Cancer du poumon et mésothéliome pleural malin
Transcription
Cancer du poumon et mésothéliome pleural malin
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©4+'*"#:'*%1/*,#$"#5+)*,#;#6778 !"#$%&'()&*+&,&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9&:& Sommaire Liste des abréviations .................................................................................... 4! 1.! Introduction........................................................................................... 5! 2.! Synthèse................................................................................................ 7! 3.! Diagnostic et bilan initial d’un cancer du poumon ........................... 10! 4.! Prise en charge thérapeutique d’un cancer du poumon .................. 16! 7.! Surveillance des traitements............................................................... 29! 8.! Suivi des cancers du poumon et mésothéliomes pleuraux malins 32! 9.! Bonnes pratiques de prise en charge communes à tous les cancers .................................................................................................. 34! Annexe 1. Liste des participants................................................................... 38! Annexe 2. Classifications .............................................................................. 40! Annexe 3. Prescription – Encadrement réglementaire ............................... 44! Annexe 4. 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Approches cytohistologiques en vue du diagnostic anatomopathologique (%& $#.C/375#0& $%& 0%15#5"$%& $%& 0./0%1& /%& 2%"5& h51%& 65.L9#& @"B.21`7& #/5%12165.5#3/& ./.53432.58393C#@"%& $%7& 2169`>%4%/57& 0%99"9.#1%7& %5=3"& 5#77"9.#1%7& 16.9#767& U& 2.15#1& $%& 9.& 5"4%"1& %5=3"& $%7& .$6/32.58#%7& .7730#6%7& I7%93/& 9%& 03/5%]5%KN& $B"/& 7#5%& 465.75.5#@"%& .00%77#L9%& 3"& %/031%& $B"/& 62./08%4%/5&29%"1.9M& (B%].4%/& ./.53432.58393C#@"%& 2160#7%& 9%& 5Y2%& 8#75393C#@"%& $%& 9.& 5"4%"1&j& 0./0%1& $"& 23"43/& U& 2%5#5%7& 0%99"9%7& I-J-K& 3"& 0./0%1& $"& 23"43/& /3/& U& 2%5#5%7&0%99"9%7&I-EJ-KM& ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& HXFH& !"#$%&'()&*+&,&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9&:& Classification histologique des cancers du poumon & & & Cancers du & poumon à petites cellules & (environ 20 %) & (CPC)& & & & & & & & & Cancers du poumon non à petites 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7"1&9%7&43$.9#567&$B.00`7&."]&1%773"10%7&%5&.#$%7&$#723/#L9%7&23"1& 9.&21#7%&%/&08.1C%N&.>%0&9%&03/03"17&$%7&.77#75./57&730#."]&o& !& 7"1& 9%7& 31C./#74%7N& $3/5& 9%7& .7730#.5#3/7& $%& 2.5#%/57N& 23">./5& 73"5%/#1&9%7&2.5#%/57&%5&9%"1&%/53"1.C%&%5&9%7&.#$%1&U&A.#1%&03//.x51%& %5&>.93#1&9%"17&$13#57M& PMPM& -./0%1&$"&23"43/&/3/&U&2%5#5%7&0%99"9%7& (%7& 0./0%17& $"& 23"43/& /3/& U& 2%5#5%7& 0%99"9%7& I-EJ-K& 73/5& 09.7767& 7%93/& 9%"1&75.$%&^E?&dM&-%55%&09.77#A#0.5#3/N&.05".9#76%&%/&F++GN&2%14%5&$B31#%/5%1& 9.&751.56C#%&5861.2%"5#@"%&#/#5#.9%M& Stades précoces (stades I et II) (.