research grants 2011-2012.xls
Transcription
research grants 2011-2012.xls
GRANTS AND BURSARIES APRIL 1, 2011 - MARCH 31, 2012 NAME AGENCY Operating Grants & Awards TITLE JGH Totals (External grants & career awards) Medicine Totals (External grants & career awards) Medicine - Totals Career Awards 38,329,515 26,298,065 23,906,008 Industrial Contracts 2,392,057 Université McGill Université McGill Institut National du Cancer du Canada Alaoui-Jamali, Moulay Alaoui-Jamali, Moulay Alaoui-Jamali, Moulay Alaoui-Jamali, Moulay Alaoui-Jamali, Moulay Alaoui-Jamali, Moulay Société Canadienne du Cancer Fondation du Cancer du Sein du Québec Fondation du Cancer du Sein du Québec Société Canadienne du Cancer Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Aloyz, Raquel Silvia Aloyz, Raquel Silvia Leukemia & Lymphoma Society of Canada Leukemia and Lymphoma Society Aloyz, Raquel Silvia Leukemia and Lymphoma Society Aloyz, Raquel Silvia Instituts de Recherche en Santé du Canada Assouline, Sarit Fonds de la Recherche en Santé du Québec 8,334 Assouline, Sarit Fonds de la Recherche en Santé du Québec 26,089 Assouline, Sarit Fonds de la Recherche en Santé du Québec 2,473 Assouline, Sarit Fonds de la Recherche en Santé du Québec 7,534 Autexier, Chantal Autexier, Chantal Université McGill Université McGill Autexier, Chantal Autexier, Chantal Autexier, Chantal Autexier, Chantal Autexier, Chantal Autexier, Chantal Investigation of the filamin signaling network's function in cancer progression. Mechanisms of Dasatinib mediated cytotoxicity in CLL cells. Assessment of a telomerase inhibitor in chronic lymphocitic leukemia (CIL). Assessment of a telomerase inhibitor in chronic lymphocitic leukemia (CIL). Mechanisms of dasatinib cytotoxicity and sensitilzation therapy in chronic lymphocytic leukemia. Telomerase structure and function. Ph.D. Program in Experimental Medicine / A McGill CIHR Drug Development Training Program Scholarship. Université McGill Faculty of Medicine Internal Studentship Awards - Ruth and Alex Dworkin Fellowship. Fonds de la Recherche en Santé du Québec Mécanismes impliqués dans la sensibilisation de cellules cancéreuses à des agents chimiothérapeutiques par l'expression d'un composant ARN mutant de la télomérase Université McGill Ph.D. Program in Experimental Medicine / A McGill CIHR Drug Development Training Program Scholarship. Fonds de la Recherche en Santé du Québec Structure, fonction et régulation de la télomérase: éléments clés controllant la prolifération et le vieillissement cellulaire Fonds de la Recherche en Santé du Québec Structure, fonction et régulation de la télomérase: éléments clés controllant la prolifération et le vieillissement cellulaire Instituts de Recherche en Santé du Canada Investigation of telomere and telomerase regulation by associated proteins and in primary malignant lymphocytes. Instituts de Recherche en Santé du Canada Supramolecular complexes as G-quadruplex binders: Towards effective telomerase inhibition. Clinical Research Awards 5,602,948 Alaoui-Jamali, Moulay Alaoui-Jamali, Moulay Alaoui-Jamali, Moulay Autexier, Chantal Study of the function of Rab-GTPase in breast cancer. Study of the function of Rab-GTPase in breast cancer. Mechanism of gap junction downregulation in mammary tumor cells and potential therapeutic implications in breast cancer. External Grants 4,996,075 Foundation 7,331,612 168,000 1,300,350 2,421 2,721 11,620 31,525 37,500 75,000 96,062 133,514 156,832 3,500 63,985 64,160 92,194 859 1,462 4,176 4,945 7,527 17,765 32,277 32,430 17,277 8/15/2012 ‐ 1 NAME AGENCY Autexier, Chantal Batist, Gerald Batist, Gerald Batist, Gerald Batist, Gerald Batist, Gerald Batist, Gerald Institut de Recherche de la Société Canadienne du Cancer Institut de Recherche de la Société Canadienne du Cancer Instituts de Recherche en Santé du Canada Telomerase structure and function. Conseil de Recherches en Sciences Alexander Graham Bell Canada Graduate Scholarship. Naturelles et Génie du Canada Fonds de la Recherche en Santé du Québec Développement et validation d'un système intégré pour évaluer la fatigue liée à la sclérodermie Instituts de Recherche en Santé du Canada A new emerging team: The Canadian scleroderma research group. Instituts de Recherche en Santé du Canada Meeting of the Canadian Consortium of Rheumatology Cohorts (CANCoRC) Instituts de Recherche en Santé du Canada Meeting of the Canadian Consortium of Rheumatology Cohorts (CANCoRC) Regroupement de Particuliers Instituts de Recherche en Santé du Canada Strategic training initiative - Canadian Scleroderma Research Group. Friedrich Ebert Stiftung Cul3 and ahr interaction in chemoresistance. Université McGill Studies in anti-cancer therapeutics resistance. Instituts de Recherche en Santé du Canada Phase 2 trial of aminoflavone for breast cancer. Université McGill Hematobilliary surgery. Regroupement de Particuliers Imaging facility. Fonds de la Recherche en Santé du Québec Batist, Gerald Batist, Gerald Batist, Gerald Batist, Gerald Batist, Gerald Regroupement de Particuliers Regroupement de Particuliers Regroupement de Particuliers Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Autexier, Chantal Autexier, Chantal Baron, Murray Baron, Murray Baron, Murray Baron, Murray Baron, Murray Baron, Murray Baron, Murray Batist, Gerald Batist, Gerald Batist, Gerald Batist, Gerald Batist, Gerald Batist, Gerald Beitel, Lenore Beitel, Lenore Beland, François Beland, François Beland, François Beland, François TITLE Oncology Research Imaging facility. Research pathology facility. 2nd Québec Conference on Therapeutic Resistance in Cancer Fonds de la Recherche en Santé du Québec Étude prospective pour identifier et valider des biomarqueurs de résistance thérapeutique dans le cancer colorectal métastatique Princess Margaret Hospital Foundation Ride 2009 Royalty collaborative research. Research Foundation Sir Mortimer B. Davis, A randomized phase III study of standard treatment +/Jewish General Hospital enoxaparin in small cell lung cancer, RASTEN study Canadian part. Fonds de la Recherche en Santé du Québec Étude prospective pour identifier et valider des biomarqueurs de résistance thérapeutique dans le cancer colorectal métastatique Amgen Canada Inc (Mississauga, Ont) Colorectal Cancer New Treatments (AMG). Regroupement de Particuliers Translational Research Center. Réseau des Centres D'excellence Fédéral Opto-Impedimetric Screening of Blood-borne Pathogens. Réseau des Centres D'excellence Fédéral Opto-Impedimetric Screening of Blood-borne Pathogens. Instituts de Recherche en Santé du Canada Qualité des soins lors des transitions des personnes âgées atteintes de maladies chroniques: une analyse des injections et des pratiques de gestion cliniques. Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Ministère de la Santé et des Services Sociaux (Québec) External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 31,414 95,724 121,604 35,000 1,069 9,424 16,758 20,133 93,278 151,500 539 1,170 2,834 12,603 1,955 3,163 4,017 4,667 4,780 5,531 8,750 17,666 46,000 70,000 71,450 238,771 245,136 6,233 18,819 13,611 2,257 3,656 26,556 8/15/2012 ‐ 2 AGENCY Beland, François Ministère de la Santé et des Services Sociaux FRELE: Fragilité, une étude longitudinale de ses expressions (Québec) et acces, utilisation et couts des services sociaux et de sante associes aux profils et trajectoires de fragilite. 92,320 Beland, François Bergman, Howard Instituts de Recherche en Santé du Canada CIHR Team in frailty and aging Fonds de la Recherche en Santé du Québec Le processus décisionnel concernant les choix de traitement chez les personnes âgées atteintes d'un cancer colorectal Instituts de Recherche en Santé du Canada Ministère de la Santé et des Services Sociaux FRELE: Fragilité, une étude longitudinale de ses expressions (Québec) et acces, utilisation et couts des services sociaux et de sante associes aux profils et trajectoires de fragilite. 105,628 Bergman, Howard Bergman, Howard Bergman, Howard Billick, Robin Blank, Volker Instituts de Recherche en Santé du Canada Acker Finley Inc. Instituts de Recherche en Santé du Canada Regroupement de Particuliers Université McGill 30,368 116,679 286,837 4,641 Blank, Volker Blank, Volker Instituts de Recherche en Santé du Canada Université McGill Blank, Volker Blank, Volker Blank, Volker Blank, Volker Blank, Volker Université McGill Université McGill Université McGill Conseil de Recherches en Sciences Naturelles et Génie du Canada Fondation du Cancer du Sein du Québec Blank, Volker Blostein, Mark Blostein, Mark Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Pharmacogenomic Study of Warfarin. Fondation des Maladies du Coeur du Québec Role of gas6 in vascular biology. 99,413 2,100 4,945 Blostein, Mark Fondation des Maladies du Coeur du Québec Role of gas6 in vascular biology. 12,055 Blostein, Mark Instituts de Recherche en Santé du Canada 15,053 Blostein, Mark Blostein, Mark Instituts de Recherche en Santé du Canada National Institutes of Health Cen, Shan Université McGill Cen, Shan Instituts de Recherche en Santé du Canada Chalifour, Lorraine Conseil de Recherches en Sciences Naturelles et Génie du Canada Bergman, Howard Bergman, Howard TITLE External Grants NAME CIHR Team in frailty and aging Ronald Oberlander Fellow. Dermatology Research. Cytokine-induced expression of mafF transcription factor in myometrial cells. Analysis of novel regulators of erythroid differentiation. Role of the MafF transcription factor in uterine and breast cancer cells. Role of Nrf3 transcription factor in carcinogenesis. The role of CNC transcription factors in carcinogenesis. Role of Nrf3 transcription factor in carcinogenesis. Regulators mediating the proinflammatory cytokine response in uterine smooth muscle cells. Contrôle de l'invasion de cellules de sein cancéreuses par des facteurs de transcription de type CNC. A double-blind, randomized control trial of post-operative low molecular weight heparin bridging therapy versus placebo bridging therepy for patients who are at high risk for arterial thromboembolism. Role of Gas6 in Vascular Biology U01HL087229 - Bridging anticoagulation in patients who Require temporary Interruption of warfarin therapy for an elective invasive proceDure or surGEry(BRIDGE) trial. Mechanisms of how vif efficiently protects HIV-1 from the attack of hA3G. The potential of APOBEC3G in the development of a novel anti-HIV-1 therapeutic. The potential of APOBEC3G in the development of a novel anti-HIV-1 therapeutic. Hemovascular Research. Career Awards Industrial Contracts Clinical Research Awards Foundation 10,998 11,850 15,388 1,130 1,750 2,000 2,635 6,000 9,033 25,000 29,610 126,395 2,382,886 5,011 81,998 4,500 8/15/2012 ‐ 3 NAME AGENCY Chalifour, Lorraine Fondation des Maladies du Coeur du Québec Endocrine disruptor re-programming of the heart: mechanism and implications for the progression to disease. Conseil de Recherches en Sciences Naturelles et Génie du Canada Instituts de Recherche en Santé du Canada Steroidal hormone programming in heart. Université de Montréal Pilot project: characterizing atypical dementias with multimodal neuroimaging. Instituts de Recherche en Santé du Canada Alzeimer's disease cooperative study - project #1. Instituts de Recherche en Santé du Canada Anomia in Alzeimer's Disease: Untangling sematic components and delivering therapy with rTMS. National Institutes of Health A randomized, double-blind, placebo-controlled, two dosearm, parallel study of the safety and effectivenes of Immune Globulin Intravenous (Human), 10% (IGIV, 10%) for the treatment of mild-to moderate Alzheimer's Disease. Instituts de Recherche en Santé du Canada Create the Canadian dementia knowledge translation network (CDKTN). National Institutes of Health Clinical assessment of patients with AD and NEC individuals. Instituts de Recherche en Santé du Canada Diagnosis, localization, and treatment of semantic memory impairment in Alzheimer's Disease. Instituts de Recherche en Santé du Canada Establishing prognostic subgroups in mild cognitive impairment. Regroupement de Particuliers Bronfman Foundation. Research Foundation Sir Mortimer B. Davis, High sensitivity blood test for early detection of colorectal Jewish General Hospital cancer. Research Foundation Sir Mortimer B. Davis, Fast-tracking genetic testing for BRCA1 and BRCA2 in Jewish General Hospital selected Montreal populations. Regroupement de Particuliers Inflammatory bowel disease. Merck Frosst Canada Inc IBD educational fund. Regroupement de Particuliers Gastroenterology Research. Janssen-Ortho Inc. Fellowship - IBD training. Instituts de Recherche en Santé du Canada Fondation Canadienne du Rein Max Bell Foundation Regroupement de Particuliers Microbiology Research. Ontario Neurotrauma Foundation Université McGill Patient Empowerment