MaCS Research Projects Scientific Concept Systems Biology

Ma CS
<
MaCS
for
The “Magdeburg Center for Systems Biology” (MaCS)
was formed in 2007 as an initiative of the University of
Magdeburg and the Max Planck Institute for Dynamics
of Complex Technical Systems. It is one of four
research centres in Systems Biology that have been
funded with financial support of the Federal Ministry of
Education and Research of Germany (BMBF). The aim of
this
initiative
so
(FORschungseinheiten
support
called
zur
FORSYS
Program
SYSstembiologie)
is
to
interdisciplinary, collaborative research units
of systems biology at universities and non university
research
institutions
that
signal
provide
an
program is 2007-2011.
Württemberg),
are
located
Heidelberg
regulation
of
cellular
•
in
Freiburg
(Baden-
(Baden-Württemberg),
Magdeburg (Saxony-Anhalt) and Potsdam (Brandenburg).
Scientific Concept
The special attribute of the Magdeburg Centre for
Systems Biology is the expertise in systems theory and
systems engineering and the combination of continuous
and discrete mathematical modelling of all kinds of
viral or bacterial infection provides as a basic for
signalling
and
redox
homeostasis
in
Cell differentiation in a eukaryotic model system:
control of sporulation in Physarum polycephalum
•
Model based modification of cellular regulation in
Saccharomyces cerevisiae
The goal is the establishment of new, broadly applicable
•
T-cell signalling
concepts for modelling and systems analysis which are
•
Dynamics of Helicobacter pylori induced responses
•
Dynamic
applicable
to
different
levels
of
molecular
in epithelial cells
and
functional complexity. MaCS is part of the research
Technology," an essential element of the Excellence
influenca
a
virus
replication
in
Systems Biology
Education
Initiative of Saxony-Anhalt.
Research Projects
of
epithelial cells
center “Dynamic Systems in Biomedicine and Process
In 2004 the diploma course “Biosystemtechnik” at Otto
Theoretical Work Packages
von Guericke University Magdeburg was established
•
Structural and functional analysis of cellular networks
which educates students in theoretical and practical
•
Dynamic modelling of regulatory and signal trans-
aspects of systems biology.
duction networks
From 2011 on this study course will be available as
•
Automatic network reconstruction
Master too.
•
Complexity reduction and modularization
In addition it is proposed to establish a special PhD
•
Thermodynamic constraints in biochemical networks
program which deals with practical and theoretical
•
Model validation, parameter analysis and experimental
aspects of systems biology in equal measure.
design
Integral parts of our educational program are national
•
Specialized visual editors for systems biology models
and
Biological Work Packages
Aim of the research program is the development of new
•
the analysis and reconstruction of molecular networks
•
research.
biological networks.
approaches in systems biology and their application to
Redox
Rhodospirillum rubrum
e.g. cells of the human immune system, that respond to
essential
systems biology in Germany. Duration of the FORSYS
centres
and
As model organisms various pro and eukaryotic species,
contribution towards strengthening existing research in
The
processing
processes.
international
colloquia,
workshops
and
summerschools.
Part of the PhD education is in line with the
Quantitative analysis of specific regulation and
International Max Planck Research School for Analysis,
global
Design and Optimization in Chemical and Biochemical
control
Echerichia coli
of
carbohydrate
metabolism
in
Process Engeneering.
MaCS Working Groups
Rolf Findeisen (OvGU)
Ma CS
Ernst Dieter Gilles (MPI)
Achim Kienle (OvGU)
Wolfgang Marwan (OvGU)
Michael Naumann (OvGU)
Udo Reichl (OvGU)
Burkhart Schraven (OvGU)
Robert Weismantel (OvGU)
Junior Research Groups
Hartmut Grammel (MPI)
Utz-Uwe Haus (OvGU)
Affiliated Junior Research Groups
Katja Bettenbrock (MPI)
Steffen Klamt (MPI)
Andreas Kremling (MPI)
Annegret Wagler (OvGU)
Cooperative Institutions
Charité - Universitätsmedizin Berlin
German Rheumatism Research Center (DRFZ)
Hamburg University of Technology
Helmholtz-Centre for Infection Research (HZI)
Leibniz Institute for Natural Product Research and
Infection Biology- Hans-Knoell-Institute
University Hospital Heidelberg
University of Stuttgart, Center Systems Biology (CBS)
Max Planck Institute for Molecular Genetics, Berlin
Chief Executive Officer
Prof. Wolfgang Marwan
Otto von Guericke University Magdeburg
Institute of Biology / IBIO
Department of Regulatory Biology
c/o Max Planck Institute for
Dynamics of Complex Technical Systems
Sandtorstr. 1
39106 Magdeburg
Phone: +49 (391) 6110 410
[email protected]
Head of Coordination Office
Dr. Susanne Hollmann
Otto von Guericke University Magdeburg
Department of Mathematics / IMO
Universitätsplatz 2
39106 Magdeburg (Germany)
Phone: +49 (391) 67 18555
Fax.: +49 (391) 67 17111
[email protected]
www.systembiologiewww.systembiologie-magdeburg.de
Magdeburg Centre
for
Systems Biology