&08#1"1C#%&03/75#5"%&9%&51.#5%4%/5&$%&16A61%/0%&$%7&-EJ-&$%&75.$%7&D&%5&DDM& !& Pour les stades IA j&."0"/&51.#5%4%/5&261#3261.53#1%&/B%75&#/$#@"6M& !& Pour les stades IB&j& 2.7& $%& 51.#5%4%/5& 261#3261.53#1%&o& %/& 2167%/0%& $%& A.05%"17& $%& 4.">.#7& 213/375#0N& 9B#/$#0.5#3/& $B"/%& 08#4#35861.2#%& .$l">./5%& 2%"5& h51%& 6>%/5"%99%4%/5& $#70"56%& $./7& 9%& 0.$1%& $%& 9.& 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IV&j&9.&08#4#35861.2#%&I#/09"./5&9%7&5861.2#%7&0#L96%7N& 7%93/&9%"17&#/$#0.5#3/7K&%75&9%&51.#5%4%/5&$%&16A61%/0%M& &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&& &d &-9.77#A#0.5#3/&^E?&%/&>#C"%"1&$%2"#7&F++G&%5&75.$%7&%/&.//%]%&FM& & ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&Xf&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Résumé des modalités techniques de prise en charge d’un Cancer non à petites cellules selon son stade TNM IA IB II IIIA IIIB IV (3) Chirurgie (exérèse complète) # # # RCP - - Radiothérapie - (1) - (1) - (2) RCP # - Chimiothérapie - RCP #& #& #& #& RCP : Modalité en option, à discuter en RCP selon le malade et sa maladie (1) : La radiothérapie peut être proposée comme une alternative à la chirurgie en cas de non-résécabilité ou non-opérabilité. (2) : Une irradiation peut être discutée en complément de la chirurgie et de la chimiothérapie en cas d’atteinte pariétale ou d’exérèse incomplète. (3) : Stade IV – incluant les cas avec épanchement pleural selon la nouvelle classification TNM. (.& 08#1"1C#%& $"& 0./0%1& $"& 23"43/N& 9.& 1.$#35861.2#%& %5& 9.& 08#4#35861.2#%& $3#>%/5&h51%&16.9#76%7&."&7%#/&$B65.L9#77%4%/57&$#7237./5&$B"/%&."531#7.5#3/& 23"1& 9B.05#>#56& $%& 73#/7& ,&51.#5%4%/5& $"& 0./0%1&:& 7%93/& 9%& $#7237#5#A& $B."531#7.5#3/& $6A#/#& 2.1& 9B.15#09%& WM&cXF*Hfd& $"& 03$%& $%& 9.& 7./56& 2"L9#@"%N& #/09"./5&9%7&01#5`1%7&$6A#/#7&2.1&9BD/75#5"5&E.5#3/.9&$"&-./0%1&fM& 4.4.1. 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$%& 73#/7& #/A#14#%17&U&$34#0#9%KM& (B.00342.C/%4%/5&$B"/&2.5#%/5&%/&A#/&$%&>#%&7%&A.#5&$./7&9%&1%72%05&$%&9.&93#& /v&F++_H*d+&$"& FF&.>1#9&F++_& 1%9.5#>%&."]& $13#57& $%7& 4.9.$%7& %5& U& 9.& A#/& $%& >#%M& ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&*d&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Annexe 1. Liste des participants T/5&2.15#0#26&U&9B69.L31.5#3/&$%&0%&C"#$%&j& Pour l’Institut National du Cancer&j& H& (.%5#5#.&m[W)TEDN&?6$%0#/N&-8%A&$%&213l%5N&)62.15%4%/5&$%7& 1%0344./$.5#3/7& H& m.961#%&?'{['r&|TVE'WN&?6$%0#/N&W%723/7.L9%&$"&$62.15%4%/5& $%7&1%0344./$.5#3/7& H& -935#9$%&<[S('DE&[(H!r[W-;[N&?6583$393C#75%N&)62.15%4%/5&$%7& 1%0344./$.5#3/7& Pour la Haute Autorité de Santé&j& '/$16&?TWDEN&?6$%0#/N&-8%A&$%&J13l%5& & Pour le groupe de travail&j& Q.L1#0%& S'W([<DN& <30#656& $%& 2/%"4393C#%& $%& 9./C"%& A1./R.#7%& I<J(QKN& J/%"43H3/0393C"%N&?.17%#99%& ?#08%9&SW'rE[WN&W.$#393C"%N&<30#656&A1./R.#7%&$%&1.$#393C#%&I<QWKN&J.1#7& '//%H?.1#%&SWT<<'W)N&(#C"%&/.5#3/.9%&03/51%&9%&0./0%1& (."1%/5& -'(<N&T/0393C"%& 46$#0.9N& Q6$61.5#3/& A1./R.