Newsletter. Université McGill Comparing the safety and efficacy of new oral anticoagulants versus warfarin for patients with atrial fibrillation: a systematic review and meta-anaylysis. Université McGill A systematic review of the cardiovascular and vascular risk related to combined oral contraceptives. Fonds de la Recherche en Santé du Québec Prévention Secondaire Chez Les Patients Ayant Subi Un Syndrome Coronaire Aigu Fonds de la Recherche en Santé du Québec Prévention Secondaire Chez Les Patients Ayant Subi Un Syndrome Coronaire Aigu Instituts de Recherche en Santé du Canada The safety of combined oral contraceptives: a systematic review and meta-analysis. Fondation des Maladies du Coeur du Québec The efficacy of weight loss interventions: a systematic review and hierarchical Bayesian meta-analysis. Instituts de Recherche en Santé du Canada Unconventional Smoking Cessation Aids: A Meta-Analysis of Randomized Controlled Trials. Génome Québec Cell therapy of cystinonsis Génome Québec Cell therapy of cystinonsis Chalifour, Lorraine Chalifour, Lorraine Chertkow, Howard Chertkow, Howard Chertkow, Howard Chertkow, Howard Chertkow, Howard Chertkow, Howard Chertkow, Howard Chertkow, Howard Chertkow, Howard Chong, George Chong, George Cohen, Albert Cohen, Albert Cohen, Albert Cohen, Albert Cohen, S Robin Cohen, S Robin Cohen, S Robin Dascal, André De Marchie, Michel Eisenberg, Mark Eisenberg, Mark Eisenberg, Mark Eisenberg, Mark Eisenberg, Mark Eisenberg, Mark Eisenberg, Mark Eisenberg, Mark Eliopoulos, Nicoletta Eliopoulos, Nicoletta TITLE External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 18,836 35,000 111,509 9,000 27,001 27,595 34,255 35,006 53,382 74,921 126,503 550,739 36,822 40,000 23,279 25,507 33,947 50,000 24,730 1,236 22,475 966 917 800 2,384 3,333 7,418 22,603 1,890 4,945 53,626 27,403 32,679 8/15/2012 ‐ 4 NAME AGENCY TITLE Eliopoulos, Nicoletta Instituts de Recherche en Santé du Canada Ernst, Pierre-Paul Ernst, Pierre-Paul Ernst, Pierre-Paul Filion, Kristian Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Richard and Edith Strauss Canadian Foundation Instituts de Recherche en Santé du Canada A study of novel anti-cancer immunomodulatory fusion proteins and transgenic cell therapy. CIHR - Quebec Respiratory Health Training Program Foulkes, William David Fonds de la Recherche en Santé du Québec Foulkes, William David Université McGill Foulkes, William David Ministère du Développement Economique, de l'innovation et de l'exportation (MDEIE) Foulkes, William David Ministère du Développement Economique, de l'innovation et de l'exportation (MDEIE) Foulkes, William David Ministère du Développement Economique, de l'innovation et de l'exportation (MDEIE) Foulkes, William David Foulkes, William David Fondation du Cancer du Sein du Québec Ministère du Développement Economique, de Séquençage de nouvelle génération en génétique moléculaire l'innovation et de l'exportation (MDEIE) pour le cancer du sein héréditaire - une nouvelle stratégie émergente Fondation du Cancer du Sein du Québec Alliance Canadienne Pour La Recherche sur Le Cancer du Sein Instituts de Recherche en Santé du Canada Mendon F. Schutt Family Fund Screening DICER-like families for large deletions in DICER1 or for mutations or deletions of DICER1-like genes. Ministère du Développement Economique, de Séquençage de nouvelle génération en génétique moléculaire l'innovation et de l'exportation (MDEIE) pour le cancer du sein héréditaire - une nouvelle stratégie émergente Fondation du Cancer du Sein du Québec National Institutes of Health PROSTATE CANCER SUSCEPTIBILITY: THE ICPCG STUDY Institute of Cancer Research (Icr) (Uk) IMPACT - Identification of Men with a Genetic predisposition to ProstAte Cancer: Targeted screening in BRCA 1/2 mutation carriers and controls. Société Canadienne du Cancer Correcting splicing in the mismatch repair gene PMS2 as a model for therapy of genetic diseases. Alliance Canadienne Pour La Recherche sur Le Cancer du Sein Société de Recherche sur Le Cancer Inc Dissemination of the creativity and prevention of mental health problems in multiethnic schools Société de Recherche sur Le Cancer Inc A multimodal genomic analysis strategy to identify novel breast cancer genes. Research Foundation Sir Mortimer B. Davis, Establishing a Quebec hereditary colorectal cancer registry. Jewish General Hospital Susan G. Komen Breast Cancer Foundation hereditary Breat Cancer: Cause and Effect. Regroupement de Particuliers Surgical Research. Foulkes, William David Foulkes, William David Foulkes, William David Foulkes, William David Foulkes, William David Foulkes, William David Foulkes, William David Foulkes, William David Foulkes, William David Foulkes, William David Foulkes, William David Foulkes, William David Foulkes, William David Foulkes, William David Foulkes, William David Difficult-to-treat asthma The cardiovascular safety of varenicline: A population-based cohort study. Progression de la caractérisation des cancers héréditaires du sein, colorectal et de la prostate au Québec. Correcting the mismatch repair gene PMSZ as a model for disase therapy. Séquençage de nouvelle génération en génétique moléculaire pour le cancer du sein héréditaire - une nouvelle stratégie émergente Séquençage de nouvelle génération en génétique moléculaire pour le cancer du sein héréditaire - une nouvelle stratégie émergente Séquençage de nouvelle génération en génétique moléculaire pour le cancer du sein héréditaire - une nouvelle stratégie émergente External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 229,515 8,125 10,000 10,584 14,231 3,709 7,527 678 1,517 1,517 2,188 2,758 3,154 4,604 4,978 5,686 6,267 6,563 7,919 11,518 12,363 14,028 17,507 17,507 34,521 41,619 46,777 8/15/2012 ‐ 5 NAME AGENCY TITLE Foulkes, William David Mendon F. Schutt Family Fund Foulkes, William David Susan G. Komen Breast Cancer Foundation Galiatsatos, Polymnia Gatignol, Anne Gatignol, Anne Research Foundation Sir Mortimer B. Davis, Jewish General Hospital Université McGill Université McGill Mutations of DICER1 and miRNA dysregulation as causes of childhood and young adult disease. Systematic characterization of dasatinib sensitivity and resistance in BrCa cells. Accuracy of biopsies for Helicobacter Pylori in the presence of intestinal metaplasia of the stomach. M.Sc. Program in Experimental Medicine Control of the regulation of PKR activcity during HIV infection. Gatignol, Anne Gatignol, Anne Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Gatignol, Anne Instituts de Recherche en Santé du Canada Gatignol, Anne Instituts de Recherche en Santé du Canada Gatignol, Anne Greenaway, Christina Instituts de Recherche en Santé du Canada Fonds de la Recherche en Santé du Québec Greenaway, Christina Fonds de la Recherche en Santé du Québec Greenaway, Christina Fonds de la Recherche en Santé du Québec Greenaway, Christina Fonds de la Recherche en Santé du Québec Greenaway, Christina Instituts de Recherche en Santé du Canada Greenaway, Christina Instituts de Recherche en Santé du Canada Hilzenrat, Nir Regroupement de Compagnies, Corporations Improved care and education for patients with Hepatitis B. Hiscott, John Hiscott, John Université McGill Instituts de Recherche en Santé du Canada Hiscott, John Hiscott, John Institut National du Cancer du Canada Instituts de Recherche en Santé du Canada Hiscott, John Hiscott, John Institut National du Cancer du Canada Instituts de Recherche en Santé du Canada Hoffer, Leonard J. Hoffer, Leonard J. Université McGill Lotte & John Hecht Memorial Foundation Hudson, Marie Instituts de Recherche en Santé du Canada Hudson, Marie Instituts de Recherche en Santé du Canada Characterization and modulation of the immune activation during HIV infection. Regulation of HIV-1 replication by RNA interference and proteins of the RISC. Exploring interactions between HIV and the RNA interference pathway. Virus-cell interactions in the regulation of HIV translation. Détermination de la stratégie optimale pour réduire le fardeau associé à l'hépatite B chez les immigrants et les réfugiés au Canada: une analyse de coût-efficacité Les maladies infectieuses chez les immigrants: Ampleur, impact, couts et interventions Les maladies infectieuses chez les immigrants: Ampleur, impact, couts et interventions Une étude de population sur l'hépatitie viral chez les immigrants: fardeau, coûts et determination de l'intervention optimale Innovative approaches for diagnosing tuberculosis in the era of HIV What's the damage? Impact of tuberculosis disease, infection, and treatment on health status. Oncolytic virus therapy for ATL. Modulation of the innate antiviral immune response during primary HTLV-1 infection. Canadian oncolytic virus consortium. Regulation of Toll-like receptor-independent and independent antiviral pathways during de novo HIV-1 infection. Canadian oncolytic virus consortium. Molecular interactions regulating RIG-I signaling to the innate antiviral response. Vitamin therapy in JGH patients Study - Intravenous vitamin C in combination with chemotherapy in lung cancer patients. Longitudinal comparison of measurements for carbon monoxide lung diffusion capacity (DLCO): single breath and corrected for alveolar volume in systemic sclerosis patients Development and validation of a patient-assessed disease activity index in systemic sclerosis. External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 50,080 59,163 4,603 835 5,836 24,730 35,000 50,000 92,667 123,042 7,500 10,096 30,764 813 7,427 11,010 190,300 2,505 4,890 52,788 159,526 160,856 176,816 2,834 100,000 4,950 12,039 8/15/2012 ‐ 6 NAME AGENCY Hudson, Marie Fonds de la Recherche en Santé du Québec Développement et validation d'un système intégré pour évaluer la fatigue liée à la sclérodermie Instituts de Recherche en Santé du Canada A new emerging team: The Canadian scleroderma research group. Instituts de Recherche en Santé du Canada Strategic training initiative - Canadian Scleroderma Research Group. Université McGill Summer Research Work Study. Regroupement de Particuliers Oncology Research Regroupement de Particuliers Oncology Research Research Foundation Sir Mortimer B. Davis, Start-up Funds. Jewish General Hospital Fonds de la Recherche en Santé du Québec Identification de biomarqueurs de prévision des lymphomes se présentant chez les adolescents et les jeunes adultes Research Foundation Sir Mortimer B. Davis, Start-up Funds. Jewish General Hospital Fondation Cole Help develop the cell library of the Quebec Leukemia Cell Bank with young adult lymphoma cells. Fonds de la Recherche en Santé du Québec Identification de biomarqueurs de prévision des lymphomes se présentant chez les adolescents et les jeunes adultes Fondation Cole Help develop the cell library of the Quebec Leukemia Cell Bank with young adult lymphoma cells. Research Foundation Sir Mortimer B. Davis, Start-up Funds. Jewish General Hospital Research Foundation Sir Mortimer B. Davis, Start-up Funds. Jewish General Hospital Instituts de Recherche en Santé du Canada The Metformin in women with type 2 diabetes in pregnancy trial ("MITY" "The Study") Fonds de la Recherche en Santé du Québec Recherche épidémiologique sur les maladies thromboemboliques: conséquences et mécanismes Fonds de la Recherche en Santé du Québec Recherche épidémiologique sur les maladies thromboemboliques: conséquences et mécanismes Sanofi-Aventis (Canada) Thrombosis Fellowship. Instituts de Recherche en Santé du Canada TIPPS (Thrombophilia in pregnancy prophylaxis study): A multicentre, multinational randomised control trial of prophylactic low molecular weight heparin (LMWH) in high risk pregnant thrombophilic women. CIHR 524E-CVD-9101-004 Hudson, Marie Hudson, Marie Jagoe, Robert Jagoe, Robert Jagoe, Robert Johnson, Nathalie Johnson, Nathalie Johnson, Nathalie Johnson, Nathalie Johnson, Nathalie Johnson, Nathalie Johnson, Nathalie Johnson, Nathalie Kader, Tina Kahn, Susan Rebecca Kahn, Susan Rebecca Kahn, Susan Rebecca Kahn, Susan Rebecca Kahn, Susan Rebecca Kahn, Susan Rebecca Kahn, Susan Rebecca Kahn, Susan Rebecca Kahn, Susan Rebecca Kahn, Susan Rebecca TITLE Heart and Stroke Foundation of Ontario (HSFO) NA6771-Recurrent venous thromboembolism risk stratification evaluation (REVERSE): long term follow-up to define if lifelong anticoagulation is required in high risk patients with a first unprovoked venous thromboembolism. Instituts de Recherche en Santé du Canada GENErVTE: Gene Gene Interactions and Recurrent Venous Thromboembolism. Fondation des Maladies du Coeur de l'ontario P. Wells - HSFO - Development and validation of clinical (Toronto, Ont) prediction ruls for bleeding for patients on anticoagulant therapy for venous thromboembolism. Instituts de Recherche en Santé du Canada Regroupement de Particuliers National Institutes of Health Step