P U B L I C A T I O N S - Jean
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P U B L I C A T I O N S - Jean
Jean-Pierre MAZAT : INTERNATIONAL PUBLICATIONS 2011 - Pérès S, Vallée F, Beurton-Aimar M, Mazat JP. ACoM: A classification method for elementary flux modes based on motif finding. Biosystems 2011 Mar;103(3):410-9. - Karine Nouette-Gaulain, M.D., Ph.D., Matthieu Biais, M.D., Jean-Pierre Savineau, Ph.D., Roger Marthan, M.D., Ph.D., Jean-Pierre Mazat, Ph.D., Thierry Letellier, Ph.D., François Sztark, M.D., Ph.D. Chronic hypoxia-induced alterations in mitochondrial energy metabolism are not reversible in rat heart ventricles. Can J Physiol Pharmacol. 2011 Jan;89(1):58-66 2010 - Jean-Pierre Mazat, Jonathan Fromentin, Margit Heiske, Christine Nazaret, Stéphane Ransac : Virtual Mitochondrion: Towards An Integrated Model Of Oxidative Phosphorylation Complexes and Beyond. Biochem. Soc. Trans. (2010) 38, 1215-1219. - Stéphane Ransac, Jean-Pierre Mazat : How antimycin inhibits the bc1 complex? A part-time twin. Biochim Biophys Acta. 2010 1797: 1849-1857. - Stéphane Ransac, Clément Arnarez and Jean-Pierre Mazat : The flitting of electrons in complex I: A stochastic approach. Biochim Biophys Acta. 2010 . ; 1797: 641-648. 2009 - F. Medja, S. Allouche, P. Frachon, C. Jardel, M. Malgat, B. Mousson de Camaret, A. Slama, J. Lunardi, J.P. Mazat, A. Lombès (2009) Development and implementation of standardized respiratory chain spectrophotometric assays for clinical diagnosis Mitochondrion 9 (2009) 331–339. - Christine Nazaret, Margit Heiske, Kevin Thurley, Jean-Pierre Mazat : Mitochondrial energetic metabolism : A simplified model of TCA cycle with ATP production. J Theor Biol. 2009 Jun 7;258(3):455-64. 2008 - Ransac, S., Parisey, N. and Mazat J.-P.: The loneliness of electrons in the bc1 complex. Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):1053-9. - Christine Nazaret and Jean-Pierre Mazat, An old paper revisited: A mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the Htransporting shuttles at varying ATPases load by V.V. Dynnik, R. Heinrich and E.E. Sel’kov .J. Theor. Biol. 2008 252(3):520-9. 2007 - Sabine Pérès, Marie Beurton-Aimar and Jean-Pierre Mazat. Classification des modes élémentaires : Application au métabolisme énergétique mitochondrial. Technique et Science informatiques, 2007, 26 (1-2) pp 197-216. 2006 - Sabine Pérès, Marie Beurton-Aimar and Jean-Pierre Mazat. Pathway classification of TCA cycle. IEE Proc. Systems Biology, 2006 153 (5): 369-371. 2005 - Aleardi, A.M., Benard G., Augereau, O., Malgat, M., Talbot, J.-C., Mazat, J.-P., Letellier, T., Dachary-Prigent, J., Soplaini, G.C., Rossignol, R. (2005) : Gradual alteration of mitochondrial structure and function by beta-amyloids: importance of membrane viscosity changes, energy deprivation, reactive oxygen species production, and cytochrome c release. J Bioenerg Biomembr. 2005 ; 37:207-225. - K. Nouette-Gaulain, Christophe Rocher, Monique Malgat, J.-P. Savineau, R. Marthan, J.-P. Mazat et F. Sztark (2005) : Time course of differential mitochondrial energy metabolism adaptation to chronic hypoxia in right and left ventricles. Cardiovascular Research 2005. 66: 132-140. - Augereau O, Claverol, S., Boudes, N., Basurko, M.J., Bonneu, M. Rossignol R, Mazat JP, Letellier T, Dachary-Prigent J. (2005) :Identification of tyrosine-phosphorylated proteins of the mitochondrial oxidative phosphorylation machinery. Cell Mol Life Sci. 62:1478-88 2004 - Augereau O, Rossignol R, DeGiorgi F, Mazat JP, Letellier T, Dachary-Prigent J. (2004) : Apoptotic-like mitochondrial events associated to phosphatidylserine exposure in blood platelets induced by local anaesthetics. Thromb Haemost. 92:104-13 - Faramarzi-Roques R, Malgat M,. Desgrandchamps F ,. Ballanger P. , Mazat J.P. (2004) : Experimental Study of Mitochondrial Metabolism in the Rat during Bladder Regeneration induced by Small Intestinal Submucosa (SIS). British J. Urology Int. 94 :419-23. 2003 - Kuznetsov AV, Kunz WS, Saks V, Usson Y, Mazat JP, Letellier T, Gellerich FN, Margreiter R. (2003) : Cryopreservation of mitochondria and mitochondrial function in cardiac and skeletal muscle fibers. Anal Biochem. ; 319 : 296-303. - Chassagnole C, Quentin E, Fell DA, de Atauri P, Mazat JP.