#7%& $%7& 3/0393C"%7& 46$#0."]&IQQT?KN&^3"93/& -9.#1%&)'E[(N&J.58393C#75%N&<30#656&A1./R.#7%&$%&2.58393C#%&I<QJKN&J.1#7& n%./H(3"#7& QWTD)[m'(N& ?6$%0#/& C6/61.9#75%N& <30#656& A1./R.#7%& $%& $30"4%/5.5#3/&%5&$%&1%08%108%&%/&46$%0#/%&C6/61.9%&I<Q)W?!KN&'4L`7& J8#9#22%& !DW'r)N& W.$#35861.2%"5%N& <30#656& A1./R.#7%& $%& 1.$#35861.2#%& 3/0393C#@"%&I<QWTKN&J.1#7& m613/#@"%& }TWE?'EN& W67%."& $%7& 4.9.$%7& $%& 9.& (#C"%N&(#C"%& E.5#3/.9%& 03/51%&9%&-./0%1& J8#9#22%&J[W[{N&?6$%0#/&03/7%#9N&-.#77%&E.5#3/.9%&W<D& <5628./#%& <-;W'??N&?6$%0#/& 03/7%#9N& -.#77%& /.5#3/.9%& $B.77"1./0%H 4.9.$#%&$%7&51.>.#99%"17&7.9.1#67& J.70.9& ^;T?'<N& <30#656& A1./R.#7%& $%& 08#1"1C#%& 5831.0#@"%& %5& 0.1$#3>.70"9.#1%&I<Q-^-mKN&-8#1"1C#%/&5831.0#@"%N&?.17%#99%& ?.15#/%& WTr<<['rN& ?6$%0#/& C6/61.9#75%N& W67%."& T/0393C#%& '1C%/5%"#9N&S%e3/7M& ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&*f&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Dans le cadre de la relecture nationale&j& J8#9#22%&'<^Tr(N&J/%"43H3/0393C"%N&?.17%#99%& J#%11%&'^('EN&?6$%0#/&C6/61.9#75%N&E#0%& ;"L%15&S'WWD[r~N&J/%"4393C"%N&'"]%11%& '9.#/&S[WE'W)N&-8#1"1C#%/&^831.0#@"%N&)#l3/& ?.10&SD[Em[ErN&T/0393C"%&46$#0.9N&-8%1L3"1C& n%./&?.1#%&STE[(N&(#C"%&/.5#3/.9%&03/51%&9%&0./0%1& )34#/#@"%&SW[D(;N&J8.14.0#%/N&S31$%."]& !#99%7&-'W)T^N&-8#1"1C#%/&5831.0#@"%N&S3"93C/%H7"1H?%1& T9#>#%1&-'<^[(E'rN&J/%"43H3/0393C"%N&<.#/5H(."1%/5H$"Hm.1& E.58.9#%&-'rE[<N&T/0393C"%&46$#0.9N&^3"93"7%& \9#7.L%58&-;TWWDEN&-'!E'^N&?6$%0#/&C6/61.9#75%N&?./$1%7H9%7HW37%7& S1"/3&-Tr)[W^N&T/0393C"%&46$#0.9N&)#l3/& n%./&)rSW[{N&-8#1"1C#%/&5831.0#@"%N&S.Y3//%& n%./&J."9&)r;'?[(N&J/%"4393C"%N&;.1A9%"1& J#%11%&[44./"%9&Q'(-T{N&-8#1"1C#%/&5831.0#@"%N&<51.7L3"1C& ?.10&Q'W'()DN&W.$#35861.2%"5%N&-342#`C/%& J.70.9&QTr-;[WN&J/%"4393C"%N&)#l3/& '//%&![E[mTD<N&W.$#393C"%N&W3"%/& ^8#%11Y&![W?'DEN&W.$#35861.2%"5%N&J3#5#%17& Q1./R3#7&('ETr[N&&-8#1"1C#%/&5831.0#@"%&%5&>.70"9.#1%N&(.&W6"/#3/& <6L.75#%/&('WDm[N&J/%"4393C"%N&?b03/& -60#9%&([&J[-;Tr~N&W.$#35861.2%"5%N&m#99%l"#A& S%1/.1$&([)r-N&T/0393C"%&46$#0.9N&S1#>%& J8#9#22%&?TW['r)N&?6$%0#/&C6/61.9#75%N&J%77.0& '$%9&E''?[[N&-8#1"1C#%/&5831.0#@"%N&-9%143/5HQ%11./$& ?#08`9%&JDW'ST^N&J/%"43H3/0393C"%N&?.17%#99%& ;%/1#&JTW^[N&-8#1"1C#%/&5831.0#@"%N&(#99%& J#%11%&WD-;'r)N&W.$#35861.2%"5%N&S31$%."]& )34#/#@"%&WTr~N&J/%"43H3/0393C"%N&'4L%15& -9."$%&<'DE^&rJ[WVN&(#C"%&/.5#3/.9%&03/51%&9%&0./0%1& S1"/3&^'mDT^N&J/%"43H3/0393C"%N&-8.93/H7"1H<.t/%& Q1./R3#7%&^;DmT([^HS[nrDN&J.58393C#75%N&&(Y3/& ^8#%11Y&rWS'EN&J/%"4393C"%N&'/C%17& W%"L%/&m[[W'J[EN&-8#1"1C#%/&5831.0#@"%&%5&>.70"9.#1%N&(.&W6"/#3/& n%./H?.10&m[WE[nTr~N&J/%"4393C"%N&S31$%."]& ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&*G&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Annexe 2. Classifications Classification TNM des cancers du poumon non à petites cellules (7e révision 12) Stades ! ! 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3"&2167%/0%&$B"/&/3$"9%&5"431.9&$#75#/05&$./7&"/&."51%&93L%&$"&23"43/&.55%#/5& NX :&9%7&C./C9#3/7&/%&2%">%/5&2.7&h51%&6>.9"67& N0 :&2.7&$%&465.75.7%&C./C9#3//.