Italie

Transcription

Italie

Biotechnologies
Liste des entreprises qui opèrent dans la région Lombardie (Italie)
ACS DOBFAR s.p.a.
Viale Addetta, 4/12
20067 Tribiano
Italy
www.acsdobfar.it
ACS DOBFAR is a privately owned Italian Company that produces bulk cephalosporins and penicillin, both
oral and for injection, and exports its API's all over the world.
Main sector: Biotechnology – R&D Services
Subsector: CMO (Contract Manufacturing Organization);
Synthesis services
Description of products
APIs :
Cefalosporins
Pencillins
Vancomycin Base
Cefalexin caps
- SMARTPAK™ is a new packaging and delivery system designed by ACS Dobfar to simplify the
reconsitution of all injectable drugs especially in the Hospital Pharmacy Compounding Center.
Areta International
Via Roberto Lepetit 34
21040 Gerenzano
Italy
www.aretaint.com
Founded year 1999 as a spin-off from public institution / NPO
Areta international is a biotech company dedicated to the contract development and manufacturing of
innovative biological drugs and advanced therapy medicinal products.
Subsector: Analytical services; CMO (Contract
Manufacturing Organization); Synthesis services
ARETA GMP portfolio includes: contract process development and manufacturing, safety and quality control
tests, filling and media fill. Furthermore Areta can help its customers in defining the strategy for process
development optimization and quality in biotech projects. Regarding manufacturing technology, the strategy
is based on disposable high surface to volume ratio bioreactors that are characterized by high containment,
ideal for safety and GMP compliance, while requiring relatively small lab space and limited staff. The
company can tailor the production schedule to the real needs of its customers, thus avoiding over-production
at a project’s early stage, which may result in losses of product and money. ARETA R&D: Areta
International’s technology platform comprises in house developed methods for the generation and production
of monoclonal antibodies, the adaptation of all kind of cells to serum free media, etc.
Technology used
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Technology platform comprises in-house developed methods for generation /production of MAbs, adaptation
of all kinds of cells to serum free media, development of rapid/efficient techniques for MAbs,rec proteins,cells
production in large quantities. The strategy regarding MAbs focuses on customized immunization
protocols,monitoring of the animal’s immune response to the antigen,proprietary fusion and screening
protocols finalized to obtain hybridomas secreting highly selective/specific MAbs. Regarding scale up
technology,the strategy is based on disposable high surface to volume ratio bioreactors, characterized by
high containment,ideal for safety and GMP compliancel. The combination of these skills enables the
production of cells and biomolecules in a very rapid/efficient/reliable way. These biomolecules/cells can be
delivered to the customer in bulk or as final products, (e.g. enzyme immunoassay kits, cell-based test,
infusion bags).
Partnering strategy / collaborations
Areta International is interested in cooperation with biotech/pharma companies on different levels :
-looking for new customers for both its divisions,
-co-development of biodrugs and participation in new research programs,
-Extra –EU companies that might need to establish a base for clinical trial supply in Europe.
A.T. Grade s.r.l.
Via Petrarca 4
20123 Milan
Italy
www.atgrade.eu
Founded year 2003
A.T. Grade s.r.l. mission is to manage laboratories for cell therapy through the provision of advanced
technology, qualified personnel, services and advice to the GMP certification of laboratories.
State of ownership:
Private / independent
Main sector: Biotechnology
Subsector: Cell culture
– R&D Services
Processing of Fibroblast/Cheratinocytes for wound healing and severe burns. Processing of Chondrocytes
for cartilage regeneration. Isolation of Pancreatic b-cells for diabete type I treatment.
Partnership with the public cells and tissues banks in order to revamp and manage GMP laboratories for
cells expansion and tissue processing
Accelera s.r.l.
Viale Pasteur 10
20014 Nerviano, Milano
Italy
www.accelera.info
Accelera is a premium tier contract research organization (CRO) providing toxicology, drug metabolism,
pharmacokinetics and bioanalysis services to the Biotech and Pharmaceutical industry. Accelera is
committed to supporting all stages of drug discovery and development by offering tailored services spanning
multiple disciplines, including early formulation development, preclinical profiling, drug safety, metabolism,
bioanalysis and pharmacokinetics (PK).
Accelera is an independent company within the Nerviano Medical Sciences Group.
State of ownership:
Subsector: Analytical services; CRO (Contract
Primary therapeutic areas:
Research Organization); Screening; Cell culture
Neoplasms / cancer / oncology
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Discovery Services
Development Services
Biologics and Biomarkers
Bioanalysis and PK
ADIENNE S.r.l.
Via Broseta 64/B
24128 Bergamo
Italy
www.adienne.com
Founded year 2004
ADIENNE Pharma & Biotech is a company dedicated to the treatment of rare and severe diseases, with
particular attention to onco-haematology, solid organ and bone marrow transplantation.
State of ownership:
Main sector: Biotechnology – Therapeutics
Primary therapeutic areas: Diseases of the blood
and blood-forming organs; immune disorders
Description of main products
TEPADINA® 100 mg (INN: thiotepa)
TEPADINA® 15 mg (INN: thiotepa)
MARGYL® (INN: phenelzine sulfate)
BEGEDINA®
MUBODINA®
ERGIDINA®
Allergy Therapeutics Italia S.R.L.
Via IV Novembre 76
20019 Settimo Milanese
Italy
www.allergytherapeutics.com
State of ownership:
Subsidiary of Allergy Therapeutics (UK)
Allergy Therapeutics (AT) is a European-based speciality pharmaceutical company focused upon the
treatment and prevention of allergy.
and blood-forming organs; immune disorders
Axxam S.R.L.
Via Olgettina 58
Biomedical Science Park
20132 Milano
Italy
www.axxam.com
Founded year 2001 as a spin-off from Bayer
Axxam S.R.L. is a technology-led research company in the field of life sciences, with expertise at the leading
edge of target identification, advanced screening assay system development, and screening. Axxam has
built up several cutting edge platforms spanning the entire “Genes to Leads” pathway.
State of ownership:
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Subsector: CRO (Contract Research Organization);
Screening
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere
classified
Photina
Services:
- Assay Development
- High-Throughput Screening
- Compound Collections for Screening
- Compound Profiling
Altana Pharma, BayerHealthCare, BioXell, Chiesi Pharmaceuticals, Dompé, GlaxoSmithKline,
Grünenthal,
NicOx,
Newron
Pharmaceuticals,
Recordati
and
Rottapharm.
Company is looking for increasing collaborations and partnerships with pharmaceutical, biotechnology
and agri-chemical companies, allowing them to access their technological platforms, expertises, know-how
and reagents in the several fields of drug discovery (“From genes to leads”).
Bio3 Research S.r.l.
Via della Moscova 6/8
20121 Milan
Italy
www.bio3research.com
Founded year 2001
Bio3 Research develops new proprietary compounds up to IND stage with potential in cardiovascular field.
The company is focused in the area of cardiovascular disorders related to HMGB1 (High Mobility Group Box
1) over-expression.
State of ownership:
Subsector: Proteins
Primary therapeutic areas: Cardiovascular; Skin
and subcutaneous tissue; Genitourinary system
HMGB1 protein
Special IP situation
PCT applications which claim use of Small Molecules and Mabs in HMGB1 related cardiovascular disorders.
Patent application for HMGB1 inhibitors and antagonists which inhibit the Atherosclerotic pathogenesis and
progression.
PCT application for HMGB1 and its fragments use as therapeutic preparations in damaged connective
tissue.
PCT application in the USA for CT301/R use in cardiovascular disorders.
PCT application for BIOCYSAN (cysteine) and Biocysan Plus (cysteine+glutathione) use in End Stage Renal
Disease.
S.I.I.T
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Biodiversity S.P.A.
Via Corfù 71
25124 Brescia
Italy
www.biodiv.it
Founded year 2002
The main mission of the Company is based on developing, using, producing and marketing new
technologies and products to be used in molecular analysis and diagnostics as well as on research activities
in different advanced fields, such as biochemistry, genomics, proteomics, biotechnology and
nanotechnology.
State of ownership:
Subsector: Analytical services; Bioinformatics; Diagnostic services; Genomics; Proteomics
Primary therapeutic areas: Diseases of the blood and blood-forming organs; immune disorders;
Diseases of the
nervous system; Cardiovascular; Digestive system; Genitourinary system
Technology used
Technology platforms include:
Thermocycler (PCR)
Real Time thermocycler (RT-PCR)
Automatic sequence of DNA
Microarrays: MGX 200
Laboratory cloning, synthesis and purification of recombinant proteins
Peptide synthesizer
Sequence of protein
Fluorescence Activated Cell Sorter (FACS)
Fluorescence microscope (Nikon)
Unit bioinformatics
Biofin Laboratories S.R.L.
Via Bachelet 89
46047 Porto Mantovano
Italy
www.biofinlabs.com
Founded year 1988
Biofin Laboratories is an Italian company mainly involved in fermentation technologies, semi-synthesis
technologies and corresponding basic engineering.
