Guillaume DRUI

Guillaume DRUI
Nationality: French
Marital status: Married
Language: french mother tong - english working knowledge
Born on 30th March 1983, Sarreguemines (France)
Professional address:
67, boulevard Pinel
69675 – BRON Cedex
Cell-phone : +33 675 246 066
Email: [email protected]
Research Interests:
decision making, motivation, normal and pathological goal-directed behaviors, dopamine
and serotonin systems, deep brain stimulation, neuropsychopharmacology and in-vivo neurochemical measurements.
Honors
-
Fellowship for one year as a junior fellow assistant lecturer (ATER).
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PhD supported by a fellowship from the Ministry of Education and Research (MNRT).
Research Activities
Research experience
2013
Postdoctoral fellow in the Cognitive Neuroscience Center – Pathophysiology of Basal Ganglia Lab – CNRS research center
UMR5229, Bron, France. Project: Neuroeconomics of value-based decision making, supported by the Swiss National Science
Foundation (SNSF). Supervisor: Dr Léon Tremblay.
2008 - 2012
PhD thesis in Neuroscience – Grenoble University - Dynamic and Physiopathology of Basal Ganglia Lab, Inserm
research center U836 – Team #10, Grenoble, France. Title: Development of an experimental model of hypodopaminergic
behaviors in rats: Evidence for the involvement of the nigrostriatal dopaminergic pathway in the syndrome of apathy in
Parkinson's disease. Supervisors: Dr M. Savasta. Thesis committees: Bioulac B. (President); Baunez C. (Reporter);
Tremblay L. (Reporter); Belin D. (Examiner); Vérin M. (Examiner).
2008
Internship of Master 2, Dynamic of neuronal networks of movement Lab, INSERM U836, Grenoble Institute of
Neuroscience, Grenoble, France. Motivational deficit like parkinsonian apathy in rat: implementation of animal model by
neurotoxic lesion of ventral tegmental area. Supervisors: M. Savasta, C. Carcenac.
2007
Internship of Master 1, Dynamic of neuronal networks of movement Lab, INSERM U704, Grenoble, France. Parkinsonian
dyskinesia induces by L-DOPA treatment and high frequency stimulation of the subthalamic nucleus: neurochemical and
immunohistochemical approaches in rat. Supervisors: S. Weiss, M. Savasta.
Education

2011-2012: Junior fellow assistant lecturer in
Grenoble University and Inserm U836 – Team #10.

2008-2012: PhD thesis in Neuroscience – Inserm
research center U836 – Team #10

2008: Second year of Master in Sciences, Technology
and Health, specialize in Integrative and Cellular
Biology.
Joseph Fourier University – Grenoble, France.

2007: First year of Master in Sciences, Technology
and Health, specialize in Cellular and Molecular
Biology.
Joseph Fourier University – Grenoble, France.

2005-2006: License of Sciences and Technology,
specialty General Biology.
Joseph Fourier University – Grenoble, France.