(2003) : Dynamic simulation of pollutant effects on the threonine pathway in Escherichia coli. C R A S, Biol. ;326: 501-8. - Sergeant N, Wattez A, Galvan-valencia M, Ghestem A, David JP, Lemoine J, Sautiere PE, Dachary J, Mazat JP, Michalski JC, Velours J, Mena-Lopez R, Delacourte A. (2003) Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease. Neuroscience. 117 : 293-303. - Rodrigue Rossignol, Benjamin Faustin, Christophe Rocher, Monique Malgat, Jean-Pierre Mazat, , and Thierry Letellier (2003) : Mitochondrial threshold effects. Biochemical J. (Review) 370 : 751-762. 2002 - Marie Beurton-Aimar, Bernard Korzeniewski, Thierry Letellier, Stéphane Ludinard, JeanPierre Mazat and Christine Nazaret (2002) : Virtual Mitochondria – metabolic modelling and control .Mol. Biol. Rep. 29 : 227-232. - Karine Nouette-Gaulain, François Forestier, , Monique Malgat, Roger Marthan, Jean-Pierre Mazat and François Sztark (2002): Effects of bupivacaine on mitochondrial energy metabolism in heart of rats following exposure to chronic hypoxia. Anesthesiology. 97:15071511. - Haberichter, T., Roux, E., Marhl, M. and Mazat, J.-P. (2002) : The influence of different InsP3 receptor isoforms on Ca2+ signalling in tracheal smooth muscle cells. Bioelectrochemistry 57 : 129-138. - De Atauri, P., Fell, D., Chassagnole, C. Magret, D., Mazat, J.-P. and Cascante, M. (2002) : Dependence of control coefficient distribution on the boundaries of a metabolic system : A generalized analysis of the effects of additional input and output reactions to a linear pathways. J. Theor. Biol. 215 : 239-251 2001 - Duclos M, Martin C, Malgat M, Mazat JP, Chaouloff F, Mormède P, Manier G and Letellier T 2001): Modulation of muscle mitochondrial metabolism by stress-induced endogenous corticosterone variations in SHR and Lewis rats Pflügers Archiv - European Journal of Physiology 443 ; 218-226. - Bernard Korzeniewski, Monique Malgat, Thierry Letellier and Jean-Pierre Mazat, (2001) : Effect of ‘binary mitochondrial heteroplasmy’ on respiration and ATP synthesis : implications for mitochondrial diseases. Biochem. J. 357, 835-842 - Jean-Pierre Mazat, Rodrigue Rossignol, Monique Malgat, Christophe Rocher, Benjamin Faustin and Thierry Letellier (2001) : What do mitochondrial diseases teach us about normal mitochondrial functions... that we already knew: threshold expression of mitochondrial defects, Biochim. Biophys. Acta 1504, 20-30 - Christophe CHASSAGNOLE, David A. Fell, Badr RAÏS and Jean-Pierre MAZAT (2001) : Control of the threonine synthesis pathway in Escherischia coli: a theoretical and experimental approach. Biochem. J. 356, 433-444. - Badr RAÏS, Christophe CHASSAGNOLE, Thierry LETELLIER, David A. Fell and JeanPierre MAZAT (2001) : Threonine synthesis from aspartate in Escherichia coli cell-free extracts: pathway dynamics Biochem. J. 356, 425-432. - Christophe CHASSAGNOLE, Badr RAÏS, Eric QUENTIN, David A. FELL and Jean-Pierre MAZAT (2001) : An integrated study of threonine pathway enzyme kinetics in Escherichia coli. Biochem. J. 356, 415-423. 2000 - François SZTARK, Karine NOUETTE-GAULAIN, Monique MALGAT, Philippe DABADIE and Jean-Pierre MAZAT : Absence of stereospecific effects of bupivacaine isomers on heart mitochondrial bioenergetics. Anesthesiology. 2000 Aug;93(2):456-62. - BAKKER A, BARTHELEMY C, FRACHON P, CHATEAU D, STERNBERG D, MAZAT JP, LOMBES A. (2000) Functional mitochondrial heterogeneity in heteroplasmic cells carrying the mitochondrial DNA mutation associated with the MELAS syndrome. Pediatr Res. 2000 Aug;48(2):143-50. - Thierry LETELLIER, Gilles DURRIEU, Monique MALGAT , Rodrigue ROSSIGNOL, Jaromir ANTOCH, Jean-Marc DESHOUILLERS, Michelle COQUET, Didier LACOMBE, Jean-Claude NETTER , Jean-Michel PEDESPAN, Isabelle REDONNET-VERNHET and Jean-Pierre MAZAT (2000) Statistical analysis of mitochondrial pathologies in childhood : Identification of deficiencies using Principal Component Analysis. Lab. Invest. 80, 10191030. - MAZAT, J.