State of ownership:
CRO (Contract Research Organization)
Bacteriostatic antibiotic API
Anticancer API
Statins
Steroids
Vitamins
Amino acids
Food additives
Client portfolio (as relevant)
BIOCHEMIE, SHID, HISUN , LUNANPHARMA, HUARONG, ZQBC, YSP, PUCHENG, ZHENYUANG ZHEJIANG,
PINGYIN, XINCHANG, XIAN PHARMACEUTICAL, TUOYANG, NUTRITION BEST GROUP, BODAPHARM, HUADONG
MUDANJANG, VOCALINO LTD, THRAKHIA, BASF, DEGUSSA, HOECHST, SKW, JCP MARTINS, THEMIS, GTBL,
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IPCA, WOCKARDT, RPG LIFE SCIENCE (SEARLE INDIA), POCHIRAJU INDUSTRIES, NATCO LTD, KREBS LTD,
BIOCON, AMBALAL SARABHAI ENTERPRISES, ALEMBIC, STRIDES, STERLING, BPPT PUSPITEK CENTRE,
CINNAGEN, TEMAD, ISFAHAN UNIVERSITY, TEVA, AVENTIS
Biogen Dompé s.r.l.
Via San Martino, 12-12/a
20122 Milano
Italy
www.dompe.it
Founded year 2004
Biogen Dompé represents the realization of a collaboration between Biogen and Dompé, which share both
the ideas and the implementation of projects for the development of biotechnological drugs, backed up by
high-tech services in specific therapeutic areas.
State of ownership:
independent
Primary therapeutic areas: Neoplasms / cancer
/ oncology; Diseases of the nervous system
PEG IFN
BG-12
Fampridine
Humanized Anti-CD20 mAb
Anti-CD80 mAb (galiximab)
HSP90 Inhibitor
MMK Inhibitor
RAF Inhibitor
Biolife Italiana S.R.L.
Viale Monza 272
20128 Milano
Italy
www.biolifeit.com
Biolife Italiana Srl is a manufacturer and distributor of high quality products for clinical, industrial and
environmental microbiology: powdered and ready to use culture media, supplements and enrichments, kits
and reagents for microbial identification.
State of ownership:
independent
Subsector: Cell culture; Diagnostic instrumentation
Bacterial Serology - Fever Micro Tests
Rapid Immunochromatographic Tests
Dehydrated Culture Media (complete range)
Supplements for CM, etc.
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BioRep S.r.l.
Via Fantoli 16/15
20138 Milano
Italy
www.biorep.it
Founded year 2005
BioRep S.r.l. is an independent service provider organization born in 2003 by the conjunctive investment of
Sapio Life, Angelantoni Industries and Integrated Systems Engineering, offering biorepository services to
public and private research institutes, to the highest standards of quality and safety. BioRep is a
technologically advanced infrastructure able to provide several services to meet the needs of the entire
Scientific Community.
State of ownership:
Subsector: Analytical services; Cell culture
Cell Colture Services
Molecular Biology Services
Microbiology Services
Custom Tissue Arrays FFPE and Frozen
Custom Cell Array
Criobiology Instrumentation (Liquid Nitrogen Containers CHART/MVE), Control Rate freezers (Planner),
Tissue Microarrayer TMA CK3500, XBlot 1000 (Integrated System Engeneering)
Turn.Key Laboratories and Biobanks Design, Construction, Start.up and Management.
Coriell Institute for Medical Research USA
Biosense Srl
Vicolo Valtellina 15
20092 Cinisello Balsamo (MI)
Italy
www.biosense.it
Founded year 1996
Biosense is a key supplier of high technology solutions to researchers for several life science applications,
covering the entire Italian market in this field.
State of ownership:
Subsector: Biochips; Cell culture; Genomics;
Proteomics; Synthesis services
Products offered include custom synthesis of oligonucleotides and peptides, custom production of polyclonal
antibodies, consumables for qualitative and quantitative PCR, systems and softwares for analysis of
genotypes and biomolecular interactions, equipment for PCR and DNA and protein microarray technology.
Sislab SaS
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Biotest Italia Srl
Via Leonardo da Vinci 43
20090 Trezzano Sul Naviglio
Italy
www.biotest.de
Founded year 2000
Biotest is a company specialising in innovative haematology and immunology products with the holistic
approach of a global pharmaceutical, diagnostics and biotherapeutics group. They develop, manufacture and
sell medicinal products for the treatment of blood and immune diseases as well as products for the hygiene
monitoring of air and work surfaces.
State of ownership:
Private / Independent
Primary therapeutic areas: Antibodies
BT-061
BT-062
BT-063
BOUTY Healthcare S.p.A.
Viale Casiraghi 471
20099 Sesto San Giovanni
Italy
www.bouty.it
Founded year 2002 as a Management buy-out
Bouty meets market and consumers needs with five division structure; Healthcare, Diagnostics,
Biotechnology, Drug Delivery Systems, International.
State of ownership: Private
/ independent
Main sector: Biotechnology – R&S Services
Subsector: Diagnostic instrumentation; Drug
delivery
SYPHILIS ELISA
CGH ARRAY, etc.
Technology used
Drug delivery advanced technologies
Bracco S.P.A.
Via E. Folli 50
20134 Milano
Italy
www.bracco.com
Founded year 1927
Bracco is an international Group active in the healthcare sector through Bracco Imaging (diagnostic
imaging), Pharma (prescription and over the counter drugs), Acist (advanced injection systems based in
Minneapolis), and the Centro Diagnostico Italiano diagnostic clinic in Milan.
State of ownership:
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Subsector: CMO (Contract
– Therapeutics + R&D Services
Manufacturing Organization); Diagnostic instrumentation; Diagnostic services; Drug
delivery
- OTC Drugs
- Ehical Drugs
- Imaging Modalities
- Contrast Injection Systems, etc.
Cambrex Profarmaco Milano S.R.L.
Via Cucchiari 17
20155 Milano
Italy
www.cambrex.com
Founded year 1946
The Cambrex Biosciences group is a supplier to the biotechnology, biopharmaceutical, and Life Science
communities.
Cambrex Profarmaco develops and sells generic active pharmaceutical ingredients (API's) and advanced
intermediates to the pharmaceutical industry.
State of ownership: Subsidiary of Cambrex Corporation, East
Subsector: CMO (Contract Manufacturing Organization)
Rutherford, NJ (NYSE:CBM)
Chiral Compounds, Pyridine Derivatives, Chloronitrobenzoic Acids and Derivatives, Dinitrobenzoic Acids and
Derivatives, Nitrobenzaldehydes and Derivatives, Nitrobenzoic Acids and Derivatives, Nitrophthalic Acids
and Derivatives, Boronic Acids, Active Pharmaceutical Ingredients, etc.
Technology used
Camouflage™ Drug Delivery Technology
Charles River Laboratories Italia srl
Via Indipendenza 11
23085 Calco
Italy
www.criver.com
Founded year 1972
Charles River provides essential products and services to help pharmaceutical and biotechnology
companies, government agencies and leading academic institutions around the globe accelerate their
research and drug development efforts.
State of ownership: Subsidiary
of Charles River Laboratories International, Inc., USA
Subsector: Analytical services; CRO (Contract Research Organization); Diagnostic services; Screening
Primary therapeutic areas: Infectious and parasitic diseases; Neoplasms / cancer / oncology; Diseases of the
blood and blood-forming organs; immune disorders; Endocrine, nutritional and metabolic diseases; Diseases
of the nervous system; Cardiovascular
- Production, husbandry & distribution of highest quality laboratory animals
- Development of new disease models
- Development of world-leading capabilities in transgenic animal science
- Preclinical Services
- Clinical Testing Services, etc
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Chiltern International Srl
Via Nizzoli 6
20147 Milan
Italy
www.chiltern.com
Founded year 1972
Chiltern International is a clinical research organization that offers clinical contract personnel services to
pharmaceutical and biotechnology clients. They also provide Clinical Operations, Project Management, Data
Management, Biostatistics, Medical Writing, Quality Assurance and Regulatory and Medical Affairs services
to the pharmaceutical, biotechnology and medical device industries.
State of ownership:
Subsidiary of Chiltern International, UK
Primary therapeutic areas: Cardiovascular
Research Organization)
- Phase I to Phase IV clinical trials
- Product development services to the pharmaceutical, biotech and device industries including Early Phase,
Global Clinical Development, Late Phase, Biometrics, Medical and Regulatory Affairs, and Resourcing
Solutions.
Clonit Srl
Via Bernardo Quaranta 57
20139 Milano
Italy
www.clonit.it
Founded year 1987
CLONIT S.r.l. offers widest range of Molecular Biology Systems for Human, Veterinary and, just recently, for
Food Diagnostics, Forensics Medicine and Oncology: the systems are offered with a complete set of
components which allow the technicians to run a Molecular Biology test either in a routine Clinical or
Industrial laboratory.
State of ownership:
Subsector: Diagnostic instrumentation
H5N1 master mix
FAST PCR Kits
Controls
10
Congenia S.p.A.
Via dei Bossi 2/a
20121 Milano
Italy
www.congenia.it
Founded year 2000
Congenia discovers and develops small-molecule compounds designed to target and modulate (activating or
inhibiting) the activity of the permeability transition pore (PTP), mitochondrial target involved in cellular
ageing, senescence and apoptosis.
State of ownership: 100%
owned by Genextra SpA.
Subsector: small molecules
Primary therapeutic areas: Diseases of the nervous
system, Cardiovascular
Cosmo Pharmaceuticals S.p.A.
Via C. Colombo 1
20020 Lainate
Italy
www.cosmopharmaceuticals.com
Founded year 1997 as a spin-off from company (purchase of contract drug manufacturing unit from Park
Davis, now Pfizer).