Monitoring to improve ARTERial health (SMARTER) Thrombosis Clinic. Pharmacomechanical catheter-directed thrombolysis for acute DVT-attract trial. External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 1,069 9,424 14,400 1,080 11,341 15,352 17,308 25,396 52,740 4,121 7,534 20,890 24,725 75,342 1,900 10,659 37,671 60,000 1,800 3,466 3,750 6,750 9,317 13,200 20,248 8/15/2012 ‐ 7 NAME AGENCY TITLE Kahn, Susan Rebecca Instituts de Recherche en Santé du Canada Kahn, Susan Rebecca Instituts de Recherche en Santé du Canada Kahn, Susan Rebecca Instituts de Recherche en Santé du Canada Kahn, Susan Rebecca Instituts de Recherche en Santé du Canada Kahn, Susan Rebecca Instituts de Recherche en Santé du Canada Karaplis, Andrew C. Fondation Canadienne du Rein Karaplis, Andrew C. Instituts de Recherche en Santé du Canada Karaplis, Andrew C. Fondation Canadienne du Rein Karaplis, Andrew C. Karaplis, Andrew C. Instituts de Recherche en Santé du Canada Susan G. Komen Breast Cancer Foundation Kavan, Petr Kavan, Petr Kleiman, Lawrence C. Kleiman, Lawrence C. Kleiman, Lawrence C. Regroupement de Particuliers Regroupement de Particuliers Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada National Institutes of Health A Pilot Study Assessing Feasibility of a Randomized, Placebocontrolled Trial of Low-Molecular-Weight-Heparin for Postpartum Prophylaxis in Women at Risk of Developing Venous Thromboembolism (pilot PROSPER Trial: PostpaRtum PrOphylaxiS for PE Randomized C Furthering innovation in thrombosis research. - TRUST Registry Study. Randomized controlled trail of anticoagulation vs. placebo for a first symptomatic isolated distal deep-vein thrombosis (IDDVT): The CACTUS-PTS Trial. A randomized, placebo-controlled trial of compression stockings to prevent the post-thrombotic syndrome: The SOX Trial. Prospective evaluation of long-term outcomes after pulmonary embolism: The ELOPE study. Hormonal and molecular regulation of phosphorus homeostasis. Co-targeting parathyroid-hormone related protein (PTHrP) signaling and osteoclast activation to counter breast cancer metastasis to bone Hormonal and molecular regulation of phosphorus homeostasis. PTHrP and osteoblast biology: relevance to osteoporosis Co-targeting Parathyroid Hormone-related Protein Signaling and Osteoclast Metabolism to Counter Breast Cancer Metastasis to Bone Glaucoma unit. Young adult program. Annealing of primer tRNALys3 to genomic RNA in HIV-1. Kleiman, Lawrence C. National Institutes of Health Langleben, David Regroupement de Particuliers Lapointe, Bernard JosephRegroupement de Particuliers Lapointe, Bernard JosephRegroupement de Particuliers Leblanc, Andréa Université McGill Leblanc, Andréa Leblanc, Andréa Leblanc, Andréa Leblanc, Andréa Leblanc, Andréa Université McGill Université McGill Instituts de Recherche en Santé du Canada Université McGill Université McGill Leblanc, Andréa Université McGill Leblanc, Andréa Université McGill Leblanc, Andréa Université McGill Development of the Gag/LysRS interaction as a target for antiHIV therapy. Development of the Gag/LysRS interaction as a target for antiHIV therapy. Cardiology Research. Pallative Care Research. Supportive Care Research. The role of inflammation in regulating neuronal Caspase-6 activation in Alzheimer Disease. Studies on an inhibitor of caspase-6. The normal function of prion protein. Graduate Studies in Cell Biology and Anatomy Fellowship. Mode of retrotranlocation of normal prion protein into the cytosol and investigation of how similar prion mutations may alter prion retrotranslation. Mode of retrotranlocation of normal prion protein into the cytosol and investigation of how similar prion mutations may alter prion retrotranslation. The role of inflammation in regulating neuronal Caspase-6 activation in Alzheimer Disease. The role of inflammation in regulating neuronal Caspase-6 activation in Alzheimer Disease. External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 25,291 25,741 31,543 120,091 139,358 12,301 31,642 37,483 82,101 99,984 5,000 7,279 86,336 148,274 154,168 477,706 44,527 3,496 53,538 2,000 2,088 2,253 2,500 4,500 5,011 5,836 8,352 11,671 8/15/2012 ‐ 8 NAME AGENCY Leblanc, Andréa Fonds de la Recherche en Santé du Québec Études sur un inhibiteur de caspases présent dans les neurones humaines Instituts de Recherche en Santé du Canada Role of the cytosolic prion protein in the regulation of Bax ubiquitination and its impact on cell survival. National Institutes of Health Phosphorylation of prion protein as a novel mechanism for conversion Instituts de Recherche en Santé du Canada Role of caspases in human neuronal cell death and in Alzheimer's Disease. Regroupement de Particuliers Alzheimer's research funds. Research Foundation Sir Mortimer B. Davis, The role of Casp6 in colon carcinogenesis. Jewish General Hospital Instituts de Recherche en Santé du Canada Role of caspases in human neuronal cell death and in Alzheimer's Disease. Instituts de Recherche en Santé du Canada Regulation of prion protein expression, trafficking and function Leblanc, Andréa Leblanc, Andréa Leblanc, Andréa Leblanc, Andréa Leblanc, Andréa Leblanc, Andréa Leblanc, Andréa Lehoux, Stephanie Lehoux, Stephanie TITLE External Grants Career Awards Industrial Contracts 35,000 44,021 61,709 63,002 69,041 78,129 136,212 989 18,411 Lehoux, Stephanie Secrétariat des Chaires de Recherche du Canada 50,137 Lehoux, Stephanie Liang, Chen Liang, Chen Instituts de Recherche en Santé du Canada Université McGill China Scholarship Council (Csc) Liang, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Chen Lin, Rongtuan Lin, Rongtuan Lin, Rongtuan Lin, Rongtuan Lin, Rongtuan Lipman, Mark L. Lipman, Mark L. Mann, Koren 50,000 Régulation de l'expression du récepteur AT1 de l'angiotensine par la contrainte de cisaillement: rôle dans l'athérosclérose. Athero-protective shear stress signalling in the vasculature An anti HIV activity of SAMHD1 in myelorid cell. Identification of Tat-interacting cellular factors and mechanistic study of their roles in HIV-1 replication. Université McGill Ëtude de l'assemblage du virus d'immunodéficience humain type-1. Fonds de la Recherche en Santé du Québec Étude de l'Assemblage du Virus d'Immunodéficience Humain Type-1 Instituts de Recherche en Santé du Canada Fusion and cell entry by oncogenic sheep retroviruses. Instituts de Recherche en Santé du Canada Fusion and cell entry by oncogenic sheep retroviruses. Instituts de Recherche en Santé du Canada The Botswana-Canada AIDS vaccine discovery partnership. Instituts de Recherche en Santé du Canada Towards a new approach for the detection of pain in adults in critical care: near-infrared spectroscopy (NIRS). Instituts de Recherche en Santé du Canada Studying the antiviral of bone marrow stromal cell antigen 2 and the countering mechanism from HIV-1 Vpu. Université McGill The activation of RIG-I pathway counteracts H1N1 Influenza virus replication. Instituts de Recherche en Santé du Canada Cross-talk between host antiviral and apoptotic signaling pathways in de novo Dengue virus infection. Instituts de Recherche en Santé du Canada Oncolytic virus therapy for HTLV-1 induced adult T cell leukemia. Instituts de Recherche en Santé du Canada Innate immunity and Hepatitis C virus infection. Instituts de Recherche en Santé du Canada Molecular interactions regulating RIG-I signaling to the innate antiviral response. Regroupement de Particuliers Renal Research. Regroupement de Particuliers Hemodialysis Research. Université McGill The role of tungsten in preB acute lymphocytic leukemogenesis. Foundation 13,808 Université McGill M.Sc. Program in Experimental Medicine Fonds de la Recherche en Santé du Québec Mécanismes impliqués dans la réduction de la plaque d'athérosclérose par la contrainte de cisaillement. Secrétariat des Chaires de Recherche du Régulation de l'expression du récepteur AT1 de l'angiotensine Canada par la contrainte de cisaillement: rôle dans l'athérosclérose. Lehoux, Stephanie Clinical Research Awards 127,729 1,507 4,747 9,685 9,686 19,160 57,584 89,793 96,770 144,269 835 18,750 149,738 174,307 176,816 125,473 167,219 1,209 8/15/2012 ‐ 9 NAME AGENCY Mann, Koren Université McGill TITLE Mann, Koren The role of macrophages polarization in arsenic carcinogenicity Université McGill The potential of tungsten to induce DNA damage in B-cells in vivo Université McGill Mechanisms of arsenic induced apoptosis Université McGill The role of tungsten in preB acute lymphocytic leukemogenesis. Fonds de la Recherche en Santé du Québec Effets toxicologiques des métaux. Mann, Koren Leukemia Research Foundation Mann, Koren Mann, Koren Mann, Koren Instituts de Recherche en Santé du Canada Research Foundation Sir Mortimer B. Davis, Jewish General Hospital National Institutes of Health Mann, Koren Michel, Caroline Instituts de Recherche en Santé du Canada National Institutes of Health Michel, Caroline Miller, Mark A. Aventis Pharma Santé Canada Miller, Wilson Instituts de Recherche en Santé du Canada Miller, Wilson Université McGill Miller, Wilson Université McGill Miller, Wilson Instituts de Recherche en Santé du Canada Miller, Wilson Miller, Wilson Miller, Wilson Université McGill Fondation Cole Fondation Cole Miller, Wilson Instituts de Recherche en Santé du Canada Miller, Wilson Miller, Wilson Fondation Cole Fondation Cole Miller, Wilson Regroupement de Particuliers Miller, Wilson Research Foundation Sir Mortimer B. Davis, Jewish General Hospital American Association For Cancer Research (Philadelphia, Pa) Mann, Koren Mann, Koren Mann, Koren Miller, Wilson The role of tungsten exposure in the development of preB acute lymphoblastic leukemia. Mechanisms of arsenic-enhanced atherosclerosis. The role of tungsten exposure in the development of preB acute lymphoblastic leukemia. The role of LXR/RXR heterodimers in arsenic-induced atherosclerosis. Mechanisms of arsenic-enhanced atherosclerosis. Xanthine oxidase inhibition for hyperuricemic heart failure patients. Heart failure clinic equipment donation. Vancomycin-resistant enterocci (VRE) occurrence report protocol Canadian nonsocomial infection surveillance program (CNISP). Investigating the molecular mechanisms of retinoids as antivirals in paramyxovirus infections Examine the role of EIF4E during the TGF-beta induced epithelial to mesenchyme-like transition (EMT). Correlating mutations in histone modifying enzymes to sensitivity to histone deacetylase inhibitor in B-cell nonhodgekin's lymphoma. Improving combination therapies involving histone deacetylare inhibitors and DNA methyltransferare inhibitors in hematological malignancies Mechanisms of the anti-cancer actions of arsenic. Cole Foundation Fellowship Programme By coupling molecules with retinoid and histone deacetylase inhibitor (HDACi) activity we're hoping to improve antineoplastic efficacy. The aim of the project is to explore the effects of this novel type of drug. Improving combination therapies involving histone deacetylare inhibitors and DNA methyltransferare inhibitors in hematological malignancies Cole Foundation Fellowship Programme By coupling molecules with retinoid and histone deacetylase inhibitor (HDACi) activity we're hoping to improve antineoplastic efficacy. The aim of the project is to explore the effects of this novel type of drug. 8th International Conference of differentiation therapy Montreal October 3-6,1999. Ribavirin as a breast cancer therapeutic. Targeting eIF4E with ribavirin in poor prognosis breast cancer. External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 2,000 2,000 2,250 9,033 55,025 24,765 27,290 45,672 57,894 91,507 19,705 229,789 23,660 875 2,000 2,000 3,531 4,945 5,440 5,440 10,759 16,575 16,575 6,425 36,822 66,748 8/15/2012 ‐ 10 NAME AGENCY TITLE Miller, Wilson Instituts de Recherche en Santé du Canada Miller, Wilson Leukemia and Lymphoma Society Miller, Wilson Instituts de Recherche en Santé du Canada Miller, Wilson Samuel Waxman Cancer Research Foundation Instituts de Recherche en Santé du Canada Molecular mechanisms of retinoids as anti-virals in respiratory virus infections CRU - A phase II study of Ribavirin in refractory or relapsed acute myelocytic leukemia M4 and M5 subtypes (Protocol # Borden-001-002). LLS - The eukaryotic translation initiation factor eIF4E: a novel therapeutic target in myeloid leukemia. Targeting the eukaryotic translation factor elF4E with ribavirin in breast cancer. Development of novel anti-cancer therapies using arsenic trioxide. Novel mediators of response and resistance to epigentic therapy of leukemia. Miller, Wilson Miller, Wilson Miller, Wilson Monette, Johanne Monette, Johanne Monette, Johanne Mouland, Andrew Mouland, Andrew Mouland, Andrew Mouland, Andrew Mouland, Andrew Mouland, Andrew Mouland, Andrew Mouland, Andrew Panasci, Lawrence Panasci, Lawrence Panasci, Lawrence Panasci, Lawrence Panasci, Lawrence Panasci, Lawrence Panasci, Lawrence Pantopoulos, Kostas Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Fonds de la Recherche en Santé du Québec Utilisation des services médicaux d'urgence et hospitaliers chez la clientèle âgée de 75 ans et plus : Quel est l'impact de l'accès aux ressources médicales et communautaires de première ligne ? Université McGill Molecular & virological studies of HIV-1. Université McGill The RNA and cell biology of HIV-1 infection. National Commission of Scientific Research HIV integrase. and Technology (Conicyt) (Chile) Instituts de Recherche en Santé du Canada Sheldon Biotechnology Centre: Surface Plasmon Resonance Facility. Canadian Foundation For Aids Research Implications of upframeshift suppressor protein 1 (UPF1) in (Canfar) HIV-1 genomic RNAQ fate. Canadian Foundation For Aids Research Implications of upframeshift suppressor protein 1 (UPF1) in (Canfar) HIV-1 genomic RNAQ fate. Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Understanding how the HIV-1-dependent ribonucleoprotein counters host stress responses Université McGill Synergism of Irinotecan and Oxaliplatin in the treatment of colon cancer cells by the PARP inhibitor ABT-888. Université McGill PI3K inhibitors in CLL therapy. Institut National du Cancer du Canada Sorafenib in breast cancer: A laboratory-based approach for a rational clincal development. (Post-MD Reasearch Fellowship). Regroupement de Particuliers Donations. Fonds de la Recherche en Santé du Québec Étude prospective pour identifier et valider des biomarqueurs de résistance thérapeutique dans le cancer colorectal métastatique Instituts de Recherche en Santé du Canada c-Abl-directed molecular re-engineering of chlorambucil to offer new therapeutic options to patients with chronic lymphocytic leukemia (CLL). Fonds de la Recherche en Santé du Québec Étude prospective pour identifier et valider des biomarqueurs de résistance thérapeutique dans le cancer colorectal métastatique John S.Latsis Ileians' Scholarships The role of protein HjV on the pathogenesis of Foundation hemochromatosis. The role of hemojuvelin in ron homeostasis. External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 68,988 69,679 70,880 78,428 138,305 162,500 170,356 4,514 6,560 20,712 3,881 8,901 13,199 7,966 40,000 40,110 109,807 134,164 2,000 4,050 12,115 5,070 17,666 37,410 71,450 10,652 8/15/2012 ‐ 11 Career Awards Industrial Contracts AGENCY Pantopoulos, Kostas Pantopoulos, Kostas Fonds de la Recherche en Santé du Québec Validation et caractérisation d'un mécanisme alternatif de traduction de l'ARN messager de la ferritine Fonds de la Recherche en Santé du Québec Regulation du metabolisme du fer 17,765 Pantopoulos, Kostas Fonds de la Recherche en Santé du Québec Regulation du metabolisme du fer 32,277 Pantopoulos, Kostas Instituts de Recherche en Santé du Canada Papageorgiou, Apostolos Centre de Recherche du Chu Sainte-Justine Papageorgiou, Apostolos Regroupement de Particuliers Paudel, Hemant Société Alzheimer du Canada Paudel, Hemant China Scholarship Council (Csc) Paudel, Hemant Société Alzheimer du Canada Paudel, Hemant Sir Mortimer B. Davis - Hôpital Général Juif Paudel, Hemant Société Alzheimer du Canada Paudel, Hemant Conseil de Recherches en Sciences Naturelles et Génie du Canada Paudel, Hemant Instituts de Recherche en Santé du Canada Paudel, Hemant Pollak, Michael Pollak, Michael Instituts de Recherche en Santé du Canada Université McGill Université McGill Pollak, Michael Pollak, Michael Pollak, Michael Université McGill Instituts de Recherche en Santé du Canada Novo Nordisk A/S (Danemark) Pollak, Michael Pollak, Michael Pollak, Michael Société de Recherche sur Le Cancer Inc Jewish Hospital Foundation National Institutes of Health Pollak, Michael Pollak, Michael Société Canadienne du Cancer Prostate Cancer Foundation (PCF) Pollak, Michael National Institutes of Health Pollak, Michael Pollak, Michael Cancer de la Prostate Canada Institut National du Cancer du Canada Pollak, Michael Pollak, Michael Sir Mortimer B. Davis - Hôpital Général Juif National Institutes of Health Pollak, Michael Pollak, Michael National Institutes of Health Instituts de Recherche en Santé du Canada Pollak, Michael Pollak, Michael Société Canadienne du Cancer Regroupement de Particuliers TITLE External Grants NAME Iron metabolism in health and disease: The IRE/IRP system and beyond. Placental insufficiency and aortic isthmus flow (PIAF). Neonatology Research. Transcriptional dysregulation in Alzheimer's Disease. Transcriptional dysregulation in Alzheimer's Disease. Development of a PET radioligand for phosphorylated TAU. EGR-1 and Alzheimer's disease Phosphorylation of protein phosphatase 1 during neuronal differentiation. Neurofibrillary pathology and amyloidogenesis in Alzheimer's disease: mechanistic insights. Tau protein and Alzheimer's disease. Suppression of pyruvate metabolism in cancer cells Examination of intracellular signaling downstream of the insulin and IFG-1 receptor in tumor tissue in an in vivo model of the metabolic syndrome and type 2 diabetes. Oncometabolics. Prospective evaluation of insulin-like growth factor 1 plasma/serum biomarkers and multiple myeloma. Influence of insulin on androgen production. Modifiable dietary determinants of levels of IGF-1, insulin, and risk of colorectal cancer and lethal prostate cancer. A Pilot Clinical Trial of Metformin in Prostate Cancer. Risk of multiple myeloma in relation to plasma adipokine levels: a nested case-control study in the prostate, lung, colorectal and ovarian cancer screening trial. Epidemiologic studies of diet and cancer in Hawaii. Defining and Applying "Oncometabolism": A team approach in understanding and translating the Warburg effect from oncogenic and tumour suppressing activities. Effects of metformin on colorectal epithelial cell proliferation. Breast cancer research. Foundation 11,703 128,656 9,000 26,346 8,573 9,468 11,981 16,044 18,544 34,000 65,138 67,405 1,670 2,000 2,521 2,685 3,582 New in vivo models for assessment of mitogenic and tumor growth promoting effects of insulin and insulin anologues. Segal-Goodman distinguished lectures in cancer. BFIT Study: Analysis of C-peptide levels and endometrical cancer. BFIT Study: Analysis of high molecular weight (HMW) adiponectin in relation to endometrial cancer. Effects of metformin on colorectal epithelial cell proliferation. Prevention of treatment and disease-related morbidity during androgen deprivation therapy: A multicenter proposal. Clinical Research Awards 4,339 5,000 8,433 16,027 24,765 44,166 45,205 45,803 50,000 55,288 80,128 80,724 81,696 112,677 8/15/2012 ‐ 12 NAME AGENCY TITLE Pollak, Michael Institut National du Cancer du Canada Ponka, Prem Ponka, Prem Ponka, Prem Société Canadienne du Sang Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Portnoy, Joseph Portnoy, Joseph Richard, Stéphane Regroupement de Particuliers Regroupement de Particuliers Université McGill Richard, Stéphane Université McGill Richard, Stéphane Modifiable dietary determinants of levels of IGF-1, insulin, and risk of colorectal cancer and lethal prostate cancer. Chelation, mobilization and metabolism of storage iron. Chelation, mobilization and metabolism of storage iron. Regulation of iron metabolism and heme synthesis in erythroid cells. Quality of care research. Infectious disease research. Identification of DNA damage-induced arginine methylated proteins. Riole of post-translation modifications in splicing and DNA damage. Identification of the RNA targets bound by the quaking RNA binding proteins. Société Canadienne de la Sclérose en Plaques Fonds Québécois de la Recherche sur La Nature et les Technologies Fonds de la Recherche en Santé du Québec Rôles des protèines KH liant l'ARN et la méthylation des arginines: Implications pour la sclèrose en plaques et le cancer. Société Canadienne de la Sclérose en Study microRNA and quaking RNA binding protein function on Plaques oligodendrocyte differentiation. Fonds de la Recherche en Santé du Québec Identification et étude de protéines arginine-méthylées lors de la signalisation du dommage à l'ADN dans les cellules cancéreuses Université McGill Assessing the role of sumoylation of protein arginine methlytransferase. Fonds de la Recherche en Santé du Québec Définir le rôle de l'arginine méthyltransférase PRMT7 dans la réponse cellulaire aux dommages de l'ADN. Instituts de Recherche en Santé du Canada Regulators mediating the proinflammatory cytokine response in uterine smooth muscle cells. Instituts de Recherche en Santé du Canada Lysine methylation of non-histone proteins. Institut National du Cancer du Canada The role of arginine methylation of MRE11 in mediating the DNA damage response. Institut National du Cancer du Canada The role of the QUAKING RNA binding proteins in tumorigenesis. Institut National du Cancer du Canada Role of the STAR protein Sam68 in cancer: Regulation by tyrosine kinases. Research Foundation Sir Mortimer B. Davis, The role of H2Az lysine methylation by SETD6 in estrogenJewish General Hospital dependent transcription and breast cancer. Institut National du Cancer du Canada The role of arginine methylation of MRE11 in mediating the DNA damage response. Institut National du Cancer du Canada The role of the QUAKING RNA binding proteins in tumorigenesis. Institut National du Cancer du Canada Role of the STAR protein Sam68 in cancer: Regulation by tyrosine kinases. Société Canadienne de la Sclérose en The role of the quaking protein in oligodendrocyte physiology Plaques and myelination. Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada The role of the STAR RNA binding protein Sam68 in regulating cell migration and proliferation in cancer. Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Genetic and environmental determinants of vitamin D levels in Canadians. Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richard, Stéphane Richards, Brent External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 127,091 33,170 104,213 133,831 6,076 9,336 2,967 4,945 5,000 6,329 7,418 9,643 11,301 15,055 30,000 36,667 45,000 30,311 30,412 34,169 36,822 92,362 92,671 104,120 106,360 137,473 156,661 175,420 29,712 8/15/2012 ‐ 13 NAME AGENCY TITLE Richards, Brent Richards, Brent Richards, Brent Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada The role of rare genetic variants in common disease. Fonds de la Recherche en Santé du Québec Épidémiologie génétique des fractures ostéoporotiques; des gènes de susceptibilité aux populations susceptibles Richards, Brent Richards, Brent Instituts de Recherche en Santé du Canada Fonds de la Recherche en Santé du Québec Épidémiologie génétique des fractures ostéoporotiques; des gènes de susceptibilité aux populations susceptibles Richards, Brent Génome Québec External Grants Career Awards Clinical Research Awards Foundation 45,000 45,000 2,473 5,000 7,534 GRADE: Genomics in drug repositonning and adverse effects. 10,000 Fondation Canadienne Pour l'innovation (Fci) A Laboratory to Study the Genetic Epidemiology of AgingRelated Disease Richards, Brent Instituts de Recherche en Santé du Canada Pinpointing causal variants for osteoporosis. Richards, Brent King's College London Standard operating procedures. Richards, Brent Consortium Québécois sur La Découverte du Identification de cibles thérapeutiques cruciales pour les Médicament (Cqdm) maladies auto-immunes. - Pinpointing critical drug targets for autoimmune disease. Schiffrin, Ernesto Fondation des Maladies du Coeur du Canada Remodelage des artères de petit et gros calibre dans (FMCC) l'insuffisance rénale chronique. Schiffrin, Ernesto Fondation des Maladies du Coeur du Canada Remodelage des artères de petit et gros calibre dans (FMCC) l'insuffisance rénale chronique. Schiffrin, Ernesto University of Barcelona Dr. Cristina Sierra - Paid Permit from the Hospital Clinic of Barcelona in Spain. Schiffrin, Ernesto Kao Corporation (Japan) Research on vascular disesae in hypertension: Role of endothelin, PPARs and T-lymphocytes. Schiffrin, Ernesto Secrétariat des Chaires de Recherche du Remodeling of blood vessels in hypertension. Canada Schiffrin, Ernesto Secrétariat des Chaires de Recherche du Remodeling of blood vessels in hypertension. Canada Schiffrin, Ernesto Regroupement de Particuliers Cardiohhypertension research "Fonds d'urgence". Schiffrin, Ernesto Instituts de Recherche en Santé du Canada Congenital nephron deficit and essential hypertension. Schiffrin, Ernesto Juvenile Diabetes Research Foundation Nox-derived Rox: renal and vascular complications of type 1 International diabetes. Schiffrin, Ernesto Instituts de Recherche en Santé du Canada Vascular remodeling in hypertension: From genes to mice to humans. Schiffrin, Ernesto Instituts de Recherche en Santé du Canada T-regulatory cells and vascular injury in hypertension Schiffrin, Ernesto Instituts de Recherche en Santé du Canada Endothelin, vascular inflammation and injury, and hypertension. Schipper, Hyman Morris National Institutes of Health Clinical assessment of patients with AD and NEC individuals. Schipper, Hyman Morris Instituts de Recherche en Santé du Canada Schirrmacher, Ralf Secrétariat des Chaires de Recherche du Synthesis of novel radiopharmaceuticals for PET in neurology Canada and oncology. Sheppard, Richard National Institutes of Health Immune activation and myocardial recovery in peripartum cardiomyopathy. Small, David Regroupement de Particuliers Airway center. Suissa, Samy Instituts de Recherche en Santé du Canada Propensity scores and marginal structural models in drug safety research Suissa, Samy Instituts de Recherche en Santé du Canada CIHR - Quebec Respiratory Health Training Program Suissa, Samy Instituts de Recherche en Santé du Canada Multiple medication use in the Quebec elderly and the risk of motor vehicle crash. Suissa, Samy Instituts de Recherche en Santé du Canada Canadian Network for Observational Drug Effect Studies. 