Master`s Thesis Topics Human Biology Physiology

Master‘s Thesis Topics Human Biology
Physiology
Topic
Molecular mechanisms involved in the homeostasis of phosphate
Short description
The maintenance of the extracellular concentration of inorganic phosphate (Pi)
is crucial for a variety of cellular processes, bone formation and the prevention
of vascular calcification.
Projects related to this topic will focuss on molecular aspects (cellular
regulations, interacting proteins, structure-function relationships) of different
sodium-dependent phosphate cotransporters. Also, whole animal studies aim to
understand the role of the different Na/Pi-cotransporters (in different organs)
in the physiology and pathophysiology of inorganic phosphate metabolism.
Supervisor
Institute
E-mail
Phone
Dr. Nati Hernando, Dr. Ian Forster
Institute of Physiology-University Zürich-Irchel
[email protected], [email protected]
+41 44 635 5032
Conditions
Some projects will include animal experiments
Links
www.uzh.ch/physiol
Topic
Sirtuins in atherosclerosis
Short description
Atherosclerosis is a chronic inflammatory disease of the vascular system in our
aging population. Endothelial activation and subsequent infiltration of the
arterial intima promote plaque formation. Rupture of these plaques leads to
myocardial infarction and stroke.
Sirtuins are a family of NAD-dependent deacetylases that regulate cellular
function through deacetylation of a wide range of protein targets. Many
sirtuins are critically involved in regulating metabolism and cellular fate in
age-related diseases, such as atherosclerosis. The study of sirtuins in
atherosclerosis is one of the focuses of our group and provides frequent
opportunities for master projects. Please inquire.
Supervisor
Institute
E-mail
Phone
Dr. Chrisitian Matter
Center for Molecular Cardiology, UZH, Schlieren Campus
[email protected]
+41 44 635 64 67
Conditions
None
Links
http://www.kardiologie.usz.ch/LehreUndForschung/Grundlagenforschung/
Seiten/Atherosclerosisandmetabolicdisease.aspx
Topic
Vascular Dysfunction in Aging & Disease
Short description
Vascular homeostasis is critical for the correct supply of nutrients and oxygen
to all organs. The endothelium -the innermost layer of a vessel- functions as an
active barrier to allow the passage of different substances; additionally, it
mediates vascular dilatation and constriction.In disease states the endothelium
becomes dysfuctional and through complex cascades of events leads to several
complications such as atherothrombosis. Several key factors such as free
radicals are implicated in endothelial dysfnction observed in disease states.
Our group performs research aimed at elucidating the interaction of regulators
and mediators of vascular function in disease states and aging.
Supervisor
Institute
E-mail
Phone
Dr. Giovanni G. Camici
Center for Molecular Cardiology, UZH, Schlieren Campus
[email protected]
+41 44 635 64 68
Conditions
None
Links
http://www.physiol.uzh.ch/research/CardiovascularResearch.html
Topic
MSc Projects in Cellular Oxygen Physiology
Short description
The ability of cells to sense and respond to reduced oxygen conditions
(hypoxia) is crucial in many physiological and pathophysiological processes.
The micro-environment of many tumor types is hypoxic because rapidly
proliferating tumor cells consume more oxygen than can be supplied. Hypoxia
leads to activation of the hypoxia-inducible transcription factor (HIF). In
normoxia is the HIF alpha subunit hydroxylated by HIF prolyl hydroxylases
(PHDs) and rapidly degraded. Our projects aim to understand how oxygensensing protein hydroxylases are regulated and to identify novel hydroxylation
targets.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Roland H. Wenger / Dr. Carsten Scholz
Institute of Physiology
[email protected] / [email protected]
+41 44 635-5065 / +41 44 635-5075
Conditions
Good knowledge of biochemistry, molecular and cell biology
Links
http://www.physiol.uzh.ch/research/CellularOxygenPhysiology_en.html
Topic
Human milk oligosaccharides and intestinal bacteria
Short description
Human milk contains a large group of complex oligosaccharides, which
influence the bacterial colonization of the newborn intestine. Recently,
specific human milk oligosaccharides have also been shown to regulate
immune cell functions.
Using pure milk oligosaccharides, our group investigates the role of
these compounds on intestinal bacterial composition (in vitro and in
vivo) and on the maturation of mucosal immune cells (in cell culture
and mouse models).
Methods applied are leukocyte isolation, cell culture, flow cytometry,
real-time PCR, gene expression and inactivation in bacteria.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Thierry Hennet
Institute of Physiology
[email protected]
+41 44 635 5080
Conditions
Interest in genetics and pathogenesis of diseases
Links
http://www.uzh.ch/physiol/
Topic
Mechanismen und Regulation der normalen und kranken Niere
Short description
Die Nieren spielen eine zentrale Rolle in der Regulation der Zusammensetzung
vieler Körperflüssigkeiten und beeinflussen direkt und indirekt die Funktion
von Knochen, Muskel, Metabolismus, Blutdruck, Säuren-Basengleichgewicht
etc. Verschiedene Masterarbeiten werden angeboten, die im Tier- und/oder
Zellmodell Transportfunktionen der Niere, ihre Regulation und Adaptation
und ihre Dysregulation in verschiedenen Nierenerkrankungen untersuchen.
Methodisch verwenden wir Standardtechniken der Protein- und
Molekularbiologie, Tierversuche, Zellkultur, Arbeit an Geweben,
Immunhistochemie, intrazelluläre Kalzium/pH/ Ionenmessungen mittels
Fluoreszenz in intakten Geweben/Zellen, etc.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Carsten Wagner
Institute of Physiology
[email protected]
+41 44-63 55023
Conditions
keine, Besuch des LTK Moduls1 (Einführung in Tierversuche) für manche
Projekte nützlich, aber nicht zwingend
Links
http://www.physiol.uzh.ch/research/Acidbasetransport.html
Topic
Biology of amino acid transport processes
Short description
(max. 10 Zeilen)
• The general aim of our research is to understand the control of amino acid
transport from the level of individual transporters up to its integration in the
organism. The research focuses in particular on the cooperation of amino acid
transporters within renal and intestinal epithelia and blood brain barrier
endothelium.
Understanding the mechanisms of transepithelial and transendothelial amino
acid transport could help devise strategies for treating genetic and acquired
amino acid transport disorders and for influencing drug (re)absorption.