State of ownership:
Public
Cosmo is an emerging fully-integrated speciality pharmaceutical company that aims to become a global
leader in the market of optimised therapies for selected gastro-intestinal diseases. The company’s
proprietary clinical development pipeline specifically addresses innovative treatments for Inflammatory Bowel
Diseases (IBD), such as Ulcerative Colitis and Crohn’s Disease, as well as for colon infections.
On Nov 19, 09 Cosmo Pharmaceuticals offered to buy BioXell for $40.7 million in a bid to boost its pipeline.
The acquisition is expected to increase Cosmo's financial flexibility and its free float, giving it access to about
$52.2 million in cash owned by BioXell.
Primary Stock Exchange: SIX Swiss Exchange (COPN)
Primary therapeutic areas: Digestive system
Lialda™ / Mezavant™
Budesonide MMX®
Rifamycin SV MMX®
LMW Heparin MMX®
Zacol NMX® - Nutraceutical
Technology used
MMX® technology
License agreement with Stada Group to apply MMX™ technology to budesonide.
License agreement with Shire and Giuliani to apply MMX™ technology to mesalamine.
License agreement with Sigma Tau to apply MMX™ technology to propionyl carnitine and to acetylisovaleroil carnitine.
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CTG Pharma S.r.l.
Viale Gran Sasso 17
20131 Milan
Italy
www.ctgpharma.com
Founded year 2004
CTG Pharma is an early-stage pharmaceutical company dedicated to discovering new chemical entities
derived from established drugs that are improved through a highly innovative molecular mechanism.
State of ownership:
system, Diseases of the eye, Cardiovascular, Musculoskeletal
system and connective tissue, Genitourinary system, Injury, poisoning and certain other consequences of
external causes
CTG Pharma holds several international patent applications covering NCEs in different therapeutic area.
Technology used
CTG Pharma technology allows the preparation of NCEs that are able to release gaseous trsmitters in an
effective and long-lasting way.
Several Italian and International Institutions, including NCI (USA), University of Singapore, etc.
CTI Life Sciences Limited
Via Ariosto, 23
20091 Bresso
Italy
www.celltherapeutics.com
Founded year 2000
CTI is committed to developing, acquiring, and commercializing innovative treatments for cancer.
State of ownership:
Subsidiary of Cell Therapeutics Inc., Seattle, USA (NASDAQ:CTIC).
/ oncology
CTI's product pipeline includes one commercialized product, Zevalin, and two products in late-stage clinical
development — OPAXIO™ and pixantrone — and several clinical and preclinical product candidates that
may address the therapeutic limitations of conventional cancer therapies.
Technology used
Polyglutamate Polymer Technology
Cephalon; Novartis; Systems Medicine; National Cancer Institute Development Therapeutics Program
Screening Technologies Branch; Istituto dei Tumori di Milano; Nerviano Medical Sciences.
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DAC s.r.l.
Via Adamello, 16
20139 Milan
Italy
www.genextra.it/dac.html
DAC is a fully owned subsidiary of Genextra, focused on identifying and advancing new classes of
anticancer agents designed to inhibit the activity of HDACs and HSP90.
State of ownership:
subsidiary Genextra
Subsector: small molecules
/ oncology
Dako Italia S.p.A.
Via Piero Portaluppi 11/2
20138 Milano
Italy
www.dako.it
Founded year 1966
Dako develops, manufactures and markets cell-based cancer diagnostics for both clinical diagnostics and
research use.
State of ownership:
Subsidiary of Dako Denmark A/S
Subsector: Diagnostic Instrumentation
HER2 FISH pharmDx™ Kit
ACIS® III Instrument
CISH and FISH Kits
c-Kit pharmDx™ Kits
EGFR pharmDx™ Kits
ER/PR pharmDx™ Kits, etc.
Dasit S.P.A.
Via Merendi 22
20010 Cornaredo
Italy
www.dasit.it
DASIT SpA specializes in clinical diagnostics.
State of ownership:
part of D-Group
AP22 Speedy
AP16 IF Plus
CA 125
CYFRA 21-1
Estradiol etc.
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Derming Srl
Viale Cesare Battisti 38
20052 Monza
Italy
www.derming.com
Founded year 1993
DermIng provides clinical evaluations, conducting scientific tests to determine the tolerance and activity of
skin care products and implementing and assessing bio-engineering systems for the latest non-invasive
diagnostics. Derming has UNI EN ISO 9001:2000 certification
State of ownership:
Subsector: Analytical services; Diagnostic services
Tests of Function/Efficacy
Tolerance Tests
Recruiting Volunteers
DiaMed Italiana S.R.L.
Via Alfieri, 24
20057 Vedano al Lambro (MI)
Italy
www.diamed.it
Founded year 1980
DiaMed specializes in research and development, production and world wide services for laboratory
diagnostic products. They offer a wide range of diagnostic products for hemostasis, the hematology,
infectious diseases and other diagnostic fields.
State of ownership:
Subsidiary of DiaMed AG, Switzerland
Phenotyping, antibody detection, HPF4 test
Tests for PNH, Sickle cell, FMH, control for blood cell counters
IMPACT CPA and Platelet function analysis
Malaria Rapid Diagnostic Test
Instruments and Automates for Haemostasis, etc.
Dipharma S.p.A.
Via Bissone 5
20021 Baranzate (Milano)
Italy
www.dipharma.it
Foundation year 1949
Dipharma is one of the major European producers of Active Pharmaceutical Ingredients, serving a large
base of pharmaceutical companies all around the world.
/ independent
– R&D Services
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Subsector: CMO
(Contract Manufacturing Organization); Synthesis services
ARMODAFINIL
BENAZEPRIL HCl
BOSENTAN
DEXLANSOPRAZOLE SESQUIHYDARATE
DEXLANSOPRAZOLE AMORPHOUS
DEXLANSOPRAZOLE ANHYDROUS
IMIQUIMOD
OLMESARTAN MEDOXOMIL
PALIPERIDONE
PANTOPRAZOLE SODIUM
PRAMIPEXOLE DIHYDROCHLORIDE
PRAMIPEXOLE FREE BASE
RABEPRAZOLE SODIUM
RASAGILINE MESYLATE
RASAGILINE TARTRATE
TELMISARTAN
Edmond Pharma Srl
Via G. B. Grassi, 15
20157 Milano
Italy
www.edmondpharma.it/
Edmond Pharma is involved in development and manufacturing of APIs and formulated products.
Calao and Edmond Pharma work in close collaboration to ensure maximum synergism and flexibility on the
basis of their skills.
/ independent
Primary therapeutic areas: Respiratory
Generics - Baclofen, Gliclazide, etc.
Active ingredients - Carteolol, Erdosteine, etc.
Calao
EOS S.p.A
Via Monte di Pietà n.1/A
20121 Milano
Italy
www.eosmilano.com
Founded year 2006
EOS is a biopharmaceutical company committed to the development of novel medicines for the treatment of
cancer.
/ independent
Subsector: Small molecules
/ oncology
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E/CEP-18770
E-162
E-3810
Istituto Nazionale Tumori Milano
Istituto di Ricerche Farmacologiche Mario Negri Milano
Istituto Europeo di Oncologia (IEO)
SENDO
EuroClone S.p.A.
Via Figino, 20/22
20016 Pero
Italy
www.euroclone.it
Founded year 1983
EuroClone S.p.A. is the Italian partner of many world-wide leaders in biotech and medical fields. Key fields of
activity: Cell Biology and Cytogenetics, AgroFood and Veterinary Diagnostics, Human Diagnostics, Molecular
Biology, Microgenomics, Immunology, Labware and Contamination Control Equipment, General Surgery,
Surgery, Laparoscopy, Neurosurgery, O.R.L., Meshes for Laparocele and Hernia.
State of ownership:
Subsector: Diagnostic instrumentation; Genomics;
Proteomics
husion Blood Direct PCR Kit
Red Taq
EUROFINS BIOLAB Srl
Via B.Buozzi, 2
20090 Vimodrone
Italy
www.biolab.it
Founded year 1970
Eurofins Biolab is an analysis laboratory specialising in assays and controls, and in biological,
microbiological, and chemical determinations.
State of ownership:
Main sector: Biotechnology – R&D
Subsector: Analytical services
Services
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Euticals S.p.A.
Via Valverde 20/22
21100 Varese
Italy
www.euticals.com
Founded year 1975
Euticals SpA - Varese manufacturing site - is specialized in the manufacture of nucleotides, nucleosides and
their derivative, mainly used in the field of nutraceuticals. In addition, they manufactures antisense oncology
drugs and antiviral products in segregated-FDA inspected-production units.
State of ownership:
Synthesis services
Nucleosides :
Adenosine Base
Adenosine DAB10
Adenosine Injectable grade
Cytidine
Guanosine
Uridine
Deoxynucleosides:
2’ Deoxyadenosine
2’ Deoxicytidine
2’ Deoxyguanosine
Thymidine
Nucleotides:
Adenosine 5’ monophosphate free acid (AMP)
Cytidine 5’ monophosphate free acid (CMP)
Guanosine 5’ monophosphate disodium salt (GMP)
Uridine 5’ monophosphate disodium salt (UMP)
Modified Nucleosides:
Adenine Arabinoside (Vidarabine or Ara A)
Adenine Arabinoside 5’ monophosphate (Ara AMP)
Cytosine Arabinoside (Cytarabine or Ara C)
Uracil Arabinoside (Ara U)
Fludarabine
Fludarabine phosphate
Poli Phosphorilated Nucleotides:
Adenosine 5’ triphosphate disodium salt (ATP)
Cytidine 5’ diphosphocholine sodium salt (CDPC)
Cytidine 5’ triphosphate disodium salt (CTP)
Guanosine 5’ triphosphate disodium salt (GTP)
Uridine 5’ diphosphoglucose disodium salt (UDPG)
Uridine 5’ triphosphate disodium salt (UTP).
