preliminary programme

Transcription

28TH CONGRESS OF THE
EUROPEAN COMMITTEE FOR
TREATMENT AND RESEARCH
IN MULTIPLE SCLEROSIS
10 – 13 OCTOBER 2012
LYON, FRANCE
PRELIMINARY PROGRAMME
1
www.ectrims.eu/2012
Imprint
Editor
ECTRIMS2012
c/oCongrexSwitzerlandLtd.
Publisher & Layout
bcmedienag
Druck|Verlag|NewMedia
Münchenstein/Switzerland
[email protected]
TheECTRIMSOrganisingCommitteeexpressesitsthanksandappreciationtoallthosewhoare
generouslycontributingtothesuccessoftheECTRIMS2012.
Table of Contents
Committees
Welcome Address
Programme Overview
Scientific Programme
Invited Speakers and Chairs
Call for Abstracts
Registration
Hotel Accommodation and Travel Bookings
Social Events
Important Addresses & Dates
General Information – A to Z
The City of Lyon
Travel Information
The Lyon Convention Centre – Floor Plan
Lyon City Map and Hotels
1
2
3–6
7 – 21
22
23 – 25
26/27
28/29
30
31
32 – 34
35
36
37
38/39
Committees
ECTRIMS Executive Committee
Scientific Committee 2012
M. Clanet, President Toulouse, FR
F. Fazekas
Graz, AT
R. Gold Bochum, DE
D. Miller London, UK
X. Montalban, Secretary
Barcelona, ES
P. Soelberg-Sørensen, Treasurer Copenhagen, DK
Bari, IT
M. Trojano, Vice President M. Clanet
C. Confavreux
G. Comi
J. Correale
F. Fazekas
R. Gold
E. Havrdova
L. Kappos
C. Lubetzki
D. Miller
X. Montalban
P. O‘Connor
C. Polman
P. Soelberg-Sørensen
M. Trojano, Chair
S. Vukusic
J. Wolinsky
Local Organizing Committee 2012
D. Brassat
B. Brochet
J.-P. Camdessanché
M. Clanet
P. Clavelou
C. Confavreux, Chair
F. Cotton
P.-O. Couraud
J. de Sèze
M. Debouverie
R. Du Pasquier
G. Edan
J. Honnorat
D. Laplaud
C. Lubetzki
O. Lyon-Caen
R. Marignier
T. Moreau
J. Pelletier
P. Vermersch
S. Vukusic
1
Toulouse, FR
Bordeaux, FR
Saint-Etienne, FR
Toulouse, FR
Clermont-Ferrand, FR
Lyon, FR
Lyon, FR
Paris, FR
Strasbourg, FR
Nancy, FR
Lausanne, CH
Rennes, FR
Lyon, FR
Nantes, FR
Paris, FR
Paris, FR
Lyon, FR
Dijon, FR
Marseille, FR
Lille, FR
Lyon, FR
Toulouse, FR
Lyon, FR
Milan, IT
Buenos Aires, AR
Graz, AT
Bochum, DE
Prague, CE
Basel, CH
Paris, FR
London, UK
Barcelona, ES
Toronto, CA
Amsterdam, NL
Copenhagen, DK
Bari, IT
Lyon, FR
Houston, US
Welcome Address
DearColleaguesandFriends,
TheEuropeanCommitteeforResearchandTreatmentinMultipleSclerosis(ECTRIMS)andtheLocalOrganising
Committee are delighted to welcome you to the 28th Congress of ECTRIMS which will be held in Lyon,
France,from10–13October2012.
Lyonandmultiplesclerosis(MS)gobackalongway.Onecouldbetemptedtobelievethatitdatesback
to1894,withthefirstdescriptionofacuteneuromyelitisopticabyEugèneDevic,ifthisdiseasehadnotjust
beennosologicallyseparatedfromMSasaresultoftheMayoClinicfindings.
1987,i.e.exactly25yearsago,wasanothermilestonewiththeannualECTRIMScongressalreadybeing
organisedinLyon:withonly180participantsbutalreadymanyimpassionedandexcitingdebates.
Thencamethe1990sandthefirstEuropeanConcertedActiondedicatedtoMS,undertheleadershipof
OttoHommes,withthehelpofIanMcDonaldand LuigiAmaducci. Lyon was then put in charge of the
development of the European Database for Multiple Sclerosis (EDMUS) – a project specifically for the
descriptionofMSinthecontextofacontinuousconcertationbetweenEuropeanexperts.EDMUShasnow
reachedversion4.1.1.Itisdistributedin285centresinover40countries.Itisincreasinglyusedasan
electronicmedicalrecordforthefollow-upofpatientswithMSandhasalreadyallowedsignificantprogress
intheepidemiologyofMS.IthasachievedthesettingupoftheOFSEP(ObservatoireFrançaisdelaSclérose
enPlaques),acohortgatheringofover30’000PwMSinFrance.
WiththisbackgroundofprotracteddedicationtoMScareandresearch,Lyonisproudtohostthe28thECTRIMS
Congress.Youmaybeconfidentthateveryefforthasbeenmadetoselectalistoftopicsandassemblea
panelofspeakersthatwillensureaproductiveandexcitingmeeting.
Awiselocalsayinggoes,“aftereffortscomerewards”.Inthisrespect,Lyonisanidealplace.Itisthecity
ofthetworiversandtwohillswhereyoucanenjoyapleasantstroll.Youwilleasilydiscoverthetracesof
itssuccessivesplendours:Romancapitalofthe3Gauls,medievalCatholicprimateoftheGauls,andthe
Renaissance capital of trading and banking.You will also admire its most famous achievements, as the
birthplaceofprinting,thesilktrade,andthecinema...Lastbutnotleast,youwillsavourthecuisineof
world-renownedchefsinthecapitalofgastronomy,inthebestGargantuatradition.Hopefully,theLyon
ECTRIMS2012willbeagreatvintage!
.Confavreux
C
ChairECTRIMS2012
M.Clanet
ECTRIMSPresident
X.Montalban
ECTRIMSSecretary
2
Programme Overview
Wednesday, 10 October 2012
08.30
09.00
09.30
08.30–10.00
08.30–10.00
08.30–10.00
08.30–10.00
08.30–10.00
08.30–10.00
Teaching
Course 1
Teaching
Course 2
Body fluid
biomarkers
Teaching
Course 3
Disease-modifying
therapy in MS –
current and emerging treatment
Teaching
Course 4
Teaching
Course 5
Quantitating
tissue and functional
changes in MS
Teaching
Course 6
Meet the professors
10.00
11.30
12.00
10.30 – 12.00
10.30 – 12.00
10.30 – 12.00
10.30 – 12.00
10.30 – 12.00
10.30 – 12.00
Teaching
Course 8
Teaching
Course 9
Paediatric MS
Teaching
Course 10
Teaching
Course 11
NMO: a practical
approach
Teaching
Course 12
Gender differences in MS
Teaching
Course 13
Controversies
in the natural
history of multiple
sclerosis
Issues in MS
clinical trials: study
design and results
interpretation
13.30
MRI in the diagnosis
of MS and related
disorders
12.00 – 12.30 Lunch
12.30
13.00
12.30 – 14.00
Satellite Symposium
European
Charcot
Foundation
14.00
14.00 – 15.30
Young Scientific
Investigators’
Session I
14.30
15.00
15.30
15.30 – 16.00 Coffee Break
16.00
16.00 – 17.15
Young Scientific
Investigators’
Session II
16.30
17.00
17.30
17.15 – 18.15
Satellite Symposium
18.00
Merck Serono
S.A.
18.30
19.00
19.30
20.00
20.30
3
Teaching
Course 7
From dreams to
Molecular
reality: antigenmechanisms of
specific and stem-cell tissue injury in MS
therapy in MS?