• Main experimental models: cultures of (epithelial) cells, heterologous
expression of gene products, gene-modified mice
• Techniques: transport assays, gene expression studies, immuno-biochemistry,
immuno-localization, gene arrays, (life) imaging, metabolic studies in mice,
electrophysiology etc.
Supervisor
Institute
E-mail
Phone
Prof. Dr. François Verrey, Dr. Simone Camargo
Institute of Physiology
[email protected]
+41 44 635 5044/46
Conditions
Gesucht werden KandidatInnen die in einem jungen, dynamischen Team und
einer interdisziplinären Umgebung arbeiten wollen
Links
http://www.physiol.uzh.ch/research/EpithelialTransports_en.html
Topic
Functional mouse genetic approaches to model human tumours and
identify personalized molecular targets for cancer therapy.
Our laboratory seeks to understand the molecular and cellular basis of kidney
and uterine cancers using advanced mouse genetic approaches. We have
developed a powerful lentiviral-based gene regulation system that allows the
simultaneous alteration of the expression of multiple genes. We undertake a
reverse engineering approach to attempt to “build” tumours by inducing in
primary cells and in mouse tissues the combinatorial genetic changes that are
believed to cause tumours in humans. Additionally we employ highthroughput shRNA genetic screening to identify molecular therapeutic targets
that are specific for the combinations of genetic alterations that cause each
individual tumour.
Prof. Dr. Ian Frew (together with postdoctoral scientists)
Institute of Physiology
[email protected]
+41 44 635 5004
12 month Master’s thesis preferred, enthusiasm for experimental cancer
research, strong academic background in cellular and molecular biology
http://www.physiol.uzh.ch/research/GrFrew.html
Short description
Supervisor
Institute
E-mail
Phone
Conditions
Links
Topic
Short description
Supervisor
Institute
E-mail
Phone
Conditions
Links
Topic
Short description
Role of meningothelial cells in the maintenance of cerebrospinal fluid
homeostasis
This project will explore the response of meningothelial cells (which line the
subarachnoid space of the central nervous system) to fluid flow. Experiments
will include cell culture in a dedicated flow chamber under different flow
conditions. Endpoints include cell proliferation, uptake of apoptotic cells,
cytokine secretion, and trans-cellular transport. If phenotypical changes are
observed, further examination will include preparation for phosphokinase
arrays and gene expression assays in an effort to get insights into the
underlying cell response mechanisms.
Prof. Dr. Vartan Kurtcuoglu
Institute of Physiology
[email protected]
+41 44 635 5055
12 month thesis duration preferred. Strong academic background in cell
biology and motivation to work in an interdisciplinary team.
http://interfacegroup.ch
Obesity, eating control and metabolic diseases
Obesity and type 2 diabetes are worldwide health epidemics that dramatically
increase metabolic and cardiovascular diseases. The control of food intake and
body weight involves numerous hormones released from the gastrointestinal
tract. Some of these hormones, like the pancreatic peptide amylin or GLP-1,
contribute to the control of meal ending satiation. Other hormones, like leptin,
reflect the amount of body fat stores. Our research focuses on the central
neural pathways mediating amylin’s anorectic action as well as on the
interaction of amylin with other hormones.
In addition, we study various aspects of the role of bariatric surgery (Roux-enY gastric bypass) in improving metabolism. Experimental techniques include
behavioral feeding studies, immunocytochemistry, electrophysiology and
functional tests of the reward system. Further, by using indirect calorimetry,
we can assess energy intake and energy expenditure simultaneously.
Supervisor
We are also interested in dissecting the molecular pathways of vascular disease
in the development of type 2 diabetes, and the improvement of cardiovascular
health after gastric bypass surgery. We focus on the following collaborative
projects between the Center for Molecular Cardiology at UZH, the Department
of Visceral Surgery at USZ, and the Institute of Veterinary Physiology:
- The role of pancreatic amylin on the development of vascular dysfunction in
a transgenic rat model of type 2 diabetes;
- The role of gastric bypass surgery and JNK inhibition on the improvement of
vascular dysfunction and HDL metabolism and a rat model of non-diabetic
diet-induced obesity;
- The role of gastric bypass surgery and liraglutide treatment on the
improvement of HDL metabolism in human obese patients.
Prof. Dr. Thomas A. Lutz
Institute
E-mail
Phone
Institute of Veterinary Physiology
[email protected]
+41 44 - 635 8808
Conditions
Master students willing to participate in one or more of these projects will
learn the following skills and methods: animal handling (rat) including in vivo
tests of glucose and insulin sensitivity and animal necropsy; in vitro dissecting
of molecular pathways by western blot, primary human endothelial cell
culture, blood HDL isolation and characterization, various enzymatic and
ELISA assays.
Links
www.vetphys.uzh.ch
Topic
The Impact of High Altitude on Cancer Growth
Short description
Living at high altitude (HA) correlates with reduced cancer mortality in
humans independent of ethnicity and socio-economical environment. Although
the reasons and underlying mechanisms are unknown, we hypothesize that the
systemic adaptation to hypoxia is involved in preventing cancer formation and
tumor proliferation.
Supervisor
Institute
E-mail
Phone
For this master thesis we generated tumor-bearing mice (allografts) that will be
exposed to hypoxia and HA to test tumor proliferation and response to
chemotherapy. Studies will be conducted in our lab (Hypoxia Chamber to
mimic high altitude) and at the Jungfraujoch research station (3500 m above
sea level).
Prof. Dr. Max Gassmann and Dr. Markus Thiersch
Institute of Veterinary Physiology
[email protected] or [email protected]
Conditions
+41 44 635 8816
We are looking for biology, medical or veterinary students. First experiences
in animal experimentation are appreciated but not mandatory.
Links
www.vetphys.uzh.ch
Topic
Neuronal and vascular responses to reduced oxygenation : physiology and
pathology
Short description
Efficient oxygen delivery to brain tissues is crucial for neuronal function and
thus proper brain function. Hypoxia characterises a variety of physiological
events but also contributes significantly to progression of pathogenesis and
widespread diseases including, cancer, stroke and neurodegenerative disorders.
When oxygen is limited cells activate key adaptive responses mediated largely
by hypoxia-inducible factor-1 (HIF-1). We recently found that the
multifunctional Rho GTPases are involved in the neuronal hypoxic response
and likely modulate HIF stabilisation.