5 Iodo 2’ deoxycytidine (IDC)
5 Iodo 2’ deoxyuridine (ID)
Patent in the filed of transglysidation reaction
17
Famar Italia S.p.A.
Via Zambeletti 25
20021 Baranzate Di Bollate
Italy
www.famar.gr
Famar is a European provider of Contract Manufacturing services to the Pharmaceutical and Health &
Beauty industry. Famar reliably offers:
- Pharmaceutical Production
- Pharmaceutical Development
- Health & Beauty Production and R&D
- Logistics
Italian plant: this development center has an independent, fully equipped Galenical Unit, operating under
cGMP regulations, specialized in the development of solid and semi-solid dosage forms.
State of ownership:
Subsidiary of Famar Greece
Product forms:
Powders
Pellets
Granules
Capsules
Uncoated Tablets
Chewable tablets
Coated Tablets (film or sugar coated)
Effervescent tablets
Drops
FAR.CO.S. s.r.l.
Via Guido Rossa 1
20024 Garbagnate Milanese (MI)
Italy
www.valeostudio.it/farcos/eng
Founded year 1994
FAR.CO.S. s.r.l. active in cosmetic and nutraceutical field. They provide all kind of safety and efficacy
assessment.
State of ownership:
Subsidiary of Famar Greece
Subsector: Analytical Services
Services
Microbiology services in cosmetic area
- Microbiology services in food area
- in-vitro, ex-vivo and in-vivo studies
- standard assays and designing innovative protocols.
18
Farmabios S.P.A.
Via Pavia 1
27027 Gropello Cairoli(PV)
Italy
www.pharmabios.com
Farmabios is focused on the production of active pharmaceutical ingredients belonging to main families of
Steroids, Sterile steroids, Semi-synthetic cephalosporins, Sterile semi-synthetic cephalosporins and Highly
potent drugs.
State of ownership:
Steroids
alclometasone dipropionate
aldosterone
amcinonide
beclomethasone
beclomethasone dipropinate
beclomethasone dipropinate monohydrate
clocortolone pivalate
clocortolone acetate
budesonide
deflazacort
desonide
Antibiotics
ceflonium
cefalotine
cefazedone
cefminox
cefotenan
cefuroxime acid
cefuroxime sodium
cefuroxime sodium sterile
cephacetrile sodium sterile
other products
amifostine
atracurium besilate
mivacurium
rocuronium bromide
Finchimica Group
Via Cimarosa, 4
20124 Milan
Italy
www.finchimixa.net
Founded year 1976
Finchimica Group has large capacity for sterile lyophilization of pharmaceutical raw materials.
Finchimica has developed a remarkable activity in the field of research for the development of fermentation
and synthesis technologies for the production of antibiotics.
State of ownership:
Subsector: Syntesis Services
Services
19
Flamma S.p.a.
Via Bedeschi, 22
24040 Chignolo d`Isola
Italy
www.flamma.it
Founded year 1950
Flamma specializes in the manufacture of active ingredients and intermediates for the pharmaceutical,
nutraceutical and cosmetic industries.
State of ownership:
Subsector: CMO (Contract
– R&D Services
Manufacturing Organization)
DL-Aspartic acid potassium salt
N-Acetyl-L-asparagine
Acetyl-Carnosine
N-Acetyl-L-Glutamine
L-Carnosine
Fondazione Filarete
viale ortless 22/4
20139 milano
Italy
www.fondazionefilarete.com
Founded year 2008
Creating, hosting and nurturing high-tech entreneurial initiatives in the field of Bioscience.
Fondazione Filarete has adopted a dual operation profile to support companies with a multi-disciplinary
approach:
Scientific,
technological
and
logistic
support
(over
6.000
sq.m)
- Financial advisory, business development services and financing in selected initiatives through its
subsidiady
company
Filarete
Investimenti.
The core of Fondazione Filarete is represented by 9 Technological Platforms managed. The different
platforms interact to form a unique interdisciplinary and integrated technological core combining genomics,
proteomics, cellular and animal modles, molecular imaging with nano and microtechnology able to provide
preclinical validation of therapeutically relevant molecules through the molecular profiling of their activity in
living organisms (cells and animals).
State of ownership:
Subsector: Analytical services; Biochips; Bioelectronics;
Bioinformatics; Cell culture; CRO (Contract Research
Organization); Diagnostic instrumentation; Diagnostic services; Drug delivery; Genomics; Proteomics;
Screening; Synthesis services.
Primary Therapeutics Areas: Neoplasms / cancer / oncology; Diseases of the blood and blood-forming organs;
immune disorders; Endocrine, nutritional and metabolic diseases; Mental and behavioural disorders;
Diseases of the nervous system; Skin and subcutaneous tissue; Musculoskeletal system and connective
tissue; Congenital malformations, deformations and chromosomal abnormalities; Symptoms, signs and
abnormal clinical and laboratory findings, not elsewhere classified.
20
GeneSpin
Via Celoria, 26
20133 Milano
Italy
www.genespin.com
GeneSpin is dedicated to the development and application of new methodologies and marketing of new
products in the fields of Genetics and Molecular Biology.
State of ownership:
Main sector:
Biotechnology – R&D Services
Taq Pol
- A thermostable enzyme of approximately 94kDa isolated from Thermus aquaticus.
Taq Pol RTL
- Ready to load; uses a special Orange reaction buffer which allows direct gel loading and electrophoresis of
the sample directly from the PCR* machine, whithout further manipulation.
Protein Detection System
- A highly sensitive enhanced substrate for detecting horseradish peroxidase (HRP) on immunoblots.
Monoclonal and Polyclonal antibodies.
GENEXTRA S.p.A.
Via Privata Giovannino De Grassi, 11
20123 Milan
Italy
www.genextra.it
Founded year 2003
Genextra is a private biopharmaceutical company committed to the development of innovative therapeutics
primarily for the cure of cancer, age-related and metabolic disorders.
Genextra develops its programs through four subsidiaries: Congenia, DAC, Tethis and Intercept
Pharmaceuticals.
/ independent
/ oncology; docrine, nutritional and metabolic diseases; Skin and
subcutaneous tissue
Gentium S.p.A.
Piazza XX Settembre 2
22079 Villa Guardia (CO)
Italy
www.gentium.it
Founded year 2001
Gentium S.p.A. is public (GENT - NASDAQ) biopharmaceutical company specializing in the discovery,
research, development and manufacture of active ingredients derived from natural sources as potential
therapeutic agents.
State of ownership: Public
/ oncology; Cardiovascular; Injury, poisoning and certain other
consequences of external causes
21
Defibrotide
Heparin
Urokinase
Sulglicotide
The Company holds 30 U.S. and EU patents with 70 applications pending. Defibrotide’s
Orphan Drug designation in the U.S. and Europe provides additional market exclusivity for the treatment of
VOD. Gentium continues to build on its core patents to provide additional protection.
Gepa S.r.l.
Via IV Novembre, 92
20021 Bollate (Milano)
Italy
www.gepasrl.it
Founded year 2004
Gepa S.r.l. produces and sells diagnostic and analytical medical instrumentation.
State of ownership:
Main sector: Biotechnology / R&D Services
Cardiac markers
StatStrip ™
Gnosis S.P.A.
Via Laboratori Autobianchi, 1
20033 Desio
Italy
www.gnosis-bio.com
Founded year 1989
Gnosis is a pro-active biotechnology-based company specialized in manufacturing and sales of fermentation
raw materials and natural finished products used in the pharmaceutical, nutraceutical, cosmetic, veterinary,
and agricultural industries.
State of ownership:
Main sector: Biotechnology / R&D Services
Synthesis services
SAM-e Granular
Glutathione
Coenzyme Q10
AKG
22
HO.p.e. Srl
via Roberto Lepetit, 34
21040 Gerenzano
Italy
www.hopekit.com
Founded year 2007 as a spin-off from University of Milan
HO.p.e. is engaged in the development and clinical validation of a kit prototype for the determination of the
somatotrope pituitary function in man based on the integrated evaluation of multiple growth hormone (GH)dependent parameters.
State of ownership: Private / independent
Areta International srl
ICROM S.p.A.
via delle Arti, 33
20049 Concorezzo, Milano
Italy
www.icrom.com
Founded year 1969
ICROM is specialized in the GMP manufacturing and in contract manufacturing of GMP intermediates and
GMP active pharmaceutical ingredients (APIs). ICROM is the partner of choice for pharmaceutical
outsourcing.
Since 1996 ICROM is part of the French chemical group PROTEX INTERNATIONAL.
Amisulpride
bisbuthylcarboethylene
bromopride
calcium dobesilate
dibromotyrosine
epinastine HCl
glibenclamide (glyburide)
glipizide
gliquidone
levosulpiride
metoclopramide
metoclopramide HCl
minoxidil
minoxidil sulphate
pentetrazole
sulpiride
sultopride HCl
tiapride HCl, etc.
23
InCura Srl
Via Staffolo 56
26041 Vicomoscano, Cremona
Italy
www.incura.it
Founded year 2001
InCura specializes in the development and marketing of products for Molecular Biology, Diagnostics and
Immunology.