lesions
10.30
11.00
Neuro-inflammation,
neurodegeneration,
and tissue repair – in
RRMS, SPMS, PPMS
18.30 – 19.30
Satellite Symposium
Novartis Pharma
AG
Welcome Reception at Les Halles de Lyon
08.30–10.00
Programme Overview
Thursday, 11 October 2012
08.30
08.30–10.00
Plenary Session 1
Opening Session
09.00
Welcome to Lyon
09.30
10.00
10.00 – 10.30 Coffee Break & Poster Viewing
10.30
10.30 – 12.00
10.30 – 12.00
10.30 – 12.00
Parallel Session 1
Parallel Session 2
Parallel Session 3
From environment to MS
From genetics to MS
Adaptive and innate immunity in MS
11.00
11.30
12.00
12.00 – 12.30 Lunch & Poster Viewing
12.30
12.45 – 13.45
Satellite Symposium
13.00
Genzyme, a Sanofi Company
13.30
14.00
14.00 – 15.30
10.30 – 12.00
10.30 – 12.00
Parallel Session 4
Parallel Session 5
Parallel Session 6
Neurons and oligodendrocytes in MS
From inflammation to
neurodegeneration
Biology of recovery
14.30
15.00
15.30
16.00
16.30
17.00
17.00 – 17.45
Hot Topic 1
Devic‘s neuromyelitis optica spectrum
17.00 – 17.45
Hot Topic 2
PML and IRIS
17.00 – 17.45
Hot Topic 3
Temporal changes in MS epidemiology
17.30
18.00
18.00 – 19.00
Satellite Symposium
Almirall
19.15 – 20.15
Satellite Symposium
Teva Pharmaceutical Industries
18.30
19.00
19.30
20.00
20.30
4
Programme Overview
Friday, 12 October 2012
08.30
09.00
09.30
09.15 – 10.15
09.15 – 10.15
09.15 – 10.15
Free Communications 1
10.00
10.30
11.00
11.30
12.00
10.45 – 12.15
10.45 – 12.15
10.45 – 12.15
Parallel Session 7
Parallel Session 8
Parallel Session 9
Beyond clinical monitoring of
progression in MS
From natural to treated history
From databases and cohorts to
pharmaco-epidemiology
12.30
13.00
12.45 – 13.45
Satellite Symposium
Bayer HealthCare
13.30
14.00
14.30
15.00
14.00 – 15.30
14.00 – 15.30
14.00 – 15.30
Parallel Session 10
Parallel Session 11
Parallel Session 12
Pregnancy
Imaging
Disease-modifying treatments
15.30
16.00
16.30
17.00
17.30
17.00 – 17.45
17.00 – 17.45
Hot Topic 4
Hot Topic 5
Imaging and cognition
Paediatric MS
18.00
18.00 – 19.00
18.30
Satellite Symposium
Biogen Idec
19.00
19.30
20.00
20.30
5
Official Conference Dinner at La Sucrière
17.00 – 17.45
Hot Topic 6
Symptomatic treatments
Programme Overview
Saturday, 13 October 2012
08.30
08.30 – 10.00
Parallel Session 13
Late-Breaking News
09.00
09.30
10.00
10.30
10.30 – 12.00
Plenary Session 2
Closing Session
11.00
From MS to Devic‘s neuromyelitis optica
Highlights and awards
11.30
12.00
12.00 – 12.30 Lunch
12.30
13.00
Advance Notice
29th Congress of the European Committee for
Treatment and Research in Multiple Sclerosis
2 – 5 October 2013, Copenhagen, Denmark
©: www.copenhagenmediacenter.com
6
Teaching Courses
08.30 – 10.00Meet
the Professors: A case-based approach to diagnosis and management of MS
Chairs: A. Miller (New York, US); D. Bates (Newcastle, UK)
Teaching Course 1
In this programme, two experienced MS clinicians, from either side of the Atlantic
Ocean will engage the audience in an interactive programme that reviews several
clinically important issues regarding the diagnosis and management of MS and related
demyelinating disorders. Recently revised diagnostic criteria will be discussed, as well
as the use of an increasing number of disease-modifying therapies. Strategies for drug
selection that incorporate risk-benefit analysis will be considered.
08.30 – 10.00
Body fluid biomarkers
Teaching Course 2
Chairs: C. Teunissen (Amsterdam, NL); J. Kuhle (Basel, CH)
Basic introduction on biomarkers in body fluids
C. Teunissen (Amsterdam, NL)
Biomarkers in MS. State of the art
J. Kuhle (Basel, CH)
Future use of biomarkers in daily clinical practice
F. Sellebjerg (Copenhagen, DK)
There is a strong interest in body fluid biomarkers for multiple sclerosis. Biomarkers
are objective, dynamic and relatively cheap aids in the diagnosis, prognosis and monitoring of disease progression in MS. This BioMS-eu Teaching Course will provide an
introduction in the area of biobanking and biomarker research, including the choice
and definition of control groups in CSF biomarker studies. We will give an update on
the current state of biomarkers in MS – from DNA to proteins and metabolites. Furthermore, the future use of these biomarkers in daily clinical practice will be discussed.
08.30 – 10.00Disease-modifying
therapy in MS – current and emerging treatment
Chairs: H. Wiendl (Münster, DE); C. Lubetzki (Paris, FR)
Teaching Course 3
First-line therapies (ABCR drugs)
H. Wiendl (Münster, DE)
Monoclonal antibodies
C. Lubetzki (Paris, FR)
Oral drugs
L. Kappos (Basel, CH)
Disease-modifying treatment (DMT) is subject to dynamic change and complexity of
the treatment landscape emerges. This course will give the audience an overview of
7
established DMTs including mode of action and recent trials on targeted immunotherapies. While ABCR drugs have the advantage of high general safety under long-term
treatment, their problem is their magnitude of effectiveness: partial, non-response or
tolerability issues are not uncommon. Immune escalating therapy, especially the group
of monoclonal antibodies, is more effective, but carries significant safety risks. For the
monoclonal antibody natalizumab the first steps have been taken to allow the individual risk stratification under and before therapy. After successful phase III trials, several
agents have filed in for approval, possibly expected already in 2013 (Teriflunomide,
BG12, Alemtuzumab). Chances and pitfalls are elaborated here, especially introducing
“burden of therapy” in current and future therapy decisions.
08.30 – 10.00Neuro-inflammation, neurodegeneration
and Teaching Course 4
tissue repair in RRMS, SPMS, PPMS
Chairs: W. Brück (Göttingen, DE); C. Lucchinetti (Rochester,US)
The normal-appearing brain in MS
N. Schaeren-Wiemers (Basel, CH)
Neuro-inflammation in the cortex
C. Lucchinetti (Rochester, US)
Inflammation and degeneration in MS
W. Brück (Göttingen, DE)
This course concentrates on the relationship between inflammation, neurodegeneration and repair in MS, in the different MS disease courses and disease stages.
N. Schaeren-Wiemers will focus on molecular changes in the normal-appearing white
and grey matter of MS brains. Here, early molecular changes occur that may help in
identifying possible pathogenetic mechanisms of lesion development. The grey matter
is substantially involved in the pathology of MS and reveals extensive demyelination
from early disease on and increases with progression. C. Lucchinetti will describe in
detail the quantity and quality of inflammation in cortical MS lesions and their role
in the development of grey-matter demyelination in the different disease courses.
W. Brück will focus on the correlation between inflammation and neurodegeneration,
especially axonal damage, in early and chronic MS lesions. He will also describe the
extent of spontaneous remyelination in different disease stages and discuss the cause
of remyelination failure in MS.
8
08.30 – 10.00Quantification
of tissue damage and functional changes in MS
Chairs: M. Filippi (Milan, IT); A. Rovira (Barcelona, ES)
Teaching Course 5
Monitoring MS lesion evolution
A. Rovira (Barcelona, ES)
Fibre tracts and functionality
O. Ciccarelli (London, UK)
Resting state fMRI
M. Filippi (Milan, IT)
Despite the fact that conventional magnetic resonance imaging (MRI) has a high sensitivity in detecting macroscopic tissue abnormalities related to MS, it lacks specificity
to the heterogeneous pathological substrates of the disease and, as a consequence,
conventional MRI metrics are only weakly correlated to disability. The aim of this
Teaching Course is to provide a state-of-the-art knowledge of how quantitative structural and functional MRI techniques are contributing to characterise disease-related
abnormalities of the central nervous system at various stages of MS and on adaptive
mechanisms with the potential to limit the severity of clinical manifestations associated with irreversible tissue damage. The role of these techniques to monitor longitudinal changes in these patients, especially when treated, will be also discussed.
08.30 – 10.00From
dreams to reality: antigen-specific and stem cell therapy in MS?
Chairs: K. Selmaj (Lodz, PL); A. Ucelli (Genoa, Italy)
Teaching Course 6
Antigen-specific therapy of MS
K. Selmaj (Lodz, PL)
Autologous mesenchymal stem cells for the treatment of MS
A. Ucelli (Genoa, IT)
Autologous haematopoetic stem cells for the treatment of MS
D. Karussis (Jerusalem, IL)
Antigen-specific therapy selectively targets cells specific for a given antigen and
disables only a small part of the immune system in contrast to all currently available
therapies in MS. Several approaches have been tried with respect to antigen-specific
therapy with varied outcomes. We will provide an overview on the currently developing
antigen-specific therapies leading to induction of immune tolerance in MS patients.
The recent advances in our understanding of stem cell biology have launched stem cell
treatments as one of the most exciting and difficult challenges in the MS field. Here
we provide an overview about the current status of stem cell research in MS focusing
on secured actuality, reasonable hopes and unrealistic myths.
9
08.30 – 10.00Molecular
mechanisms of tissue injury
Teaching Course 7
in MS lesions
Chairs: H. Lassmann (Vienna, AT); J. van Horssen (Amsterdam, NL)
The role of T-cells in MS pathogenesis
R. Liblau (Toulouse, FR)
Interplay of free radicals and mitochondrial dysfunction in MS
J. van Horssen (Amsterdam, NL)
Amplification of oxidative damage in MS brain by iron
H. Lassmann (Vienna, AT)
We will provide an overview of molecular mechanisms that contribute to MS pathology.
R. Liblau will focus on the role of T-cells and discuss the presence of distinct T-cell
subsets in MS lesions and how T-cells mediate CNS tissue damage. J. van Horssen will
focus on the molecular mechanisms underlying impaired mitochondrial metabolism
and free-radical production in MS and discuss the potential of antioxidant protection.