22,487 Richards, Brent Industrial Contracts 27,224 75,957 300,000 8,078 9,890 12,139 40,000 49,863 150,549 684 56,444 73,769 112,147 156,659 159,344 59,313 136,571 100,000 1,865 42,690 7,033 8,125 93,926 3,180,100 8/15/2012 ‐ 14 External Grants Career Awards NAME AGENCY TITLE Szilagyi, Andrew Institut Danone/Dannon Szilagyi, Andrew Tagalakis, Vicky Regroupement de Particuliers Fonds de la Recherche en Santé du Québec Tagalakis, Vicky Fonds de la Recherche en Santé du Québec Tagalakis, Vicky Instituts de Recherche en Santé du Canada Tagalakis, Vicky Fondation des Maladies du Coeur du Québec Tagalakis, Vicky Fondation des Maladies du Coeur du Québec Differential biologic impact of lactose consumption in lactase persistent and non-persistent populations: Evaluation of microflora and insulin/glycemic response. Fructose study. Recherche épidémiologique et pharmacoépidémiologique en thrombose veineuse Recherche épidémiologique et pharmacoépidémiologique en thrombose veineuse Lots about clots and cancer: what cancer patients and their families should know about deep vein thrombosis and pulmonary embolism. Screening for previously undiagnosed malignancy in patients with unprovoked venous thromboembolism: a randomized controlled trial using comprehensive computed tomography of the abdomen/pelvis. Screening for previously undiagnosed malignancy in patients with unprovoked venous thromboembolism: a randomized controlled trial using comprehensive computed tomography of the abdomen/pelvis. Tagalakis, Vicky Fondation des Maladies du Coeur du Québec 25,000 Therrien, Judith Instituts de Recherche en Santé du Canada 13,815 Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Analyzing and Reducing Health disparities in Adult Congenital Heart Disease. Instituts de Recherche en Santé du Canada Reporting of conflicts of interest in Coshrane reviews of trials of pharmacological treatments. Fonds de la Recherche en Santé du Québec Améliorer le dépistage de la dépression dans les cliniques de Rhumatologie: Détection de la dépression persévérante versus aiguë dans les patients souffrant de la sclérodermie Fonds de la Recherche en Santé du Québec La Dissatisfaction avec l'Image Corporelle: Développement d'une Echelle auprès de Patients Atteints de Sclérodermie Instituts de Recherche en Santé du Canada Université McGill Development and validation of a pruritus measure for patients with systemic sclerosis. Instituts de Recherche en Santé du Canada Improving depression screening in rheumatology clinics: Detection of persistent verus acture depression in Scleroderma patients. Instituts de Recherche en Santé du Canada Development and validation of a fatique assessment protocol for Scleroderma. Instituts de Recherche en Santé du Canada Improving depression screening in rheumatology clinics: Detection of persistent verus acture depression in Scleroderma patients. Instituts de Recherche en Santé du Canada Prevalence of major depression in patients with cardiovascular disease: a meta-analysis of the role of the method of depression assessment Fonds de la Recherche en Santé du Québec Ameliorer l'evaluation de la fatigue en sclerodermie pour en arriver a une mesure uniforme Fonds de la Recherche en Santé du Québec La fréquence de la dépression majeure dans la maladie cardiovasculaire: Une méta-analyse du rôle de la méthode d'évaluation de la dépression Instituts de Recherche en Santé du Canada Development of assessment tools for fatigue related to systemic sclerosis: Research, diagnostic, and screening applications. Industrial Contracts Clinical Research Awards Foundation 1,114 1,318 8,562 26,666 3,000 4,945 12,055 1,500 4,377 4,698 4,950 5,836 6,000 7,308 7,308 7,308 8,753 15,000 60,000 8/15/2012 ‐ 15 NAME AGENCY Thombs, Brett Fonds de la Recherche en Santé du Québec Développement et validation d'un système intégré pour évaluer la fatigue liée à la sclérodermie American College of Rheumatology (Atlanta, ACR REF/Abbott Health Professional Graduate Sutdent Ga) Research Preceptorship. Fonds de la Recherche en Santé du Québec Écoles, culture et santé mentale: une articulation à repenser dans une société en transformation Fonds de la Recherche en Santé du Québec La sclérodermie: Un Programme d'Etude Portant sur l'Expérience de la Maladie selon la Perspective des Patients Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Consortium for behavioural, psychological , and educational trials in Scleroderma. Instituts de Recherche en Santé du Canada A new emerging team: The Canadian scleroderma research group. Scleroderma Society of Canada International Consortium for Bevavorial/Educational/Psychological Interventions for Scleroderma. Instituts de Recherche en Santé du Canada Scleroderma Patient-Centred Intervention Network (SPIN) planning meeting. Instituts de Recherche en Santé du Canada Strategic training initiative - Canadian Scleroderma Research Group. Scleroderma Society of Ontario International Consortium for Bevavorial/Educational/Psychological Interventions for Scleroderma. Research Foundation Sir Mortimer B. Davis, International Consortium for Jewish General Hospital Bevavorial/Educational/Psychological Interventions for Scleroderma. Instituts de Recherche en Santé du Canada Emerging Team: The Scleroderma patient-centered intervention Network. Research Foundation Sir Mortimer B. Davis, International Consortium for Jewish General Hospital Bevavorial/Educational/Psychological Interventions for Scleroderma. Instituts de Recherche en Santé du Canada Will routine depression screening benefit patients in cardiovascular care settings? An updated systematic review. Fonds de la Recherche en Santé du Québec A la recherche des variants de séquences et des profils de méthylation des gènes de réparation de l'ADN qui modulent la présentation clinique et la réponse au Ministère du Développement Economique, de Séquençage de nouvelle génération en génétique moléculaire l'innovation et de l'exportation (MDEIE) pour le cancer du sein héréditaire - une nouvelle stratégie émergente Ministère du Développement Economique, de Séquençage de nouvelle génération en génétique moléculaire l'innovation et de l'exportation (MDEIE) pour le cancer du sein héréditaire - une nouvelle stratégie émergente Ministère du Développement Economique, de Séquençage de nouvelle génération en génétique moléculaire l'innovation et de l'exportation (MDEIE) pour le cancer du sein héréditaire - une nouvelle stratégie émergente Ministère du Développement Economique, de Séquençage de nouvelle génération en génétique moléculaire l'innovation et de l'exportation (MDEIE) pour le cancer du sein héréditaire - une nouvelle stratégie émergente Mendon F. Schutt Family Fund Screening DICER-like families for large deletions in DICER1 or for mutations or deletions of DICER1-like genes. Sir Mortimer B. Davis - Hôpital Général Juif Proteomic analysis of surface receptors of scleroderma fibroblasts Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Thombs, Brett Tischkowitz, Marc Tischkowitz, Marc Tischkowitz, Marc Tischkowitz, Marc Tischkowitz, Marc Tischkowitz, Marc Trifiro, Mark A TITLE External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 1,069 1,509 1,537 3,709 5,531 8,515 9,200 9,424 12,500 20,885 21,600 25,000 37,500 49,996 75,000 85,091 9,111 746 746 1,356 3,082 3,735 3,939 8/15/2012 ‐ 16 NAME AGENCY TITLE Trifiro, Mark A Trifiro, Mark A Trifiro, Mark A Instituts de Recherche en Santé du Canada Saudi Arabian Cultural Bureau in Canada Conseil de Recherches en Sciences Naturelles et Génie du Canada Université McGill Conseil de Recherches en Sciences Naturelles et Génie du Canada Scleroderma Society of Ontario Cancer de la Prostate Canada Expression profiling of keratinocytes in scleroderma. AR Androgen receptor ubiquitination. Miniaturized nanoplasmonic biosensors for infectious diseases detection. McGill / GSK Lecture on Metabolism. Miniaturized nanoplasmonic biosensors for infectious diseases detection. Bench Research Funding AR-mediate alternative RNA splicing - Impact on prostate cancer progression. Trifiro, Mark A Trifiro, Mark A Trifiro, Mark A Trifiro, Mark A Vedel, Isabelle Vedel, Isabelle Vedel, Isabelle Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Wainberg, Mark A. Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Ministère de la Santé et des Services Sociaux (Québec) Université McGill Université de Montréal Instituts de Recherche en Santé du Canada Diagnostic et prise en charge de la démence au sein des GMF: bilan de l'implantation des interventions pilotes. Drug resistance in HIV integrase. Bourse Departementale Defining effective anti-viral combinations in order to decrease the sexual transmission of HIV. Characterising the sensitivity of CCR5 co-receptor inhibitor resistant HIV-1 to neutralising antibodies. CIHR MD/Ph.D. Studentships. The contribution of cellular PRMT6 to HIV-1 pathogenesis. Drug resistance of HIV to second generation integrase inhibitors. Instituts de Recherche en Santé du Canada Addition of exogenous Tat during early infection to inhibit the establishment of latency. Réseau Canadien sur les Essais Cliniques du HIV-1 subype-specificity and resistance to integrase inhibitors. HIV Ministère des Relations Internationales du Characterization of drug resistant HIV circulating in Shandong Québec province. Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Infection of the put by HIV-1. Canadian Foundation For Aids Research Are there HIV-1 subtype specific differencs in resistance to (Canfar) integrase inhibitors? Canadian Foundation For Aids Research Are there HIV-1 subtype specific differencs in resistance to (Canfar) integrase inhibitors? Instituts de Recherche en Santé du Canada Methylation of HIV viral proteins as key steps in viral replication. Instituts de Recherche en Santé du Canada Studies on HIV integrase as key components of effective therapy: Molecular pathogenesis studies. Instituts de Recherche en Santé du Canada The impact of HIV drug resistance mutations in different viral subtypes on viral fitness and phenotype. Instituts de Recherche en Santé du Canada Patterns of drug resistance and viral evolution in patients undergoing primary HIV-infection. Centre de Recherches Pour Le TanZamBo capacity building for HIV prevention research Développement International (Crdi) network. Instituts de Recherche en Santé du Canada Regulation of Toll-like receptor-independent and independent antiviral pathways during de novo HIV-1 infection. External Grants Career Awards The Botswana-Canada AIDS vaccine discovery partnership. Clinical Research Awards Foundation 4,950 8,744 1,598 4,638 17,170 25,000 45,205 4,514 8,493 21,871 865 2,102 2,500 Réseau Canadien sur les Essais Cliniques du HIV Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Instituts de Recherche en Santé du Canada Industrial Contracts 13,599 22,000 22,000 32,500 35,000 41,438 2,260 10,000 12,900 39,000 40,110 55,595 88,538 91,507 96,413 142,680 159,526 166,667 224,483 8/15/2012 ‐ 17 NAME AGENCY TITLE Wainberg, Mark A. Wainberg, Mark A. Warshawsky, Paul Wassmann, Sven Instituts de Recherche en Santé du Canada National Institutes of Health Regroupement de Particuliers Secrétariat des Chaires de Recherche du Canada Secrétariat des Chaires de Recherche du Canada Instituts de Recherche en Santé du Canada The Canadian HIV Trials Network HIV risk dynamics, genetic patterns, and control. ICU Surgical Research. Wassmann, Sven Wassmann, Sven External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 303,218 611,697 12,840 50,000 50,137 79,025 JGH Foundation (including designated donations, bequests and endowments) Lipman M. Lipman M. Lipman M. M.Tamilia Michel, C. Miller M. Miller M. Miller W. Miller W. Panasci L. Pollak M. Pollak M. Portnoy J. Portnoy J. Portnoy J. Richard S B. Rudski, L Schiffrin A. Schiffrin, E. Schiffrin, E. Schiffrin, E. Schiffrin, E. Schipper H. Schondorf R. Schweitzer M. Schweitzer M. Sebag I. Small D Suissa S. Szilagyi A. Therrien Trifiro M. Trifiro M. Trifiro M. Trifiro M. Trifiro M. Trifiro M. Trifiro M. Wainberg M. Wainberg M. Wainberg M. Warshawsky Paul Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Foreign Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Grouping of Canadian Individuals Hemodialysis Research. Renal Research. Research Nephrology Thyroid Tumor Research. R&D Infectious Diseases Research. R&D R&D 8th Int. Conf. of Differentiation Therapy, Mtl, QC 1999 Donations. Breast Cancer Research. Cpru - Stroll - Cancer Screening. Infectious Diseases Research. Infectious Disease Research. Quality of Care Research. R&D R&D Diabetes Research. Cardiovascular Prevention Centre. Dr. E. Schiffrin-Dept. Medecine Endow Dr. E. Schiffrin-Dept. Medecine Endow (Auxiliary) Cardiohhypertension Research - ""Fonds D'urgence"". Alzheimer's Research. Autonomic Dysfunction Research. Lipid Research. Cardiac Endocrinology Research. Cardiology Research. Pulmonary Research. Priv-Suissa S.