State of ownership:
Subsector: Diagnostic instrumentation; Synthesis
services
CrusKit Real Time - Crustacean DNA detection Real Time PCR kit
MollusKit Real Time - Mollusk DNA detection Real Time PCR kit
LupiKit - Lupin DNA detection Real Time PCR kit
PistacKit Real Time - Pistachio DNA detection Real Time PCR kit
Innovate Biotechnology srl
Via Marconi 3
27029 Vigevano
Italy
www.innovatebiotechnology.com
Founded year 2001
Innovate Biotechnology provides technology to pharmaceutical, agrochemical and fine chemical companies
for the development and implementation at pilot scale enzyme-based processes. The technology consists of
new synthetic routes selection and the optimization of large-scale chemical processes utilizing biocatalysts
and integrating enzymatic conversions with conventional chemistry.
/ independent
Subsector: Analytical services; Synthesis services
Preparation and commercialization of immobilized biocatalysts.
Planning and scale-up of chemo-enzymatic synthesis.
Technology transfer of chemo-enzymatic process.
Synthesis of analytical standards and fine chemicals.
Instrumentation Laboratory S.p.A.
Viale Monza, 338
20128 Milano
Italy
www.il-italia.it
Founded year 1959
Instrumentation Laboratory develops and markets in vitro diagnostic systems for blood gas, electrolytes,
hemostasis-coagulation and clinical chemistry.
Main sector:
/ independent
Biotechnology – R&D Services
24
Subsector:
Analytical services; Diagnostic Instrumentation
GEM® Premier™ 3000 with iQM™ Synthesis™
IL 682 CO-OX
GEM OPL™(Oxygenation Portable Laboratory)
Coagulation GEM PCL™ Plus (Portable Coagulation Laboratory)
ACL™
HemosIL™
IL now holds more than one hundred patents vital to the advancement of medicine.
Beckman Coulter in Italy
Invitrogen S.R.L.
Via Tolstoj 86 (Iº piano Scala H)
20098 San Giuliano Milanese (MI)
Italy
www.invitrogen.com
Founded year 1994
Invitrogen is a biotechnology company which provides products and services that support academic and
government research institutions as well as pharmaceutical and biotechnology companies.
State of ownership: subsidiary
of Life Technologiy Corporation
Subsector: Cell culture; Diagnostic instrumentation;
Screening; Synthesis services
Antibodies & Secondary Detection Reagents
Beads & Microspheres
Buffers & Chemicals
Cell Culture & Transfection Reagents
Columns, Resins & Plates
Competent Cells & Strains
Controls, Standards & Ladders
DNA Vectors, Clones & Libraries
Eukaryotic Cells
Gels, Fractionation Strips, & Membranes, etc.
Istituto Biochimico Pavese IBP Pharma S.p.A.
Viale Certosa, 10
27100 Pavia
Italy
www.ibppharma.com
Founded year 1938
IBP Pharma is involved in the production of anti-inflammatory products, vitamins, antibiotics and other
pharmaceuticals specialties such as anti-histamines. IBP provides contract manufacturing and research
services.
of Life Technologiy Corporation
Synthesis services
25
Somatostatin
Clindamycin
Vancomycin
Kendle Italia
Vicolo del Caldo, 36
21047 Saronno
Italy
www.kendle.com
Founded year 1981
Kendle is a global clinical research organization that provides the biopharmaceutical industry with
outstanding strategy as well as a full complement of quality clinical development and regulatory services to
accelerate the drug development process.
of Kendle, USA
Subsector: CRO (Contract Research Organization)
- Clinical Development (Phases I to III)
- Regulatory Affairs (Consulting and submission services, pharmacovigilance/safety)
- Biometrics (Clinical data management, biostatistics and scientific programming)
- Late Phase (Phase IIIB/IV, health economics and outcomes, scientific events, education and publications)
Kos Genetic srl
Via Podgora 7
20122 Milano
Italy
www.kosgenetic.com
Kos Genetic integrates genomic and post genomic services to exploit the information coded by genes that
make up the human, animal and vegetal genome.
of Kendle, USA
Subsector: Bioinformatics; Genomics
system; Cardiovascular
Rich experience in the correlation between genes, environment and phenotypes for the study of
complex traits human diseases and the identification of genes involved in livestock production traits like
quantity/quality of milk or ponderal growth.
They offer this type of studies and also genotyping and gene-sequencing services based on Illumina
platform.
The team of Kos Genetic is tightly integrated with the research team of the Genomic & Bioinformatic Platform
of the Filarete Foundation: more than 40 researchers who share the same organization, processes,
equipments and informatic solutions even in the sharp division of the jobs and the related accounting
statements.
The technological platform includes:
* Illumina iScan and Illumina beadscan
* Illumina Genome Analyser GXII
* an innovative bioinformatics platform to integrate, correlate and analyze genomic, phenotypic and
environment data.
26
We develop 3 types of projects:
* projects funded by EU and based on the study of correlation between genes, environment and phenotypes
for the better comprehension of complex traits human diseases and the identification of genes involved in
livestock production traits like quantity/quality of milk or ponderal growth.
* genotyping and gene sequencing services to Italian and European associations of breeders: cattle, poultry
and swine
* pharmaco genomics studies and genotyping/gene sequencing services to research centres of universities,
pharma and hospitals.
In the first area, the integrated team of Kos Genetic and Filarete Foundaion is involved in:
* “HYPERGENES” (10.2 m€ of European contribution): European Network for Genetic Epidemiological
Studies – building a method to dissect complex genetic traits, using essential hypertension as a disease
model – http://www.hypergenes.eu/
* POCEMON” (8.4 m€ of European contribution): Point-Of-Care MONitoring and Diagnostics for Autoimmune
Diseases (Sclerosi Multipla ed Artrite Reumatoide) - http://www.pocemon.eu/
* “QUANTOMICS” (5.9 m€ of European contribution): From sequence to consequence - Tools for the
exploitation of livestock genome - http://www.quantomics.eu/page.php.
* “ATHENA” (3 m€ of European contribution). The overall objective of the ATHENA project is to provide a
robust scientific foundation for improved dietary recommendations that include foods with high levels of
anthocyanins and related polyphenols to promote health and to protect against chronic disease.
Laboratori Alchemia S.R.L.
via San Faustino 68
20134 Milano
Italy
www.laboratorialchemia.it
Founded year 1965
Laboratori Alchemia is involved in the field of the production of active ingredients and intermediates for the
pharmaceutical industry.
State of ownership:
Synthesis services
Alacepril
Amrinone
Indapamide
Ketotifene fumarate
Lidamidine hydrochloride
Midodrine hydrochloride
Pizotifen malate
Procaterol hydrochloride
Tetraglycol (Glycofurol)
Thonzilamine hydrochloride, etc.
Laboratori Derivati Organici S.P.A.
VIA BAROZZI 4
20122 MILANO
Italy
State of ownership:
27
Laboratorio Chimico Internazionale S.p.a.
Via B. Cellini, 20
20090 Segrate
Italy
www.labochim.com
Founded year 1966
The Company is engaged in the production of bulk APIs and intermediates for the pharmaceutical, nutritional
and healthcare industries. The Company is a member of the INFA Group.
State of ownership:
Synthesis Services
Acamprosate
Allopurinol
Alpha Lipoic Acid and Salts
Amiodarone Hydrochloride
Bezafibrate
Butamirate Citrate
Calcium Folinate
Carisoprodol
Ciprofibrate
Diclofenac Potassium
Diclofenac Sodium
Fenofibrate
Flupentixol Decanoate
Flupentixol Dihydrochloride
Gabapentin
Gemfibrozil
Gliclazide
Melitracen Hydrochloride
Pentoxifylline
Pregabalin (for R&D purposes only)
Propentofylline
R (+) Alpha Lipoic Acid and Salts
S (-) Alpha Lipoic Acid and Salts
Vitamin B6 Dipalmitate
Vitamin B6 Tripalmitate, etc.
Technology used
Acylation
Alcoholysis
Alcoxilation
Alkilation
Bromination
Carbomethylation, etc.
28
Leaf Bioscience S.r.l.
Via G.Puccini
20100 Milano
Italy
www.leafbioscience.com
Founded year 2003
Leaf Bioscience's mission is to provide professional IT support, bioinformatic software development and
consultancy to the life science community and in new emerging biotech areas.
State of ownership:
Subsector: Bioinformatics
– R&D Services
Development of databases and LIMS
Solutions for data integration (XML/RDF for the representation of knowledge in the context of the Semantic
Web) and Semantic Web-based Knowledge Management Systems for diverse types of professional
networks
Microarray data analysis and databases
Consultancy on standards (MAGE/MIAME for standard information on microarray data)
Bioinformatic open source software customization
Liosintex S.R.L.
Via Mantova, 8/10/12
20020 Lainate (MI)
Italy
www.liosintex.it
Founded year 1973
Liosintex is into lyophilization of antibiotics betalactamics both cephalosporanics and penicillamics as third
party manufacturer.
State of ownership:
Cephadroxil Lysinate Sterile
Metilol Cephalexin
Lysinate Sterile
Cephalexin Lysinate Sterile
Cefazedone Sodium Sterile
Cefazolin Sodium Sterile
Cefmetazole Sodium Sterile
Cefonicid Bisodium Sterile
Cefoperazone Sodium Sterile
29
Lisapharma S.p.A.