Our group performs research investigating the molecular mechanisms of
neuronal and vascular adaptation to oxygen deprivation with emphasis on the
role of RhoGTPases in regulation of HIF-1 in primary neurons and other brain
specific cells in disease states and during aging.
Supervisor
Institute
E-mail
Phone
Dr. Lara Ogunshola
Institute of Veterinary Physiology
[email protected]
+41 44 635 8805
Conditions
Basic knowledge in molecular biology and/or medical physiology
Links
www.vetphys.uzh.ch
Anatomy
Topic
Kontrolle der Salzausscheidung und des Blutdruckes durch die Nieren
Short description
Die Nieren regulieren den Salzhaushalt und spielen eine wichtige Rolle bei der
Kontrolle des Blutdruckes. Wir untersuchen die zugrundeliegenden zellulären
und molekularen Mechanismen unter Nutzung einer Vielzahl von
experimentellen Systemen (Mausmodell, Zebrafisch, Zellkultur, heterologe
Expressionssysteme). Zur Anwendung kommen diverse Methoden zur
Phänotypisierung der Mausmodelle inkl. Urin- und Plasma-analysen,
Blutdruck-Messungen, qRT-PCR, Licht- und Elektronenmikroskopie,
Ionentransportstudien, Immunoblots, Immunohistochemie, etc.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Johannes Loffing
Anatomisches Institut
[email protected]
+41 44 635 5320
Conditions
Links
http://www.anatom.uzh.ch/research/Divisionloffing_en.html
Endocrinology and Diabetes
Topic
Insulin receptor substrates and the development of type 2 diabetes
Short description
We study the function of insulin receptor substrates in the context of the
regulation of blood glucose homeostasis. IRS1 and IRS2 are required in the
periphery for insulin action and in the pancreas for β-cell function. Candidates
can choose between several topics such as control of β-cell mass and function,
insulin resistance and molecular mechanisms of signal transduction in general.
Supervisor
Institute
E-mail
Phone
Dr. Markus Niessen
UniversitätsSpital, Endokrinologie und Diabetologie, Rämistr. 100
[email protected]
044-255 22 25
Conditions
Links
http://www.research-projects.uzh.ch/p6959.htm; http://www.researchprojects.uzh.ch/p6960.htm; http://www.med.uzh.ch/ZKF/Website1/ResearchGroups/AlphabeticOrder/Niessen.html
Experimental Ophthalmology
Topic
Molecular Mechanisms of Retinal Degeneration
Short description
Many blinding diseases are caused by the degeneration of photoreceptor cells.
Using several animal models of induced and inherited retinal degeneration, our
research aims at the understanding of the molecular mechanisms and signaling
pathways induced during the degenerative process. The acquired knowledge of
the cell death pathways is used to develop and test neuroprotective strategies to
improve cell viability and to rescue vision.
Available projects are dealing with different aspects of molecular mechanisms
during retinal degeneration and neuroprotection.
Supervisor
Institute
Prof. Dr. Christian Grimm
Lab for Retinal Cell Biology
Dept Ophthalmology,
University Hospital Zurich
[email protected]
044 255 3905
E-mail
Phone
Conditions
Interest in various aspects of the visual system. Background in molecular
biology desirable. Good knowledge of the english language is an advantage.
Links
http://www.research-projects.uzh.ch/a1009.htm
Medical Molecular Genetics
Topic
Short description
Genetic Basis of Eye Diseases
A Master / Diploma student position is available to identify new genes
involved in the pathogenesis of exudative vitreoretinopathy (EVR) and to
investigate their function in order to better understand the molecular basis of
this group of eye diseases.
In our lab, we focus on the investigation of the molecular pathophysiology of
the disease phenotype, which is quite similar in this group of vasoproliferative
blindness diseases, especially with regard to the defects in the retinal
vasculature. More information is also available on our website:
http://www.medmolgen.uzh.ch/research/eyediseases/norriedisease.html
We found several, probably disease-causing, DNA sequence alterations in
different genes of patients with EVR which are now being characterized in
more detail. The project involves functional analysis of mutations in vitro and
sequencing of new candidate genes for EVR.
Duration: Nine month to one year.
Entrance upon: As soon as possible.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Wolfgang Berger
Institute of Medical Molecular Genetics
[email protected]
044 655 70 34
Conditions
Motivated students in the area of biology, biomedical sciences or equivalent
are encouraged to send applications. Interest in human genetics as well as
basic training or practical experience in molecular genetics and molecular
biology is an advantage.
Links
www.medmolgen.uzh.ch
Topic
Membrane Transporter SLC16A12 (MCT12) and Cataract
Short description
The avascular lens in the eye requires special membrane transporters that
allow the supply of metabolites and the removal of waste products to and from
the central part of the lens. If this process is disturbed, opacities may result,
which will cause cataracts and impaired vision. The project involves screening
for additional mutations by DNA sequencing of patient DNA. Function will be
studied by constructing the mutations and testing their expression and function
in cell culture using RT-PCR, luciferase reporter assay, statistics,
immunohistochemistry, Western blots, bioinformatics.
Supervisor
Institute
E-mail
Phone
Dr. Barbara Kloeckener-Gruissem
Institute of Medical Molecular Genetics
[email protected]
044 655 70 34
Conditions
Basic knowledge of molecular genetics and techniques in molecular biology,
being curious and motivated.
Links
www.medmolgen.uzh.ch
Cancer
Topic
Inflammatory microenvironment and metastasis
Short description
Metastasis is the primary cause of cancer-related mortality. Tumor
microenvironment is composed of leukocytes and stromal cells that
significantly affect cancer progression. Chemokines are the key cytokines,
which promote the recruitment and the polarization of leukocytes.
Our projects aim to understand the function of particular chemokinechemokine receptors pairs using in vitro techniques (e.g. co-culture assays)
and validate their role in vivo.