H. Lassmann will describe disturbances in iron metabolism in MS brain and how iron
can amplify oxidative damage in MS brain.
10.30 – 12.00Issues
in MS clinical trials: study design and results interpretation
Chairs: M. P. Sormani (Genoa, IT); F. Lublin (New York, US)
Teaching Course 8
Statistical issues and results interpretation in MS clinical trials
M. P. Sormani (Genoa, IT)
Outcomes in MS clinical trials
F. Lublin (New York, US)
Surrogate outcomes for immunomodulation and neuroprotection
J. Wolinsky (Houston, US)
This course will focus on methodological issues specific of clinical trials in MS. One
section will be devoted to design, with a review of the basic principles for sample size
calculations and a focus on the case of non-inferiority and equivalence trials. Caveats
in results interpretation will be highlighted, signalling the problems of indirect comparisons of treatment effects across trials. A critical review of the classical endpoints for
phase II and phase III trials will be offered, together with a discussion about potential
surrogate markers valid for immunomodulation and for neuroprotection and repair.
10
10.30 – 12.00
Paediatric MS Teaching Course 9
Chairs: B. Banwell (Toronto, CA); C. Hemingway (London, UK)
Environmental and genetic factors in paediatric multiple sclerosis
B. Banwell (Toronto, CA)
Relapse severity, recovery and progression in paediatric MS
E. Waubant (San Francisco, US)
Acute disseminated encephalomyelitis in children and MS
C. Hemingway (London, UK)
This course will discuss the clinical and epidemiological features of MS in children, as
well as the clinical course and outcome. In addition, the key features of acute disseminated encephalomyelitis will be presented and contrasted with those of paediatric MS.
10.30 – 12.00MRI
in the diagnosis of MS and
Teaching Course 10
related disorders
Chairs: N. De Stefano (Siena, IT); M. Wattjes (Amsterdam, NL)
Lesion characteristics in MS: brain and spinal cord
M. Wattjes (Amsterdam, NL)
The “radiologically isolated syndrome”
N. De Stefano (Siena, IT)
Pitfalls in diagnosing “active MS”
C. Enzinger (Graz, AT)
This course will focus on the use of MRI for the diagnosis of MS. After reviewing the
relevance for making the diagnosis of MS of white- and grey-matter lesions in the
brain and spinal cord in terms of lesion characteristics (lesion distribution pattern and
lesion heterogeneity), peculiar entities such as the radiologically isolated syndrome
(RIS) and active/unusual MS will be discussed. Criteria useful for making the diagnosis
of these two conditions and the exclusion of differential diagnosis will be provided,
together with potential markers of short-term prognosis.
11
10.30 – 12.00
NMO: a practical approach Teaching Course 11
Chairs: D. Wingerchuk (Scottsdale, US); J. Palace (Oxford, UK)
Pathogenesis of NMO
K. Fujihara (Sendai, JP)
NMO diagnostic criteria: are they really so distinct in clincal practice?
D. Wingerchuk (Scottsdale, US)
Treating patients with NMO
R. Marignier (Lyon, FR)
Neuromyelitis optica (NMO) is a relapsing inflammatory demyelinating CNS disease
that has several distinguishing features. However, the spectrum of recognised NMO
manifestations continues to broaden and may overlap with MS, resulting in diagnostic
confusion and therapeutic uncertainty. The aims of this course are: 1) to review current
understanding of NMO pathogenesis, including the role and mechanisms of aquaporin-4 autoantibodies; 2) provide a practical guide to NMO diagnosis using existing
diagnostic criteria and integrating new serological and neuro-imaging observations;
and 3) outline a practical approach to treatment NMO, including management of
acute attacks and strategies for attack prevention.
10.30 – 12.00
Gender differences in MS Chairs: H. Harbo (Oslo, NO); M. Tintoré (Barcelona, ES)
Teaching Course 12
Genetic aspects and gender differences in disease onset and progression
H. Harbo (Oslo, NO)
Effects of sex hormones, the menstrual cycle and pregnancy on MS
M. Tintoré (Barcelona, ES)
Gender differences in the immune system and response to immunotherapy
R. Gold (Bochum, DE)
This course aims to provide an updated overview of gender differences in MS and their
implications. The causes for the significant and increasing prevalence of MS among
women compared to men are still not quite clear. Gender appears to play a role in development but also in progression and treatment effects of MS. This course will review
current knowledge of gender differences in MS, both from a genetic, immunologic and
clinical perspective. The impact of female hormones, pregnancy and breastfeeding on
the disease as well as treatment strategies will also be discussed.
12
10.30 – 12.00Controversies
in the natural history of multiple sclerosis
Chairs: C. Confavreux (Lyon, FR); A. Scalfari (London, UK)
Teaching Course 13
Relapses and long-term disability accumulation
A. Scalfari (London, UK)
Age, prognosis and the MS disease course
H. Tremlett (Vancouver, CA)
Emerging concepts from natural history studies: an overview
C. Confavreux (Lyon, FR)
Several concepts have emerged from the recent analyses of the natural history of MS
in representative cohorts of patients. A. Scalfari will focus on the lack of a clear association between relapses and long-term disability accumulation, the MS onset being
exacerbating-remitting or progressive. H. Tremlett will discuss the association between
the patients‘ age and the MS clinical course and disability milestones. C. Confavreux
will merge these observations with the concept of MS being one disease with different
clinical phenotypes, infer about pathophysiology and treatments, and discuss the need
for a revised clinical classification of MS.
Call for Teaching Courses
The ECTRIMS Executive Committee would like to thank all those who have submitted a Teaching
Course proposal for the ECTRIMS 2012 and therewith helped to build this year’s programme. Also
for the ECTRIMS 2013, the Committee would like to encourage everyone with an interest in multiple
sclerosis to submit a proposal. The proposal should include the following: main title of the course, full
names of two organisers, titles of three lectures, full names of proposed lecturers.
The deadline for submitting proposals is 30 November 2012. Please send your proposals to:
ECTRIMS 2012
Administrative Secretariat
c/o Congrex Switzerland Ltd.
Peter Merian-Strasse 80
4002 Basel / Switzerland
13
Satellite Symposium
12.30 – 14.00
European Charcot Foundation
Young Scientific Investigators’ Sessions
14.00 – 15.30 Young Scientific Investigators’ Session I
Chairs: P. Calabresi (Baltimore, US); J. de Sèze (Strasbourg, FR)
16.00 – 17.15
Young Scientific Investigators’ Session II
Chairs: J. Palace (Oxford, UK); C. Stadelmann (Göttingen, DE)
Satellite Symposia
Satellite Symposium
17.15 – 18.15
Merck Serono S.A.
18.30 – 19.30
Satellite Symposium
Novartis Pharma AG
Social Event
Official Welcome Reception at Les Halles de Lyon (see page 30 for details)
14
Plenary Session
08.30 – 10.00
Welcome Address and ECTRIMS Lecture Chairs: M. Clanet (Toulouse, FR); C. Confavreux (Lyon, FR)
Plenary Session 1
Welcome to Lyon
ECTRIMS Lecture: Biotherapies in MS: hopes and threats
H.-P. Hartung (Düsseldorf, DE)
Parallel Sessions
10.30 – 12.00
From Environment to MS Chairs: G. Ebers (Oxford, UK); M. Debouverie (Nancy, FR)
Parallel Session 1
From infections to MS
R. Du Pasquier (Lausanne, CH)
From physico-chemical agents exposure to MS
S. Ramagopalan (Oxford, UK)
Platform presentation of related original papers
10.30 – 12.00
From Genetics to MS Parallel Session 2
Chairs: M. Comabella (Barcelona, ES); B. Fontaine (Paris, FR)
From the genes to MS
J.S. Sawcer (Cambridge, UK)
Expectations from Omics in MS
D. Brassat (Toulouse, FR)
10.30 – 12.00
Adaptative and Innate immunity in MS Chairs: R. Liblau (Toulouse, FR); R. Gold (Bochum)
B- and T-lymphocytes in MS
R. Hupperts (Maastricht, NL)
Microglia and astroglia in MS
R. Ransohoff (Cleveland, US)
15
Parallel Session 3
Satellite Symposium
12.45 – 13.45
Satellite Symposium
Genzyme, a Sanofi Company
Parallel Sessions
14.00 – 15.30
Neurons and Oligodendrocytes in MS Chairs: H. Lassmann (Vienna, AT); P.-O. Couraud (Paris, FR)
Parallel Session 4
Neurons in MS
D. Mahad (Newcastle-upon-Tyne, UK)
Oligodendrocytes in MS
T. Kuhlmann (Münster, DE)
14.00 – 15.30
From Inflammation to Neurodegeneration Chairs: W. Bruck (Göttingen, DE); P. Giraudon (Lyon, FR)
Parallel Session 5
From focal inflammation to neurodegeneration
F. Zipp (Mainz, DE)
From diffuse inflammation to neurodegeneration
D. Merkler (Geneva, CH)
14.00 – 15.30
Biology of Recovery Parallel Session 6
Chairs: N. Scolding (Bristol, UK); S. Chandran (Edinburgh, UK)
Ion channels and recovery
J. Black (New Haven, US)
Remyelination
C. Lubetzki (Paris, FR)
Poster Session
15.30 – 17.00
Poster Session
16
Hot Topics
17.00 – 17.45
Devic’s Neuromyelitis Optica Spectrum
Chairs: A. Vincent ( Oxford, UK); D. Wingerchuk (Scottsdale, USA)
Hot Topic 1
Immunobiology
CRION/RION
D. Bichuetti (Sao Paulo, BR)
17.00 – 17.45
PML and IRIS Chairs: T. Weber (Hamburg, DE); H. Wiendl (Münster, DE)
Hot Topic 2
The PML spectrum
D. Clifford (St. Louis, US)
Epidemiology of Natalizumab-associated PML and IRIS in MS
P. Vermersch (Lille, FR)
17.00 – 17.45
Temporal Changes in MS Epidemiology Chairs: P. De Jager (Boston, USA); M. Pugliatti (Sassari, IT)
Overview
N. Koch-Henriksen (Aalborg, DK)
The French OFSEP experience
T. Moreau (Dijon, FR)
Satellite Symposia
18.00 – 19.00MS
spasticity symptoms management.