2003-2004: First cycle of medical study.
Joseph Fourier University – Grenoble, France.
Technical competences
Anatomical observation: Histology, immunohistochemistry, immunofluorescence on brain slice and cryostat.
Surgical skill: stereotaxic surgery, intracerebral microdialysis, electrical stimulation of brain structures, intracerebral infusion of
pharmacologic agent, intracardiac perfusion.
Technical analysis of animal behaviors: set up and evaluation of sensitivity to reward (conditionned place preference and two
bottles choices), of operant behaviors (instrumental conditioning, runway paradigm), of anxiety (elevated plus-maze,
light/dark box) and depressive behaviors (FST). Analysis of fine and global motors skills (rotarod and stepping test,
locomotion in openfield, Gaitlab).
Teaching
2011-2012
Junior fellow assistant lecturer, Life Sciences Department – Grenoble University, France. 100H of teaching in
different specialties of biology.
2010-2011
Tutorials, Life Sciences Department – Grenoble University, Grenoble, France - 36H of practical Animal Biology.
Supervisor teacher: Corinne Mercier - License 1 « Sciences de la Vie ».
2009/2010
Tutorials, Life Sciences Department – Grenoble University, Grenoble, France - 36H of practical Animal Biology.
Superviser teacher: Corinne Mercier - License 1 « Sciences de la Vie ».
Scientific publications
Articles
G. Drui, S. Carnicella*, C. Carcenac, M. Favier, A. Bertrand, S. Boulet and M. Savasta. Loss of dopaminergic nigrostriatal
neurons accounts for the motivational and affective deficits in Parkinson’s disease. Molecular Psychiatry, 2013 doi:10.1038/mp.2013.3, IF : 14,89. *co-first author.
M. Favier, C. Carcenac, G. Drui, S. Boulet, S. El Mestikawy and M. Savasta. High-frequency stimulation of the subthalamic
nucleus modifies the expression of vesicular glutamate transporters in basal ganglia in a rat model of Parkinson’s disease.
BMC Neuroscience, 2013 - 14(1):152. doi: 10.1186/1471-2202-14-152, IF: 3,00.
Poster communications
2013
G. Drui, S. Carnicella, C. Carcenac, M. Favier, A. Bertrand, S. Boulet and M. Savasta. Loss of dopaminergic nigrostriatal
neurons accounts for the motivational and affective deficits in Parkinson’s disease. 11th Seminar of French Neuroscience
Society – Lyon, France.
2011
G. Drui, S. Carnicella, M. Favier, C. Carcenac, P. Krack and M. Savasta. Effect of different lesions of mesencephalic
dopaminergic system on motivational and cognitive functions: insights into neuropsychiatric disorders in Parkinson’s
disease. 41st Society for Neuroscience’s meeting – Washington DC, USA.
G. Drui, S. Carnicella, M. Favier, C. Carcenac, P. Krack and M. Savasta. Effect of dopaminergic nigrostriatal lesions on
motivational and emotional functions: insights into neuropsychiatric disorders in Parkinson’s disease. 10th Seminar of
French Neuroscience Society – Marseille, France.
2010
G. Drui, S. Carnicella, M. Favier, C. Carcenac, P. Krack and M. Savasta. Partial denervation of mesocorticolimbic
dopaminergic system in rat: a model of hypodopaminergic behaviors observed in Parkinson’s disease. 7th International
Congress on Mental Dysfonctions & Other Non-motor features in Parkinson’s disease & related disorders (MDPD) –
Barcelona, Spain.
G. Drui, S. Carnicella, M. Favier, C. Carcenac, V. Coizet, C. Feuerstein, P. Krack P. and M. Savasta
Partial and bilateral lesion of VTA dopaminergic neurons: a rat model of non-motor hypodopaminergic behaviors? 7th Forum of
European Neuroscience Societies (FENS) – Amsterdam, Netherlands.
M. Favier, G. Drui, C. Carcenac and M. Savasta Changes of expression of vesicular glutamate transporters induced by high
frequency stimulation of subthalamic nucleus. 7th Forum of European Neuroscience Societies (FENS) – Amsterdam,
Netherlands.
2009
G. Drui, C. Carcenac, P. Krack and M. Savasta. Bilateral and partial lesions of the VTA dopaminergic neurons in rat: a model
of parkinsonian apathy in rats? 9th Seminar of French Neuroscience Society – Bordeaux, France.
Oral communications
2013
S. Carnicella, G.Drui & M. Savasta. Locus neurobiologique de la dénervation dopaminergique dans un modèle rat de la
maladie de Parkinson : un nouvel endophénotype de la vulnérabilité aux déficits de la motivation. Symposia at the 11th
Seminar of French Neuroscience Society – Lyon, France.
G. Drui, S. Carnicella & M. Savasta. Réversion de déficits motivationnels via l’activation des récepteurs dopaminergiques D3 :
possible implication thérapeutique pour le traitement de l’apathie dans la maladie de Parkinson. Joint meeting of Basal
Ganglia and Abnormal Movements Clubs – Lyon, France
2011
G. Drui, S. Carnicella, M. Favier, C. Carcenac, P. Krack and M. Savasta. Lésion des neurones dopaminergiques du
mésencéphale: un modèle des troubles neuropsychiatriques de la maladie de Parkinson chez le rat. 6th Congress of
Physiology, Pharmacology and Therapeutic – Grenoble, France.
2009
G. Drui, C. Carcenac, P. Krack and M. Savasta. Lésion partielle et bilatérale des neurones dopaminergiques de l’Aire
Tegmentale Ventrale : un modèle d’apathie parkinsonienne chez le rat ? Joint meeting of Basal Ganglia and Abnormal
Movements Clubs – Bordeaux, France.