Supervisor
Institute
E-mail
Phone
PD Dr. Lubor Borsig
Institute of Physiology
[email protected]
044 635 5134
Conditions
The project may include animal models
Links
http://www.physiol.uzh.ch/research/institutegroups/grborsig.html
Topic
Identifikation und Charakterisierung von Krebsstammzellen in
pädiatrischen Sarkomen
Short description
Am Modell des Rhabdomyosarkoms werden in diesem Projekt erstmals bei
einem pädiatrischen Sarkom Krebsstammzellen isoliert, auf der Basis der
funktionellen Bildung von Zell-"Spheres". Diese werden ausgehend von
Krebszellen sowie von adulten myogenen Stammzellen gebildet und
eingehend vergleichend charakterisiert. Dies umfasst u.a. das
Differenzierungspotential, klonogene Wachstumseigenschaften, sowie
mögliche Stammzell-Unterpopulationen. Im weiteren sollen die "Spheres" mit
ausgewählten zielgerichteten Medikamenten behandelt, und Proliferation,
Zelltod sowie Transkriptome vergleichend gemessen werden.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Beat W. Schäfer
Universitäts-Kinderklinik, Onkologie
[email protected]
044 2667553 oder 6348852
Conditions
Links
www.kispi.uzh.ch/onkologie
Topic
Strahlenresistenz auf molekularer und zellulärerEbene
Short description
Schädigung der DNA ist die wichtigste Ursache für den
strahleninduzierten Zelltod. Während den letzten Jahren zeigte die
moderne Krebsforschung jedoch, dass ionisierende Strahlung auch
Signalübermittlungskaskaden unabhängig von der DNA-Schädigung in der
Zelle auslöst, welche das Therapieansprechen und die Therapieresistenz
massiv mitbestimmen. Das Ziel unserer Projekte ist a) die molekulare und
zellbiologische Untersuchung solcher strahleninduzierten Signalübermittlungskaskaden in genetisch-kontrollierten und klinisch-relevanten
Tumormodellen, und b) die Entwicklung von Kombinationstherapiemodalitäten mit klinisch-relevanten Substanzen, die zur Ueberwindung der
Strahlenresistenz führen.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Martin Pruschy
Labor Molekulare Radiobiologie, Universitätsspital Zürich
[email protected]
044 255 8549
Conditions
Links
http://www.cnz.uzh.ch/pruschy.html
Topic
Hermatologic malignancies
Short description
Different MSc projects are available in the leukemia research group at the
University Children's Hospital Zurich. Projects will deal with different aspects
of drug resistance in childhood acute leukemia. One project will address the role
of an alternative cell death mechanism, necroptosis, in the resensitization of
resistant leukemia cells to steroids. We have furthermore developed a platform
to analyze the antileukemic potential of new agents in primary leukemia cells
from highly drug resistant patients. This project will deal with the analysis and
characterization of the hereby identified new antileukemic agents also with
respect to their activity in combination with current chemotherapy.
Supervisor
Institute
E-mail
Phone
PD Dr. Jean-Pierre Bourquin / Dr. Beat Bornhauser
Labor Molekulare Dept of Oncology, University Children's Hospital
[email protected] / [email protected]
044 266 7304; 044 634 88 17
Conditions
Commitment and motivation
Links
http://idcmskispi.unizh.ch/lenya/kispi/live/af/ForschungLehre/onkoonco/
Leukaemie_de.html
Topic
Short description
Detection of BRAF mutations in non-small cell lung carcinoma (NSCLC)
using microfluidic probe (MFP) based DNA extraction
BRAF mutations are found in a subset of non-small cell lung carcinoma. The
mutation is predictive for response to targeted BRAF inhibition. Tumor
initiation by oncogenic BRAF renders cancer cells susceptible to TGFβinduced epithelial-mesenchymal transition (EMT).
In order to assess the BRAF mutation status in both tumor epithelia and
surrounding stroma of formalin-fixed and paraffin-embedded NSCLC tumors
and to correlate it with the expression of EMT-related proteins we will use the
microfluidic probe (MFP) technology, developed by IBM Rüschlikon.
Supervisor
Institute
E-mail
Phone
Conditions
Links
PD Dr. Peter Schraml
Institute of Surgical Pathology
[email protected]
044 255 2114
Interest in cancer research and biomedical engineering. Motivated, self-driven
and keen to work on experiments.
Master thesis:12 months
http://www.klinische-pathologie.usz.ch/
Clinical Chemistry
Topic
Anti-Inflammatory Pathways in Atherosclerosis
Short description
Atherosclerosis is the pathogenetic process leading to myocardial infarction
and stroke and still is the leading cause of death in Western civilisation.
Chronic inflammation plays a major role in atherogenesis and lack of
resolution of inflammation aggravates the vicious circle of inflammation in
atherogenesis. Functional polymorphisms in genes involved in the resolution
of inflammation will eventually alter the balance between pro- and antiinflammation. We screen these genes for polymorphisms in the Caucasian
population, investigate the functionality of such newly discovered
polymorphisms in cell culture and investigate their association with
atherosclerosis in patients with coronary artery disease.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Martin Hersberger
Division of Clinical Chemistry and Biochemistry
University Children's Hospital Zürich
Steinwiesstrasse 75
CH-8032 Zürich
[email protected]
044 / 266 75 41
Conditions
Experience with cell cultures is an advantage
Links
http://www.kispi.uzh.ch/af/ForschungLehre/ClinicalChem_de.html
Topic
The Role of Lipid Mediators in Chronic Inflammatory Diseases
Short description
We are interested in the regulation and in the effect of the resolution of
inflammation on chronic inflammatory diseases, like atherosclerosis and
asthma with the aim to find pathogenetic mechanisms, new genetic factors for
disease risk prediction, and novel therapeutic approaches. For this, we
investigate the genetic regulation and the molecular pathways of enzymes and
receptors, which are involved in lipid mediator synthesis and in their signal
transduction.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Martin Hersberger
Division of Clinical Chemistry and Biochemistry
University Children's Hospital Zürich
Steinwiesstrasse 75
CH-8032 Zürich
[email protected]
044 / 266 7541
Conditions
Experience in mass spectrometry is an advantage
Links
http://www.kispi.uzh.ch/af/ForschungLehre/ClinicalChem_de.html
Topic
Intracellular transport of HDL in endothelial cells
Short description
Plasma levels of HDL are inversely correlated with the risk of cardiovascular
diseases and exert potentially anti-atherogenic properties within the arterial
wall. However, it is unknown how they are transported from the blood stream
through the endothelium into the vascular wall. Therefore we investigate the
interaction of HDL with this barrier. The aim of the study is to characterize the
interaction of native and reconstituted HDL with cultivated endothelial cells.
In a second step we will use RNA interfence to identify the receptors and
transporters which are needed to mediate endothelial transcytosis of HDL
particles.