Endocannabinoid system modulator data
beyond clinical trials
Almirall
19.15 – 20.15
Satellite Symposium
Teva Pharmaceutical Industries
17
Hot Topic 3
07.30 – 09.00 ECTRIMS Council Meeting
Council members, by invitation only
Free Communications
09.15 – 10.15
Platform presentation of selected abstracts Free Communication 1
Chairs: J. Wolinsky (Houston, US); E. Wassmer (Birmingham, UK)
09.15 – 10.15
Platform presentation of selected abstracts Free Communication 2
Chairs: M. Tintoré (Barcelona, ES); J. Hillert (Stockholm, SE)
09.15 – 10.15
Platform presentation of selected abstracts
Free Communication 3
Chairs: E. Havrdova (Prague, CZ); D. Karussis (Jerusalem, IL)
10.15 – 10.45 Coffee break & Poster Viewing
Parallel Sessions
10.45 – 12.15
Beyond Clinical Monitoring of Progression in MS Chairs: C. Pozzili (Rome IT); F. Cotton (Lyon, FR)
Parallel Session 7
Biological markers
A. Petzold (Amsterdam, NL)
MR and OCT markers
D. Miller (London, UK)
10.45 – 12.15
From Natural to Treated History Parallel Session 8
Chairs: J. Rio (Barcelona, ES); P. Soelberg Sørensen (Copenhagen, DK)
Standpoint of the neurologist
Standpoint of the methodologist
M.P. Sormani (Genoa, IT)
10.45 – 12.15From
Databases and Cohorts to Pharmaco-Epidemiology
Chairs: M. Trojano (Bari, IT); M. Clanet (Toulouse, FR)
Parallel Session 9
Pharmaco-epidemiology: methodological aspects
G. Tognoni (Chieti, IT)
18
The example of MS
S. Vukusic (Lyon, FR)
Satellite Symposium
12.45 – 13.45
Satellite Symposium
Bayer HealthCare Pharmaceuticals
Parallel Sessions
14.00 – 15.30
Pregnancy Parallel Session 10
Chairs: J. Nogales (Santiago, CL); H. Tremlett (Vancouver, CA)
Natural history
M. P. Amato (Florence, IT)
Treatments
E. Waubant (San Francisco, USA)
14.00 – 15.30
Imaging Chairs: M. Filippi (Milan, IT); J. Pelletier (Marseille, FR)
Parallel Session 11
Demyelination and remyelination
F. Barkhof (Amsterdam, NL)
PET scan and molecular imaging
B. Stankoff (Paris, FR)
14.00 – 15.30
Disease-Modifying Treatments Chairs: G. Comi (Milan, IT); G. Edan (Rennes, FR)
Oral treatments: past, present, future
C. Polman (Amsterdam, NL)
Therapeutic strategies in 2012
X. Montalban (Barcelona, ES)
19
Parallel Session 12
Poster Session
15.30 – 17.00
Poster Session
Hot Topics
17.00 – 17.45
Imaging and Cognition Chairs: O. Lyon-Caen (Paris, FR); A. Feinstein (Toronto, CA)
Hot Topic 4
Morphological imaging
Functional imaging
17.00 – 17.45
Paediatric MS Chairs: M. Tardieu (Paris, FR); A. Ghezzi (Gallarate, IT)
Hot Topic 5
The spectrum of paediatric MS and related disorders
Y. Mikaeloff (Paris, FR)
Disease-modifying treatments in paediatric MS
17.00 – 17.45
Symptomatic Treatments Chairs: A. Thompson (London, UK); B. Brochet (Bordeaux, FR)
Hot Topic 6
Pitfalls in assessing symptomatic treatments
B. Uitdehaag (Amsterdam, NL)
Cannabinoids
J.P. Zajicek (Plymouth, UK)
Satellite Symposium
18.00 – 19.00
Satellite Symposium
Biogen Idec
Social Event
Official Conference Dinner at La Sucrière (see page 30 for details)
20
Parallel Session
08.30 – 10.00
Late-Breaking News Chairs: L. Kappos (Basel, CH); P. O’Connor (Toronto, CA)
10.00 – 10.30 Coffee break and poster viewing
Parallel Session 13
Plenary Session
10.30 – 12.00
Closing Session Chairs: M. Clanet (Toulouse, FR); C. Confavreux (Lyon, FR)
Plenary Session 2
From MS to Devic’s neuromyelitis optica
B. Weinshenker (Rochester, US)
Treatments highlights
G. Giovannoni (London, UK)
Scientific highlights
A. Ascherio (Boston, US)
Presentation of selected poster awards, awards for best oral
presentations by young researchers and the MSIF award
M. Clanet (Toulouse, FR), M. Trojano (Bari, IT)
Welcome to Copenhagen
P. Soelberg-Sørensen (Copenhagen, DK)
End of meeting
21
Invited Speakers and Chairs
A
F
M
T
M. Amato (Florence, IT)
A. Ascherio (Boston, US)
A. Feinstein (Toronto, CA)
M. Filippi ( Milan, IT)
B. Fontaine (Paris, FR)
K. Fujihara (Sendai, JP)
D. Mahad
(Newcastle-upon-Tyne, UK)
D. Merkler (Geneva, CH)
Y. Mikaeloff (Paris, FR)
A. Miller (New York, US)
D. Miller (London, UK)
X. Montalban (Barcelona, ES)
T. Moreau (Dijon, FR)
Y. Tardieu (Paris, FR)
C. Teunissen (Amsterdam, NL)
A. Thompson (London, UK)
M. Tintoré (Barcelona, ES)
G. Tognoni (Chieti, IT)
H. Tremlett (Vancouver, CA)
M. Trojano (Bari, IT)
B
F. Barkhof (Amsterdam, NL)
D. Bates (Newcastle, UK)
D. Bichuetti (Sao Paulo, BR)
D. Brassat (Toulouse, FR)
J. Black (New Haven, US)
B. Brochet (Bordeaux, FR)
W. Brück (Göttingen, DE)
C
P. Calabresi (Baltimore, US)
S. Chandran (Edinburgh,UK)
O. Ciccarelli (London,UK)
M. Clanet (Toulouse, FR)
D. Clifford (St. Louis,US)
M. Comabella (Barcelona, ES)
G. Comi (Milan, IT)
F. Cotton (Lyon, FR)
P.-O. Couraud (Paris, FR)
G
A. Ghezzi (Gallarate, IT)
G. Giovannoni (London, UK)
P. Giraudon (Lyon, FR)
R. Gold (Bochum, DE)
N
H
H.-P. Hartung (Düsseldorf, DE)
H. Harbo (Oslo, NO)
E. Havrdova (Prague, CZ)
C. Hemingway (London, UK)
J. Hillert (Sockholm, SE)
R. Hupperts (Maastricht, NL)
K
U
A. Ucelli (Genoa, IT)
B. Uitdehaag (Amsterdam, NL)
J. Nogales (Santiago, CL)
V
O
P. O’Connor (Toronto, CA)
P
J. Palace (Oxford, UK)
J. Pelletier (Marseille, FR)
A. Petzold (Amsterdam, NL)
C. Polman (Amsterdam, NL)
C. Pozzili (Rome, IT)
M. Pugliatti (Sassari, IT)
J. Van Horssen (Amsterdam, NL)
P. Vermersch (Lille, FR)
A. Vincent (Oxford, UK)
S. Vukusic (Lyon, FR)
W
E. Wassmer (Birmingham, UK)
M. Wattjes (Amsterdam, NL)
E. Waubant (San Francisco, US)
T. Weber (Hamburg, DE)
B. Weinschenker (Rochester, US)
H. Wiendl (Münster, DE)
R
D
S. Ramagopalan (Oxford, UK) D. Wingerchuk (Scottsdale, US)
P. De Jager (Boston, US)
R. Ransohoff (Cleveland, US) J. Wolinsky (Houston,USA)
J. De Sèze (Strasbourg, FR)
L
J. Rio (Barcelona, ES)
H. Lassmann (Vienna, AT)
Z
A. Rovira (Barcelona, ES)
M. Debouverie (Nancy, FR)
R. Liblau (Toulouse, FR)
J.P. Zajicek (Plymouth, UK)
R. Du Pasquier (Lausanne, CH) C. Lubetzki (Paris, FR)
F. Zipp (Mainz, DE)
S
F. Lublin (New York, US)
J. Sawcer (Cambridge, UK)
O. Lyon-Caen (Paris, FR)
E
A. Scalfari (London, IT)
C. Lucchinetti (Rochester, US) N. Schären-Wiemers (Basel, CH)
G. Ebers (Oxford,UK)
G. Edan (Rennes, FR)
N. Scolding (Bristol, UK)
F. Sellebjerg (Copenhagen, DK)
K. Selmaj (Lodz, PL)
P. Soelberg -Sorensen
(Copenhagen, DK)
M.P. Sormani (Genoa, IT)
C. Stadelmann (Göttingen, DE)
B. Stankoff (Paris, FR)
L. Kappos (Basel, CH)
N. Koch-Henriksen
(Aalborg, DK)
D. Karussis (Jerusalem, IL)
J. Kuhle (Basel, CH)
T. Kuhlmann (Münster, DE)
22
Call for Abstracts
The Scientific Committee welcomes the submission of abstracts for presentation at the 28th Congress of the
European Committee for Treatment and Research in Multiple Sclerosis
Deadline for submission of abstracts:
Wednesday, 23 May 2012
Abstracts may only be submitted online.