#1%&9Y428.5#@"%&16C#3/.9%& N1 :& 465.75.7%& $./7& 9%7& C./C9#3/7& 9Y428.5#@"%7& #/51.2"943/.#1%7N& 261#L13/08#@"%7& %5=3"& 8#9.#1%7#9.561."]N&Y&03421#7&2.1&%/>.8#77%4%/5&$#1%05& N2&j& 465.75.7%& $./7& 9%7& C./C9#3/7& 9Y428.5#@"%7& 46$#.75#/."]& #27#9.561."]& %5=3"& 73"7H 0.1#/.#1%7& N3&j& 465.75.7%& $./7& 9%7& C./C9#3/7& 9Y428.5#@"%7& 46$#.75#/."]& 03/5139.561."]N& 8#9.#1%7& 03/5139.561."]N&70.9`/%7&3"&73"7H09.>#0"9.#1%7#9.561."]&3"&03/5139.561."]& MX :&9%7&465.75.7%7&U&$#75./0%&/B3/5&2.7&2"&h51%&6>.9"6%7& M0 :&.L7%/0%&$%&465.75.7%&U&$#75./0%& M1 :&465.75.7%&U&$#75./0%& M1a :& E3$"9%I7K& 5"431.9& $#75#/05& $./7& "/& 93L%& 03/5139.561.9&o& 5"4%"1& .>%0& /3$"9%7& 29%"1."]& 3"&62./08%4%/5&29%"1.9&I3"&261#0.1$#@"%K&4.9#/& M1b :&465.75.7%&U&$#75./0%& & &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&& &XF &D/5%1/.5#3/.9&'7730#.5#3/&A31&58%&<5"$Y&3A&("/C&-./0%1N&!39$751.O&JN&-13O9%Y&nN&-8./7ZY&}N& !#13"]& )nN& !1334%& J', et al.& ^8%& D'<(-& ("/C& -./0%1& <5.C#/C& J13l%05&j& 213237.97& A31& 58%& 1%>#7#3/& 3A& 58%& ^E?& 75.C%& C13"2#/C7& #/& 58%& A3158034#/C& I7%>%/58K& %$#5#3/& 3A& 58%& ^E?& -9.77#A#0.5#3/&3A&4.9#C/./5&5"43"17M&n&^831.0&T/039&F++d&o&F&IfK&j&d+cHXPM& & ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&P+&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Classification par stades Cancer occulte Stade 0 Stade IA Stade IB Stage IIA Stade IIB Stade IIIA Stade IIIB Stade IV ^~& ^#7& ^X.N&L& ^F.& ^X.N&L& ^F.& ^FL& ^FL& ^*& ^XN&^F& ^*& ^P& ^P& ^3"5&^& ^3"5&^& E+& E+& E+& E+& EX& EX& E+& EX& E+& EF& EXN&EF& E+N&EX& EF& E*& ^3"5&E& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?X& ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&PX&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Classification des cancers du poumon à petites cellules Maladie localisée (atteinte accessible à un seul champ d’irradiation) !& ^"4%"1&53"08%&"/&7%"9&23"43/& !& !./C9#3/7&8#9.#1%7&%5&46$#.75#/."]& 83439.561."]&%5&03/5139.561."]N& 7"709.>#0"9.#1%&83439.561."]& Maladie étendue !& ^"4%"1&L#9.561.9%& !& '55%#/5%&$"&261#0.1$%N&29%"167#%& 0.10#/34.5%"7%& !& !./C9#3/7&L#9.561."]& !& ?65.75.7%7&%/&$%8317&$"&5831.]& Classification des tumeurs pleurales – TNM IMIG T1 T1a T1b T2 T3 T4 ^"4%"1&9#4#56%&U&9.&29`>1%&2.1#65.9%&83439.561.9%&•&46$#.75#/.9%& •&$#.281.C4.5#@"%& '55%#/5%&$%&9.&29`>1%&>#7061.9%&83439.561.9%&i&r/&62./08%4%/5& %75&%/&1`C9%&2167%/5& ^"4%"1&$%&9.&29`>1%&2.1#65.9%N&46$#.75#/.9%N&$#.281.C4.5#@"%N&%5& 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%]5%/7#3/&$#1%05%&."]&31C./%7&46$#.75#/."]N&."&1.08#7N&U&9.& A.0%&#/5%1/%&$"&261#0.1$%N&."&4Y30.1$%& ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&PF&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Score de performance (PS) de l’OMS +& X& F& '05#>#56&28Y7#@"%&#/5.05%&i&[AA3157&2377#L9%7&7./7&9#4#5.5#3/& W6$"05#3/&$%7&%AA3157&i&'"53/34#%&03429`5%& *& J%173//%&$62%/$./5%&i&(%>%1&2377#L9%&4.#7&/%&A.