Supervisor
Institute
E-mail
Phone
Dr. Lucia Rohrer / Prof. Dr. A. von Eckardstein
Institut für Klinische Chemie, Universitätsspital
[email protected]
044 255 4793
Conditions
Links
Topic
Serine-Palmitoyltransferase and Sphingolipid Metabolism
Short description
Sphingolipids and their metabolites are ubiquitous constituents of cell
membranes and involved in various cellular functions like apoptosis, signal
transduction and membrane trafficking. The serine-palmitoyltransferase (SPT)
is the key regulatory enzyme in the sphingolipid synthesis pathway. Mutations
in the SPT gene result in an inherited sensory neuropathy (HSN1).
Pathological changes in sphingolipid metabolism have been implied to play
pathogenetic roles in various diseases including Diabetes Type 2,
atherosclerosis and cancer. We previously identified and characterized a third
subunit of SPT and offer several MSc projects to further characterize the
structure, function and regulation of the subunits of SPT.
Supervisor
Institute
E-mail
Phone
Dr. Thorsten Hornemann
Inst. für Klinische Chemie (IKC), Unispital Zürich
[email protected]
0041 1 255 4719
Conditions
Experiences in cell culture, protein chemistry and molecular biology are
preferable
Links
Topic
Identification of protein biomarkers for atherosclerosis
Short description
Ruptures of atherosclerotic plaques in coronary arteries lead to acute coronary
syndromes (heart attack). We are looking for proteins that leak from
atherosclerotic lesions into the blood stream, which can be used as diagnostic
markers. We use antibody phage display to generate antibodies against
proteins from atherosclerotic plaques and antibodies against certain
posttranslational modifications, which are believed to occur in atherosclerotic
plaques and leak into the blood stream. These antibodies are used to detect the
proteins in plasma samples from patients, and to purify these proteins so that
they can be identified by mass spectrometry.
Supervisor
Institute
E-mail
Phone
Dr. Danielle Hof / Prof. Dr. Arnold von Eckardstein
University Hospital Zurich, Institute for Clinical Chemistry
[email protected]
044 255 30 24
Conditions
A background and interest in molecular biology, biochemistry, or
biotechnology.
Links
www.ikc.usz.ch
Metabolic Medicine
Topic
Neurodegeneration due to mutant methylmalonyl-CoA mutase
Short description
Methylmalonic aciduria is a rare inborn error of metabolism that
predominantly presents in infancy with neurological symptoms including acute
metabolic and encephalopathic crises. It is caused by deficiency of the
methylmalonyl-CoA mutase (MCM) which plays a key role in the catabolism
of various amino acids, as well as of odd-chain fatty acids and the side chain of
cholesterol. MCM binds cobalamin to form the active holoenzyme, and defects
of MCM can be subdivided into responder and non-responder to cobalamin.
The aim of this thesis is to express human and murine MCM in vitro as a
prerequisite to validate a mutant MCM that will be used to generate a
transgenic knock-in mouse as a new model for methylmalonic aciduria.
Supervisor
Institute
E-mail
Phone
Prof. Dr. M. Baumgartner, Prof. Dr. Beat Thöny
Universitäts-Kinderkliniken Zürich, Abteilungen Stoffwechsel und Klinische
Chemie und Biochemie
[email protected]
044-266 76 22
Conditions
Keine
Links
www.kispi.uzh.ch/Kinderspital/Medizin/Medizin/Stoffwechsel_de.html;
www.kispi.uzh.ch/af/ForschungLehre/ClinicalChem.html
Topic
Neurometabolic defects in newborns due to splicing errors in the
tetrahydrobiopterin (BH4)-biosynthetic gene PTS
Short description
Gene mutations affecting correct pre-mRNA splicing are often found in introns
of genes and commonly disrupt the use of constitutive splice sites leading to
exon loss. Alternatively, such cis-acting mutations may also activate cryptic
splice sites leading to the recruitment of pseudo-exons - often Alu
retrotransposons - a phenomenon called exonization. We have identified two
new intronic mutations in the PTS gene from a patient with autosomal
recessive tetrahydrobiopterin (BH4)-cofactor deficiency. The PTS gene
product is required for BH4 biosynthesis, and the cofactor is essential for a
number of enzymes including the aromatic amino acid hydroxylases that
degrade phenylalanine and synthesize the monoamine neurotransmitter
precursors L-dopa and 5-OH-tryptophan. The aim of this thesis is to prove that
our newly identified intronic mutations in the PTS are responsible for exon
deletion and/or exonization by applying an exon trapping assay with minigene
constructs transfected into an indicator cell line.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Beat Thöny
Universitäts-Kinderkliniken Zürich, Abteilung für Klinische Chemie und
Biochemie, Steinwiesstrasse 75, 8032 Zürich
[email protected]
044-266 76 22
Conditions
keine
Links
www.kispi.uzh.ch/af/ForschungLehre/ClinicalChem.html
Clinical Research
Topic
Klinische Forschung
Short description
Das Clinical Trials Center des Zentrums für Klinische Forschung verfügt über
eine klinische Forschungsstation im UniversitätsSpital Zürich und unterstützt
alle Kliniken und Institute bei der Planung und Durchführung klinischer
Studien gemäss Good Clinical Practice. Durch aktive Mitarbeit in
verschiedenen klinischen Studien sowie in sämtlichen Studienphasen von der
Konzeption bis zum Abschluss einer Studie kann die gesamte Methodik der
Pharmazeutischen Medizin und Klinischen Forschung erlernt werden.
Supervisor
Institute
PD Dr. Gabriela Senti
Clinical Trials Center, Zentrum für Klinische Forschung
Universität und Universitätsspital Zürich
[email protected]
044 634 55 09
E-mail
Phone
Conditions
Selbständiges Arbeiten, Organisations- und Teamfähigkeit, Grundkenntnisse
der Klinischen Forschung von Vorteil
Links
www.ctc-zkf.usz.ch
Topic
„Thermal grill illusion“ – die Illusion von Schmerz
Short description
Die gleichzeitige Applikation von warmen und kühlen nicht schmerzhaften
Reizen (z.B. mit der kalten Hand unters warme Wasser) wird als schmerzhaft
wahrgenommen (‚Thermal-Grill Illusion‘). Mit dem ‚Thermal Grill‘- Device
kann man diese ‚schmerzhafte Illusion‘ in gesunden Personen induzieren.