To submit your abstract please go to the congress website
www.ectrims.eu/2012
In order to standardise the abstract layout, we kindly ask you to read the guidelines at this link carefully.
Guidelines for preparation of abstracts
1. Abstracts may only be submitted online. Abstracts submitted by fax or email will not be accepted.
2. Abstracts must be submitted in English. Please use UK English spelling.
3. The presenting author of an accepted abstract must register and attend the congress.
4. Poster presenters must be present and stand by their posters during their assigned poster sessions.
5.Abstracts should contain only original material not published or presented elsewhere prior to
10 October 2012.
6.Use a short specific title indicating the nature of the investigation. The background and goals of the
study should appear clearly to the reader. The methods and results must contain data, and the
conclusions should be clearly expressed.
7.All abbreviations must be defined the first time they appear in your text (but, do not define in the title).
Example: Multiple Sclerosis Impact Scale (MSIS), before being used as an abbreviation only.
8.Avoid complex mathematical formulae. For the symbols ≤ or ≥, type instead <= or >=. For superscript
use caret (^) e.g. 10^6 instead of 106. Do not use Greek letters and symbols. Instead of “IFN-” use
for example “IFN-g” or “IFN-gamma”.
9. Use generic drug names.
10.Tables, charts or other graphics may not be included and will be deleted by the editors.
11.The abstract text may not be longer than 2’500 characters including spaces (ca. 500 words).
12. Authors should indicate their presentation preference:
• poster presentation only
• oral or poster presentation
“Poster only” implies that your abstract will be considered for poster presentation only and will not
be eligible for the poster prize (see corresponding paragraph).
The Programme Committee reserves the right to decide on the final allocation and presentation method.
13.A selected number of abstracts will be accepted for oral presentation based on their scientific merits and on their relation to the topics addressed in the scientific programme of the
Congress. We therefore encourage submissions on the main topics covered in the scientific
programme.
23
Call for Abstracts
14.Disclosure of conflict of interest (e.g. grant support, consultancy, membership on advisory councils,
speaker’s bureau) and source of funding is mandatory. Each listed author should prepare a
one-sentence statement to this effect.
15.Please make sure to state your correct e-mail address. After having submitted your abstract, you will
receive a confirmation by e-mail with the following information:
• reference number of your abstract (for correspondence and questions that might arise)
• your personal user code and password.
(if you do not receive a confirmation by e-mail please contact the Abstract hotline!)
16.Should you wish to make corrections to an abstract already submitted or if you wish to submit other
abstracts later, you may use your personal access codes. This will shorten the submission procedure.
Corrections to abstracts can only be made up to the deadline of 23 May 2012.
If you have difficulties in submitting your abstracts or if you need any further information, please contact
the Abstract Hotline (Monday – Friday during CET business hours): Tel. +41 61 686 77 22.
Topics
Authors are requested to select a topic under which they wish their abstract to be reviewed:
Clinical aspects of MS
1. Diagnosis and differential diagnosis
2. MS variants
3. Devic’s NMO spectrum
4. Paediatric MS
5. Natural history
6. Epidemiology
7. Databases and pharmacoepidemiology
8. MS symptoms
9. Pregnancy and MS
10. Clinical assessment tools
11. Economic burden
Pathology and pathogenesis of MS
12. Pathology
13. Grey-matter damage in MS
14. Experimental models
15. Genetics / transcriptomics
16. Adaptative and innate immunology
17. MS and infections
18. Environmental risk factors
19. Neurobiology
20. Biology of recovery
21.Imaging
22.Neurophysiology
23.Neuropsychology and fatigue
Therapy – disease-modifying
24. Immunomodulation
25. Immunosuppression
26. Neuroprotection
27. Long-term treatment monitoring
28.Risk management for disease-modifying
treatments
29. Tools for detecting therapeutic response
30. Others
Therapy – symptomatic
31. Treatment of specific symptoms
32. Comprehensive care and rehabilitation
33. Quality of life
34.Neuro-ophthalmology
35.Biomarkers
36.Chronic cerebro-spinal venous
insufficiency (CCVI)
24
Call for Abstracts
Notification
Each abstract will be reviewed by 4 – 5 external experts and then by the Scientific Committee. Authors will
be notified of acceptance by e-mail in mid July. Full instructions concerning preparation and presentation
will be included.
Publication
All accepted abstracts will be published in a supplement to “Multiple Sclerosis Journal”. This will be handed
out to all registered participants with the congress documents onsite.
• Full text of accepted abstracts will be viewable online at the congress website 2 weeks prior to the Congress.
• Full text of “late breaking news” abstracts will be viewable online at the congress website from the first
day of the congress.
Presentation available on the ECTRIMS website
The posters and PowerPoint-slides of accepted presentations will be posted on the ECTRIMS website after
the congress.
All authors will be asked to agree to the publication of their actual poster or Power-Point-slides of the oral
presentation. For agreement please click the appropriate checkbox during the online abstract submission.
Young Scientific Investigators’ Sessions
Abstracts submitted by presenting authors who are aged 35 or younger (born on or after 1 January 1977)
may be considered for the Young Scientific Investigators’ Session. Selected presenters will be invited to make
a 15-minute presentation (including discussion). If you wish to be considered for this session, please click
the appropriate checkbox during the online abstract submission process. You will be required to upload a
copy of your passport with readily readable date of birth as proof of eligibility.
Prepare this document in one of the following formats: MS Word document, gif, jpg or pdf file.
Applications without passport copy or arriving after 23 May 2012 will not be considered.
Travel Grants
A limited number of travel grants will be made available to young scientists (born on or after 1 January
1977) whose abstracts have been accepted for oral or poster presentation. Interested scientists should click
the appropriate checkbox during the online abstract submission process. You will be required to upload a
copy of your passport with readily readable date of birth as proof of eligibility.
Prepare this document in one of the following formats: MS Word document, gif, jpg or pdf file.
Applications without passport copy or arriving after 23 May 2012 will not be considered.
Applicants will be notified in mid July (just after acceptance notification).
If you have difficulties uploading your passport copy, please contact the Abstract Hotline on +41 61 686 7722
Late-Breaking News Abstract Deadline
Late-Breaking News abstracts containing important findings not available before the general abstract deadline can be submitted until Monday, 23 July 2012.
Please contact the Abstract Hotline for further details: Tel. +41 61 686 77 22
25
Prizes
Five prizes will be awarded to the best poster presentations (e 1’000 each).
Award winning poster authors will give a short presentation in the Plenary Session on Saturday, 13 October
2012.
Two additional prizes of e 1’500 each will be awarded to the two best oral presentations given by young
investigators (born on or after 1 January 1977).
Prizes will be awarded in the closing plenary session.
Registration
Registration Fees (in Euros)
As From
16 August 2012
Until
15 August 2012
Congress delegates ECTRIMS
E 450
E 600
Physicians in training, researchers and therapists*
E 200
E 300
Analysts
E 450
E 600
Teaching Courses 1 – 13
E 30
E 40
* Physicians in training: colleagues born after 1 January 1977; copy of passport required
Therapists and researchers: confirmation from head of department required
What’s included?
The registration fee for participants includes unlimited access to all scientific sessions, the industrial
exhibition, the welcome reception, one congress bag, one copy of the final programme, lunch (first come, first
served), coffee during the breaks and, according to the participant’s choice, either one copy of the abstract
suplement or the abstract CD Rom. While registering online the participant needs to order the abstract book
or the abstract CD.
Online Registration
Participants can register for the congress and social events via the congress website www.ectrims.eu/2012.
Please follow the instructions on the website carefully.
For online registration, payment by credit card and bank transfer is possible. Please do not use the online
registration for group registrations!
Manual Registration Processing Surcharge
Registrations received by fax, mail or e-mail are subject to an administration surcharge of EUR 20. Therefore,
we encourage you to use the online registration system which is safe, quick and easy and also gives you an
immediate confirmation along with the invoice.
