Introduction of UMR 8256 - IBPS

IBPS
Institute of Biology Paris-Seine
Biological Adaptation
and Ageing
UMR 8256
(Jussieu & Charles Foix)
ERL U1164
Plan Quinquennal 2014-2018: UMR 8256 unité constituante de l’IBPS
IBPS
Fédération de recherche
(UPMC, CNRS)
Campus de JUSSIEU
• Cinq Unités de recherche :
- Adaptation Biologique et Vieillissement (B2A) - CNRS, Inserm, UPMC
- Biologie Computationnelle et Quantitative - CNRS, UPMC
- Biologie du Développement - CNRS, Inserm, UPMC
- Evolution - CNRS, UPMC
- Neurosciences - CNRS, Inserm, UPMC
• Un département « Plates-formes et développement technologique »
UMR 8256: Biological Adaptation and Ageing
Head : Bertrand Friguet
Deputy head : Rachel Sherrard
Transverse axis 1
Cellular adaptation: stress responses
and ageing
Transverse axis 2
Neuronal adaptation: function, repair, ageing
and pathologies
Transverse axis 3
Cardiovascular adaptation: age-related muscle
dysfunction and diseases
10 équipes
Margaret Ahmad E01
Bertrand Friguet / Mustapha Rouis E02
Olivier Jean-Jean E03
Christian Neri E04
Etienne Jacotot / Jean-Michel Peyrin E05
Rachel Sherrard / Jean Mariani E06
Pierre Vincent E07
Isabelle Limon E08
Zhenlin Li / Mathias Mericskay E09
Onnik Agbulut E10
76 permanent personnel
10 temporary personnel
34 PhD students & Post-Docs
Total : 120 personnel
E
R
L
U
1
1
6
4
Functional Capacity
Rationale: adaptation during lifetime
Reserve for stress response
Ageing
Basic physiological needs
Time
Balance between protective and stress cellular mechanisms:
a shift during lifetime
•Protein
•Proteinhomeostasis
homeostasis
(synthesis,
(synthesis,degradation)
degradation)
••Synaptic
Synapticstability
stability
••2nd
2ndmessengers
messengers
interaction
interaction
••DNA
DNARepair
Repair
………….
………….
Whatever the cell type and the model systems :
C. elegans, mice, human ….
Time
Pathologies
•Protein homeostasis
(synthesis, degradation)
• Synaptic stability
• 2nd messengers
interaction
• DNA Repair
…….
Predisposition genes
Environnemental factors
Acute or chronic stressors
stress
••Oxidative
Oxidative stress
Inflammation
••Inflammation
•
Apoptosis
• Apoptosis
Cellular
••Cellular
senescence
senescence…
Pathologies
Time
• Oxidative stress
• Inflammation
• Apoptosis
• Cellular
senescence…
Rationale: adaptation during lifetime
Predisposition genes
Environmental factors
Chronic stress
Functional Capacity
Disease
Healthy Ageing
Reserve for stress response
Ageing
Ageing + Diseases
Basic physiological needs
Time
Scientific project – 5 year plan
Aims
• To identify mechanisms underlying the cellular
adaptation to input/stressors and how this changes
during our lifetime
• To apply such knowledge to the neural and
cardiovascular systems
Scientific project – 5 year plan
Cellular
response to stress
Team 3:
Jean-Jean
Team 1:
Ahmad
Team 4:
Neri
Team 6:
Sherrard/Mariani
Team 5:
Jacotot/Peyrin
Team 7:
Vincent
Neural adaptation
and pathology
Team 8:
Limon
Team 2:
Friguet/Rouis
Team 10:
Agbulut
Team 9:
Li/Mericskay
Cardiovascular
adaptation and
dysfunction
Technological innovation in B2A
Oxiproteome (team 2)
Microfluidics systems for neuronal networks
(team 5)
Cy2 Total
Protein
Cy5 Oxidized
Protein
Biosensors Imaging (team 7)
Magnetic stimulation, rTMS (team 6)
In vivo
In vitro:
cells or explants
In vitro
T=0
In vivo
T = + 10
Technological innovation in B2A
Oxiproteome (team 2)
Microfluidics systems for neuronal networks
(team 5)
Cy2 Total
Protein
Cy5 Oxidized
Protein
T=0
T = + 10
Training through research
Teaching to undergraduate biology, medicine and interdisciplinary programs
Master’s teaching in the field of biology of ageing and longevity, neurosciences,
physiology and physiopathology : specialities of Masters BIP, BMC, CME in
gerontology for MD
Direction or co-direction of the international master program “Brain and mind
sciences” and 5 master programs: “Biology of ageing and longevity”, “Biology and
pharmacology of ageing”, “Physiology and physiopathology”, “Nutrition, quality and
health”, “Therapeutic molecules”.
Master internships, PhD supervision and board members of 3 Doctoral Schools
Students trained from 2007 to 2012: 95
Other degree
courses
Master 1
11%
21%
PhD
37%
Master 2
31%
Other
countries
23%
France
77%
PhD origin
Interaction with scientific and medical environment
IDEX: SUPER « Sorbonne Universités »
LABEX: BIOPSY « Biological Psychiatry », coordinator JA Girault
REVIVE « Cellules souches et médecine régénérative »,
coordinator S Tajbakhsh
KIC: INNOLIFE « Healthy living and active ageing »
DHU: FAST « Fight against Ageing and STress »
coordinator J Mariani
Aim: reduce the burden of multi-morbidity and comorbidity associated with
acute stress (COMASS)
Most teams
of B2A UMR
Basic & translational
research (molecular
profiling)
UPMC/AP-HP geriatric and
emergency units
Clinical research
(cohorts & modelling)
Care & quality of life
(UPMC /AP-HP)
B2A, UPMC
& AP-HP
Training and
continuing education
Research Training
Grant and research
networks
Team
complimentarity
B2A
Molecular
Mechanisms
Technological
innovations
Industry
partnerships
Ageing
Biological adaptations
throughout lifespan
Repair and
intervention
Cellular models
and model
organisms
13
Jussieu
Pitié-Charles Foix
IBPS
Institute of Biology Paris-Seine
Biological Adaptation
and Ageing
UMR 8256
(Jussieu & Charles Foix)
ERL U1164