Présentation des projets financés au titre de l`édition 2011 du

Présentation des projets financés au titre de l’édition 2011 du
Programme « ERA-NET EMIDA»
ACRONYME et titre du projet
Page
CamChain
Campylobacter in chicken production: survival, virulence and control
2
CARES
Coping with Anthelmintic RESistance in ruminants
3
GOAT-TSE-FREE
Towards breeding of goats for genetically determined TSEs resistance
4
MOLTRAQ
Molecular Tracing of Viral Pathogens in Aquaculture
iPUD
Integrated system approach for preventing uterine disease in dairy cattle
MYCOBACTDIAGNOSIS
Development of novel diagnostic strategies for the
immunodiagnosis of bovine tuberculosis and Johne's Disease
ante-mortem
RiftVectors
Vector competence of European mosquitoes to Rift Valley fever virus
1
6
7
9
Programme « ERA-NET EMIDA"
Edition 2011
Titre du projet
Résumé
Partenaires
CamChain - Campylobacter in chicken
production: survival, virulence and control
The project addresses EMIDA programme ‘C1: Control strategies
for Campylobacter in poultry’. Our aim is to develop science-led
interventions to reduce consumer exposure to Campylobacter.
The project will have partners in the EU poultry industry and
other stakeholders. We will identify intervention strategies onfarm and during processing to control contamination and will
provide knowledge on population, transmission, and infection
biology of Campylobacter. The consortium comprises groups in
the UK, Austria, Denmark, Finland, France, Italy, Lithuania,
Thailand and Viet Nam. The Thai and Vietnamese governments
will fund their work directly and through related food safety
poultry projects. Our studies will address: (i) Molecular
epidemiology and surveillance tools; (ii) Survival and
propagation in the chicken production chain from farm to fork;
(iii) Virulence mechanisms and host-pathogen interactions; (iv)
Modelling transmission within flocks and risk progression along
the production chain; (v) Intervention based on enhanced
biosecurity and improved host resistance.
University of Liverpool (UK)
Lithuanian University of Health Sciences, Veterinary Academy
(LT)
University of Cambridge (UK)
University of Helsinki (FI)
Austrian Agency for Health and Food Safety (AGES) (AT)
Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise
'G. Caporale' (ICT) (IT)
ANSES Site de Ploufragan (FR)
DTU Veterinary Institute (DK)
University of Veterinary Medicine Vienna (AT)
Coordinateur
Tom HUMPHREY (UK)
Correspondent français : Marianne CHEMALY
Aide de l’ANR
161 000 € (partenaire français)
Début et durée
Référence
Juin 2012, 36 mois
ANR-11-EMIDA-002
2
Titre du projet
Résumé
Partenaires
CARES – Coping with Anthelmintic RESistance in
ruminants
Infections with gastrointestinal nematodes (GIN) are a major
threat to ruminant health, welfare and production and thus to
the viability of the ruminant livestock industries in the EU and
worldwide. Anthelmintic resistance (AR) is the single-most
important problem facing EU ruminant farmers today in relation
to sustainable GIN control. AR is a constantly expanding
process, from small ruminants to cattle; from the first
commercialised anthelmintics (AH) to the modern ones and from
single drug AR to multiresistant cases. Therefore, Coping with
Anthelmintic RESistance (CARES) is pivotal to all existing and
up-coming means of control.
CARES believes that within a foreseeable future the most
sustainable strategy is a combination of approaches, namely i)
early detection of AR, ii) use of bioactive crops with documented
AH properties, iii) improved farm management, feeding and
selective use of AH drugs. This applied approach needs support
by basic research and better understanding of mechanisms of
development and reversion of AR. The project CARES will
address these key issues.
The consortium is built on cross-linking criteria to address the
objectives. Indeed, CARES brings together 8 partners from 5 EU
countries plus a world leading research partner from Canada.