-P., ROSSIGNOL, R., MALGAT, M., and LETELLIER, T. (2000) : Simple models of threshold curves in the expression of inborn errors of metablism : application to some experimental observations. Dev. Neurosci. (2000) 22, 399-403. - JOFFROY, S., LETELLIER, T., ROSSIGNOL, R., MALGAT, M., DELAGE, J.-P., POWELL, J.A., MAZAT, J.-P. and KOENIG, J. (2000) : Modification of mitochondrial metabolism in fibroblasts from mice with a skeletal mutation (muscular dysgenesis) Differentiation. 65: 261-270. - ROSSIGNOL, R., LETELLIER, T., MALGAT, M., ROCHER, C. AND MAZAT, J.-P. (2000) : Tissue variation in the control of oxidative phosphorylation : Implication for mitochondrial diseases. Biochem. J. 347 : 45-53. 1999 - ROSSIGNOL, R., MALGAT, M., MAZAT, J.-P and .LETELLIER, T. : Threshold effect and tissue specificity. Implication for mitochondrial cytopathies. 1999 J. Biol. Chem. , 274: 33426-33432. - PEDESPAN JM, JOUAVILLE SL, CANCES C, LETELLIER T, MALGAT M, GUIRAUD P, COQUET M, VERNHET I, LACOMBE D, MAZAT JP (1999) : Menkes disease study of the mitochondrial respiratory chain in three cases. European Journal of Pediatric Neurology,3:167-170 1998 - DENIS-GAY M., PETIT, J.-M., MAZAT, J.-P. and RATINAUD, M.-H. Modification of Oxido-reductase activities in adriamycin-resistant leukaemia K562 cells. Biochememical Pharmacology 1998. 56 451-457. - OUHABI, R., BOUE-GRABOT, M.and MAZAT, J.-P. Mitochondrial ATP synthesis in permeabilized cells: assessment of the ATP/O values in situ. Anal. Biochem. 1998. 263 169175. - SCHUSTER S. , OUHABI, R., RIGOULET, M. and MAZAT, J.-P. Modelling the interrelation between the transmembrane potential and pH difference across membranes with electrogenic proton. Bioelectrochem. Bioenerg. 1998. 45: 181-192. - MAZAT, J.-P., LETELLIER, T., MALGAT, M. ROSSIGNOL, R. KORZENIEWSKI, B., DEMAUGRE, F. and LEROUX, J.-P.: Inborn errors of metabolism in the light of metabolic control analysis. 1998 Biochem. Soc. Trans. , 26: 141-145. - ICHAS, F. and MAZAT, J.-P.: From calcium signaling to apoptosis : the two faces of the mitochondrial permeability transition pore; On Bax, Bcl-2, Ca2+ and the PTP. 1998, Biochem. Biophys. Acta 1366: 33-50. - LETELLIER, T., MALGAT, M. ROSSIGNOL, R. and MAZAT, J.-P. : Metabolic control analysis and mitochondrial pathologies Molec. Cell. Biochem. 1998, 184: 409-417. - JOUAVILLE, L.S. , ICHAS, F. and MAZAT, J.-P. : Modulation of cell calcium signals by mitochondria Mol. Cell. Biochem. 1998, 184: 371-376. - SELIVANOV, V., ICHAS, F., HOLMUHAMEDOV, E.L., JOUAVILLE, L.S., EVTODIENKO, Y.V., and MAZAT, J.-P. (1998) : A model of mitochondrial Ca2+-induced Ca2+ simulating the Ca2+ oscillations and spikes generated by mitochondria : Biophysical Chemistry 72: 111-121. - SZTARK, F. , MALGAT, M., DABADIE, P. and MAZAT, J.-P. Comparison of the Effects of Bupivacaine and Ropivacaine on Heart Cell Mitochondrial Bioenergetics. 1998, Anesthesiology, 88, : 1340-1349. 1997 - SZTARK, F. , OUHABI, R., DABADIE, P. and MAZAT, J.-P. Effects of the Local Anesthetic Bupivacaine on Mitochondrial Energy Metabolism: Change from Uncoupling to Decoupling Depending on the Respiration State. Biochem Mol Biol Int, 1997 ; 43: 997-1003 - ICHAS, F., JOUAVILLE, L.S. and MAZAT, J.-P. (1997): Mitochondria are excitable organelles capable of genrating and conveying electrical and calcium signals Cell 89 11451153. - DURRIEU, G., LETELLIER, T., ANTOCH, J., DESHOUILLERS, J.-M., MALGAT, M. and MAZAT, J.-P. (1997): Identification of Mitochondrial Deficiency using Principal Component Analysis. Molec. Cell. Biochem. 174 149-156. - MAZAT, J.-P., LETELLIER, T., BEDES, F., MALGAT, M., KORZENIEWSKI, B., JOUAVILLE, S.L. and MORKUNIENE, R. (1997) : Metabolic Control Analysis and Threshold Effect in Oxidative Phosphorylation. Implications for Mitochondrial Pathologies. Molec. Cell. Biochem. 174 143-148. 1996 - EVTODIENKO, Y.V., TEPLOVA, V.V., SIDASH, S.S., ICHAS, F. and MAZAT, J.-P.(1996) : Microtubule-active drugs suppress the closure of the permeability transition pore in tumour mitochondria : F.E.B.S. Letters 393 86-88. - MAZAT, J.-P., REDER C. and LETELLIER, T. (1996) : Why are most Flux Control Coefficients so small ? J. Theor. Biol. 182 253-258. - KORZENIEWSKI, B. and MAZAT, J.