Brain-Dedicated PET Instrumentation: A Status Report on Current

Transcription

Brain-Dedicated PET
Instrumentation: A Status Report
p
of
on Current Development
PET/MRI and PET only Scanners
M. Wissmeyer, MD
Department of Nuclear Medicine
University Hospital of Geneva (HUG)
Switzerland
PET
PET/CT
©2006 Hôpitaux Universitaires de Genève
PET/MRI
2
Development of Brain PET/MR Scanners
Animal PET/MR
Pichler et al. Semin Nucl Med. 2008 May ; 38(3): 199-208
3
From Animal PET/MR to Human Brain PET/MR
Pichler et al. Eur Radiol (2008) 18: 1077-1086
4
From Animal PET/MR to Human Brain PET/MR
5
Technical Challenge: Replacement of Conventional PMT’s
6
Aims
7
Aims
8
Aims
9
Aims
10
Potential Future Design
Courtesy of Siemens Healthcare
11
Other Vendors
• Philips Healthcare:
• Engaged
g g
in WB PET/MR
• Potential use also in brain applications
• No information on development of dedicated brain
PET/MR
• GE Healthcare:
• No information on development of PET/MR scanners
12
Courtesy H. Z
C
Zaidi
Challenges in Brain PET/MR
13
Courtesy H. Z
C
Zaidi
14
15
MR guided Attenuation Correction
• Differences in quantitative measurements
Kops et al. IEEE 2007
16
17
18
Applications of Brain PET/MR
General Benefits
• Decrease
D
off radiation
di ti
exposure
• PET/MR as “One“One
One-Stop
OneStop--Shop
Shop”
• Op
Optimization
a o of
o
• Image fusion
• Partial volume correction
• Gray matter extraction
19
Clinical Benefits
20
Clinical Benefits
Wehrl et al. Eur J Nucl Med Mol Imaging (2009) 36 (Suppl 1):S56-S68
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Clinical Benefits
Heiss WD Eur J Nucl Med Mol Imaging (2009) 36 (Suppl 1):S105-S112
22
Clinical Benefits
Meningioma imaged by 68Ga-DOTA-TOC
Pichler et al. J Nucl Med 2010; 51: 333-336
23
Clinical Benefits
Chandra et al. Epilepsia 47(9):1543-1549, 2006
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Clinical Benefits
• ASL and FDG PET in Tuberous Sclerosis
Wissmeyer et al. J Neuroradiol2009
25
PET Only Scanners
Current Status
• Since introduction of hybrid PET/CT scanners no
further development of commercial PET only
scanners
• Many research sites maintain their available PET
only scanners:
• Satisfactory Imaging Properties
p
and normal collectives for statistical
• Further use of templates
analysis of images (SPM)
26
PET Only Scanners
Siemens Healthcare / CTI
• ECAT Exact HR+
• BGO Detectors
• Intrinsic resolution: 4mm
• HRRT
• LSO Detectors
• Intrinsic resolution: 2.5mm
27
PET Only Scanners
Other Commercial Vendors
• GE Healthcare
• Philips
p Healthcare
• Toshiba
• Others…
=> Also still in use
28
Conclusions I
• Ongoing development of dedicated brain PET/MR
scanners:
• Scanner design
• PET detector inserts
• Challenges:
• MR based attenuation correction (quantitative imaging!!!)
• “PET specific” MR sequences
• Benefits:
Benefits
• Decrease of Radiation Exposure
• Workflow optimization (“one(“one-stop
stop--shop”)
• Partial volume correction and gray matter extraction
29
Conclusions II
• Research Applications
•
•
•
•
Stroke imaging
Neurodegenerative disorders
Epilepsy
Neuro--oncology
Neuro
• Clinical Applications
=> To be established
30
Acknowledgements
• Nuclear medicine, HUG:
• Prof. O. Ratib, MD, PhD
• H. Zaidi, PhD
• Neuroradiology,
gy, HUG:
• Karl
Karl--Olof Lövblad, MD
• Philips Healthcare:
• T. Havens
• R. Veigel
• Siemens Healthcare:
• T. Broennimann
• F.
F Schoenahl
S h
hl
31

Brain-Dedicated PET Instrumentation: A Status Report on Current

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