Group Registration
For group registration please contact the Administrative Secretariat ([email protected]) who is
pleased to offer you special group registration facilities. Please do not use the online registration for group
registrations!
Group Registration Form
Goup Registration Policy
On-site Registration
The registration desk at the Cité Centre de Congrès is open during the following hours:
Friday,
12 October 2012
07.30 – 19.00
07.00 – 18.30
07.45 – 18.30
08.15 – 12.00
All documents including registration packets (congress bag, personal name badge, abstract book or CD Rom,
vouchers) will be handed over to the registered participants.
On-site registration will be available but availability of all congress documents cannot be guaranteed. Please
arrive early, if you wish to register on-site.
26
Registration
Payment of Fees
All fees for congress registration and social events should be paid in Euro (€) to the ECTRIMS 2012
Administrative Secretariat – clearly stating the participant’s name and address:
• by bank transfer (free of charge) to
- UBS AG, 4002 Basel / Switzerland, Account No. 233-110477.60M (EUR) - Beneficiary: Congrex Switzerland Ltd., ECTRIMS 2012
- IBAN Code: CH40 0023 3233 1104 7760 M
- BIC: UBSWCHZH80A
• by credit card (Visa, Mastercard, American Express)
Confirmation
Upon receipt of the correct registration fee, each participant will receive a confirmation of registration.
Please bring this confirmation to the registration desk at the congress centre as proof of your registration.
Cancellation / Refund Policy
Refund of registration fees, less 25% administrative charges, can be applied for in writing until 31 August
2012 to the Administrative Secretariat in Basel, Switzerland. After this date no refund will be possible.
For any change of names, a fee of € 30 will be charged. On-site changes of name badges due to incorrect
submission of names and/or address data will be charged at € 10.
Responsibility
The participant acknowledges that he / she has no right to lodge damage claims against the organisers
should the holding of the congress be hindered or prevented by unexpected political or economic events
or generally by force majeure, or should the non-appearance of speakers or other reasons necessitate
programme changes. With registration, the participant accepts this proviso.
Information
For further information and group registration please contact:
ECTRIMS 2012
P.O. Box
27
Phone Fax E-mail Web
+41 61 686 77 77
+41 61 686 77 88
[email protected]
www.ectrims.eu/2012
Hotel Accommodation
and Travel Booking
Official Travel Agency
ECTRIMS has appointed Congrex Travel Ltd. to serve as the official agent for accommodation and travel.
Hotel Accommodation:
Congrex Travel Ltd.
P.O. Box
Travel Bookings:
Congrex Travel Ltd.
P.O. Box
Phone
Fax
E-mail
Phone
Fax
E-mail
+41 61 690 94 11
+41 61 690 94 14
[email protected]
+41 61 560 75 60
+41 61 690 92 14
[email protected]
Hotel Accommodation
Hotel rooms in various price categories in the city of Lyon and nearby cities have been reserved.
Online Reservation
Participants can book their hotel room online via www.ectrims.eu/2012. Full prepayment by credit card
is mandatory. Each participant will receive a confirmation. After 15 August 2012 hotel accommodation is
subject to availability. In addition, a late reservation fee of E 30.– will be charged.
Manual Registration Processing Surcharge
Hotel bookings received by fax, mail or e-mail are subject to an administration surcharge of E 20. Therefore,
we encourage you to use the online hotel booking system that is safe, quick and easy and also gives you an
immediate confirmation.
Payment Policy
To guarantee your reservation a deposit of E 200 is required. Please include either a copy of your bank transfer, your credit card details or a cheque made payable to Congrex Travel Ltd. Hotel requests without payment
can not be accepted. All requests will be handled on a “first come-first served basis”.
Cancellation and Refund Policy
If your hotel reservation is cancelled until 15 August 2012, the deposit will be refunded less E 60 handling
fee. If your reservation is cancelled after 15 August 2012 or if you arrive later or leave earlier than indicated
on your reservation, the total accommodation amount will be charged and no refunds can be made. Any
change of reservation will be subject to a handling fee of E 30. Changes or cancellations have to be made
in writing. The hotels will not accept direct changes.
Hotel Desk
Congrex Travel Ltd. will be present with a desk in the registration area during the conference.
28
Hotel Accommodation
and Travel Booking
Flight Bookings
The ECTRIMS has designated event-travel specialist Congrex Travel to serve as the official agent for travel.
Congrex Travel offers reduced airfares for participants attending the 28th ECTRIMS in Lyon. These special
fares are available for flights to Lyon and back between 3 October and 20 October 2012. Savings of up to
20% are possible, depending on the route and availability.
Book online at www.ectrims.eu/2012 or contact Congrex Travel:
Congrex Travel Ltd.
P.O. Box
Opening hours: 8 am – 5.30 pm, Monday – Friday
29
Phone
Fax
E-mail
+41 61 560 75 60
+41 61 690 94 14
[email protected]
Social Events
Welcome Reception
20.00 – 23.00
We are pleased to invite you to the official Welcome Reception of the 28th Congress of ECTRIMS 2012. The
event will take place at the Halles de Lyon – the city’s largest gourmet indoor market. Since 1971 this
gastronomical hub gathers the “crème de la crème” of Lyon’s food vendors and contributes to the city’s
international reputation for fine French cuisine.
Amongst the numerous market stalls you will find butchers, greengrocers, oyster sellers, cheese makers,
wine sellers and bakers, all defending with fervour and conviction the exquisite taste of their various wares
to epicurean customers. We invite you to take a stroll at Les Halles de Lyon, enjoy the atmosphere and taste
the various delicacies Lyon has to offer.
Price: free of charge, registration is compulsory
Conference Dinner
20.30 – 23.00
The official Conference Dinner will be held at La Sucrière. In the 1930s the building was used as a sugar
warehouse and has now been renovated while retaining its original character. Its unique concept makes
La Sucrière an exceptional and atypical venue.
The building is situated on the Docks in Lyon’s new and trendy La Confluence district. While the area was
formerly dedicated to the needs of a bustling shipping and supply industry, it is today increasingly home to
communication and media company headquarters, institutions, trendy bars, restaurants and art galleries.
La Sucrière now serves as a flagship of the area and hosts various events, art exhibitions and fashion shows.
Price: € 70 per person
© F. Schaff - Lyon People
Reservations for the Welcome Reception and the Conference Dinner must be made online.
30
Important Addresses
and Dates
Important Addresses
Scientific Secretariat
Prof. Christian Confavreux
Hôpital Neurologique Pierre Wertheimer – GHE
Neurology A Department
59 Boulevard Pinel
69677 Bron cedex / France
ECTRIMS 2012
P.O. Box
Phone Fax E-mail Phone
Fax
E-mail
Web
+33 47 268 13 10
+33 47 235 75 25
[email protected]
+41 61 686 77 77
+41 61 686 77 88
[email protected]
www.ectrims.eu/2012
Official Agent for Accommodation and Travel
Hotel Accommodation
Congrex Travel Ltd.
P.O. Box
Flight Bookings
Congrex Travel Ltd.
P.O. Box
Phone
Fax
E-mail
Phone
Fax
E-mail
+41 61 690 94 11
+41 61 690 94 14
[email protected]
+41 61 560 75 60
+41 61 690 92 14
[email protected]
Important Dates
23 May 2012 Mid July 2012
15 August 2012 October 2012
10 – 13 October 2012
31
Deadline for submission of abstracts
Notification of abstract authors
Deadline for early registration fee
Publication of Final Programme
28th Congress of the European Committee for Treatment and Research in
Multiple Sclerosis
Abstracts
Deadline for the submission of abstracts is 23 May 2012 (online submission only). For detailed instructions
please refer to page 23.
ECTRIMS 2012
P.O. Box
Phone Fax E-mail Web
+41 61 686 77 11
+41 61 686 77 88
[email protected]
www.ectrims.eu/2012
Application for Mobile Devices
The application will allow participants to navigate through the entire ECTRIMS programme from their mobile
device, view sessions by day and category, access the abstracts being presented, locate exhibitors through
the interactive map and directory and to create a personalised itinerary. The application will be available for
download in October 2012.
Cameras and Recordings
Cassette recorders, cameras and video cameras are prohibited in lecture halls during all sessions.
CME Credits
The 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis is seeking
accreditation by the European Accreditation Council for Continuing Medical Education (EACCME) to provide CME credits for medical specialists. The EACCME is an institution of the European Union of Medical
Specialists (UEMS, www.uems.be). EACCME credits are recognised as Physician’s Recognition Award by the
American Medical Association.
Serono Symposia International Foundation has submitted, in compliance with the procedures indicated by
the Italian Ministry of Health, the main conference programme, entitled “28th Congress of the European
Committee for Treatment and Research in Multiple Sclerosis” for CME accreditation to the Italian National
Commission for Continuing Medical Education. The accreditation is valid for the Teaching Courses and the
main congress programme only and does not cover the company-sponsored symposia.
Congress Venue
The ECTRIMS 2012 meeting will take place at the Lyon Convention Centre which is situated in a beautiful
setting between the River Rhone and the Parc de la Tête d’Or. The building has been designed by famous
architect Renzo Piano and offers newly built spaces and modern facilities.