-Pharmacoepidemiology Fructose Study. Cardiology Research. Endocrinology Research and Development. Genetics Research. Kennedy Disease. Insulin Fund. Endocrinology Research. Medical Genetics Research. Diabetes Research. Québec Conference. R&D Aids Research. ICU Surgical Research. 175,569 126,334 204 1,439 9,415 5,009 5,000 21,122 6,425 5,070 149,221 52,623 204,011 11,270 6,076 12,400 14,920 31 28,835 19,848 3,784 684 205 145 10,000 4,035 1,063 60,067 26,000 1,318 33,837 144,078 95,031 4,271 2,936 656 362 61 23,000 16,066 1,276 16,656 8/15/2012 ‐ 18 NAME AGENCY TITLE Industrial Contracts Agulnik, Jason Boehringer Ingelheim (Canada) Ltd Agulnik, Jason Boehringer Ingelheim (Canada) Ltd Agulnik, Jason Glaxo Wellcome Inc. Agulnik, Jason Morphotek Inc Assouline, Sarit Hoffmann-La Roche Limitée, Canada Assouline, Sarit Hoffmann-La Roche Limitée, Canada Assouline, Sarit Aegera Therapeutics Inc. Assouline, Sarit Proteolix Multi-country, cross-sectional, prospective quality of life survey of patients with advanced NSCLC. A multi-center, randomized, double-bleind, phase III trial to investigate the efficacy and safety of oral BIBF1120 plus standard Pemetrexed therapy in patients with stage IIIB/IV or recurrent non-smokers. 109493: A double-blind, randomized, placebo-controlled phase III study to assess the efficacy of recMAGE-A3-A3+ antigen-specific cancer immunotherapeutic as adjuvant therapy in patients with MAGE-A3-positive non-small cell lung cancer. A randomized double-blind, placebo-controlled, study of the safety and efficacy of Farletuzumab in combination with a platinum containing doublet in chemotherapy-naïve subjects with stage IV adenocarcinoma of the lung. CRU - A two-stage phase 1b study to investigate the pharmacokinetics, safety and tolerability of rituximab subcutaneous (SC) formulation in patients with follicular lymphoma (FL) as part of maintenance treatment. CRU - A two-stage phase 1b study to investigate the pharmacokinetics, safety and tolerability of rituximab subcutaneous (SC) formulation in patients with follicular lymphoma (FL) as part of maintenance treatment. CRU - AEG35156-204: a phase 1-2, multicenter, open-label study of the x-linked inhibitor of apoptosis (XIAP) antisense AEG35156 in patients with relapsed or refractory chronic lymphocytic leukemia, and indolent B cell lymphomas. CRU - PX-171-003 - An open-label, single-arm, phase 2 study of Carfilzomib in patients with relapsed and refractory Multiple Myeloma. Assouline, Sarit Assouline, Sarit Assouline, Sarit Celgene Corporation Proteolix Glaxo Smith Kline Assouline, Sarit Glaxo Smith Kline Assouline, Sarit Hoffmann-La Roche Limitée, Canada Assouline, Sarit Methylgene Inc. Assouline, Sarit Genzyme Corp. CRU - A three-part study of Eltrombopag in thrombocytopenic subjects with myelodysplastic syndromes or acute myeloid leukemia (part 1: open label, part 2: randomized, double-blind, part 3: extension. An extension study of eltrombopag olamine (SB-497115-GR) in adults, with idiopathic thrombocytopenic purpura (ITP), previously enrolled in an eltrombopag study. CRU - BO21003 - An open-label, multi-centre, dose escalating, phase I/II study to investigate the safety and tolerability of RO5072759 given as monotherapy in patients with CD20+ malignant disease. CRU - A phase II study of MGCD0103 given three-times weekly in patients with relapsed and refractory lymphoma. CRU - A phase 3, randomized, double-blind, placebocontrolled, multi-center study confirming the efficacy and safety of Genz-112638 in patients with Gaucher Disease Type 1. External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 12,012 16,829 29,168 68,412 1,000 3,000 3,000 3,016 3,674 4,014 5,000 7,784 16,340 16,740 18,732 8/15/2012 ‐ 19 External Grants Career Awards Industrial Contracts Clinical Research Awards NAME AGENCY TITLE Assouline, Sarit Novartis Pharma Canada Inc. CRU - A phase IA/II, multi-center, open-label study of HCD122 administered intravenously once weekly for four weeks in adult patients with advanced non-Hodgkin's or Hodgkin's lymphoma who have progressed after at least two prior therapies. 19,182 Assouline, Sarit Hôpital Maisonneuve Rosemont 21,960 Assouline, Sarit Proteolix Assouline, Sarit Assouline, Sarit Wyeth - Ayerst Canada Inc. (St-Laurent, Qc et North York, On) Onyx Industries Inc. Assouline, Sarit Ariad Pharmaceuticals Inc. Assouline, Sarit Hoffmann-La Roche Limitée, Canada Assouline, Sarit Hoffmann-La Roche Limitée, Canada Assouline, Sarit Genentech Inc. Assouline, Sarit Genentech Inc. A prospective randomized phase II study evaluating the optimization of the residual plasmatic level of Dasatinib (Sprycel®) in patients newly diagnosed with chronic phase chronic myelogenous leukemia (CP-CML). CRU - An open-label, single-arm, phase 2 study of carfilzomib maintenance therapy in subjects previously enrolled in carfilzomib treatment protocols. CRU - A phase 1/2 study of SKI-6-6 in Philadelphia chromosome positive leukemias. CRU - A randomized, multicenter, phase 3 studycomparing carfilzomib, lenalidomide, and dexamethasone (CRd) vs. lenalidomide and dexamethasone (Rd) in subjects with relapsed multiple myeloma. CRU - A pivotal phase 2 trial of Ponatinib (AP24534) in patients with refractory chronic myeloid leukemia and ph+ acute lympnobastic leukemia. CRU-An adaptive,comparative,randomized,parallelgroup,multi-center,phase lb study of subcutaneous (SD) rituximab versus intravenous rituximab both in combination with chemotherapy (fludarabine and cyclophosphamide),in patients with previously untreated... CRU-A multi-center, open-label, phase I study of single agent R7112 administered orally in patients with acute myelogenous leukemia (AML) acute lyphocytic leukemia (ALL), chronic myelogenous leukemia (CML) in blast phase, or refractory chronic lymphocytic CRU - An open-label, multicenter, phase I trial of the safety and pharmacokinetics of escalating doses of DCDS4501A in patients with relapsed or refractory B-cell non hodgkin's lymphoma and chronic lymphocytic leukemia. CRU-An open-label, multicenter, randomized, phase III study to investigate the efficacy and safety of bendamustine compared with bendamustine + RO5072759 (GA101) in patients with rituximab-refractory, indolent non-hodgkin's lymphoma. Assouline, Sarit Millennium Pharmaceuticals Inc (Cambridge, Ma, Usa) Novartis Pharma Canada Inc. Q-CROQ-02 - A randomized phase II study of oral panobinostat (LBH1589) with or without rituximab (the "Study Drug") to treat relapsed or refractory B-cell non-Hodgkin lymphoma. Astrazeneca Ab (Sweden) OSKIRA-3 A phase III, multi-centre, randomized, double-blind, placebo-controlled, parallel group study of two dosing regimens of Fostamatinib Disodium in rheumatoid arthritis patients with inadequate response to TNF-alpha antogonist. United Therapeutics Corporation 86,847 Assouline, Sarit Baron, Murray Baron, Murray Foundation 23,183 25,647 29,275 33,462 39,800 53,700 69,900 84,508 190,089 500 736 8/15/2012 ‐ 20 NAME AGENCY TITLE Baron, Murray United Therapeutics Corporation Baron, Murray Abbott Laboratories Baron, Murray Amgen Canada Inc (Mississauga, Ont) Baron, Murray Amgen Canada Inc (Mississauga, Ont) Baron, Murray Actelion Pharmaceuticals Canada Inc. DISTOL-1: Digital Ischemic Lesions in Scleroderma treated with oral treprostinil diethanolamine: a randomized, doubleblind, placebo-controlled, multicenter study. Real life evaluation of rheumatoid arthritis in Canadians taking HUMIRA. 20070301 - CAnadian Methotrexate and Etanercept Outcome study: an open label randomized trial of etanercept and methotrexate versus etanercept alone in the treatment ot rheumatoid arthriris CAMEO" A multicenter, open label study to describe the safety of daily subcutaneous injections of Anakinar (r-metHuIL-1ra) in patients with rheumatoid arthritis. AC-052-510 - A two-stage prospective observational cohort study in scleroderma patients to evaluate screening tests and the incidence of plumonary arterial hypertension and pulmonary arterial hypertention and pulmonary hypertension. Baron, Murray Baron, Murray Hospital Mount Sinai Pfizer Canada Inc. Batist, Gerald Blostein, Mark Blostein, Mark Blostein, Mark Chertkow, Howard Cohen, Albert Cohen, Albert Cohen, Albert A phase 2A randomized double-blinded, placebo & active controlled two cohort two doses cross-over multi-center clinical study to assess efficacy of a once daily administration of a phosphodiesterase 5 inhibitor (PF-00489791) for the treatment of vasospasm Pfizer Canada Inc. PF-046691502-Phospho-Nrf2 as a novel biomarker for identifying patients for PI3K-mTOR inhibition to achieve selective chemosensitization. Boehringer Ingelheim (Canada) Ltd Resource utilization associated with oral anticoagulant management (ROAM) in Canada: a multicentre, prospective study. Sanofi-Aventis (Canada) ENOXA_L_02260-VTE Registry - National, prospective, observational cohort study of venous thrombembolism management with the low molecular weight heparin, enoxaparin, in the outpatient setting in Canada. Bristol-Myers Squibb Canada Inc. A phase 3, active (Warfarin) controlled, randomized, doubleblind, parallel-arm study to evaluate efficacy and safety of apixaban in preventing stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Janssen Alzheimer Immunotherapy A phase 3 extension, multicenter, double-blind, long term safety and tolerability treatment trial of bapineuzumab (AAB001, ELN115727) in subjects with Alzheimers's disease who participated in study ELN115727-301 or in study ELN115727302. Abbott Laboratories M10-223 - A multicenter, open-label study of the human antiTNF monoclonal antibody adalimumab to evaluate the long term safety and tolerability of repeated administration of adalimumab in subjects with ulcerative colitis. Robarts Research Institute (Formerly John P. A randomized double-blind, placebo-controlled study to Robarts Research Institute) investigate the efficacy and safety of GSK1605786A in the treatlment of subjects with moderately to severrely active crohn's disease. Robarts Research Institute (Formerly John P. An open-label extension study to assess the safety of Robarts Research Institute) GSK1605786A in subjects with Crohn's disease. External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 2,482 2,700 5,162 9,675 10,093 17,000 26,267 70,000 3,675 11,300 66,486 9,854 1,599 3,874 4,137 8/15/2012 ‐ 21 TITLE External Grants Career Awards Industrial Contracts NAME AGENCY Cohen, Albert Robarts Research Institute (Formerly John P. A 52 week randomised, double-blind, placebo-controlled study Robarts Research Institute) to investigate the efficacy and safety of GSK1605786A in the maintenance of remission in subjects with Crohn's disease. 