Via Licinio, 11
22036 Erba (Como)
Italy
www.lisapharma.it
Founded year 1925
Lisapharma is active in manufacturing sterile injection products, non-sterile liquids, and semisolids.
State of ownership:
Drug Delivery
Liquids in ampoules and vials
Powders in vials, etc.
Patented Patch-non-Patch systems, DOME matrix in oral drug delivery, Chimerical Agglomerates for nasal
delivery.
Technology used
Dome Matrix™, oral platform
Patch-non-Patch™, transdermal platform
Chimerical Agglomerates™, inhalation nasal platform
Sucralfate Gel, as unti-ulcer for GI tract and skin wounds
Lusochimica S.P.A.
Via Giotto 9
23871 Lomagna(LC)
Italy
www.lusochimica.it
Founded year 1964
Lusochimica S.p.A. is an Italian manufacturer of bulk active ingredients for pharmaceuticals (API).
Betaxolol Hydrochloride
Carteolol Hydrochloride
Diltiazem Hydrochloride
Indoramin Hydrochloride
Nicardipine Hydrochloride
Nimodipine
Nimodipine
Nitrendipine
Barnidipine
Benidipine
Candesartan Cilexetil
Manidipine
Bambuterol
Levo-Salbutamol (Base and Sulfate)
Montelukast Sodium
Tiotropium Bromide
Glipizide
Dolasetron Mesylate
Albuterol / Salbutamol Sulfate
30
Fenoterol Hydrobromide
Formoterol Fumarate
Ipratropium Bromide
Mepifilline
Metaproterenol / Orciprenaline Sulfate
Reproterol Hydrochloride
Terbutaline Sulfate
Dihydroxydibutylether
Isoxsuprine Hydrochloride
Pramiracetam Sulfate
Pyrisuccideanol Dimaleate
Ritodrine Hydrochloride
Silver Sulfadiazine
Tolnaftate, etc.
Medi Service s.r.l.
G. Matteotti 43/b
20041 Agrate Brianza
Italy
www.mediservice.it
Founded year 1991
Medi Service S.R.L. is a Clinical Research organization carrying out international and local clinical trials
including every phase of clinical development from phase I through IV to post- marketing.
State of ownership:
Primary therapeutic areas: Diseases of the nervous system;
Cardiovascular; Digestive system
Medi Service offers the following services:
- Phase I/II clinical drug trials
- Clinical research and monitoring
- Medical writing
- Regulatory activity
- Data management and biostatistics
- Centralized laboratory
- Clinical supplies.
Mitim s.r.l.
Via Cacciamali 34
25125 Brescia
Italy
www.mitim.it
Founded year 1972
Mitim has always been capable to manage the several requests from the pharmaceutical industries, offering
a great deal of services relating to the different phases of developing, manufacturing and quality control for
pharmaceutical products according to the Good Manufacturing Practice (GMP) and to the leading
pharmacopoeias such as EP, BP, USP, JP etc.
31
Beta-lattamic antibiotics- injectable sterile powder, tablets, capsule, oral suspensions
injectable sterile solutions- asepsis or sterilisable vials
oral solids- tablets, hard capsules, dry/wet granulates
oral liquids- syrups, suspensions, disposable bottle also equipped with measured cork
Semi-solids- gels, creams.
Montefarmaco Spa
Via G. Galilei, 7
20016 Pero(MI)
Italy
www.montefarmaco.com/eng
Founded year 1945
Montefarmaco spa (Ph.) is a pharmaceutical and dietetic contract development and manufacturing company.
AQ TECH is the holding company.
Pharmaceutical contract manufacturing:
-Solids: Granules, Tablets, Sugar coated tablets, Film coated tablets, Capsules (hard gelatine)
-Liquids: Syrups, Suspensions, Drops, Eye drops, Extemp. single dose solutions, Aerosol solutions
Semi-solids (fluids): Creams, Ointments, Gels
Dietetic contract manufacturing:
-Solids: Tablets, Film coated tablets, Capsules (hard gelatine)
-Liquids: Single dose vials with solid fase cap tanker, Single dose vials.
Molmed SpA
Via Olgettina, 58
20132 Milano
Italy
www.molmed.com
Founded year 1996 as a joint venture between Boehringer Mannheim and Science Park Raf
MolMed S.p.A. is a medical biotechnology company focused on discovery, R&D, and clinical validation of
innovative therapies for the treatment of cancer.
State of ownership:
Public
Main sector: Biotechnology –Therapeutics
Subsector: Cell therapy; Gene therapy; Proteins; Cell culture
Primary therapeutic areas: Neoplasms / cancer / oncology
TK
NGR-hTNF
MolMed’s patent portfolio assures solid protection of the company’s products and core technologies and
consists of 27 patent families, with 92 issued patents and 79 patent applications.
1. Takara Bio Inc. (Japan): out-license and development agreement to develop and market of MolMed’s TK
products in Asia.
2. Telethon Foundation and HSR-TIGET: co-development and manufacturing of novel investigational cell
and gene therapy products for rare diseases.
32
3. MSD Biologics: optimisation and scale-up of drug manufacturing for NGR-hTNF.
4. MolMed is partner in several EU-funded cell & gene therapy projects under FP-7: STEMS, OPTISTEM,
PERSIST, ATTRACT.
Montegen
Via delle Rosine n. 1
10123 Milano
Italy
www.montegen.com
Founded year 1994
MONTEGEN, privately owned, offers integrated business solutions in the biotechnology industry sector
(referred in particular to the "proteomics" and the "biopharmaceutical processing").
Montegen has a subsidiary company in Florida/USA.
State of ownership:
Subsector: Analytical services; Proteomics
Integrated biz solutions for the TT process
-Integrated business solutions for the technology transfer in the biotech industry sector.
-The catalytic action, based on a reverse engineering process, is focused on (i) analyzing the competitive
market strategy of the client’s firm (including its innovative policy) , (ii) on searching for product, processes or
services to purchase, licensing or lease that can fit with the client’ requests, (iii) on transferring the
knowledge matching the customer’s needs and (iv) on its integration into the core business, through an
intelligence interpretation process ( “The A.S.T.I. Strategy Cycle” of the technology interpreter). The A.S.T.I.
strategy includes a ”mission back” approach to improve integration, innovation and performance of the
targeted activities / processes and to measure success or failure.
Technology used
The "ASTI (Analyzing, Searching, Transferring, Integrating)" strategy for technology transfer.
Outsourcing services [microbial fermentation, protein purification, covalent structure determination of
peptides and proteins (by TEPSO, Team Protein Structure Operations), enzymatic catalysis].
Intelligence Analysis Tools (supported by the company Intelligence-Net Office).
Naicons scrl
via G. Fantoli, 16/15
20138 Milano
Italy
www.naicons.com
Founded year 2006 as a Consortium of private and industrial partners
NAICONS (New Anti-Infectives CONSortium) is an independent organisation with the mission to re-establish
in a fully integrated way the research and development activities in the anti-infective field in Italy. NAICONS
aims at integrating resources in Infectious Diseases to create a strategic and operative hub dedicated to
discover and develop novel antibiotics targeting unmet medical needs, by combining biological and chemical
diversity.
Subsector: Anti-infectives; Peptides
Primary therapeutic areas: Infectious
and parasitic diseases; Skin and subcutaneous tissue
33
NAICONS main assets currently include new antibiotic compounds (late discovery assets) active against
multi-drug resistant pathogens by novel mechanisms of action, and a library of more than 65,000 producer
microorganisms isolated over several years (discovery tools) and available to interested parties.
NAICONS lead candidate NAI-107 represents a major opportunity to address some of the emergent medical
needs associated with the spread of multi-drug resistant pathogens, particularly MRSA and VRE. NAICONS’
second candidate, NAI-acne, is a novel antibiotic indicated for the topical treatment of acne and endowed
with
a
unique
antimicrobial
profile,
targeting
exclusively
Propionibacterium
acnes.
NAICONS plans to exploit the library of producer microorganisms, alone or in collaboration with other parties,
to search for new products for various therapeutic areas, including novel antibiotics for life-threatening
infectious diseases.
Offer the exploitation of collection of producer organisms to third parties with flexible collaboration
agreements that include running the whole screening process in house or provide the samples to partners or
alternative solutions to be agreed.
Sanofi Aventis
NEED Pharmaceuticals
Via Gaudenzio Fantoli 16/15
20138 Milan
Italy
www.needpharma.com
NeED Pharmaceuticals is a biopharmaceutical Company focused on the discovery and development of
novel anti-infective drugs for the treatment of serious and neglected infectious diseases, where a large
unmet medical need and market opportunity are clearly present.
State of ownership:
Subsector: Anti-infectives; Small molecules
Primary therapeutic areas: Infectious and parasitic
diseases
ND-401
ND-801
ND-200
University of Milan
CISI-Milan
University of Sassari
San Raffaele Foundation, Milan
Nerviano Medical Sciences
Viale Pasteur, 10
20014 Nerviano (MI)
Italy
www.nervianoms.com
Founded year 2004 as a spin-off from Pfizer
Nerviano Medical Sciences is a pharmaceutical R&D facility in Italy and one of the largest oncology-focused,
integrated discovery and development companies in Europe.
