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CURRICULUM VITAE
1.
Personal information
Family name
First name
Date of birth
Nationality
Private address
Professional address
Wider
Christian
April 19, 1973
Swiss
Chemin du Rionzi 1, 1052 Mont-sur-Lausanne
Phone : +41-79-744-6350
Email : [email protected]
Service de Neurologie, CHUV BH13, Bugnon 46, 1011 Lausanne
Phone : +41-79-556-8117
Fax : +41-21-314-1244
Email : [email protected]
2.
Academic titles, appointments
April 2003
Chief resident in Neurology
June 2005
Certificate in electroencephalography (EEG)
April 2006
Doctorate in Medicine
Title : « Long-duration response to levodopa in patients with advanced
Parkinson’s disease treated with subthalamic deep brain stimulation »
June 2006
Board certification in Neurologie
March 2010
Médecin Associé (Consultant) in Neurology and Neurogenetics, Department of
Clinical Neurosciences, CHUV, Lausanne
June 2010
Privat-docent, Senior Lecturer and Researcher, Faculty of Biology and Medicine,
Lausanne University
3.
Pre-graduate training
April 1992
College degree type C (scientific)
November 1998
Medical degree (Faculty of Medicine, Lausanne University)
4.
Post-graduate training
1999 (2 months)
Resident, Internal Medicine
Department of Internal Medicine, Clinique de Genolier, Dr. Ph. Glasson
1999 – 2000
Resident, Internal Medicine
Department of Internal Medicine – CHUV, Lausanne, Prof. P. Nicod
2000 – 2001
Resident, General Neurology
Department of Neurology – CHUV, Lausanne, Prof. J. Bogousslavsky
2001 – 2002
Resident, Electroencephalography
Department of Neurology – CHUV, Lausanne, Prof. P.A. Despland
2002 – 2003
Resident, Movement Disorders
Department of Neurology – CHUV, Lausanne, Prof. F. Vingerhoets
2003 – 2004
Chief Resident, General Neurology
Department of Neurology – CHUV, Lausanne, Prof. J. Bogousslavsky
2004 – 2006
Chief Resident, Movement Disorders
Department of Neurology – CHUV, Lausanne, Prof. F. Vingerhoets
2006 – 2009
Research Fellow, Movement Disorders, Genetics of Neurodegenerative Diseases,
Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL (USA)
Profs. Z.K. Wszolek and M.J. Farrer
2007 (1 week)
Cold Spring Harbor Course on Molecular Neurology and Neuropathology
Profs. J. Hardy, M. Cookson, H. Orr
2009 – 2010
Research Collaborator, Departments of Neurology and Neuroscience, Mayo Clinic,
Jacksonville, FL (USA)
2009 – 2010
Chief Resident, Neurology and Neurogenetics
Department of Neurology – CHUV, Lausanne, Prof. R. Frackowiak
5.
Grants and awards
2005
Smith Fellowship Award, Mayo Clinic, Jacksonville, FL (USA), $36’000
2006
Fellowhip Grant, Swiss Parkinson Foundation, SFr27,000
2006
Young Investigator Fellowship Grant, Swiss National Science Foundation (SNSF)
(PBLAB – 115478), SFr 33’000
2008
Research Grant, Swiss Téléthon Foundation (PI: Vingerhoets), SFr50,000
“Imaging of asymptomatic at-risk members of a Parkinson’s disease family”
2008
G. Shahin Award for Research by a Physician in Training in Duval County (Review
Article) – Presented by the Duval County Medical Society, Jacksonville, FL (USA)
2008
Advanced Researcher Fellowship Grant, Swiss National Science Foundation (SNSF)
(PASMP3 – 123268/1), $39’000
2009
Jon Stolk Award in Movement Disorders for Young Investigators, 61st Annual Meeting of
the American Academy of Neurology, Seattle, WA (USA)
2009
2009
2010
2010
2011
2011
International Research Grant Program (IRGP), Parkinson Disease Foundation (PDF),
$150,000 for 2 years (PI: Wider)
“LINGO1 and LINGO2 in Parkinson disease”
G. Shahin Award for Research by a Physician in Training in Duval County (Clinical
Observation) – Presented by the Duval County Medical Society, Jacksonville, FL (USA)
Research Grant, Swiss Parkinson Foundation (PI: Wider), SFr 50’000
“Identification of a novel PD gene using next generation sequencing”
Déjerine-Dubois Award, Swiss Society of Neurology, First Annual Meeting of the Swiss Federation
of Clinical Neuro-Societies (SFCNS), Basel, Switzerland, for :
“LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease”
Leenaards Foundation, Career Development Award, SFr 480’000 for 4 ans (PI: Wider)
Research Grant, Swiss National Science Foundation (SNSF 271-1) (PI: Draganski), SFr 370’000
“Anatomical and functional segregation within cortico-basal ganglia circuits”
6.