-P. (1996) :Theoretical Studies on Control of Oxidative Phosphorylation in Muscle Mitochondria at Different Energy Demands and Oxygen Concentrations. Acta Biotheoretica 44 : 263-269. - KORZENIEWSKI, B. and MAZAT, J.-P. (1996) :Theoretical Studies on the Control of Oxidative Phosphorylation in Muscle Mitochondria - Application to Mitochondrial Deficiencies. Biochem. J. 319 : 143-148 . 1995 - F. SZTARK, ICHAS, F., OUHABI, R., DABADIE, P. and MAZAT, J.-P. (1995) : Effects of the aneasthetic propofol on the calcium-induced permeability transition of rat heart mitochondria : direct pore inhibition and shift of the gating potential. F.E.B.S. Letters 368 101-104. - MALGAT, M., LETELLIER, T., JOUAVILLE, S.L. and MAZAT, J.-P. (1995): Value of the control theory in the study of cellular metabolism - Biomedical implications J. Biol. Syst. 3, 165-175. - RAIS B. , CHASSAGNOLE, C. and MAZAT J.-P. : (1995) : Control of threonine pathway in E.coli . Application to biotechnologies. Acta Biotheoretica 43 285-297. - RAIS B. and MAZAT J.-P. : (1995) : Contrôle de la chaîne de biosynthèse de la thréonine chez E.coli Acta Biotheoretica 43 143-153. - VITAL, C., COQUET, M. and MAZAT, J.-P.: Mitochondrial abnormalities on the muscle biopsy of a cycling champion. Muscle & Nerve (Letter to the Editor) (1995) 18 673 1994 - ICHAS, F., JOUAVILLE, L.S., SIDASH, S.S., MAZAT, J.-P.and HOLMUHAMEDOV, E.L. : Mitochondrial calcium spiking : a transduction mechanism based on calcium-induced permeability transition involved in cell calcium signaling. FEBS Letters (1994) 348 211-215. - LETELLIER, T., HEINRICH, R., MALGAT, M. and MAZAT, J.-P.: The kinetic basis of the threshold effects observed in mitochondrial diseases : a systemic approach Biochem. J. (1994) 302 171-174. - SZTARK,F., TUEUX, O., ERNY, P., DABADIE, P. and MAZAT, J.-P. (1994): Effects of bupivacaine on cellular oxygen consumption and adenine nucleotide metabolism. Anesth. Analg. 78 335-339. 1993 - COQUET, M., DEGOUL, F., VITAL, A., MALGAT, M., MAZAT, J.-P., LOUVETGEINDAJ, C., FONTAN, D., TISON, F., DIRY, M. and MARSAC, C. (1993) : MERRF family with 8344 mutation in tRNA (lys). Evidence of a mitochondrial vasculopathy in muscle biopsies. Neurol. Disord. 3 593-597. . - COQUET, M., DEGOUL, F., VITAL, A., MALGAT, M., MAZAT, J.-P., LOUVETGEINDAJ, C., FONTAN, D., TISON, F., DIRY, M. and MARSAC, C. (1993) : MERRF family with 8344 mutation in tRNA (lys). Evidence of a mitochondrial vasculopathy in muscle biopsies. Neurol. Disord. 3 593-597. - BIOULAC-SAGE, P., PARROT-ROULAUD, F., MAZAT, J.-P., LAMIREAU, T., COQUET, M., SANDLER, B., DEMARQUEZ, J.-L., CORMIER, V., MUNNICH, A., CARRE, M. and BALABAUD, C. (1992): Fatal neonatal liver failure and mitochondrial cytopathy (oxydative phosphorylation deficiency): A light and electron microscopic study of the liver. Hepatology 18 839-846. - CONSTANS, J., LEHERISSIER, A., COQUET, M., MAZAT, J.-P., LETELLIER, T., DURANDET, P., ROUDAUT, R., GOSSE, P., CONRI, C., and DALLOCCHIO, M. (1993) : Ventricular arrhythmia revealing mitochondrial myopathy in a 69-year-old woman. Eur. Heart. J. 14 1137-9. - AYMARD, C., MALGAT, M., MAZAT, J.-P. and KOENIG J. (1993): Effet de la mutation "muscular dysgenesis" sur le métabolisme mitochondrial de fibroblastes in vivo. C.R.Acad.Sci Paris 316 529-532. - LETELLIER, T., MALGAT, M. and MAZAT, J.-P. (1993): Control of oxidative phosphorylation in rat muscle mitochondrial. Implication to mitochondrial myopathies. Biochim. Biophys. Acta. 1141, 58-64. 1992 - FASSY, F., HERVAGAULT, J.-F., LETELLIER, T., MAZAT J.-P., REDER, C., and VILLALOBOS, P. : (1992) : Application of the metabolic control theory to the study of the dynamics of substrate cycles Acta Biotheoretica 40 121-129. - SCHÖNFELD, P., SZTARK, F., SLIMANI, M., DABADIE, P. and MAZAT, J.-P. : (1992) Is bupivacaine a decoupler, a protonophore or a proton-leak-inducer ? FEBS Letters 304 273-276. - FAYON, M. LAMIREAU,T. BIOULAC-SAGE, P. LETELLIER, T. MORETTO, B. PARROT-ROULAUD, F. COQUET, M., MALGAT, M., SARLANGE, J., BALABAUD, C. and DEMARQUEZ, J.-L., MAZAT, J.-P. (1992): Fatal neonatal liver failure and mitochondrial cytopathy: An observation with antenatal ascites. Gastroenterology 103 1332-1335. - LETELLIER, T., MALGAT, M., COQUET, M., MORETTO, B., PARROT-ROULAUD, F. and MAZAT J.