4,137 Cohen, Albert Pfizer Canada Inc. 5,700 Cohen, Albert Laboratoires Abbott Ltée Cohen, Albert Quintiles Canada Inc. CRU - A4021018 - Randomized, open-label, phase 3 trial of Erlotinib alone or in combination with CP-751,871 in patients with advanced non-small cell lung cancer of nonadenocarcinoma histology. A multicenter, randomized, double-blind, placebo-controlled study of the human anti-TNF monoclonal antibody adalimumab for the induction and maintenance of clinical remission in subjects with moderately to serverly active ulcerative colitis. #M06-827 A phase 3, randomized, placebo-controlled, blinded, multicenter, multiple dose study for the induction and maintenance of clinical response and remission with MLN0002 in patients with moderate to severe ulcerative colitis. Cohen, Albert Quintiles Canada Inc. 14,797 Cohen, Albert Abbott Laboratories Cohen, Victor Pfizer Canada Inc. Cohen, Victor Novartis Pharma Canada Inc. Cohen, Victor Pfizer Canada Inc. Cohen, Victor Novartis Pharma Canada Inc. Cohen, Victor Pharmaceutical Research Associates Inc. Eisenberg, Mark Pfizer Canada Inc. Greenaway, Christina Agennix, Inc. Hilzenrat, Nir Merck Frosst Canada Inc A phase 3, randomized, placebo-controlled, blinded, multicenter study, of the induction and maintenance of clinical response and remission with MLN0002 in patients with moderate to severe Crohn's disease. An open-label, multicenter, efficacy and safety study to evaluate two treatment algorithms in subjects with moderate to severe Crohn's disease - CALM. CRU - A4021016 - Randomized, open label, phase III trial of CP-751,871 in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer. CRU - A phase II, multi-center, open-label study of AUY922 administered IV on a once-weekly schedule in patients with advanced non-small-cell lung cancer who have received at least two lines of prior chemotherapy. EML4-ALK mutated non-small cell lung cancer in a western population_ a clinicopathologic study. CASA404A2302 - A phase III, randomized, double-blind, placebo-controlled multi-center stuty of ASA404 in combination with docetaxel in second-line treatment of patients with advanced metastatic (stage IIIB/IV) non-small cell lung cancer (NSCLC). A multi-center phase III randomized, double-blind placebocontrolled study of the cancer vaccine Stimuvax (L-BLP25 or BLP25 liposome vaccine) in non-small cell lung cancer (NSCLC) subjects with unresectable stage III disease. GA3041Z4-Evaluation of Varenicline-(ChampixTM) in smoking cessation for patients post-acute coronary syndrome (EVITA) trial. A phase 2/3 randomized, double-blind, placebo-controlled study of the safety and efficacy of Talactoferrin Alfa in patients with sever sepsis. Study P04257: Effect of Infliximab in Hepatitis-C Genotype 1 Naïve Patients with High TNF-alfa on the Efficacy of Pegylated Interferon-alfa2b/Ribavirin Therapy. Clinical Research Awards Foundation 7,072 7,407 269,066 2,000 14,094 14,457 14,457 24,111 149,825 5,437 2,920 8/15/2012 ‐ 22 NAME AGENCY TITLE Hilzenrat, Nir Glaxo Wellcome Inc. Hilzenrat, Nir Novartis Hirsch, Andrew Sunnybrook Health Sciences Centre (Toronto, On) Hirsch, Andrew Sanofi-Aventis (Canada) Hirsch, Andrew Gilead Sciences TPL108390 - Randomised, placebo-controlled, multi-centre study to assess the efficacy and safety of eltrombopag in thrombocytopenic subjects with hepatitis C virus (HCV) infection who are otherwise eligible to initiate antiviral therapy (suite ds résumé) Pharmacogenomic analysis of blood samples to identify host genomic profiles that segregate responders from nonresponders following treatment with Peg-interferon and ribavirn in HCV-infected subjects (genotype 1). A randomized phase III study of standard treatment +/enoxaparin in small cell lung cancer, RASTEN study Canadian part. DIREG_C_04823 - CANTARISK - A prospective, noninterventional, cohort survey on VTE risk in patients receiving a new chemotherapy for cancer. AARTEMIS-PH: A phase 3, randomized, double-blind, placebocontrolled, multi-center, parallel-group study to evaluate the efficacy and safety of ambrisentan in subjects with idiopathic pulmonary fibrosis and pulmonary hypertension. Hirsch, Andrew Bayer Canada Inc. Hirsch, Andrew Bayer Canada Inc. Hoffer, Leonard J. Immunotec Recherche Kahn, Susan Rebecca Aventis Pharma Kahn, Susan Rebecca Lawson Health Research Institute Kahn, Susan Rebecca Quintiles Canada Inc. Kahn, Susan Rebecca Boehringer Ingelheim (Canada) Ltd Karaplis, Andrew C. Amgen Canada Inc (Mississauga, Ont) External Grants Career Awards Industrial Contracts Foundation 3,279 14,075 3,712 8,420 19,703 Study 11348-Randomized, double-blind, placebo-controlled, multi-centre, multi-national study to evaluate the efficacy and safety of oral BAY 63-2521 (1 mg,1.5 mg, 2 mg, or 2.5 mg tid) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Study no 11349 - Long-term extension, multi-centre, multinational study to evaluate the safety and tolerability of oral BAY 63-2521 (1 mg, 1.5 mg, 2 mg, or 2.5 mg tid) in patients with chronic thromboembolic pulmonary arterial hypertension. 25,322 Method development to measure plasma amino acids and reduced total cysteine. A double-blind, placebo-controlled, parallel, multicenter study on extended VTE prophylaxis in acutely III medical patients with prolonged immobilization. A prospective study of upper extremity deep vein thrombosis to determine the prevalence of post-thrombotic syndrome in patients managed with anticoagulation. A phase III, randomized, double-blind, double-dummy, parallel group, multi-center, multi-national study for evaluation of efficacy and safety of (LMW) Heparin/Edoxaban versus (LMW) Heparin/Warfarin in subjects with symptomatic deep-vein thrombosis and/or 1160.46 - A phase III, randomised, double blind, parallel-group study of the efficacy and safety of oral dabigatran etexilate (150 mg bid) compared to warfarin (INR 2.0-3.0) for 6 month treatment of acute symptomatic venous (suite ds résumé) 8,196 Prospective observational study to evaluate persistence with Prolia (denosumab) in postmenopausal women with osteoporosis in routine clinical practice. Clinical Research Awards 32,628 1,977 12,250 23,276 61,050 8,635 8/15/2012 ‐ 23 NAME AGENCY TITLE Kavan, Petr Covance Inc. Kavan, Petr Sanofi-Aventis (Canada) Kavan, Petr Amgen Canada Inc (Mississauga, Ont) Kavan, Petr Oncozyme Pharma Inc. Kavan, Petr Novartis Pharma Canada Inc. Kavan, Petr Sanofi-Aventis (Canada) Kavan, Petr Sanofi-Aventis (Canada) Kavan, Petr Sanofi-Aventis (Canada) Kavan, Petr Covance Inc. Kavan, Petr Oncozyme Pharma Inc. Kavan, Petr Boehringer Ingelheim (Canada) Ltd Kavan, Petr Merrimack Pharmaceuticals A RANDOMIZED, DOUBLE BLIND, PLACEBOCONTROLLED, MULTICENTER PHASE III TRIAL OFBEVACIZUMABAND TEMOZOLOMIDE VERSUS PLACEBO,TEMOZOLOMIDE ANDRADIOTHERAPY FOLLOWED BY PLACEBOAND TEMOZOLOMIDE INPATIENTSWITH NEWLY DIAGNOSED GLIOBLASTOMA. Gemcitabine and Oxaliplatin with Concomitant Radiotherapy as Neoadjuvant Therapy for Potentially Resectable Pancreatic Cancer A Phase 3, Randomized, Double-blind, Placebo-Controlled Study of Pegfilgrastim Administered to Subjects With Newly DX, Locally-Advanced or Metastatic Colorectal Cancer Treated With Bevacizumab and Either 5-Fluorouracil, Oxaliplatin, Leucovorin (Folfox) or A PHASE 1/11 CLINICAL STUDY USING PENTAMIDINE PATIENTS WITH LOCALLY ADVANCED OR METASTATIC PANCREATIC CANCER UNDERGOING STANDARD THERAPY A randomized, open-label, multi-center phase III study to evaluate the efficacy and safety of nilotinib versus imatinib in adult patients with unresectable or metastatic gastrointestinal stromal tumors A Randomised Phase III Study of Capecitabine or 5Fluorouracil-Based Regimen with or without Oxaliplatin as 2nd Line Treatment of Advanced or Metastatic Pancreatic Cancer in Patients Who Have received Gemcitabine-Based Chemotherapy A Multicenter, Randomized Double-Blind Placebo-Controlled Phase III Study Assessing the Efficacy of Oral Glutamine in the Prevention of Oxaliplatin Inducted Neurotoxicity in Patients with Colorectal Cancer Treated with Oxaliplatin in Adjuvant of 1st ... Gemcitabine and Oxaliplatin with Concomitant Radiotherapy as Neoadjuvant Therapy for Potentially Resectable Pancreatic Cancer A RANDOMIZED, DOUBLE BLIND, PLACEBOCONTROLLED, MULTICENTER PHASE III TRIAL OFBEVACIZUMABAND TEMOZOLOMIDE VERSUS PLACEBO,TEMOZOLOMIDE ANDRADIOTHERAPY FOLLOWED BY PLACEBOAND TEMOZOLOMIDE INPATIENTSWITH NEWLY DIAGNOSED GLIOBLASTOMA. A phase II clinical study using Pentamidine in patients with metastatic cancer undergoing standard chemotherapy (mFOLFOX6 or FOLFIRI) as second-line treatment. BIBW 2992 WITH OR WITHOUT DAtLY TEMOZOLOMIDE IN THE TREATMENT OF PATIENTS WITH RECURRENT MALIGNANT GLIOMA Signaling Signature of Osteoclastogenesis External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 1,317 2,473 2,846 3,972 4,291 4,697 5,433 7,534 12,025 12,040 15,042 20,207 8/15/2012 ‐ 24 NAME AGENCY TITLE Kavan, Petr Enzon Inc Langleben, Adrian Boston Biomedical Inc. (Bbi) Langleben, David Gilead Sciences Langleben, David Actelion Pharmaceuticals Canada Inc. Langleben, David Glaxo Wellcome Inc. Langleben, David Actelion Pharmaceuticals Canada Inc. Langleben, David Bayer Canada Inc. CRU - A phase 2 study of EZN-2208 (PEG-SN38) administered with or wihout Cetuximab in patients with metastatic colorectal Carcinoma (mCRC). CRU - BBI608-101 - A phase I clinical study of BBI608 in adult patient with advanced solid tumour. A phase 2, randomized, double-blind, placebo-controlled, multicenter, dose-ranging study of cicletaninie in subjects with pulmonary arterial hypertension. AC-065A303: Long-term single-arm open-label study, to assess the safety and tolerability of Act-293987 in patients with pulmonary arterial hypertension. AMB110094 - A post marketing observational surveillance programme for Ambrisentan (VOLT). A multicenter, double-blind placebo-controlled phase 3 study to demonstrate the efficacy and safety of ACT-293987 in patients with pulmonary arterial hypertension. Study 12934 - Randomized, double-blind, placebo-controlled, multi-centre, multi-national study to evaluate the efficacy and safety of oral BAY 63-2521 (1 mg, 1.5 mg, or 2.5 mg tid) in patients with symptomatic pulmonary arterial hypertension. Langleben, David Actelion Pharmaceuticals Canada Inc. Langleben, David Bayer (Canada) Inc. Lapointe, Bernard JosephWex Pharmaceuticals Inc. Lapointe, Bernard JosephPfizer Canada Inc. Lau, Susie Kit Sze Michel, Caroline Centre de Recherche du Centre Hospitalier de l'université de Montréal (Crchum) Bayer Canada Inc. Miller, Mark A. Merck Frosst Canada Inc AC-066A301/EPITOME-2: A multicenter, single-arm, openlabel, phse 3b study to assess the effects of switching from Flolan to ACT-385781A in patients with (PAH). AC-066A302/EPITOME-2 extention: An open-label extension of ACT-385781A. CRU-TEC-006-A multicentre, randomized, double-blind, placebo-controlled, parallel-design trial of the efficacy and safety of subcutaneous tetrodotoxin (Tectin TM) for moderate to severe inadequately controlled cancer-related pain. CRU - A randomized, double-blind, placebo-controlled study of a fixed dose of subcutaneous methylnatrexone in adults with advanced illness and opioid-induced constipation: Efficacy, safety, and additional health outcomes. Protocol: 3200K1-4000/B2541005 External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 34,367 109,320 504 2,500 3,385 7,205 47,235 70,087 93,691 31,559 31,604 18,896 Study 143-08 - A randomized, double-blind, placebocontrolled, parallel-group, multi-center study to evaluate the hemodynamic effects of riociguat (BAY 63-2521) as well as study & kinetics in patients with pulmonary hypertension associated with left... V212-001 A phase III, double-blind, randomized, placebocontrolled, multicenter clinical trial to study the safety, tolerability, efficacy , and immunogenicity of V212 in recipients of autologous hematopoietic cell transplants (HCTs). 