Ad hoc reviewer activity, scientific committees, thesis supervision
Ad hoc reviewer
2005 –
European Neurology
2006 –
Parkinsonism and Related Disorders
2007 –
European Journal of Neurology
2007 –
American Journal of Medical Genetics
2007 –
National Medical Research Council (NMRC), Singapore
2008 –
Journal of Neural Transmission
2008 –
Cerebrovascular Diseases
2009 –
Movement Disorders
2009 –
Journal of Alzheimer’s Disease
2010 –
Alzheimer’s and Related Diseases Research Award Fund (ARDRAF), USA
2010 –
Acta Neuropathologica
2010 –
Neurodegenerative Diseases
2010 –
Neurology
2010 –
Fondation France Parkinson
2011 –
ANR (Agence Nationale de Recherche)
2011 –
Telethon Fondazione Italia
2012 –
Molecular Neurodegeneration
2012 –
Journal of Neurology
2012 –
Journal of Clinical Imaging Science
2012 –
Journal of Clinical Neurosciences
Editor, member of Editorial Board
2011 –
PLoS ONE (éditeur académique; relecteur)
2012 –
Parkinsonism and Related Disorders (membre du comité éditorial)
2013 –
Clinical Cases in Neurology (membre du comité éditorial)
Research Committees
2008 – 2009
Neurology Research Committee, Mayo Clinic, Jacksonville (membre et relecteur)
2010 – 2013
Commission de la Recherche, Dépt. des Neurosciences Cliniques, CHUV (membre)
2013 –
Commission de la Recherche, Dépt. des Neurosciences Cliniques, CHUV (Vice-Président)
Thesis supervision
2011 – 2013
Supervision travail de Master en Médecine, CHUV-UNIL, Mr. Maurice Stauffacher
Titre : « Paroxysmal Extreme Pain Disorder (PEPD) : Investigation clinique et génétique »
Thesis expert and reviewer
2012
Expert, thèse de Master en sciences de la vie et technologie, EPFL, Lausanne
Mme Duygu Deniz Bas, Titre: « Exploring the cell biology of VPS35 in Parkinson’s disease »
2013
Expert, thèse de Doctorat en Sciences (PhD), UNIGE, Genève, Mme Virginie Licker
Titre : « Proteomic Analysis of the Substantia Nigra in Patients with
Parkinson’s Disease »
Supervision of clinical, postdoctoral fellows
2012 – 2013
Dresse Federica Esposito (postdoctoral fellow)
7.
8.
Memberships
1998 –
2006 –
2010 –
2010 –
2010 –
Fédérations des Médecins Helvétiques (FMH)
American Academy of Neurology (AAN)
Société Suisse de Neurologie (SSN)
Société Vaudoise de Médecine (SVM)
European Huntington Disease Network (EHDN)
Oral communications
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1. Double Atteinte Vestibulocochléaire: à propos de deux cas. Colloque ONO, Lausanne, January 2001.
2. Hépatite fulminante sur lamotrigine: A propos d’un cas. Rencontre Franco-Romande de Neurologie,
February 2002.
3. Main douloureuse et doigt instable tactilo-sensible. Rencontre Franco-Romande de Neurologie, Dijon,
France, March 2005.
4. Five-year outcome in 50 consecutive advanced PD patients treated with STN-DBS. World Parkinson
Congress, Washington, February 2006.
5. Long-term outcome in 50 consecutive advanced PD patients treated with STN-DBS. 58th Annual Meeting of
the American Academy of Neurology, San Diego, April 2006.
6. Study of a Swiss Dopa-Responsive Dystonia Family with a Multiexonic Deletion in GTP Cyclohydrolase-I.
59th Annual Meeting of the American Academy of Neurology, Boston, May 2, 2007.
