vlL=_o.4o7[_lo2a]. 500c=p_riso_ofeff.ots

_vlL=_o.4o7[_lo2a]
. 500
c=p_riso_
ofeff.ots
_
LSM(_I02m)
J.M.
_I_0GERTY,
J.H., DILL£,
_
For a preliminary report on the pharmacological
_ffects
of LSM see Gogerty and Dille, Fed.Proc./.% 428
@_1956).
LSM is made available by $andoz and also by
_li
Lilly. The present study was made on material
"[_/'upp]ledby the latter firm.
(EK 12'610)
T/Dr.Bs/Dr.Spi/pz 558
Comparaison de la morpholide de l'acide
d-lysergique et du TSn
GOGERTY_ J.H., DILLE, J.M. (Dept.of Pharmacol., School.
of Med._ Univ.ofWashington_Seattle)
,
Pharmacolo_
,
(Pharmacologie de la morpholide de l'acide d-lysergique
'
of d-lys_rg_c acid morpholid_ (LSM).
J.Pharmacol.Exper.Therap.
j
_2Q, 340 (1957).
Les effets pharmagologiques de la morpholide de
l'acide d-lysergique (LSM) ressemblent _ ceux du LSD.
"
La dose d_ LSM n_cessaire pour _lever la t@mp_ratu+_,,
du corps du lapin est 3 x plus forte que celle du LSD_ •
et la dur6e de l'effet est plus courte.
_--;
,
,
"'_"
Sur Itut6z_ASisol_ d_ ia ratt_
_
l'efficacit_ du
LSM est _ peu pros 1/12 de celle de LSD quant _
_onisme vis-a-vis de la 5-hvdroxvtrv_+_O.
.
Les effets du LSM sur le comDortem_$ _'anlm_nv
"
ressemblent _ ceux du LSD, mais les doses n@cessaires.
sont _ peu pros 1/3 plus fortes et l'effet dure molns;_
Iongtemps.
_'_-.
i
(2 sujets)_ les effets du LSM sont
qualitativement similaires a ceux du LSD_ mais les doses
n_cessaires sont au moins 1/3 plus fortes et l'effet
dure molns longtemps.
e_
°
J
'
F
105 11/13
<?
/
G@vl[_afl_0n of _-ly_r_ic
acid
merpholide
and LSD
GOGERTY, J.H., DIL_.P, J.M. (Dept.of Pharmacol.,
of Med., Univ.of Washington, Seattle)
Pha._macolo_v of d-lys_r_ic
acid moroholide
J.Pharmacol.Exper.Therap.
School
(LSM).
120, 340 (1957).
The pharmacological effects of d-lysergic acid
_orpholide (LSM) are similar to those of LSD.
The dose of LSM required to raise body temperature
_n the rabbit is three times as great as that of LSD
_md the effect is of shorter duration.
On the isolated rat uterus LSM is approximately
1/12 as effective as LSD in anta_onisin_ 5-hvdroxvtrvoThe behavioural $_fects o_ LSM in animals are similar to those of LSD but the doses required are approximately 1/3 greater and the effects are of shorter
duration.
In _t_an beings (2 volunteers) the effects of LSM
were qualitatively similar to those of LSD but the dose
required was at least 1/3 larger and the duration of
action was shorter.
L_
!o5 z!/13
r
_
effects
.ovl
LsD
.o.
_o7
t_102aJ
M5oo
oo_p_ri.o_
of
LSM(§io_)
_
GOGERTY, J.H., DILLE, J.M.
i
For a prellmina_j report on the pharmacological
effects of LSM see Gogerty and Dille, Fed.Proc..l_
428
(1956). LSM is made available by $andoz and also by
Eli Lilly. The present study was made on material
supplied by the latter firm.
,
I
b
w5 (EK 12'610)
NKT/Dr.Bs/Dr.Spl/pz 558
J
Vcrgleioh yon D-Lysergs_uremorpholid
und L_D
,
,
i
._, GOGERTYp J.H., DIT.TR_ J.M. (Dept.of Pharmacol., School of
_'-_ Mecl., Unlv.of Washington, Seattle)
PharmacoloKy
of d-lyser_ic acid morpholide
(Pharmakologie von D-Lysergs_uremorpholid
J.Pharmacol.Exper.Therap.
Die pharmakologischen
(LSM) sind Rhnlich
wie
(LSM).
(LS_I).
120, 340 (1957).
Wirkungen
yon D-LysergsRuremorpholid
die yon LSD.
Die zur Erh_hun_ der KSrpertemperatur
forderliche
LSM-Dosis
ist
3 x hSher als
Wirkungsdauer
ist kUrzer.
des
beim
Kaninchens
erLSD, ,M die
Hi'nsichtlich des 5-Hydroxytryptami_anta_onismus am isol.
Rattenuterus besitzt LSD ann_hernd 1/12 der Wirksamkeit yon
LSD.
Die LSD-Wirkung auf das Verhalten yon Tieren entspricht
der des LSD, doch sind die erforderlichen Dosen um an_hernd
1/3 grSsser und die Wirkuns von kttrzerer Dauer.
Beim Menschen (2 Versuchspersonen) wirkt LSM qualitativ
Rhnlich wie LSD, doch ist die erforderliche Dosis mindestens
um 1/3 grosset und die Wirkur_ yon k_rzerer l_uer.
D
105 II/13
_vl LSDNo. 4o7 j_lo2_lM 5oooo_pari_o_of
effects
(D_E)
LSM (§ 102m)
GOGERTY,
J.H.,
DILL_,
J.M.
For a preliminary/ report on the pharmacological
effects of LSM see Gogerty and Dille, Fed.Proc. ,I_ 428
(1956). LSM is made available by $andoz and also by
Eli Lilly. The present study was made on material
supplied by the latter firm.
w5 (EK 12'61o)
NKT/Dr .Bs/Dr
,
.Spi/pz
558