Calcul du RM)
IRSST
Mixie: Mixtures of substances in the workplace
Tool for the assessment of potential combined acute
effects of chemical in mixtures
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Target for the
Future
Our Customers
People from the
general public
Politicians
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Target for the
Future
Factor’s’
Safety
Security
Ajustment
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Target for the
Future
Ways
to oriented
global effort
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Target for the
Future
Donner un sens à
nos données pour
mieux être à
même de les
vulgariser
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