-P. : Mitochondrial myopathy studies on permeabilized muscle fibres. Pediatr. Res.(1992) 32 17-22. 1991 - C. DUMORA, A.-M. LACOSTE, A. CASSAIGNE and J-P. MAZAT (1991): Allosteric regulation of phosphonoacetaldehyde hydrolase by n-butylphosphonic acid. Biochem. J. 280 557-559. - MAZAT J.-P. and LETELLIER, T. : (1991) : La théorie du contrôle du métabolisme. Contrôle et Régulation. Acta Biotheoretica 39 207-212. - T. LETELLIER, C. REDER and MAZAT J.-P. , (1991) : 'CONTROL' : A software for the Analysis of the Control of Metabolic Networks. Comp. Appl. in the Biosci. 7 383-390. - PARROT-ROULAUD, F., CARRE, M., LAMIRAU, T., LETELLIER, T., MALGAT, M., MAZAT, J.-P., MUNNICH, A. et DEMARQUEZ, J.-L. : Fatal neo-natal hepatocellular deficiency with lacticacidosis : A defect of the respiratory chain. J. Inherit. Met. Dis. 1991; 14; 289-292. 1990 - GROUSELLE, M., TUEUX, O. , GEORGESCAUD, D. and MAZAT, J.-P.(1990) : Uncoupling effect of local anesthetics on mitochondria in cell cultures. Biochem. J. 271 269272. - MAZAT J.-P. , T. LETELLIER, and C. REDER (1990). Metabolic Control Theory : The geometry of the triangle. Biomed. Biochem. Acta .49 801-810. 1988 - RIGOULET,M. , AVERET, N., MAZAT, J.-P., GUERIN, B., and COHADON, F. (1988) : Redistribution of the flux control coefficients in mitochondrial oxidative phosphorylations in the course of brain edema.Biochim. Biophys. Acta 932 116-123 - MAZAT, J.-P. and JEAN-BART, E. (1988) : How two steps can control a flux. Biochemical Education 16 28-30. 1987 - DABADIE, P., BENDRISS, P. ERNY, P. and MAZAT, J.-P. (1987) Uncoupling effects of local anesthetics on rat liver mitochondria. FEBS Letters 226 77-82. 1986 - MAZAT, J.-P. and MAZAT, F. Double Site Enzyme and Squatting : Where one regulatory ligand is also substrate of the reaction. (1986) J. theor. Biol. 121 89 - 103. - MAZAT, J.-P., JEAN BART, E., RIGOULET, M. and GUERIN, B. : Control of oxydativephosphorylation : the role of phosphate transport. (1986) Biochim. Biophys. Acta 849 7-15 1985 - DUPONT, C-.H., MAZAT, J.-P. and GUERIN, B. : Role of adenine nucleotides in the energization of the inner membrane of mitochondria from ρ+ et ρo strain of Saccharomyces cerevisiae (1985) B.B.R.C. 132 1116-1123. - DUVERT, M., BARETS, A., MAZAT, J.P. : Intermitochondrial junctions in frog heart: a thin section and a freeze-fracture study. (1985) Cell and Tissue Research 241 129-137. 1984 - DUPONT, C.H., CAUBET, R., MAZAT, J.P. and GUERIN, B. (1984). Isolation and characterization of an uncoupler-resistant mutant of Saccharomyces cerevisiae. Current Genetics, 8, 507-516. 1982 - MAZAT, J.P., MERLE, M., GRAVES, P.V., MERAULT, G., GANDAR, J.C. and LABOUESSE, B. : Kinetic anticooperativity in pre-steady-state formation of tryptophanyl adenylate by tryptophanyl - tRNA - synthetase from beef pancreas. A consequence of the tryptophan anticooperative binding. (1982) Eur. J. Biochem., 128 , 389-398. - AVERET, N.A., BRETHES, D., MAZAT, J.P., SARGET, C. and CHEVALLIER , J. : Solution and characterization of different oligomeric forms of sarcoplasmic reticulum soluble Ca2+-ATPase (1982). Biochimie, 64 , 69-73. . 1981 - MAZAT, J.P., GRAVES, P.V. and LABOUESSE, B. (1981). J. Theor. Biol. 89 53-67. Coupling in relaxation experiments as a diagnostic tool to discriminate among different anticooperative models. - MAZAT, F., LANGLA, J. and MAZAT, J.P. : The measure of synergy in enzymatic regulation : a general coefficient (1981). Biochimie 63, 107-111. 1980 - BARDSLEY, W.G., WOOLFSON, R. and MAZAT, J.P. : Relationships between the magnitude of Hill plot slopes, apparent binding constants and factorability of binding polynomials and their Hessians (1980). J. Theor. Biol. 85 , 247.284. - GRAVES, P.V., de BONY, J., MAZAT, J.P. and LABOUESSE, B. : Stoichiometry and spectroscopic analysis of formation of beef pancreas tryptophanyl - tRNA - synthetase tryptophanyl adenylate complex (1980). Biochimie 62 , 33-41. - RABAUD, M., DANIEL-LAMAZIERE, J.M., MAZAT, J.P., BRICAUD, H. and LEFEBRE, F. Isolation and biological properties of a rabbit antibody to porcine pancreatic elastase and its use as a ligand for elastase purification. (1980). Connective Tissue Research 7, 97-103. 