University of Copenhagen (DK)
INRA/ ToxAlim UMR 1331 Toulouse (FR)
INRA UMR IHAP Toulouse (FR)
Technical University of Denmark, National Veterinary Institute
(DUT-VET) (DK)
McGill University (CA)
National Agricultural Research Foundation (NAGREF) (GR)
Central Veterinary Research Laboratory (IE)
Swedish University of Agricultural Sciences (SE)
INRA/ UR 143 (URZ)/ INRA Antilles-Guyanne (FR)
Coordinateur
Stig Milan THAMSBORG
Correspondants français:
Anne LESPINE
Herve HOSTE
Marie-Magdeleine CARIE
Aide de l’ANR
116 189 € (partenaires français)
Début et durée
avril 2012, 36 mois
Référence
ANR-11-EMIDA-003
3
Titre du projet
Résumé
GOAT-TSE-FREE – Towards breeding of goats for
genetically determined TSEs resistance
Currently, in goats the only measures for control of
transmissible spongiform encephalopathies (TSEs or prion
diseases) are a complete cull of the entire herd. Such practices
are highly undesirable for both the farming and non-farming
society. Moreover, in contrast to cattle, goats are hardly
subjected to active control measures anymore, therefore TSE
positive goats or their products can enter the human food chain.
Selection possibilities to exclude genetically susceptible animals
or to enrich for TSE resistant ones, as is being implemented in
the EU with success for sheep, are emerging but they are not
yet accepted for application. From progress in field studies at
various geographical regions as well as in ongoing EU GoatBSE
funded experimental work (www.goatbse.eu), two alleles of the
prion protein (PrP) have emerged behaving similarly to the
proven sheep 171R (ARR) allele associated with resistance. This
proposal wishes to investigate and supply the necessary
experimental data to enable the implementation of a breeding
programme towards TSE resistant goats. Participating partners
have made progress in understanding the influence on disease
risk with several of the candidate resistance/susceptibility
alleles, and will here focus their studies on the 222K and 146S/D
PrP codons; one or the other occur in all regions and goat
breeds of Europe, with frequencies varying between 0.5-25%.
The proposed project is a logical follow-up to knowledge
collected on goats over the last 8 years in some national
ongoing programmes, and EU projects \"NeuroPrion TSEgoat\"
and \"GoatBSE\", and various national activities in goat TSEs
eradication. Specific objectives are: 1) to collect experimental
data to ascertain the degree of resistance conferred by the 146
and 222 codon alleles against TSEs in goats, specifically scrapie
and BSE; 2) to prepare and where possible initiate small scale
breeding for resistance activities that will generate information
for professional goat breeders and producers necessary as
support for a more general breeding strategy for TSE resistance
in goats. 3) Preparing policy makers and stakeholders towards
TSE resistance breeding.
4
Partenaires
Central Veterinary Institute of Wageningen UR (NL)
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e
Valle d'Aosta (IT)
INRA_UMR ENVT 1225 (FR)
Instituto Nacional de Investigación y Tecnología Agraria y
Alimentaria (INIA) (ES)
Universidad de Zaragoza (UNIZAR) (ES)
Animal Health and Veterinary Laboratory Agencies (AHVLA)
(UK)
National Agricultural Research Foundation – NAGREF (GR)
Friedrich-Loeffler-Institut (DE)
Coordinateur
Jan LANGEVELD (NL)
Correspondant français: Olivier ANDREOLETTI
Aide de l’ANR
140 000 € (partenaire français)
Début et durée
Référence
septembre 2012, 36 mois
ANR-11-EMIDA-004
5
Titre du projet
Résumé
Partenaires
MOLTRAQ – Molecular Tracing of Viral Pathogens
in Aquaculture
This project will i)generate and use spatio-temporal
epidemiological data, phylogeographic data and gene expression
data for important host-viral pathogen systems to identify
important factors affecting the spread of diseases in
aquaculture, and ii)integrate these in scenario simulation models
to assess effects of various control strategies for selected hostpathogen systems. The purpose of the project is to increase
knowledge on transmission, prevention and control of viral
diseases in aquaculture and develop a generic approach to viral
disease control by using information on epidemiological and
physiogenetical attributes from several important aquatic animal
viruses.
The specific objectives are: 1) Collection of isolates of specific
important aquatic animal viruses and their respective
epidemiological data (from as wide host ranges, broad
geographic distributions and variable pathogenicities as
possible), 2) Characterisation of the isolates by phylogenetic and
expression analyses and 3) Constructing scenario simulation
models to assess effects of different control strategies. The
project partners cover different fields of expertise and will
contribute accordingly.