Lyon Convention Centre (Cité Centre de Congrès)
50 Quai Charles de Gaulle
69463 Lyon cedex 06
France
www.ccc-lyon.com
32
Currency
All official prices are indicated in Euro (€). The official currency in France is the Euro. All major credit cards
are accepted in most hotels, restaurants and shops.
Exhibition
During the congress an industrial exhibition will be arranged. Companies from all over the world will be
given ample opportunity to display their latest products, services and technical innovations. The exhibition
will be located in Forums 4, 5 and 6 in immediate vicinity to congress activities such as lecture halls and
catering areas. The detailed exhibit prospectus can be obtained from:
ECTRIMS 2012
Exhibition Department
P.O. Box
Phone
Fax
E-mail
+41 61 686 77 77
+41 61 686 77 88
[email protected]
Final Programme
The final programme will be available online in October 2012. It will also be distributed to all participants
upon registration together with the other congress documents. Please visit the ECTRIMS 2012 website
which includes continuously updated information:
www.ectrims.eu/2012
Insurance
The congress organisers cannot accept liability for personal injuries sustained, or for loss or damage of
property belonging to conference participants, either during, or as a result of the meeting. Please check the
validity of your own insurance.
Invitation Letters
Individuals requiring an official letter of invitation in order to attend the meeting may write to the Administrative Secretariat. This procedure is designed to assist participants to obtain a visa or permission to attend
the meeting and does not apply to registration fees or other expenses.
Please note that invitation letters can only be sent if the registration and the respective
payment have been received by the Administrative Secretariat.
Language
The congress language is English. Simultaneous translation will not be provided.
Lunch
Lunch will be served in the exhibition area of the congress venue from Wednesday to Saturday.
33
Official Italian Agency
Italian participants requiring specific authorisation from the Italian Health Ministry are advised to contact:
TWT
Ms Romina Baldolini
Via Cagliari 13
00198 Rome / Italy
Phone
Fax
E-mail
+39 06 442 493 21
+39 06 442 493 27
[email protected]
Poster Exhibition
The poster exhibition will be situated close to the industrial exhibition in the Foyers of Forums 1 – 6 of the
Lyon Convention Centre. Information regarding poster format, set-up and dismantling times will be sent to
the authors along with their notification of acceptance in mid July 2012.
Press
Accredited journalists are welcome to cover the ECTRIMS 2012. Please request the registration form at
[email protected] and clearly mark “Press”, together with a letter asking for accreditation. You will also
be requested to show your press identification upon registration. A fully equipped press centre will be at
your disposal during the ECTRIMS 2012.
Registration
For detailed information please refer to page 26.
Speakers’ Service Centre (SSC)
There will be a centrally located Speakers’ Service Centre connected to all lecture halls. All speakers will be
asked to hand in their PowerPoint presentations at the SSC at least 1 hour before their lecture.
Transportation in Lyon
The dense TCL (Transports en Commun Lyonnais) network allows rapid and easy transportation from one
place to another in the city and its suburbs. Please refer to “Travel Information” for more details (page 36).
WLAN
WLAN access will be available to participants throughout the congress venue. This service is sponsored
by Novartis Pharma AG and access codes can be obtained from the Novartis booth in the industrial
exhibition.
Visa Requirements
In order to visit France you may need to apply for an entry visa. Please check the website of the Ministry of
Foreign Affairs (www.diplomatie.gouv.fr). The website will provide you with visa information. Please be well
aware of the time needed for processing visa applications in order to ensure you apply in sufficient time for
your visit.
34
The City of Lyon
Lyon is the second largest city in France and has a history dating back over more than 20 centuries.
Established by the Roman Emperor Augustus in 1BC as the capital city of the Gauls, it rapidly became one
of the major economic, military, religious and political centres in France over the following centuries. Its
location at the confluence of Rhone and Saone rivers enabled the town to develop major trading activities.
As a result Lyon became the birthplace of the French silk industry, producing refined pieces of this precious
fabric for the court of Louis XIV.
Ever since the Middle Ages Lyon has been considered the French capital of gastronomy. Today this is
illustrated by the impressive number of restaurants within the city and surrounding area, ranging from the
famous bouchons (typical local eateries) to Michelin star-awarded establishments. Lyon is also home to the
internationally renowned chef Paul Bocuse and his celebrated restaurants. Serving as a stage for more than 2’000 years of history, the city has a remarkable architectural heritage.
Expanding towards the east throughout the centuries, without destroying the existing areas, 500 hectares
of its city centre became a Unesco World Heritage Site in 1998. Wandering around Lyon is like embarking
on a fascinating journey through time.
As for culture, the National Opera, one of the 20 most prestigious ballets in the world, and the Célestins
Theatre offer an ambitious programme all year round. Furthermore, the city has museums that exist nowhere
else in the world, such as the Lumière Institute, the Fabric Museum, the Lyon History Museum, the Fine Arts
Museum and the Puppets of the World Museum.
Thanks to a number of events hosted in Lyon, the city is vibrant all year round. Among the most appealing
are the Festival of Lights, the Contemporary Art Biennial Event, the Dance Biennial Event, the Nuits Sonores
(music and sound festival), the Nuits de Fourvière (cultural festival), Quais du Polar (Thriller festival) and the
latest addition, the Grand Lyon Film Festival, all attracting millions of visitors each year.
Bolstered by its past but resolutely focused on the future, the city abounds with a number of ambitious
projects, among which the Confluence district, one of the biggest town planning development projects in
Europe, which is gradually taking shape.
For more information on Lyon’s sites, shopping and restaurants please visit www.en.lyon-france.com
35
Travel Information
Free airport shuttle bus
On Wednesday, 10 October 2012 from 7.00 –14.00h as well as on Saturday, 13 October 2012 from
10.00 – 14.00h a free shuttle service will be in operation between the airport and the Lyon Convention
Centre.
Travel Information
The Lyon Convention Centre is located approximately 30 minutes from Lyon Saint Exupéry Airport by car, taxi
and public transport. Visit www.lyonaeroports.com for up-to-date flight information, airport services and
connections to the convention centre.
Rhone Express
The Rhone Express connects the airport to Lyon’s train station Part-Dieu which is the main train hub in the
city centre. The journey is less than 30 minutes and allows travel without risk of congestion.
For information and timetables please consult www.rhonexpress.fr
Busses
Bus lines C1 and C2 directly connect Part-Dieu station to the Lyon Convention Centre (Stop: Cité International). The journey takes about 10 minutes. Lines C4 and C5 connect different stations within Lyon with the
convention center. Various other bus lines allow convenient travel within the city of Lyon. For details and
timetables, please refer to www.tcl.fr
Trains
Frequent time schedules allow travel to various destinations via TGV within France. Trains can be boarded at
Part-Dieu or directly at the airport’s train station which lies within 5 minutes walking distance of the terminal
building. For details and timetables please refer to www.sncf.com
Coaches
The coach station within the airport terminal links Lyon Saint Exupéry to various destinations within the
Rhône-Alp region. For details and timetables please refer to www.lyonaeroports.com (link “Access & car
parks” then “Buses”)
Ticket for public transportation
ECTRIMS delegates will be able to use the public transport system free of charge. Onsite, delegates will
receive a ticket together with the congress documents which is valid for all means of public transportation
within the city of Lyon.
The travel card is valid for all congress days on the entire TCL transport network. Upon the first journey, the
card has to be validated by touching it on a card reader. Each time you enter a station or board a bus or
tram, you need to “check-in” and “check-out” by touching the card reader.
This service is sponsored by
Partenaire
36
The Lyon Convention Center –
Floor Plan
LEVEL 3
ROSERAIE
LEVEL 2
GRATTE-CIEL
LEVEL 2
SAINT-CLAIR
Salon
Pasteur
Salle Rhône 3
LEVEL 1
TÊTE-D’OR
Auditorium
Pasteur
LEVEL 1
SALLE RHÔNE 3
M
En ain
tra
nc
e
L’Amphithéâtre
(Main Auditorium)
GROUND LEVEL
CORDELIERS
LEVEL -1
BELLECOUR
Registration &
Secretariat
LEVEL -1
LUMIÈRE
FORUM 2+3
Industrial Exhibition
LEVEL -2 FORUMS
Lecture halls
Industrial exhibition
37
GROUND LEVEL
TERREAUX
LEVEL -2 FORUMS
Auditorium Lumière
Poster exhibition
Meeting rooms
ÉR
10
PH
e
RI
ôn
PÉ
MO
NT É
7
E D
E
LA BOU
CL
Sa
36
4
13
CUIRE
C
18
Centre de Congrès
E
C
36
36
FOCH
EVELT
S F. ROOS
RÈ
UR
JAU
CO
E
53
E
NU
JEA
N
AV
E
UE
AG
III
NU
E
JEA
42
ST-PRIEST
LAËNNEC
N
ME
RM
aéroport
Saint Exupéry
OZ
17
BOU LEVARD
IS
36
MINGUETTES
36
38
PIN EL
SURVILLE
Route de Vienne
38
Ambroise Paré
MERMOZ PINEL
-UN
STADE DE GERLAND
12
NE
Rockfeller
Facultés
Médecine,
Pharmacie
S
AT
ÉT
États-Unis
MINGUETTES
38
28
28
S
AV E
N
SS
38
Maison de la Danse
DE
Parc de Gerland
CA
AV E
D
10
MEYZIEU Z.I.