Dieses Projekt beschäftigt sich mit der Frage, ob & in welchem Ausmaß man
die TGI an verschiedenen Stellen des Körpers auslösen kann.Training:
Studienplanung, -durchführung und -auswertung, Arbeit mit Probanden (evtl.
Patienten), Einführung in neurophysiologische Messungen (SSEP, CHEPs,
NLG).
Supervisor
Institute
E-mail
Phone
Dr. M. Bolliger, Prof. Dr. A. Curt
Uniklinik Balgrist
[email protected]
044 386 37 33
- Bachelorabschluss in Biologie.
- Selbständiges Arbeiten; Interesse, etwas Neues zu lernen.
- Deutsche Muttersprache und fliessend Englisch
http://www.sci-research.uzh.ch/index.html
Conditions
Links
Topic
Short description
Supervisor
Institute
E-mail
Phone
Pancreatic regeneration and tumorigenesis
Pancreatitis is a debilitating inflammation of the pancreas and a major risk
factor for developing pancreatic cancer, one of the most lethal human
malignancy. No effective cure exists for these pancreatic diseases and the lack
of effective strategies is linked to the incomplete understanding of their
pathophysiology. MSc projects are available to study the molecular
mechanisms regulating pancreatic acinar cell replication, a critical step both in
the context of regeneration following pancreatitis, and during tumor
development. Experimental techniques will include: immunohistochemistry,
microscopy, real-time PCR, western blotting, in vitro cell culture.
Dr. Sabrina Sonda
University Hospital Zürich
[email protected]
044 255 97 86
Conditions
Motivated students with strong background in cell biology are encouraged to
apply.
Links
http://www.pancreaslab.ch
Circadian Cycles and Sleep Research
Topic
Molecular Analysis of Human Biological Clocks
Short description
Our laboratory studies mammalian biological clocks and the molecular
pathways by which they control behavior and physiology. Our approach is a
broad one, and includes everything from in-vitro biochemistry and cell biology
of cultured cells, to transgenic and knock-out mouse models, to genetic and
clinical studies involving human beings. More detailed descriptions of current
projects, as well as downloadable files of recent publications, can be found on
our lab website.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Steven A. Brown
Institut für Pharmakologie und Toxikologie
[email protected]
044-635-5999
Conditions
Knowledge of basic molecular biology techniques. Fluency in English or
French.
Links
www.sbrownlab.com
Topic
Short description
The role of the dopaminergic system in sleep-wake regulation
A sleep deprivation study will be performed on healthy volunteers genotyped
for different polymorphisms modulating dopamine levels. They will also be
given Tolcapone, used in Parkinson patients to increase dopaminergic tone.
The Master’s project will consist of developing a LC-MS protocol for the
measurements of Tolcapone and dopamine and its metabolite from salivary
samples collected during the study. This work will provide valuable
knowledge on the effects of genetic variants on circadian dopamine levels, and
their interaction with a potential wake-stimulant drug.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Hans-Peter Landolt
Institute of Pharmacology and Toxicology
[email protected]
044 – 635 59 53
Conditions
interest in pharmacology or chemistry
Links
http://www.pharma.uzh.ch/research/chronobiology/areas/psychopharmacology
.html
Child Development Center
Topic
Einfluss von Stress und Bewegung auf die Entwicklung von Kleinkindern
Short description
Im Rahmen eines Nationalfondprojektes wird der Einfluss von Stress und
Bewegungsaktivität auf die physische und psychische Entwicklung von
Vorschulkindern untersucht.Dazu werden in Zusammenarbeit mit der
Universitäten Fribourg und Lausanne verschiedene Aspekte analysiert, u. a.
die motorische Entwicklung, die kognitive Leistung, das psychische
Wohlbefinden und das Körpergewicht.
Supervisor
Institute
Prof. Dr. Oskar Jenni
Entwicklungspädiatrie, Kinderspital Zürich und Institut für Sozial- und
Präventivmedizin
[email protected]
044 266 77 51
E-mail
Phone
Conditions
Links
zuverlässige Arbeitsweise, Freude im Umgang mit Kleinkindern, gute
Computerkenntnisse, Basiswissen über statische Analysen
http://www.kispi.uzh.ch/Kinderspital/Medizin/Medizin/AWE_de.html
http://www.ispm.uzh.ch/aboutus/pdundtp/susikriemler.html
Topic
Die Rolle des Schlafes für das emotionale Gedächtnis bei Kindern und
Jugendlichen
Short description
Eine Reihe von Studien an Erwachsenen belegen, dass die Speicherung neu
gelernter Gedächtnisinhalte massgeblich im Schlaf stattfindet. Das kindliche
Gehirn ist nicht nur durch eine hohe Plastizität gekennzeichnet, Kinder
schlafen auch länger und wesentlich tiefer als Erwachsene. In der geplanten
Studie soll die Rolle des Schlafes für die emotionale Gedächtnisbildung bei
Kindern und Jugendlichen untersucht werden. Die Aufgaben eines
Masterstudenten/ einer Masterstudentin umfassen die Mithilfe bei der Planung,
Durchführung und Datenanalyse.
Supervisor
Institute
Prof. Dr. Reto Huber, Dr. Ines Wilhelm
Interdisziplinäres Schlafzentrum, Entwicklungspädiatrie, Kinderspital Zürich
E-mail
Phone
Conditions
[email protected]
044 266 8187
Flexibilität, Zuverlässigkeit und Verantwortungsbewusstsein,
die Bereitschaft, Nächte im Schlaflabor zu verbringen, Interesse an der Arbeit
mit Kindern und Jugendlichen
Links
www.kispi.uzh.ch/sleep
Child and Adolescent Psychiatry
Topic
Brainmapping von Lesenlernen und Aufmerksamkeitsentwicklung
Short description
Lesenlernen, Handlungskontrolle und Aufmerksamkeit sind Meilensteine der
kindlichen Entwicklung. Klinische Störungen treten oft schon bei
Schulkindern auf (ADHD – Aufmerksamkeitsdefizit – Hyperaktivitätsstörung;
Dyslexie – Lesestörung; OCD - Zwangsstörung).