7. Study of a Multigenerational Family with Autosomal Dominant Dopa-responsive Parkinsonism. 59th Annual
Meeting of the American Academy of Neurology, Boston, May 2, 2007.
8. Perry syndrome is a unique TDP-43 proteinopathy. 17th World Federation of Neurology (WFN) Congress on
Parkinson’s disease and related disorders, Amsterdam, Netherlands, December 11, 2007.
9. TDP-43-positive inclusions are characteristic of Perry syndrome. 60th Annual Meeting of the American
Academy of Neurology, Chicago, IL, April 17, 2008.
10. Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS): a challenging diagnosis. Parkinson
Study Group Annual Meeting 2008, Salt Lake City, UT, September 21, 2008.
11. LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease. First Meeting of
the Swiss Federation of Clinical Neuro-Societies, Basel, June 5, 2010.
12. MAPT, APOE and SNCA: Impact on the burden of Alzheimer and Lewy body pathology. 135th Meeting of the
American Neurological Association, Dementia and Ageing Special Interest Group, San Francisco,
September 12, 2010.
9.
Invited lectures
1. Le malade parkinsonien : adaptation thérapeutique jour après jour. Symposium Nouveautés en Gériatrie,
Montreux, January 2005.
2. Génétique des maladies neurodégénératives: des formes mendéliennes aux formes sporadiques. Colloque
des Neurosciences Cliniques, CHUV, Lausanne, June 17, 2009.
3. Genetics of Parkinson’s disease – a clinical perspective. First Swiss Movement Disorders Symposium,
Lucerne, September 4, 2009.
4. Génétique et maladies neurodégénératives. Jeudis de la Société Vaudoise de Médecine (SVM), CHUV,
Lausanne, September 24, 2009.
5. Update on Dopa-responsive dystonia. Teaching course, 14th Annual Meeting of the European Federation of
Neurological Societies (EFNS), Genève, September 25, 2010.
6. Advances in genetics : Implications for neurodegenerative diseases. Brain Meeting, Laboratoire de
Recherche en Neuroimagerie (LREN), CHUV, Lausanne, November 26, 2010.
7. Neurogenetics. Neurophage, Alpha Palmiers Hotel, Lausanne, June 23, 2011.
8. Genetic testing should be performed routinely in neurodegenerative diseases. Third Swiss Movement
Disorders Symposium, Lucerne, September 2, 2011.
9. Molecular genetics in dystonia. XIX World Congress on Parkinson’s Disease and Related Disorders,
Shanghai, China, December 14, 2011.
10. La maladie de Parkinson est d’origine génétique. Symposium Mémorial A. De Rothschild « Maladie de
Parkinson : enjeux et espoirs ». Geneva University Hospital (HUG), Geneva, May 7, 2012.
11. Genetic investigation helps differentiate between various forms of parkinsonism. Symposium “Abnormal
movements and Parkinson’s disease”, Lugano, January 24, 2013.
10.
Pre- and post-graduate teaching
1. Hydrocéphalies. Cours post-gradué de Neurologie, Lausanne, March 2003.
2. Nutrition et Cerveau. Cours post-gradué annuel de Neurologie, Lausanne, November 2003.
3. Maladie de Parkinson : diagnostic et prise en charge. Cours post-gradué de Médecine Interne, Vevey, May
2004.
4. Troubles de la marche : aspects physiologiques et sémiologiques. Cours post-gradué du Département de
Médecine Interne, Lausanne, June 2004.
5. Dystonia Diagnosis and Treatment. Neurology Core Lecture Presentation, Mayo Clinic College of Medicine.
Jacksonville, January 18, 2007.
6. Familial Forms of Dystonia (DYT Loci). Mayo Clinic College of Medicine Friday Subspecialty Conference,
Movement Disorders Conference, Jacksonville, FL, June 29, 2007.
7. Tremor. Mayo Clinic Clinical Conference, Mayo Clinic, Jacksonville, FL, August 20, 2007.
8. Dystonia: from syndromes to genetics. Department of Neurology Grand Rounds, Mayo Clinic, Jacksonville,
FL, October 17, 2007.
9. Familial Forms of Dystonia: Genes Blurring the Picture. Department of Neurology Grand Rounds, Mayo
Clinic, Jacksonville, FL, January 7, 2008.