1979 - GRAVES, P.V., MAZAT, J.P., JUGUELIN , H., LABOUESSE, J. and LABOUESSE, B. Anticooperative binding of L-tryptophan to tryptophanyl - tRNA - synthetase from beef pancreas. Study at equilibrium by dialysis and changes in spectroscopic properties. (1979) Eur. J. Biochem., 96 , 509-518. 1977 - MAZAT, J.P., LANGLA, J. and MAZAT, F. Double site enzyme and squatting (1977) J . Theor. Biol., 68, 365-383. 1976 - MAZAT, J.P. and PATTE , J.C (1976) Biochemistry 15, 4053-4058. Lysine-sensitive aspartokinase of E .coli K 12. Synergy and auto synergy in the allosteric V-system. 1974 - RICHAUD, C., MAZAT, J.P., FELENBOK, B. and PATTE, J.C. (1974) Eur. J. Biochem. 48, 147-156. The role of lysine and leucine binding on the catalytical and structural properties of Aspartokinase III of E.coli K 12. 1973 - RICHAUD, C., MAZAT, J.P., GROS, C. and PATTE, J.C. (1973) Eur. J. Biochem. 40, 619629. Subunit structure of Aspartokinase III of E.coli K 12. . Jean-Pierre MAZAT : Revues françaises de vulgarisation - Jean-Pierre Mazat, Christine Nazaret et Sabine Pérès, Structure et modélisation des réseaux métaboliques Biofutur 275, Mars 2007 : 31-35. - Jean-Pierre Mazat et Stéphane Ransac : Le complexe bc1 de la chaîne respiratoire mitochondriale fonctionne selon l’hypothèse du cycle Q de Mitchell. La preuve par une approche stochastique ? Médecine/Sciences. Dec 2010 CHAPTERS or PAPERS IN BOOKS : 1. MATUS, A.I., NG, M.L. and MAZAT, J.P. Protein phosphorylation in synaptic membranes : problems of interpretation in bioregulation. 1st F.M.I.-EMBO Workshop. Eds : THOMAS, G., PODESTA, E. and GORDON, J., S. KAEGER BASEL (1979). 2. MAZAT, J.P., LANGLA, J. and MAZAT, F. : Enzymes double-site et squatting. Exemples de régulations et applications. Actes du premier séminaire de l'Ecole de Biologie Théorique - CNRS et ENS. Ed. H. Le Guyader et T. Moulin. PARIS 1981. 3. MAZAT, J.P., LANGLA, J., et MAZAT, F. : Enzymes double site et squatting - Exemples de régulation et d'application. In collection de Biologie Evolutive. MASSON. PARIS (1982). 4. MAZAT, F. et MAZAT, J.P. : Enzymes double-site et squatting - cas où l'un des ligands est substrat de la réaction. Actes du deuxième séminaire de l'Ecole de Biologie Théorique. Ed. Le Guyader et T. Moulin. PARIS (1982). 5. MAZAT, J.P. : Une lecture de "La connaissance objective" de K. POPPER. Théorie de la connaissance et théorie de l'évolution. Actes du deuxième séminaire de l'Ecole de Biologie Théorique. Ed. LE GUYADE R et T. MOULIN. PARIS (1982). 6. MAZAT, J.P., RIGOULET, M., JEAN BART, E. and GUERIN, B. (1985). Contrôle et régulation du métabolisme cellulaire. 4ème séminaire de l'Ecole de Biologie Théorique. Ed. Demongeot et Benchetrit, Ed. du CNRS. 7. MAZAT, J.P. and JEAN BART, E. La notion d'étape limitante, un concept limité. (1985) Biochimie 67 n°2 XIXIII. 8. BENDRISS, P., DABADIE ,P. ERNY,P., LETELLIER, L. et MAZAT, J.-P. : Mécanisme d'action des anesthésiques locaux. Annales de la Société Française d'Anesthésie-Réanimation 7 189-197. 9. MAZAT, J.-P . et JEAN-BART, E. Contrôle du métabolisme I : Comment deux étapes peuvent simultanément contrôler un flux à l'état stationnaire ? 5ème séminaire de l'Ecole de Biologie Théorique. Ed. du CNRS.(1988) 213-222. 10. JEAN-BART, E. et MAZAT, J.-P. Contrôle du métabolisme II : Simulation du contrôle d'une chaîne linéaire. 5ème séminaire de l'Ecole de Biologie Théorique. Ed. du CNRS. (1988) 223-231. 11. MAZAT, J.-P. et JEAN-BART, E. Contrôle du métabolisme III : Minirevue. 5ème séminaire de l'Ecole de Biologie Théorique . Ed. du CNRS. (1988) 233-253. 12. MAZAT, J.-P. et REDER, C. : (1988) Aspects géométriques de la théorie du contrôle du métabolisme. in Contrôle du Metabolisme Cellulaire. Mazat and Reder (Ed.).77-96. 13. MAZAT, J.-P. , C. REDER and T. LETELLIER (1990) : The structural approach to metabolic control theory : Geometrical aspects. in Control of Metabolic Processes. Cornish-Bowden and Cardenas (Ed.) Plenum Press (N-Y and London) pp129-138 . 