49,302 33,271 8/15/2012 ‐ 25 External Grants Career Awards Industrial Contracts Clinical Research Awards NAME AGENCY TITLE Miller, Mark A. Actelion Pharmaceuticals Canada Inc. 38,037 Miller, Mark A. Covance Inc. Miller, Mark A. Cubist Pharmaceuticals, Inc. Miller, Wilson Novartis Pharma Canada Inc. Miller, Wilson Glaxo Wellcome Inc. Miller, Wilson Pfizer Canada Inc. Miller, Wilson Glaxo Smith Kline A multi-center, double-blind, randomized, active reference, parallel group sutdy to evaluate the efficacy, safety and tolerability of a 10-day twice daily oral administration of 3 doses of ACT-179811 in subjects with Clostridium difficile infection (DSI) Prospective observational study of nosocomial Clostridium difficile toxin antibody concentrations, incidence, and recurrence. A randomized, double-blinded, active-controlled, dose ranging study of CB-183,315 in patients with clostridium difficile infection (CDI). CRU-A phase Ib/IIa, trial of LBH589 in combination with trastuzumab in adult female patients with HER2 positive metastatic breast cancer whose disease has progressed during or following therapy with trastuzumab. CRU- LPT109747 - An exploratory, phase II trial to determine the association of lapatinib induced fluropyrimidine gene changes with efficacy parameters of lapatinib and capecitabine in first line gastric cancer. CRU - A3671016 - A phase I dose escalation trial of CP675,206 in combination with Gemcitabine in patients with chemotherapy-naïve metastatic pancreatic cancer. CRU - EGF105485 - A randomized, double-blind, multicenter, placebo-controlled study of Adjuvant La patinib in women with early-stage ErbB2 overexpressing breast cancer. Miller, Wilson Bristol-Myers Squibb Canada Inc. 2,264 Miller, Wilson Pfizer Canada Inc. Miller, Wilson Biovex Ltd (Uk) Miller, Wilson Ym Biosciences Inc. CRU - CA184-024 - A multicenter, randomized, double-blind, two-arm, phase III study in patient with untreated stage III (unresectable) or stage IV melanoma receiving Dacarbazine Plus 10mg/kg of Ipilimumab (MDX-010) vs. Dacarbazine with placebo. CRU-A6181037-A SU011248 expanded access protocol for patients with cytokine-refractory or cytokine-intolerant metastatic renal cell carcinoma who are ineligible for participation in other SU011248 prot. but may derive benefit from treatment with SU011248. CRU - A randomized phase 3 clinical trial to evaluate the efficacy and safety of treatment with OncoVEXGM-CSF compared to subcutaneously administered GM-CSF in melanoma patients with unresectable stage IIIb, IIIc and VI disease. CRU - A phase II, open-label extension study evaluating the long-term safety, tolerability and efficacy of orally-administered CYT387 in primary myelofibrosis or post-polycythemia vera or post-essential thrombocythemia myelofibrosis (CCL09101E). Miller, Wilson Ym Biosciences Inc. 8,300 Miller, Wilson Novartis Canada Ltd CRU - A phase I/II, open-label, study evaluating twice-daily administration of CYT387 in primary myelofibrosis or postpolycythemia vera or post-essential thrombocythemia myelofibrosis. CRU - A study II study of oral LBH589 in adult patients with refractory cutaneous T-cell lymphoma. Foundation 55,828 56,550 500 500 750 1,474 4,477 4,798 5,800 11,824 8/15/2012 ‐ 26 NAME AGENCY TITLE Miller, Wilson Bayer (Canada) Inc. Miller, Wilson Glaxo Smith Kline Miller, Wilson Bayer Canada Inc. CRU - A phase I, non-randomized open-label study to evaluate the effect of BAY 73-4506 (regorafenib) on probe substrates of CYP 2C9 (warfarin), 2C19 (omeprazole) and 3A4 (midazolam) in a cocktail approach (Group A) and on a probe substrate of CYP 2C8. CRU - VEG108844 - A study of Pazopanib versus Sunitinib in the treatment of subjects with locally advanced and/or metastatic rena cell carcinoma. CRU - A randomized, double-blind, placebo-controlled phase III study of regorafenib plus BSC versus placebo plus BSC in patients with metastatic colorectal cancer (CRC) who have progressed after standard therapy. (Study 14387). Miller, Wilson Infinity Pharmaceuticals Miller, Wilson Pfizer Canada Inc. Miller, Wilson Hoffmann-La Roche Limitée, Canada Miller, Wilson Novartis Pharma Canada Inc. Miller, Wilson Infinity Pharmaceuticals Miller, Wilson Ym Biosciences Inc. Miller, Wilson Glaxo Smith Kline Miller, Wilson Glaxo Smith Kline Palayew, Mark Boehringer Ingelheim (Canada) Ltd Pollak, Michael Oncogenex Technologies Inc. CRU - A phase 1b/2 study evaluating IPI-926 in combination with Gemcitabine in patients with metastatic pancreatic cancer. CRU-A two-arm randomized open label phase 2 study of CP751, 871 in combination with exemestane alone as a first line treatment for postmenopausal patients with hormone receptor positive advanced breast cancer. CRU - A multi-center, open-label, first-in-human, phase I doseescalation study of single agent RO5503781, a small molecule MDM2 antagonist, administered orally in patients with advanced malignancies, except leukemia. Protcol no NP27872. CRU - A phase Lb open-label dose escalation study of MEK162 plus RAF265 in adult patients with advanced solid tumors harboring RAS or BRAFV622E mutations. CRU - Phase 2 combination with gemcitabine in patients with metastatic pancreatic cancer. CRU-Phase I/II, open-label, dose-escalation study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of orally-administered CYT387 in primary myelofibrosis or post-polycythemia vera or post-essential thrombocythemia myelofibrosis. BRF113929: A phase II open-label, two-cohort, multicentre study of GSK2118436 a a single agent in treatment naïve and previously treated subjects with BRAF mutation-positive metastatic melanoma of the brain. CRU - BRF113683: a phase III randomized, ope-label study comparing GSK2118436 to DTIC in previously untreated subjects with BRAF mutation positive advanced (stage III) or metastatic (stage IV) melanoma. A randomised, active-controlled, double-blind, double-dummy, parallel group design, multi-center trial to compare the efficacy and safety of 2.5 ug and 5 ug Tiotropium Inhalation Solution delivered by the Respimat Inhaler with Tiotropium inhalation capsul OGX-011-07 - A pilot study evaluating the safety and feasibility of OGX-011 in combination with second-line chemotherapyt in patients with hormone refractory prostate cancer. External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 14,319 18,688 20,953 24,169 27,490 38,000 46,489 48,583 87,552 102,385 157,995 14,084 2,235 8/15/2012 ‐ 27 NAME AGENCY TITLE Pollak, Michael Pfizer Canada Inc. Pollak, Michael National Institutes of Health CRU-A4021011-A phase 2, randomized, non-comparative, two-arm open label, multiple-centre study of CP-751,871 in combination with Docetaxe/Prednisone in chemotherapyNaîve (Arm A) and Docetaxe/Prednisone refractory (Arm B) patients (suite) The breast radiology evaluation and study of tissues ("BREAST") stamp. Pollak, Michael Pollak, Michael Pfizer Inc. (Usa) Teva Pharma Industries Cda Pollak, Michael National Institutes of Health Pollak, Michael Pfizer Canada Inc. Pollak, Michael American Cancer Society Pollak, Michael Novo Nordisk A/S (Danemark) Pollak, Michael Schiffrin, Ernesto Regroupement de Particuliers Kao Corporation (Japan) Schiffrin, Ernesto Novartis Pharmaceuticals Corporation Sheppard, Richard New England Research Institutes (Neri) (Usa) Treatment Of preserved cardiac function heart failure with an Aldosterone anTagonist (N01-HC-45207TOPCAT). Novartis Pharma Canada Inc. CSPP100A2368 - A multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the 6 moths efficacy and safety of aliskiren therapy on top of stardard therapy, on moribidity and mortality when intitiated early after hosp Pharmaceutical Product Development, Ppd Inc. Pfizer Canada Inc. Post-operative venous thromboembolism in patients with cancer: A population based cohort study (WS462014) Sanofi-Aventis (Canada) Determining the timing of venous thromboembolism in the post-operative setting: a population-based cohort study. Eisai Research Institute FRAG-A001-401 - Dalteparin sodium injection (FRAGMIN), multi-center, open label, single-arm, controlled long-term (52 weeks) study for understanding safety and efficacy in subjects with malignancies and symptomatic venous thromboembolism. Hamilton Health Sciences BAV - Beta-blockers and angiotensin receptor blockers in bicuspid aortic valve aortopahy. Sheppard, Richard Small, David Tagalakis, Vicky Tagalakis, Vicky Tagalakis, Vicky Therrien, Judith CRU - A randomized phase 3 comparing standard first-line Docetaxel/Prednisone to Docetaxe/Prednisone in combination with Custirsen (OGX-011) in men with metastatic castrate resistant prostate cancer. C-peptide, adipocytokine, and inflammatory biomarkers related to obesity and pancreatic cancer. Phase I safety and tolerability study of figitumumab combined with pegvisomant in patients with advanced solid tumors. Measure C-peptide, leptin, adiponectin, high molecular weight adiponectin, and TFG-beta levels in blood samples collected from CPS-II participants who developed pancreatic cancer and a group of matched controls. Murine models to study the effect of diabetes and diabetes treatments, including insulin analogues, on cancer behavior. IGF and breast cancer. Research on vascular disesae in hypertension: Role of endothelin, PPARs and T-lymphocytes. A double-blind, randomized, parallel design study to compare the effectiveness of Aliskiren versus Hydrochlorothizide in mildto -moderate hypertensive type II diabetes mellitus patients in reversing the remodeling of resistance arterisand correcting ... External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 5,500 8,263 9,439 26,120 33,928 39,590 129,934 200,000 271,535 10,016 25,491 7,550 13,750 15,575 10,000 29,354 36,118 5,500 8/15/2012 ‐ 28 NAME AGENCY TITLE Trifiro, Mark A Boehringer Ingelheim (Canada) Ltd Trifiro, Mark A Trifiro, Mark A Genome Prairie Instituts de Recherche en Santé du Canada Vaitekunas, Susan Hoffmann-La Roche Limitée, Canada Wainberg, Mark A. Merck Sharp & Dohme Research Laboratory Wainberg, Mark A. Zaharatos, Gerasimos International Science and Technology Partnerships Canada (Istp) Dynavax Technologies Corporation A phase III, randomised, double-blind, placebo-controlled, parallel group, efficacy and safety study of BI 10773 (10mg and 25mg administered once daily) as add on to pre-existing antidiabetic therapy over 52 weeks in patients with type 2 diabetes mellitus Total utilization flax genomics (TUFGEN). Innovative approaches to functional characterization of the androgen receptor in prostate cancer. Multicenter, randomized, double-blind, placebo-controlled, parallel-group two year study to evaluate the effect of subcutaneous RO4909832 on congnition and function in prodromal Alzheimer's disease. Part 1: Impact of subtype-specific variability on hte effectiveness of integrase inhibitor. Novel HIV integrase inhibitors. Clinical Research Awards Agulnik J. Department of Medicine, JGH Assouline S. Department of Medicine, JGH Baron M. Blostein M. Department of Medicine, JGH Department of Medicine, JGH Blostein M. Department of Medicine, JGH Blostein M. Department of Medicine, JGH Greenaway C. Department of Medicine, JGH Gyger, G. Department of Medicine, JGH Hilzenrat, N. Department of Medicine, JGH Kader T. Department of Medicine, JGH Miller M Nessim, S. Department of Medicine, JGH Department of Medicine, JGH Rudski L. Department of Medicine, JGH External Grants Career Awards Industrial Contracts Clinical Research Awards Foundation 11,045 30,000 116,923 9,450 224,304 400,000 18,034 Utility of different non-surgical biopsies in the genetic profiling and cellular differentiation of non-small cell lung cancer (NSCLC) Combination of imatinib and chlorambucil for the treatment of patients with relapsed chronic lymphocytic leukemia and Efficacy of ribavirin for the treatment of acuter myeloid leukemia subtypes M4 and M5 Statins in scleroderma 1. TIPPS (Thrombophilia in Pregnancy Prophylaxis Study): A multicenter, multinational randomised control trial of prophylactic low molecular weight heparin (LMWH) in high risk pregnant thrombophilic women 2. A Phase 3, Active (Warfarin) Controlled, Randomized, Double-blind, Parallel Arm Study to Evaluate Efficacy and Safety of Apixaban in Preventing Stroke and Systemic Embolism in Subjects with Atrial Fibrillation 3. A Double-blind Randomized Control Trial of Post-Operative Low Molecular Weight Heparin Bridging Therapy versus Placebo Bridging Therapy for Patients Who Are at High Risk for Arterial Thromboembolism (PERIOP 2) The Burden of Infectious Diseases in Immigrants and Refugees: Reviewing the Evidence Videocapillaroscopy in systemic sclerosis and inflammatory myopathy Short Term Memory Defect in Hepatitis C Patients Treated with Interferon C-peptide levels and how they predict insulin response in type two diabetic patients who have failed oral agents Household transmission of C. difficile The Relationship Between Peritoneal Transport Status and Vitamin D Deficiency Among Peritoneal Dialysis Patients Echocardiography-based research on the right heart 4,000 4,000 4,000 4,000 12,000 12,000 12,000 4,000 4,000 12,000 4,000 8/15/2012 ‐ 29 NAME AGENCY TITLE Sakr, L. Department of Medicine, JGH Schweitzer M. Tagalakis, V. Department of Medicine, JGH Department of Medicine, JGH Sheppard, R. Department of Medicine, JGH Elizov, M. Dascal, A Department of Medicine, JGH Department of Medicine, JGH Palayew, M. Department of Medicine, JGH Roshdy, O. Department of Medicine, JGH Szilagyi, A. Department of Medicine, JGH Wyse, J. Department of Medicine, JGH Understanding Phenotypical Heterogeneity of Potentially Curable Non-Small Cell Lung Cancer Using Cluster Analysis Atorvastatin treatment in abdominal aortic aneurysm (AAA) Epidemiology of venous thrombosis and pharmacoepidemiology Dysfunction of stress response systems and adverse cardiac remodeling after myocardial infarction Mentorship in Clinical Medicine Microbiome Replenishment Strategies to Treat and Protect against C. difficile The Airways Centre at the Jewish General Hospital: Aspects of care in COPD patients Analysis of the direct growth inhibitory effect of ipilimumab on melanoma cells IBD Epidemiology: Relationships with Vitamin D and population lactase distributions The value of Botox-A in Acute Radiation Proctitis TOTALS External Grants Career Awards Industrial Contracts Clinical Research Awards 12,000 Foundation 4,000 12,000 12,000 12,000 8,000 8,000 8,000 8,000 8,000 23,906,008 2,392,057 4,996,075 168,000 1,300,350 8/15/2012 ‐ 30