10. Genetics of Movement Disorders. Department of Neurology Grand Rounds, Mayo Clinic, Jacksonville, FL,
April 6, 2009.
11. Update on familial forms of dystonia. Department of Neurology Grand Rounds, Mayo Clinic, Jacksonville,
FL, June 22, 2009.
12. Tremor. Mayo Clinic Clinical Conference, Mayo Clinic, Jacksonville, FL, August 6, 2009.
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13. Genetic forms of dystonia. Department of Neurology Grand Rounds, Mayo Clinic, Jacksonville, FL,
December 21, 2009.
14. Maladie de Parkinson. Cours de formation continue – Neuropsychologues, CHUV, Lausanne, January 21,
2010.
15. Mouvements anormaux : aspects génétiques. Cours de formation FMH neurologie, CHUV, Lausanne,
January 26, 2010
16. Révolution génétique : un espoir pour les maladies neurodégénératives. Conférence du Département de
Médecine Interne, CHUV, Lausanne, March 25, 2010.
17. Sémiologie Neurologique. Société Vaudoise d’Ostéopathie, Lausanne, May 8, 2010 (4 hours).
18. Sémiologe Neurologique. Cours-bloc, étudiants en médecine de 4e année (UNIL), CHUV, Lausanne, May 17
2010.
19. Troubles neurologiques de la personne âgée – Troubles de la marche. Jeudi de la PMU, CHUV, Lausanne,
June 10, 2010.
20. Génétique des maladies neurodégénératives. Course à option UNIL #10 (3 hours), DBCM, Lausanne,
September 30, 2010.
21. Sémiologie neurologique. Société Vaudoise d’Ostéopathie, Lausanne, October 9, 2010 (4 hours).
22. Maladie de Parkinson – Mise au point. Matinales de formation post-graduée, Hôpital de Sylvana, Lausanne,
November 12, 2010.
23. Génétique des Maladies Neurodégénératives. Colloque mensuel de neurologie, Hôpital de Sion, Sion,
January 13, 2011.
24. Nerfs crâniens. Enseignement pratique pré-gradué aux tuteurs de Skills, 2 heures, CHUV, Lausanne,
February 24, 2011.
25. Nerfs crâniens. Enseignement théorique pré-gradué B3.4, 1 hour, CHUV, Lausanne, March 3, 2011.
26. Vertiges. Enseignement théorique pré-gradué B3.4, 1 hour, CHUV, Lausanne, March 3, 2011.
27. La génétique a-t-elle révolutionné le domaine des maladies neurodégénératives ? Leçon inaugurale pour
titre de Privat-docent, enseignement théorique pré-gradué B3.4, 1 hour, CHUV, Lausanne, March 16,
2011.
28. Génétique des maladies neurodégénératives. Cours à option UNIL #10 (3 hours), Biopôle III, Lausanne,
October 20, 2011
29. Ataxie cérébelleuse – sémiologie. Cours UNIL « skills » B3.8 (1 hour), CHUV, Lausanne, February 29,
2012.
30. Nerfs crâniens VII à XII. Cours UNIL « skills » B3.8 (1 hour), CHUV, Lausanne, February 29, 2012.
31. Ataxies cérébelleuses. Cours UNIL B3.4 (1 hour), Lausanne, March 1, 2012.
32. La génétique a-t-elle révolutionnée les maladies neurodégénératives ? Colloque de Neurologie, Hôpital
Pourtales, Neuchâtel, March 15, 2012.
33. Génétique des maladies neurodégénératives. Cours à option UNIL #10 (3 hours), Biopôle III, Lausanne,
October 18, 2012.
34. Ataxie cérébelleuse : Sémiologie et examen clinique. Cours UNIL B2.3 (1 hour), DBCM, Lausanne,
Decembre 5, 2012.
35. Ataxie cérébelleuse – sémiologie. Cours UNIL « skills » B3.8 (1 hour), CHUV, Lausanne, February 20,
2013.
36. Maladies Neurogénératives. Cours à option UNIGE (3 hours), 3rd year medical students, UNIGE, February
28, 2013.
37. Ataxie cérébelleuses. Cours UNIL B3.4 (1 hour), Lausanne, March 1st, 2013.
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