In diesem Spannungsfeld untersuchen wir neurophysiologisch Entwicklung,
Störungen, und Training von Laut-Schrift-Lernen, Lesen, Aufmerksamkeit und
Handlungskontrolle. Die Masterarbeiten in diesen Schwerpunkten erhalten
Einblick in funktionelles Brainmapping durch ereignisbezogene EEG
Potentiale (ERP) und funktionelle Magnetresonanz (fMRI).
Aktuell erforschen wir warum Lesestörungen andauern, vergleichen
Zwangsstörungen und ADHD, und messen physiologische Hirnentwicklungen
bei ADHD.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Daniel Brandeis, Dr. Silvia Brem
Zentrum für Kinder- und Jugendpsychiatrie, Universität Zürich
[email protected]
043 556 40 81
Conditions
Freude an der Arbeit mit Kindern und Interesse an kognitiven
Neurowissenschaften, gute Deutschkenntnisse, Computerkenntnisse,
Grundlagenkenntnisse in Statistik, sorgfältige und strukturierte
Arbeitsweise
Links
http://www.kjpd.uzh.ch/; http://www.neuroscience.uzh.ch/
Tissue Engineering
Topic
Supervisor
Institute
E-mail
Phone
Muscle Tissue Engineering
The capability of engineering tissue that is more than a few cubic millimeters
in volume requires the formation of new blood capillaries in order to supply
essential nutrients and oxygen. Slow Release vasuclar endothelial growth
factor (VEGF) administered two weeks prior to cell therapy and muscle cells
autonomously expressing VEGF may offer a novel method to deliver
angiogenic factors to bioengineered muscles and improve volume preservation
and functional outcome.The master thesis will imply determination of
feasibilty of modifying Muscle Precursor Cells to release VEGF and
determination the phenotypic and functional characteristics of engineered
muscle tissue supplemented with VEGF in a mouse model.
PD Dr. Daniel Eberli
University Hospital Zürich, Urology Department
[email protected]
044 255 93 01
Conditions
-
Links
http://www.urologie.usz.ch/LehreUndForschung/Grundlagenforschung/Projekt
e/Seiten/Tissue-Engineering.aspx
Topic
Heart valve tissue engineering
Short description
One of the promising projects of our Regenerative Medicine Program is the
tissue engineering of heart valves to overcome the drawbacks of currently used
mechanical or bioprosthetic valves for treating valvular heart disease. Our
major goal is to develop a clinically relevant tissue engineered living heart
valve, with the capacity of regeneration and growth which can be implanted by
minimally invasive catheter technology. A highly interdisciplinary approach
combines basic sciences, medical research, engineering and clinical practice.
This large promising ongoing project currently embraces smaller in-vitro and
in-vivo studies to further optimize the final end product. Master projects can
be designed to fit the interest and qualities of the student and could be related
to for example optimization of cell sources, culture process, in-vivo
remodeling, etc. Students will have the opportunity to be trained in (among
others) the following techniques: literature review, project planning, cell
culture, tissue engineering, histology, quantification of extracellular matrix,
analyzing results, reporting and presenting their results.
Supervisor
Institute
Prof. Dr. Simon P. Hoerstrup
Regenerative Medicin Program; Division of Surgical Research; University and
University Hospital Zurich
[email protected], [email protected]
044 6345687
Short description
E-mail
Phone
Conditions
Motivated students in the area of biology, biomedical sciences or equivalent
are encouraged to send applications. Experience with cell cultures is an
advantage.
Links
www.ReMedi.uzh.ch
Immunology
Topic
Mechanisms of Inflammation
Short description
Macrophages play a pivotal role in inflammatory processes. They respond to
inflammatory mediators such as microbial agents or chemokines and
themselves produce and release pro-inflammatory cytokines and chemokines,
thereby communicating with other cell types such as vascular endothelial cells.
We investigate novel inflammatory signaling pathways as well as antiinflammatory mechanisms in human macrophages aiming to a better
understanding of severe diseases such as sepsis/septic shock, macrophage
activation syndromes, and unusual host responses to microbial pathogens.
Various MSc projects are available, cutting edge technologies in cell and
molecular biology will be applied in all projects.
Supervisor
Institute
Prof. Dr. G. Schoedon-Geiser, and research group leaders
Molecular and Clinical Inflammation Research Unit
Department of Medicine, University Hospital of Zürich
[email protected]
E-Mail
Phone
Conditions
Completed bachelor level with outstanding grades (5 or higher), special
interest in cell and molecular biology
Links
http://www.research-projects.uzh.ch/a1568.htm
Topic
Neuroimmunology
Short description
A) Virtually all disorders of the nervous system display an inflammatory
component. To this day it remains unclear whether the inflammation
coinciding with damage mediated by CNS-intrinsic degenerative effects is
destructive or regenerative. Using in vivo models and immune based
methodology, several projects in this direction are being pursued.
B) Autoimmune disorders of the CNS are mediated by the conduct of adaptive
and innate immunity against „self”. The nature of this immune response
remains ill-defined and we seek a better understanding of encephalitogenic
immunity
Supervisor
Institute
Prof. Dr. Burkhard Becher
University of Zurich, University Hospital
Institute of Experimental Neuroimmunology
Y44-J7 (Office), J38/42 (Lab)
Winterthurerstrasse 190
CH-8057 Zürich
[email protected]
+41-44-635-3703
Fax: +41-44-635-6883
E-mail
Phone
Conditions
Solid understanding of basic immunology and molecular biology. Good
communication skills. Interest to work in a highly motivated, vibrant and
young research environment
Links
http://www.neuroimmunology.uzh.ch
Infectiology
Topic
Infectiology: from veterinary to human medicine
Short description
Infectious diseases are of great importance; increased mobility leads to fast
spread of infectious agents and climate changes are associated with emerging
diseases. Infections of wild, pet and farm animals may have a zoonotic
potential. In addition, animal models serve as an important prerequisite to
investigate therapeutic interventions or immunoprophylactic strategies.
Various veterinary infectiology projects with relevance for human medicine
are available; projects include a variety of molecular, cell culture and/or
serological methods.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Regina Hofmann-Lehmann
Clinical Laboratory, Vetsuisse Faculty
[email protected]
044 635 83 22
Conditions
Candidates should be highly motivated, committed and good team players.