Bachut-Mairie du 8e
Parc Relais
Stade de Gerland
ST-GENIS-LAVAL
T
AR
EV
B
Bus
LO
S
Institut Lumière
UL
12
V IEN NE
Faculté Lyon I
LA
Jean XXIII
Maryse Bastié
HE
RÈ
GRANGE BLANCHE
Villon
RT
1 11
MONPLAISIR
LUMIÈRE
AS
Jet d'eau
Mendès France
DEBOURG
Tramway
OM
Monplaisir
BE
39
Halle Tony Garnier
14
TH
RT
BO
A7
NU
DE
UR
BE
BONNEVAY
Ï
Reconnaissance
Balzac
XX
AV E
S
S
LE
MÉ
CL
TR
ER
Route de Vienne
TE
Ecole Normale Supérieure
SA
L
JAU
N
11
S TO
Montchat 32
E
AY
T2
RO U
Gerland
Métro
Campus
universitaire
MW
NU
SANS SOUCI
Manufacture
des Tabacs
Faculté Lyon III
54
PLACE
JEAN JAURÈS
UR
Parc Relais
TRAMWAY T3
Dauphiné
Lacassagne A
VE
TA
Garibaldi
Berthelot
O B
C
10
51
TP
AST
E
OD
ET
E
6
e n s er v ice dé c e m b re 2 00
M is e
11
JEA
FAU R E
FÉ LI X
UE
AV E N
CO
12
PON
TR
RU
47
36
E
MA
LE
TRA
19
38
500 m
12
12
0
MÉ
MB
JEAN MACÉ
25
Montrochet
N
GA
4 11 18
Ste-Blandine
18
GARIBALDI
Centre Berthelot
Suchet
AR
CH
Confluent
RS
45
52
T2
AY
T1
GN
26
MW
Quai
Claude Bernard
44
28
J
36
FRANCHEVILLE
Findez
30
TRA
l'Université
56
1
TO L
TR EA
AM N
W
AY
30
CH
T
30
AN
8
11
35
Rue de
50
20
37
Part-Dieu Servient
URS
15
22
ME RL E
41
A
PERRACHE
21
CO
49
VI VI ER
D
57
CO
U
SaintAndré
46
A
1
LAFAYETTE
COURS
GARE PART-DIEU
C
B D
Guillotière
2
GRATTE-CIEL
A
Gratte-Ciel
Thiers-Lafayette
TRAMWAY T1
SAXE GAMBETTA
12
Les Quais
Facultés Lyon I,
Lyon II, Lyon III
11
36
Victor Hugo
RO
L. BONNEVAY
Bourse du Travail
28
MÉ T
Z O LA
Collège Bellecombe
PLACE GUICHARD
O B
AMPÈRE
4
GUILLOTIÈRE
1
28
Liberté
Université
catholique
T
CO
29
28
Saxe-Préfecture
10 12 30 A D
É M IL E
D
Place
Bellecour
24
Villeurbanne
CO U R S
B
40
Palais de Justice
Mairie du 3e
BELLECOUR
RÉPUBLIQUE
A B
BROTTEAUX
4 18
AN
MÉTRO A
28
théâtres romains
9
MÉ T R
E
ST JUST
30
AR
16
MINIMES
ÈR
Charles Hernu
BD
VI
28
CORDELIERS
23VILLEURBANNE
Le Tonkin
31
VITTON
LYON
LAFAYETTE
4 1
1 18
UR
cathédrale St Jean
D
1 18
CLINIQUE
DU TONKIN
Brotteaux
COURS
28
FO
30
Cathédrale
VIEUX LYON
30
DE
RO
6 Presqu’île
38
38
EL
MÉ T
13 A C
SA XE
NN
33
DE
TU
HÔTEL DE VILLE
Place des
Terreaux
3
FOURVIÈRE
DU
RU E
La Doua
Gaston Berger
Condorcet
13
Croix Luizet
INSA-Einstein
1
AY T
EV
AR
1
AV EN UE
ST PAUL gare
GORGE DE LOUP
Parc Relais
MM
CR
COURS
MW
CHARPENNES
ES
Parc Relais
UL
Opéra national
C
27
LG
MASSÉNA
4
CROIX-PAQUET
BE
IUT-Feyssine
BO
18
13
S
C
13 18
CO
TRA
DE
O
CROIX - RO
US SE
13
BOU LEVARD
TR
DE
CROIX-ROUSSE
TU NN EL DE
LA
VALMY
Vaise 55
BD
AY
EV
38
MÉ
18
36
Parc de la Tête d’Or
P
CH ONT
UR W
CH .
ILL
Croix-Rousse
36
D
NN
Campus de la Doua
Université Lyon 1
HENON
BO
T
38
Parc Relais
12
43
5
BO UL E VA R D L
13
GARE DE VAISE
C
EN
AU R
28 38
CROIX-ROUSSE
Nord
IQ
36
34
CITÉ INTERNATIONALE
MONTESSUY
Gutenberg
38
R
UE
NO
Rh
ôn
e
DUCHÈRE
Plateau
STA LING RAD
D
GARE DE
VÉNISSIEUX D
Plan
Hotel
Cat.
Metro (M) / Bus (B) /
Tramway Station (TwS)
1
Le Royal Lyon
2
Sofitel Lyon Bellecour
3
Villa Florentine
4
Best Western du Pont Wilson
5Hilton Lyon
(next to the Lyon Convention Centre)
6
Cour des Loges
7 De la Cité – Concorde Lyon (next to the Lyon Convention Centre)
8
Grand Hotel Mercure Château Perrache
9
Grand Hotel Mercure Saxe Lafayette
10
Lyon Metropole
11
Mercure Lyon Brotteaux
12
Mercure Lyon Charbonnieres
13
Mercure Lyon Charpennes
14
Mercure Lyon Lumière
15
Mercure Lyon Part-Dieu
16
Mercure Plaza Republique
17
NH Lyon Aeroport
18
Novotel Lyon Confluence
19
Novotel Lyon Gerland
20
Novotel Lyon Part Dieu
21
Radisson BLU Lyon
22
All Seasons Lyon Part-Dieu
23
Alliance Hotel Lyon-Villeurbanne
24
Ariana
25
Axotel Perrache
26
Best Western Charlemagne
27
Best Western Saphir Lyon
28
Campanile Lyon Centre
29
Citadines Lyon Part Dieu
30
Citadines Lyon Prequ‘Ile
31
Des Congrès
32
Expotel Lyon-Chassieu
33
Grand Hotel des Terreaux
34
Ibis Lyon Caluire Palais des Congrès
35
Ibis Lyon Centre (Université)
36
Ibis Lyon Centre Perrache
37
Ibis Lyon Gare La Part Dieu
38
Ibis Lyon Gerland Pont Pasteur
39
Ibis Lyon Gerland Rue Merieux
40
Ibis Part Dieu les Halles
41
Mercure Beaux-Arts
42
Résidence Odalys Bioparc
43
Résidence Temporim Cité Internationale
44
Résidence Temporim Part Dieu
45
ResidHotel Lyon Part Dieu
46
APPART‘CITY
47
APPART‘CITY Lyon
48
APPART‘CITY Lyon lll 1
49
Campanile Lyon Part-Dieu
50
Campanile Lyon Perrache
51
Kyriad Lyon Centre Perrache
52
Premiere Classe Part Dieu
53
Résidence OTELIA
54
Séjours & Affaires Park Avenue
55
Séjours & Affaires Park Lane
56
Séjours & Affaires Saint-Nicolas
57
Séjours & Affaires Saxe-Gambetta
5
5
5
4
4*
M: Bellecour
M: Bellecour
Gare: Saint-Paul
TwS: Liberté
1 minute by foot
4
4*
Gare: Saint-Paul
1 minute by foot
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
M: Perrache
TwS: Saxe-Préfecture
M: Cuire
M: Brotteaux
Gare:Arrêt des Flachères
M: Charpennes
M: Sans Souci
Gare: de la Part-Dieu
M: Bellecour
TwS:Aéroport Lyon Saint-Exupéry
TwS: Montrochet
M: Debourg
TwS: Part-Dieu – Servient
TwS: INSA – Einstein
TwS: Centre Berthelot
TwS: Suchet
TwS: Suchet
M: Gorge de Loup
M: Guillotière
TwS: Palais de Justice
M: Cordeliers Bourse
TwS: Le Tonkin
n/a
M: Hôtel de Ville – Louis Pradel
n/a
M: Jean Macé
M: Perrache
M: Place Jean Jarès
M: Stade de Gerland
TwS: Part-Dieu – Servient
M: Bellecour
M: Laennec
5 minutes by foot
M: Flachet
M: Bellecour
TwS/Gare: Part-Dieu
M: Perrache
TwS: Sainte-Blandine
TwS: Route de Vienne
M: Place Jean Jarès
M: Valmy
M: Saxe-Gambetta

preliminary programme

Transcription

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