14. LETELLIER, T., GELLERICH, F. N. and MAZAT,J-P. : CONTROL : A software for the analysis of the control of metabolic networks : Application to a system utilizing and generating ATP. BioThermoKinetics H. Westerhoff ed. Intercept Ltd, Andover, Hollande (1994). 15. JOUAVILLE, S., ICHAS, F., LETELLIER, T., MALGAT, M. and MAZAT, J.-P. : Control of ATP synthesis in muscle mitochondria. Comparison with the control of O2 consumption. Modern Trends in Biothermokinetics (1993) 319-325 Schuster, Rigoulet, Ouhabi and Mazat Eds. Plenum Press. 16.PORTAIS, J.-C., SCHUSTER, R., GARDERET, F., MERLE, M., MAZAT, J.-P. and CANIONI, P. (1993) : Calculation of metabolic fluxes by mathematical modeling of Carbon-13 distribution in metabolites. II. Application of C6 cells metabolism. . Modern Trends in Biothermokinetics 443-447 (Schuster, Rigoulet, Ouhabi and Mazat Eds. Plenum Press). 17. RAÏS, B., HEINRICH, R. and MAZAT, J.-P.(1993) : Threonine synthesis in E.Coli ; experimental and theoretical results. Modern Trends in Biothermokinetics 269-274 (Schuster, Rigoulet, Ouhabi and Mazat Eds. Plenum Press). 18. SCHUSTER, S. and MAZAT , J.-P. (1993) : A minimal model for the interrelation between the transmembrane potential and pH difference across the mitochondrial inner membrane. Modern Trends in Biothermokinetics 3944 (Schuster, Rigoulet, Ouhabi and Mazat Eds. Plenum Press). 19. SZTARK, F., SCHÖNFELD, P., DABADIE, P. and MAZAT, J.-P. (1993): Mechanism of bupivacaine uncoupling in rat heart mitochondria. Modern Trends in Biothermokinetics 17-22 (Schuster, Rigoulet, Ouhabi and Mazat Eds. Plenum Press). 20. MAZAT, J.-P., LETELLIER, T. and MALGAT, M. (1993) : The molecular basis of threshold effects observed in mitochondrial diseases. Modern Trends in Biothermokinetics 343-346 (Schuster, Rigoulet, Ouhabi and Mazat Eds. Plenum Press). 21. R. OUHABI, M. BOUE-GRABOT and J.-P. MAZAT (1994): ATP Synthesis in permeabilized cells : Assessment of the ATP/O ratios in situ. What is controlling life? Modern Trends in BioThermokinetics Vol 3 141-144. (E. Gnaiger, F.N. Gellerich and M. Wyss Eds. Innsbruck University Press). 22. F. ICHAS, L.S. JOUAVILLE, S. SIDASH, J.-P. MAZAT and E. HOLMUHAMEDOV (1994) : Mitochondrial calcium Spiking : The physiological face of permeability transition.,Modern Trends in BioThermokinetics Vol 3 159-162. (E. Gnaiger, F.N. Gellerich and M. Wyss Eds. Innsbruck University Press). 23. J.-P. MAZAT, T. LETELLIER,, M. MALGAT, L.S. JOUAVILLE, R. MORKUNIENE (1994) : Application of control analysis to the study of metabolic diseases in mitochondria. Metabolic expression of mitochondrial DNA mutations. Modern Trends in BioThermokinetics Vol 3 272-274. (E. Gnaiger, F.N. Gellerich and M. Wyss Eds. Innsbruck University Press). 24. F. SZTARK, F. ICHAS, R. OUHABI, P. DABADIE, J.-P. MAZAT (1994) : Effects of propofol on the calciuminduced permeability transition of rat heart mitochondria. In : Modern Trends in Biothermokinetics vol 3, Innsbruck University Press, Innsbruck. E. Gnaiger et al. Eds. pp 174. 25. SZTARK F, OUHABI R, DABADIE P, MAZAT JP. Change from uncoupling to decoupling effect of the local anesthetic bupivacaine depending on the respiration state. In: Biothermokinetics of the living cell. Biothermokinetics Press, Amsterdam. Westerhoff HV et al. eds. pp 58-60, 1996. 26.V. MILDAZIENNE, A. MARCINKEVICIUTE, R. BANIENE, J.-P. MAZAT (1996) : Supra-physiological concentration of calcium inhibits phosphorylation, respiratory subsystem and uncouples rat heart mitochondria. In : BioThermoKinetics of the Living Cell, 168-173. (H.V. Westerhoff, J.L. Snoep, J.E. Wijker, F.E. Sluse and B.N. Kholodenko Eds. BioThermoKinetics Press, Amsterdam). 27. V. SELIVANOV, F. ICHAS, E.L. HOLMUHAMMEDOV, L.S. JOUAVILLE, Y. EVTODIENKO, J.-P. MAZAT (1996) : A theoretical model of Ca2+ oscillations generated by mitochondria. In : BioThermoKinetics of the Living Cell, 268-273. (H.V. Westerhoff, J.L. Snoep, J.E. Wijker, F.E. Sluse and B.N. Kholodenko Eds. BioThermoKinetics Press, Amsterdam). 28. J.-P. MAZAT (1998) : L'évolution de l'évolution ou des mécanismes généraux des évolutions. Transdiscipline 4/5 pp 173-185 (Ed. L'harmatan). 29. SELIVANOV, V., ICHAS, F. and MAZAT, J.