Links
www.vetlabor.uzh.ch
Toxicology
Topic
Investigating the role of soluble epoxide hydrolase in lipid metabolism
Short description
Mammalian soluble epoxide hydrolase (sEH) comprises an epoxide hydrolase
as well as a phosphatase activity, both involved in lipid metabolism. The sEH
is implicated in cardio-vascular and inflammatory diseases, mostly based on
the metabolism endogenous epoxides by the EH. The phospha-tase turns over
intermediates of the cholesterol biosynthesis pathway. We will analyse the role
of sEH in sterol and lipid homeostasis to investigate the mechanistic link
between these two sEH activities. Techniques: mass spectrometry, cell culture,
molecular biology and protein biochemistry
Supervisor
Institute
E-mail
Phone
Prof. Dr. Michael Arand
Institute of Pharmacology and Toxicology
[email protected]
044 635 59 79
Conditions
-
Links
http:// www.pharma.uzh.ch
Neurophysiology
Topic
Molecular Neurobiology: Understanding the role of Gephyrin in GABAA
receptor clustering at synapses.
Short description
GABAA receptors are major inhibitory receptors in the brain. Defects in
GABAA receptor function has been implicated in epilepsy, depression, alcohol
addiction etc. Hence, its important to understand how the receptors are brought
to the synapse and maintained at the synapses. The research project will
involve studying the interaction of GABAA receptor subunits with the
scaffolding protein gephyrin and its implications on synaptic clustering of the
receptor.
The project will use techiques in Molecular biology, biochemistry, cell culture
and fluorescence microscopy.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Jean-Marc Fritschy/ Dr. Shiva Tyagarajan
Pharmacology and Toxicology
[email protected]
044-63 55937
Conditions
I am looking for a motivated and interested person who will fit into our fun
and friendly lab environment.
Links
http://www.pharma.uzh.ch/neuromorpho_website/index.html
Topic
Eco-evolutionary adaptations of adult hippocampal neurogenesis
Short description
New neurons are continuously added into the hippocampus of most mammals.
The functional relevance of these new neurons is still debated. Apparently,
both evolutionary constraints as well as species-specific requirements for
behavioral flexibility influence the magnitude of cell proliferation and
neuronal integration. We are interested in the phenomenon of adult
neurogenesis from a broad, comparative view. We investigate various small to
medium sized mammels, in the wild and also in the laboratory. Each master
project concentrates on one species, investigating behavioral performance
(ecological niche, learning, physical exercise), followed by the estimation of
the number of immunohistologically identified cell types in the hippocampus.
Supervisor
Institute
E-mail
Phone
Dr. Irmgard Amrein
Institute of Anatomy
[email protected]
044/635 5342
Conditions
Bachelor in Biology, neuroscience knowledge required
Links
http://www.anatom.uzh.ch/research/DivisionWolfer_en.html
Topic
Automatisierte Erfassung von Lernverhalten bei Mäusen im
Sozialverband
Short description
Unsere Gruppe setzt selbst entwickelte Lernkäfige (IntelliCage) ein, die mit
einem Minimum an Stress kognitive Fähigkeiten von Mäusen im
Gruppenkäfig erfassen und speichern. Für eine Masterarbeit erwarten wir, dass
die individuellen Fähigkeiten der Tiere sowohl im automatisierten System als
auch in klassischen Einzeltests für Lernverhalten (z.B. Schwimmnavigation,
Vermeidungslernen) erfasst werden. Die Daten werden dann miteinander und
allenfalls mit neuronanatomischen Parametern korreliert.
Supervisor
Institute
E-mail
Phone
Prof. Dr. David P. Wolfer,
Anatomisches Institut, Universität Zürtich-Irchel
[email protected]
044/63 55360
Conditions
Interesse an Verhaltensforschung mit Mäusen, Computerkenntnisse,
Grundkenntnisse Statistik
Links
http://www.uzh.ch/anatom/forschung/f_forschung_e.htm
Neuropathology
Topic
Various MSc Projects in Prion Science
Short description
Various MSc project are available in the realm of prion science. It is possible
to choose between projects dealing with (1) diagnosis of human prion diseases,
(2) prion immunology, (3) prion genetics, and (4) prion models in simple
genetically tractable organisms (fruitfly, worm). Candidates should have an
outstanding academic track record: for Swiss candidates, all grades must be 5
or higher. Candidates should be prepared to commit themselves fully to their
thesis in a very demanding research environment.
Supervisor
Institute
E-mail
Phone
Prof. Dr. Adriano Aguzzi
Institut für Neuropathologie
[email protected]
Conditions
100% commitment. Above-average grades in molecular biology.
Links
http://www.uzh.ch/pathol/neuropathologie/index.html
Psychiatry Research
Topic
Alzheimer’s disease - Molecular pathology and the development of
immunotherapy.
Short description
Transgenic mouse models will be used to analyze mechanisms of toxicity and
neurodegeneration, and to develop novel approaches for treatment. A
particular focus is the development of immunotherapy designed to reduce betaamyloid-related neurotoxicity in transgenic mice..
Supervisor
Institute
E-mail
Phone
Prof. Dr. Roger Nitsch
University of Zurich Division of Psychiatry Research
[email protected]
044 634 8871
Conditions
Basic knowledge of molecular biology
Links
http://www.dpr.uzh.ch/
http://www.nccr-neuro.uzh.ch/resp2.html
http://www.neurozh.ch/e/groups/nitsch00.htm
Evolutionary Medicine
Topic
Evolutionary perspectives of human disease
Short description
Evolutionary perspectives of human health and disease can be studied
on a macroscopic or molecular level. For example, musculoskeletal
disorders are extremely common in modern people. One factor in their
aetiology is biomechanical stress, part of which might be directly
attributable to modern daily behavior. Using radiographs, comparative
anatomical studies and analyses of the fossil / skeletal and soft tissue
record help to investigate important etiological disease factors.
Using ancient DNA techniques from a number of archaeological
contexts e.g. mitochondrial DNA sequences can be compiled and also
functional gene data can be compared across different regions and time
period. Such molecular analyses allow e.g. to achieve a more complete
picture of the evolutionary dynamics of human immunity and pathogen
susceptibility.
Opportunities for Master theses exist in different areas of the
interdisciplinary research field.
Supervisor
Institute
E-mail
Phone
Prof Dr. Dr. F. Rühli
Institute of Evolutionary Medicine, University Zürich-Irchel
[email protected]
044 635 01 11
Conditions
None (for aDNA projects own DNA needs to be analysed to be able to rule out
modern contamination)
Links
http://www.iem.uzh.ch/