State of ownership:
Main sector:
Biotechnology – Therapeutics
34
Primary therapeutic areas: Neoplasms
/ cancer / oncology
Aurora inhibitors
Cyclin-dependent kinases (Cdks) inhibitors
Nemorubicin
Technology used
Chemical Core Technologies
-parallel medicinal chemistry and combinatorial technologies
-analytical chemistry
-structural chemistry for protein X-ray crystallography
-NMR-based screening and target-ligand interaction studies
-molecular modeling and design, structure-based drug design
-chemo-informatics
Pfizer Inc., Bristol-Myers Squibb Co. and Genentech Inc.
Neuro-Zone Srl
Via Podgora 7
20122 Milano
Italy
www.neuro-zone.com
Founded year 2007 as a spin-off from the University
Neuro-Zone’s mission is to support drug discovery programs by providing well controlled physiologically
relevant primary cell models and a multiparametric cell-based assay platform in order to increase efficiency
of lead optimization projects. By combining over 15 years of research expertise in culturing physiologically
relevant cell systems with innovative approaches in the fields of microengineering, microfluidics and
advanced biocompatible materials, Neuro-Zone supports primary cell culturing activities and high profile lead
optimization screening services.
State of ownership:
Subsector: Diagnostic services; Screening
Diseases of the nervous system
PRODUCTS:
1. CNS Area
* Cortical Astrocytes (rat/mouse)
* Hippocampal Astrocytes (rat/mouse)
* Cortical Neurons (rat/mouse)
* Hippocampal Neurons (rat/mouse)
* Microglia (rat/mouse)
2. Stem Cell Area
* Adipose Tissue-derived MSC (rat/mouse/human)
* Bone Marrow-derived MSC (rat/mouse/human)
* Amniotic Membrane-derived MSC (human)
* Wharton's Jelly MSC (human)
* Multipotent Cord Blood Unrestricted Somatic Stem Cells (human)
* Amniotic Epithelial Stem Cells (human)
SERVICES:
1. In Vitro
* Compound Validation
35
* Transfections
* Pharmacological Treatments
* Cell culture preparation
* Customer-tailored solutions
2. In Vivo
* Surgical Services
* Pre-conditioning services
* Phenotyping Services
* Pharmacokinetics.
Neuro-Zone s.r.l. is undergoing collaborative research project with prestigious European academic and
industrial institutions.
Biotech companies involved in drug discovery /small compounds / lead validation / in the field of
neuroscience.
NexThera Biosciences srl
Via G. Fantoli 16/15
20138 Milano
Italy
www.nexthera.com
Founded year 2008
NexThera is an emergent Italian biopharmaceutical company focused to rapidly bringing to market novel
drugs which fulfill unmet medical needs and will generate substantial financial returns in Infectious Diseases.
State of ownership:
Subsector: Anti-infectives
diseases
NexThera current portfolio includes two advanced assets, NAI-107 and NAI-acne.Description of main
products
Newron Pharmaceuticals S.p.A.
via Ludovico Ariosto 21
20091 Bresso
Italy
www.newron.com
Founded year 1999 as a spin-off company from Pharmacia & Upjohn
Newron Pharmaceuticals S.p.A. is a biopharmaceutical company focused on novel therapies for diseases of
the central nervous system and pain.
system; Musculoskeletal system and connective tissue;
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
Safinamide: Indication. early-mid to late stage PD
Ralfinamide: Indication Neuropathic Low Back Pain and Inflammatory
36
HF0220: Indication Neuroprotection
HF0299: Indication: Neuropathic pain
NW-3509: Indicazion Schizophrenia/Mania
HF1220: Indication Neuroprotection
Ion Channels: Indication CNS related disorders/pain
New Anti-Infectives Consortium Scrl
Via Fantoli 16/15
20138 Milano
Italy
www.naicons.com
Founded year 1999 as a spin-off company from Pharmacia & Upjohn
/ independent
Subsector: Anti-infectives; Peptides
diseases; Skin and subcutaneous tissue
NAI-107
NAI-acne
ITB-CNR
University of Milan
KtedoGen
NeED Pharma
Accelera
University of Illinois
NiKem Research srl
Via Zambeletti, 25
20021 Baranzate (Mi)
Italy
www.nikemresearch.com
Founded year 2011 as a spin-off from GSK
NiKem Research Srl is a new chemitechnology CRO and offers services focused on Lead Optimization,
Lead Generation by Rational Drug Design and Hit Validation. Services were also expanded to rodents
pharmacokinetics, metabolism, disposition and distribution studies along with a series of in vitro assays as
ADMET surrogates
/ independent
Research Organization); Screening; Synthesis services
Lead Optimization, Lead Generation by Rational Drug Design and Hit Validation. Rodents pharmacokinetics,
metabolism, disposition and distribution studies, in vitro ADMET assays.
GLP bioanalysis. Ex vivo imaging by mass spectrometry.
37
NicOx Research Institute SRL
Via Ariosto 21
20091 Bresso (MI)
Italy
www.nicox.com
Founded year 1996
NicOx is a product-driven biopharmaceutical company dedicated to the development and future
commercialization of investigational nitric oxide-donating drugs to meet unmet medical needs.
NicOx headquarters are located in Sophia Antipolis, a technological park near Nice. Thus, NicOx S.A. is a
French
biotech
company
having
a
research
center
located
in
Italy.
NicOx S.A. is listed since 1999 at the Euronext (Euronext Paris: Eurolist Next Economy:7413).
NicOx S.A, France
Primary therapeutic areas: Blood-forming organs;
immune disorders; Diseases of the nervous system; Diseases of
the eye; Cardiovascular; Musculoskeletal system and connective tissue
NCX 6560
NCX 116(PF-03187207)
TPI 1020
NCX 1510
Obtained IP approval on a variety of new therapeutics based on NO-releasing drug.
As of March 2006, 685 patents have been granted. Moreover a high number of patent applications are
currently under evaluation.
Technology used
NicOx Nitric Oxide-donating technology
Merck, Pfizer, Orexo AB, Ferrer Grupo, Topigen.
Nucleus Ricerca Italia
via Baschenis 9/e
1-24122 Bergamo
Italy
www.nucleus-ricercaitalia.com
Founded year 2009
Nucleus Ricerca's mission is to discover and develop new anticancer compounds for clinical development.
State of ownership:
/ oncology
Apoptosis inducers
Cell signalling inhibitors
Dual inhibitors
Protein complex inhibitors
38
Phadia S.r.l.
Via Libero Temolo, 4
201 26 Milano
Italy
www.diagnostics.it/
Founded year 2009
Phadia develops, manufactures and markets complete blood test systems to support the clinical diagnosis
and monitoring of allergy, asthma and autoimmune diseases.
State of ownership:
Subsidiary of Phadia AB and Formerly Pharmacia Diagnostics S.P.A.
ImmunoCAP Rapid
PharmEste
Via Ariosto 21
20091 Bresso (Milan)
Italy
www.pharmeste.com
Founded year 2003 as a spin-off of the University of Ferrara
PharmEste is a private biopharmaceutical company based on a unique Transient Receptor Potential (TRPs)
ion channel technology platform that brings together strong expertise on TRPs area and industrial
competences in research & development process applied to small molecule therapeutics. The Company
mission is to play a leading role in the discovery and development of fully proprietary high affinity and
selective TRP channel therapeutics for the treatment of neuropathic pain, overactive bladder and other TRPmediated diseases.
State of ownership:
system; Genitourinary system
PHE377
Second generation of TRPV1 antagonists
TRPs antagonists
Pierrel S.P.A.
Via Alberto Falck, 15
20099 Sesto San Giovanni
Italy
www.pierrel.it
Pierrel S.p.A. is a global provider to the pharmaceutical and life science industries, specializing in research
and development (Contract Research) and production (Contract Manufacturing) of drug products.
CRO (Contract Research Organization)
Clinical Operations:
- Phase I Services
39
- Phase II-III Studies
- Phase IV and PMS studies
- Outcome and non-interventional studies
Contract Manufacturing:
- Pharmaceutical Development
- Commercial Manifacturing Packaging
- EMEA Production
- Quality Compliance.
Primary stock exchange: Milan Stock Exchange (Borsa Italiana) (PRL)
Primm Srl
Via Olgettina 58
San Raffaele Biomedical Science Park
20132 Milano
Italy
www.primm.it
Founded year 1990
Primm is an international leading company engaged in the manufacturing, marketing and sale of Biotech
Services and Products. It is also active in the areas of peptide synthesis, polyclonal and monoclonal
antibodies, kits for DNA purification, DNA and protein sequencing, mass spectrometry, development of
recombinant proteins and immunometric assays, animal services and pre-clinical studies.
State of ownership:
Subsector: Analytical services; Genomics; Proteomics;
Synthesis services
DNA and RNA Synthesis
DNA Sequencing
Gene Cloning and Expression
Peptide Synthesis
Monoclonal Antibodies Custom Service
Polyclonal Antibodies Custom Service
Analysis of Proteins and Peptides.
Axxam
astra zeneca, pfizer, menarini, cytos, fidia, schering plough.
Prion Diagnostica S.r.l.
V.le F. Borromeo, 4
20017 Rho (MI)
Italy
www.priondiagnostica.com
Founded year 1998
Prion Diagnostica is a company operating in research, development and commercialization of diagnostic
systems and services based on innovative biotechnology processes.
State of ownership:
– R&D Services
40
Subsector:
Diagnostic instrumentation
PROCOS SpA
Via Matteotti, 249
28062 Cameri
Italy
www.procos.it/
Founded year 1945
PROCOS S.p.A. is an Italian CMO (Contract Manufacturing Organization) specialised in development, scaleup and production of APIs and GMP advanced intermediates for the pharmaceutical industry; since 2006
PROCOS
belongs
to
CBC,
a
Japanese
multinational
company.
