Study of DNA Copy Numbers Variations and Gene Expression

Study of DNA Copy Numbers Variations and Gene Expression
Profile of Bone Marrow Plasma Cells From MGUS and SMM.
Status: Active, not recruiting
Study Phase: N/A
Start Date: November 2010 | Completion Date: November 2018
Condition(s): Monoclonal Gammopathy of Undetermined Significance, Smoldering
Myeloma
Full Title of Study
Large Scale Study of DNA Copy Numbers Variations and Gene Expression Profile of
Bone Marrow Plasma Cells From Monoclonal Gammopathy of Undetermined
Significance (MGUS) and Indolent Myeloma (SMM).
Overview
The purpose of this study is to describe DNA copy number variations and gene
expression profiles of bone marrow plasma cells of monoclonal gammopathy of
undetermined significance (MGUS) and smoldering multiple myeloma (SMM). The
final objective is to search for correlations with the risk of progression in order to
establish a predictive model of early malignant transformation.
Study Details
Study Type: Observational
Study Design: Observational Model: Cohort, Time Perspective: Prospective
Investigator Details
Lead Sponsor: Rennes University Hospital
Collaborator: Intergroupe Francophone du Myelome
Principal Investigator: Olivier DECAUX, MD Rennes University Hospital
Trial Location Details
Facility: Rennes University Hospital Rennes, France
Facility: Nantes University Hospital Nantes, France
Facility: CHU Amiens - médecine interne Amiens, France
Facility: CHU Angers Angers, France
Facility: Centre Hospitalier H.Duffaut - Avignon Avignon, France
Facility: Hôpital Jean Minjoz - Besancon Besancon, France
Facility: Service de Médecine interne - Centre Hospitalier Blois, France
Facility: Bordeaux Bergonié Bordeaux, France
Facility: Bordeaux Haut Leveque Bordeaux, France
Facility: Polyclinique Bordeaux Nord Aquitaine Bordeaux, France
Facility: Hôpital A.Morvan Brest Brest, France
Facility: Centre F.Baclesse Caen, France
Facility: CHU Caen Caen, France
Facility: Hôpital d'instruction des armées Percy Clamart, France
Facility: CHU Clermont Ferrand Clermont Ferrand, France
Facility: CH Colmar Colmar, France
Facility: CH Dijon Dijon, France
Facility: CHG Dunkerque Dunkerque, France
Facility: CH Grenoble Grenoble, France
Facility: CH La Roche sur yon La Roche sur yon, France
Facility: CH Laval Laval, France
Facility: Le Mans Victor Hugo Le Mans, France
Facility: Hôpital Claude Huriez Lille, France
Facility: Centre Hospitalier Yves Le Foll de Saint Brieuc - Service d'Hématologie
Saint Brieuc, France
Facility: CHU Toulouse Purpan Toulouse, France
Facility: CHU Toulouse Rangueil Toulouse, France
Facility: Service d'Hématologie - Hôpital de Brabois Vandoeuvre, France
Interventions
Genetic: Genetic study of DNA copies
Gene expression profiling, DNA copy number variation
Information Source
ID Number: RCB 2008-A01023-52
NCT Identifier: NCT01079429
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
Full Source of Clinical Trial Data: https://clinicaltrials.gov/show/NCT01079429
ClinicalTrials.gov processed this data on September 30, 2016
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