Norwegian Veterinary Institute (NO)
Technical University of Danemark, National Veterinary
Institute (DK)
ANSES, technopole Brest Iroise (FR)
Friedrich-Loeffler-Institut (DE)
Institut Français de recherche pour l'exploitation de la mer
(FR)
Institut de recherche pour le Développement (FR)
Norwegian computing Center –NR (NO)
Coordinateur
Edgar BRUN (NO)
Correspondants français :
Laurent BIGARRE
Tristan RENAULT
Jean-Christophe AVARRE
Aide de l’ANR
419 654 € (partenaires français)
Début et durée
avril 2012, 36 mois
Référence
ANR-11-EMIDA-006
6
Titre du projet
Résumé
MYCOBACTDIAGNOSIS - Development of novel
diagnostic strategies for the ante-mortem
immunodiagnosis of bovine tuberculosis and
Johne's Disease
Mycobacterial infections such as bovine tuberculosis (bTB) or
Johne\'s disease (JD) exact an enormous cost on European
agriculture. Current diagnostic tests are based on immune
responses to bovine, avian and johnin tuberculin, reagents
which
have
specificity,
sensitivity
and
standardisation
constraints. The absence of adequate JD diagnostic tools for
early detection of latently infected livestock severely interferes
with animal welfare. Further, JD infection interferes with bTB
diagnosis in dually infected herds. Significant common ground
exists between the immunobiology of these two infections to
propose an integrated approach to develop improved diagnostic
tests based on assay platforms (skin testing, serology and
defined bTB and JD antigens) that can be applied across both
diseases. The overarching objective of this proposal is to
improve the diagnosis of both infections and to generate tools
that are not compromised in sensitivity or specificity by coinfection. This multi-disciplinary consortium bridges both fields
with experience in the biology of these diseases: experimental
infection and co-infection models; cellular immunology;
bioinformatics; antigen mining; lipid and protein biochemistry;
test development and exploitation. Our multi-pronged
translational research approach consists of: validating already
prioritised bTB and JD antigens (proteins, peptides, lipids) and
platforms such as skin test, interferon-gamma release assays,
conventional serology (WP1); an applied research arm of generic
platform development and antigen discovery by multiplexing
serology and cytokine assays and bioinformatical and
biochemical mining of protein and glycolipid antigens (WP2, 3);
and a fundamental and basic research arm investigating and
characterising T cell populations recognising non-proteinaceous
antigens such as glycolipids (WP4). In addition we will also
define potential biomarker signatures of latency based on
regulatory cytokine expression and effector/memory cell
dynamics (WP4).
7
Partenaires
Animal Health and Veterinary Laboratories Agency (UK)
INRA Centre de Tours Nouzilly (INRA 1282) (FR)
Central Veterinary Institute-WUR (NL)
Enfer Scientific (IE)
Friedrich-Loeffler-Institut (FLI) (DE)
Agri-Food and Biosciences Institute Stormont (UK)
Istituto Zooprofilattico Sperimentale della Lombardia ed
Emilia-Romagna (IT)
Istituto Zooprofilattico Sperimentale delle Venezie
Moredum Research Institute (IT)
Univ. College Dublin-Central Veterinary Research laboratory
(IE)
Coordinateur
Martin VORDERMEIER (UK)
Correspondant français : Franck BIET
Aide de l’ANR
209 000 € (partenaire français)
Début et durée
Référence
avril 2012, 36 mois
ANR-11-EMID-005
8
Titre du projet
Résumé
Partenaires
RiftVectors - Vector competence of European
mosquitoes to Rift Valley fever virus
Rift Valley fever virus (RVFV) is an arbovirus infecting humans
and livestock after amplification in wild animals. It is readily
transmitted through several mosquito genera including Aedes
and Culex mosquitoes, and has a large host range. The recent
expansion of the geographical range of RVFV clearly indicates
that RVFV is not restricted to Africa. It has been proposed that a
single infected person or animal that enters a naive country is
sufficient to initiate an outbreak. This transmission scenario is
becoming more probable due to the expansion of worldwide
trade and travel. We aim to further understand the vector
biology of natural RVFV vectors and their counterparts in Europe
to assess and the risk of RVFV to be established in Europe, and
how vectors can be manipulated to prevent the risk of RVFV
transmission.
University of Glascow (UK)
Istituto Zooprofilattico Sperimentale delle Regioni lazio e
Toscana (IZSLT) (IT)
University of Oxford (UK)
Institut Pasteur (FR)
University of Saint Andrews (UK)
Institute of Animal Health (UK)
Coordinateur
Alain KHOL (UK)
Correspendant français: Anna-Bella FAILLOUX
Aide de l’ANR
358 700 € (partenaires français)
Déb t et durée
Référence
mai 2012, 36 mois
ANR-11-EMIDA-001
9