CURRICULUM VITAE Married, 2 children. 2012 - RMSB

CURRICULUM VITAE
Gisèle Clofent-Sanchez, born April 1960
Married, 2 children.
Degrees and diplomas
1989 : PhD Biochemistry, Immunology, Molecular Biology
(University of Montpellier2)
1992: Recruited as CNRS researcher
2001 : HDR (Habilitation à Diriger les Recherches) (University of
Bordeaux2)
Present situation
Director of Research CNRS (CNRS UMR 5536/University Bordeaux Segalen)
146 rue Léo Saignat (case 93), F-33076 Bordeaux cedex
E. mail: [email protected];
Tel: +33 5 57 57 11 75/ +33 6 11 45 46 93 ; Fax: : +33 5 57 57 45 56
FIELD OF RESEARCH: Molecular Imaging and therapy of atheroma using human antibodies
HEAD OF Molecular Targeting of Atheroma group in UMR 5536.
My focus is on translational research from the conception of human recombinant antibodies to their
transfer in potential diagnostic and/or therapeutic agents. I have acquired expertise in in vivo selections
to have access to antibodies recognizing molecules in the microenvironment context. My field of
interest extends now to contrast agents, imaging modalities and theranostic strategies to
accurately target multi-modal nanoparticles loaded with iron oxide and medicine to its intended goal,
with the intention of maximising effectiveness and minimising side effects.
Supervisions
PHD : (1) Jeanny Laroche-Traineau, CNRS engineer ; (2) Sophie Lucas-Samuel, Pharmacist in AFSSAPS;
(3) Marie-Josée Jacobin, CNRS engineer ; (4) Laurent Macchi, Doctor ; (5) Julie Vialard, Pharmacist in
hospital; (6) Rémy Robert : 2007, post-doc in Australie; (7) Kamel Déramchia : 2010, medical studies; (8)
Mélusine Larivière : 2013 (IdEx (Initiative d’Excellence) grant) in co-direction with Christoph Hagemeyer;
(9) Audrey Hémadou (Director of thesis: Marie-Josée Jacobin-Valat): 2014 (grants from Région Aquitaine
and ANR ATHERANOS)
POST-DOCTORANTS Christoph Hagemeyer (CNRS) ; Sophie Lajus (Lilly France) ; Marie-Pierre Barrouillet
(OSEO) ; Stéphane Bonetto (CNRS, IMATHABIO) ; Amélie Vallet (CNRS, IMATHABIO) ; Line Pourtau
(LIRYC)
Publications during the last 5 years
Patent« Antibodies for molecular imaging of vulnerable plaques in atherosclerosis ».
Registered under the number PCT/EP2012/072787.
Publications
1Kamel Deramchia, Marie-Josée Jacobin-Valat, Jeanny Laroche-Traineau, Stéphane Bonetto,
Stéphane Sanchez, Pierre Dos Santos, Philippe Massot, Jean-Michel Franconi, Pierre Martineau, Gisèle
Clofent-Sanchez. By-passing large screening experiments using sequencing as a tool to identify scFv
fragments targeting atherosclerotic lesions in a novel in vivo phage display selection. Int J Mol Sci.
2012;13(6):6902-23.
2Kamel Deramchia, Marie-Josée Jacobin-Valat, Amélie Vallet, Hervé Bazin, Xavier Santarelli,
Stéphane Sanchez, Pierre Dos Santos, Jean-Michel Franconi, Stéphane Claverol, Stéphane Bonetto and
Gisèle Clofent-Sanchez. New human antibody fragments homing to atherosclerotic endothelial and
subendothelial tissues: an in vivo phage display targeting. Am J Pathol. 2012 Jun; 180(6): 2576-89.
3Clofent-Sanchez G, Jacobin-Valat MJ, Laroche-Traineau J: The growing interest of fibrin imaging
in atherosclerosis, Atherosclerosis 2012 May;222(1):22-5.
4Boris Garnier, Sisareuth Tan, Céline Gounou, Jeanny Laroche-Traineau, Marie-Josée JacobinValat, Gisèle Clofent-Sanchez, Alain R. Brisson. Development of a platform of antibody-presenting
liposomes. Biointerphases 2012 Dec;7(1-4):11.
5Jacobin-Valat MJ, Deramchia K, Mornet S, Hagemeyer CE, Bonetto S, Robert R, Biran M, Massot
P, Miraux S, Sanchez S, Bouzier-Sore AK, Franconi JM, Duguet E, Clofent-Sanchez G. MRI of inducible
P-selectin expression in human activated platelets involved in the early stages of atherosclerosis. NMR
Biomed 2011 24, 413-424.
6Lajus S, Clofent-Sanchez G, Jais C, Coste P, Nurden P, Nurden A. Thrombocytopenia after
abciximab use results from different mechanisms. Thromb Haemost 2010;103(3):651-661.
7Bouzier-Sore AK, Ribot E, Bouchaud V, Miraux S, Duguet E, Mornet S, Clofent-Sanchez G,
Franconi JM, Voisin P. Nanoparticle phagocytosis and cellular stress: involvement in cellular imaging
and in gene therapy against glioma. NMR Biomed 2010;23(1):88-96.
8Pezzini J, Brenac Brochier V, Barrouillet MP, Cerruti M, Clofent-Sanchez G, Schapman A, Topol
A, Robert R, Cabanne C, Cerruti P, Santarelli X. Rapid screening of purification strategies for the capture
of a human recombinant F(ab')2 expressed in baculovirus-infected cells using a micro-plate approach and
SELDI-MS. J Chromatogr B Analyt Technol Biomed Life Sci 2009;877(24):2428-2434.
9Clofent-Sanchez G, Harizi H, Nurden A, Coste P, Jais C, Nurden P. A case of profound and
prolonged tirofiban-induced thrombocytopenia and its correction by intravenous immunoglobulin G. J
Thromb Haemost 2007;5(5):1068-1070.
10Robert R, Jacobin-Valat MJ, Daret D, Miraux S, Nurden AT, Franconi JM, Clofent-Sanchez G.
Identification of human scFvs targeting atherosclerotic lesions: selection by single round in vivo phage
display. J Biol Chem 2006;281(52):40135-40143.
11Robert R, Clofent-Sanchez G, Hocquellet A, Jacobin-Valat MJ, Daret D, Noubhani AM, Santarelli
X. Large-scale production, bacterial localization assessment and immobilized metal affinity
chromatography purification of a human single-chain Fv antibody against alphaIIb-beta3 integrin. Int J
Biol Macromol 2006;39(1-3):51-59.