PROCOS can offer process R&D expertise in a wide variety of organic chemistry, with high pressure
reactions as core technology. PROCOS can cover a GMP manufacturing range between hundred grams
(kilolab) and multi-tons (through pilot plant, semi-industrial and industrial plant), thus supporting customers
from preclinical development until market.
State of ownership:
Synthesis services
Custom and Generic API manufacturing.
Pharmaceutical companies (multinational); small- to medium-sized biotech companies (worldwide locations)
Prodotti Chimici E Alimentari S.P.A.
Via Novi, 78
15060 Basaluzzo
Italy
www.pcaitaly.it
Founded year 1946
Prodotti Chimici e Alimentari S.p.A. is a manufacturer of chemical intermediates and pharmaceutical active
ingredients.
State of ownership:
BILIARY DERIVATIVES:
CHOLIC ACID
DEHYDROCHOLIC ACID
DEOXYCHOLIC ACID
CHENODEOXYCHOLIC ACID
URSODEOXYCHOLICACID
NATURAL TAURINE
GLYCOCHOLIC ACID
TAUROCHOLIC ACID
TAUROURSODEOXYCHOLIC ACID
GLYCOURSODEOXYCHOLIC ACID
LITHOCHOLIC ACID.
41
Promega Italia s.r.l.
Via Decembrio, 28
20137 Milano
Italy
www.promega.com/it/
Founded year 1946
Promega Italia S.R.L. does production and commercialization of reagents and instrumentation for
researchers in the Life Sciences Market.
State of ownership:
Subsector: Analytical services; Diagnostic instrumentation;
Genomics; Proteomics
GoTaq® qPCR Master Mix
GoScript™ Reverse Transcription System
Wizard® Genomic DNA Isolation System
Maxwell® 16 Genomic DNA Purification Kits
Quintiles spa
Via Roma, 108
Cassina Plaza, Edificio F, scala 2
20060 Cassina De' Pecchi
Italy
www.quintiles.com
Founded year 1994
Quintiles is a fully integrated bio pharmaceutical services company offering clinical, commercial, consulting
and capital solutions worldwide.
of Quintiles Transnational Corp., USA
Biostatistics
Data Management
Clinical Monitoring and Site Management
Project management
Commercialisation Services.
Remedia S.R.L.
Via San Rocco, 802
24033 Calusco D'adda (Bg)
Italy
www. remediasrl.com
REMEDIA srl is a Drug Delivery Systems company specialized in the design, development and production of
special dosage forms aimed to improve the bioavailability of poorly absorbed drugs, both of chemical
synthesis and of biotech origin, e.g. polypeptides and proteins.
State of ownership:
Subsidiary of Quintiles Transnational Corp., USA
Subsector: Drug delivery
– R&D Services
42
REMEDIA has applied its patented delivery technologies on different drugs and developed specific products
up to different levels (in vitro characterization, animal studies, etc.), available for licensing to interested third
parties:
- Coenzyme Q10 (Ubidecarenone)
- Lecithin
- Cyclosporine
- Acetaminophen
- Domperidone
- Acyclovir
Angelini
FIDIA
Istituto Biochimico Italiano
S.A.L.A.R.S. S.p.A.
Via San Francesco 5
22100 Como
Italy
www.salars.it
Founded year 1932
S.A.L.A.R.S. S.p.A. is the manufacturer of opium derivatives, mainly narcotics, for pharmaceutical and
scientific use.
State of ownership:
CODEINE PHOSPHATE HEMIHYDRATE
DIHYDROCODEINE HYDROGEN TARTRATE
DIHYDROCODEINE THIOCYANATE
MORPHINE HYDROCHLORIDE
OXYCODONE HYDROCHLORIDE
NALOXONE HYDROCHLORIDE
NALTREXONE HYDROCHLORIDE
NALORPHINE HYDROBROMIDE
ACETHILCODEINE BASE
CODEINE PHOSPHATE HEMIHYDRATE
DIACETYLMORPHINE BASE (HEROIN) *
DIACETYLMORPHINE HYDROCHLORIDE *
DIHYDROCODEINE HYDROGEN TARTRATE
DIHYDROCODEINE THIOCYANATE
MORPHINE HYDROCHLORIDE
OXYCODONE HYDROCHLORIDE
THEBAINE BASE.
A.C.R.A.F. Angelini, Italy; Zambon, Italy; Novartis, Italy; Alpharma, U.K.; Glaxo, Australia; Tasmanian
Alkaloids, Australia (Johnson & Johnson Group U.S.A.); Merck Generics, U.K.
43
Sacace Biotechnologies
Via Scalabrini 44
22100 Como
Italy
www.sacace.com
Founded year 2001
SACACE develops, manufactures and sells Molecular Biology reagents and complete kits for research and
diagnostic use.
State of ownership:
SACACE develops, manufactures and sells more than 140 kits for human, veterinary and food diagnostics.
These kits include all the reagents for nucleic acid extraction, amplification (PCR or RT-PCR) of specific
region and detection of the amplified products.
Sekmed S.R.L.
Corso Magenta 31
20123 Milano
Italy
www.sekmed.com
Founded year 2002
Sekmed S.R.L. is a drug discovery company operating in the field of immune system related disorders.
Sekmed’s approach is to use its proprietary DC-based bioassay, DC-ONE, to screen libraries of chemical
and natural compounds. DC-ONE will allow Sekmed to identify new molecules with immunomodulatory
activity, such as immunosuppressors to be used in transplantation and immunostimulators to be used as
adjuvants in vaccine design.
/ independent
Subsector: Vaccines
and blood-forming organs; immune disorders; Symptoms,
signs and abnormal clinical and laboratory findings, not elsewhere classified
Technology used
DC-ONE Technology
Sicor Spa
Via Terrazzano 77
20017 Rho
Italy
www.sicor.it
Founded year 1983
Sicor is a pharmaceutical group manufacturing bulk active ingredients and producing injectable dosage
forms.
State of ownership:
Subsidiary
Synthesis services
44
Bulk active pharmaceuticals for both chemical synthesis and fermentation.
Sirton Pharmaceutical S.p.A.
Piazza XX Settembre 2
22079 Villa Guardia (CO)
Italy
www.sirton.it
Sirton Pharmaceuticals, is an Italian Company specialized and fully dedicated to Contract Manufacturing and
Pharmaceutical Development of finished pharmaceuticals forms, with a strong know-how and experience
also in biologicals.
State of ownership:
Synthesis services
“full service”, from the purchase of the raw materials to the release of the finished product or single
manufacturing steps, from bulk to packaging and quality control.
Sanofi-Aventis
Teva
Sandoz - Hexal
Gentium
Merk - Serono
Sulfidris
Viale Gran Sasso 17
20131 Milano
Italy
www.sulfidris.com
Founded year 2000
Sulfidris, a spin-off of Milan University, is focused on R&D of new drugs (SULFIDRACs) for the treatment and
prevention of cancer.
State of ownership:
/ oncology
HDAC inhibitors
COX inhibitors
Technology covered by several patents.
Technology used
SULFIDRACs are multi-modal safe and effective drugs, capable to act on redox-imbalance -related
pathogenetic mechanism.
Sulfidris' approach of modifying existing molecules, through its proprietary H2S-releasing technology,
decreases the risk of failure of classical drug discovery.
45
Several Italian and international institutions including NCI (USA).
TOP SrL
via Einstein, Loc. Cascina Codazza
26900 Lodi
Italy
www.top-mice.com
TOP (Transgenic Operative Products) srl is a leading company specialized in the generation of reporter
mice. These are transgenic animals that produce genetically encoded biomarkers to be detected through in
vivo imaging (biophotonic, PET or NMR). In addition TOP srl can provide reporter cells or DNA constructs for
reporter systems.
Subsector: Genomic; Screening
Services
Unibios
Via Silvio Pellico 3
28069 Trecate
Italy
www.unibios.it
Founded year 1948
The chemical Unibios Division is dedicated to the production of chemical, biochemical and active ingredients
assigned to the pharmaceutical industry. The specialization of the Unibios productive departments is
prevalently concentrated on the manufacture of quinolones, antibacterial and antiviral drugs as well as
enzymes.
/ independent
Synthesis services
Bulk drugs:
ACYCLOVIR
CHYMOTRYPSIN CRYSTALLINE
CITRULLINE
CONALBUMIN
CYTOCHROM C
FERRITIN
FLUMEQUINE
INOSINE
KALLICREIN
LYSOZYME
METHISOPRINOL
NALIDIXIC ACID
OXOLINIC ACID AND SODIUM SALT
PANCREATIN
PIPEMEDIC ACID
PIROMIDIC ACID
TRYPSIN
TRYPSIN CHYMOTRYPSIN
URSODEOXYCHOLIC ACID
Antianaemics
Iron Acetyl Ovo Transferrin
Iron Polymaltose Complex
46
Iron Sodium Gluconate Complex Powder
Iron Sodium Gluconate Complex Solution, etc.
Source: www.italianbiotech.com
Toutes données fournies sous réserve
Antenne économique du Québec à Milan
Via Camperio, 1
Ufficio 337/Bureau 337 - 3° piano/3ème étage
20123 Milano - Italie
tél. +39 02 8052210
fax +39 02 72016399
e-mail: [email protected]
47

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