-P. (1998) : A kinetic model of mitochondrial Ca2+ excitability. BioThermoKinetics in the post genomic era, 295-299. (C. Larsson, I.-L., Pählman and L. Gustafsson Eds., Göteborg 1998). 31. SZTARK F, PAYEN JF, PIRIOU V, RIGOULET M, VENTURA-CLAPIER R, MAZAT JP, LEVERVE X, G JANVIER (1999: Métabolisme énergétique cellulaire aspects physiologiques et pathologiques. Ann Fr Anesth Reanim,18: 261-269. 32. MALGAT, M., LETELLIER, T. , DURRIEU, G. and MAZAT, J.-P., (2000) : Enzymatic and polarographic measurements of the respiratory chain complexes. Mitochondrial Diseases. Models and Methods . Lestienne P ed, pp 357-377 Springer-Verlag. 33. MALGAT, M., LETELLIER, T., ROSSIGNOL, R. AND MAZAT, J.-P., : Metabolic control analysis and threshold effect in oxidative phosphorylation : study in an intermediate state of respiration. 9th International BioThermoKinetics Meeting , Stellenbosch, Afrique du Sud, 3-8 April 2000 34. BEURTON-AIMAR, M., KORZENIEWSKI, B., MAZAT, J.-P., AND NAZARET, C. : Virtual mitochondria and their control. Simulation de processus cellulaires dans le contexte de la génomique (18-21 Mars 2002, Autrans. Séminaire organisé par le Génopole d’Evry). 35. Jean-Pierre MAZAT (2003): La cinétique enzymatique et le contrôle des flux métaboliques dans Eléments de biologie pour mathématiciens et physiciens sous la direction de Ph. Tracqui et J. Demongeot : 175-206, EDP Sciences, Collection Grenoble Sciences 36. BEURTON-AIMAR, M., PERES, S., BALLET, P., ZEMIRLINE, A.,NAZARET, C. AND MAZAT, J.-P. (2003) : Hybrid system to model biological objects : application to mitochondria organelle. Proceedings of the Dieppe Spring School on Modelling and Simulation of Biological Processes in the Context of Genomics. 37. MAZAT, J.-P. et al. (2005) : Modeling of electron transport, Chap 8-3 Vol 5 in Handbook of Neurochemistry and Molecular Neurobiology , A. Lajtha ed. , Kluwer Academic/ Plenum Publishers 2006. 38 Jean-Pierre Mazat, Christine Nazaret et Sabine Pérès, Structure et modélisation des réseaux métaboliques Biofutur 275, Mars 2007 : 31-35. 39 MAZAT, J.-P. et al. (2005) : The structure of metabolic networks or (almost) all that is known about the simplest metabolic network. In Functional Plant Genomics, J.-F. Moro-Gaudry, P. Lea and J.-F. Briat eds. , Science Publishers 2007. 40 ROUX E, MAZAT J-P, MARHL M: Role of mitochondria in calcium homeostasis and contraction of smooth muscle cells. In Mitochondria: Structure, Functions and Dysfunctions. Edited by Svensson OL. Hauppauge NY: Nova Publisher; 2009. Présentation de poster ou courts articles dans des congrès avec comité de selection. [1] M. Beurton-Aimar, S. Pérès, N. Parisey, J.P. Mazat. How to lock a model from miscomposition of objects ? 13th European Conference on Object-Oriented Programming, Darmstadt, june 2003. [2] Nicolas Parisey, Mazière P., Molina F., Beurton-Aimar M., Pérès S. and Mazat JP. Proposal of metabolic network formal description to enhance process-based comparison possibilities. XIth Workshop of the BioThermoKinetics Study Group - YBTK, Oxford, september 2004 [3] Jean-Pierre Mazat, Sabine Pérès and Marie Beurton-Aimar : Classification of elementary flux modes in mitochondrial metabolism Workshop Metabolic Pathway Analysis Jena Mars 2005 (conference invitee). [4] S. Pérès, M. Beurton-Aimar & J.-P. Mazat : Analysis of large set of elementary flux modes : application to energetic mitochondrial metabolism. European Conference on Complex Systems Paris, 14-18 November 2005. (conference invitee). [5] N. Parisey, C. Lales, M. Beurton-Aimar, C. Strandh, and J.-P. Mazat : Towards modelling the Q cycle by multi-agents systems . VIIIth European Conference on Artificial Life,(ECAL 05) Canterbury,UK, Septembre 2005. [6] C. Lales, N. Parisey, M. Beurton-Aimar, J.-P. Mazat :Simulation of mitochondrial metabolism using multi-agents system. Fourth International Joint conference on Autonomous Agents and Multi Agent Systems Utrecht Juillet 2005 ; article et présentation orale. [7] N. Parisey, M. Beurton-Aimar, C. Lales, J. P. Mazat “Multi-Agent Design to Reduce Complexity of Biological Processes Description” GWAL German Workshop on Artificial Life, Iena Germany, aug. 2006.