#5&2.7&7.&53#9%55%&7%"9%& )62%/$./0%&535.9%&i&\5.5&@".7#&C1.L.5.#1%& P& J%173//%& %/031%& ."53/34%& i&<%& A.5#C"%& A.0#9%4%/5& i&E60%77#56& $%& 7%& 1%237%1&29"7&$%&c&8%"1%7&2.1&l3"1& & ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&P*&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Annexe 3. 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Introduction........................................................................................... 5! 2.! Synthèse................................................................................................ 7! 3.! Diagnostic et bilan initial d’un cancer du poumon ........................... 10! 4.! Prise en charge thérapeutique d’un cancer du poumon .................. 16! 7.! Surveillance des traitements............................................................... 29! 8.! Suivi des cancers du poumon et mésothéliomes pleuraux malins 32! 9.! Bonnes pratiques de prise en charge communes à tous les cancers .................................................................................................. 34! Annexe 1. Liste des participants................................................................... 38! Annexe 2. Classifications .............................................................................. 40! Annexe 3. Prescription – Encadrement réglementaire ............................... 44! Annexe 4. 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Approches cytohistologiques en vue du diagnostic anatomopathologique (%& $#.C/375#0& $%& 0%15#5"$%& $%& 0./0%1& /%& 2%"5& h51%& 65.L9#& @"B.21`7& #/5%12165.5#3/& ./.53432.58393C#@"%& $%7& 2169`>%4%/57& 0%99"9.#1%7& %5=3"& 5#77"9.#1%7& 16.9#767& U& 2.15#1& $%& 9.& 5"4%"1& %5=3"& $%7& .$6/32.58#%7& .7730#6%7& I7%93/& 9%& 03/5%]5%KN& $B"/& 7#5%& 465.75.5#@"%& .00%77#L9%& 3"& %/031%& $B"/& 62./08%4%/5&29%"1.9M& (B%].4%/& ./.53432.58393C#@"%& 2160#7%& 9%& 5Y2%& 8#75393C#@"%& $%& 9.& 5"4%"1&j& 0./0%1& $"& 23"43/& U& 2%5#5%7& 0%99"9%7& I-J-K& 3"& 0./0%1& $"& 23"43/& /3/& U& 2%5#5%7&0%99"9%7&I-EJ-KM& ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& HXFH& !"#$%&'()&*+&,&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9&:& Classification histologique des cancers du poumon & & & Cancers du & poumon à petites cellules & (environ 20 %) & (CPC)& & & & & & & & & Cancers du poumon non à petites 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7"1&9%7&43$.9#567&$B.00`7&."]&1%773"10%7&%5&.#$%7&$#723/#L9%7&23"1& 9.&21#7%&%/&08.1C%N&.>%0&9%&03/03"17&$%7&.77#75./57&730#."]&o& !& 7"1& 9%7& 31C./#74%7N& $3/5& 9%7& .7730#.5#3/7& $%& 2.5#%/57N& 23">./5& 73"5%/#1&9%7&2.5#%/57&%5&9%"1&%/53"1.C%&%5&9%7&.#$%1&U&A.#1%&03//.x51%& %5&>.93#1&9%"17&$13#57M& PMPM& -./0%1&$"&23"43/&/3/&U&2%5#5%7&0%99"9%7& (%7& 0./0%17& $"& 23"43/& /3/& U& 2%5#5%7& 0%99"9%7& I-EJ-K& 73/5& 09.7767& 7%93/& 9%"1&75.$%&^E?&dM&-%55%&09.77#A#0.5#3/N&.05".9#76%&%/&F++GN&2%14%5&$B31#%/5%1& 9.&751.56C#%&5861.2%"5#@"%&#/#5#.9%M& Stades précoces (stades I et II) (.&08#1"1C#%&03/75#5"%&9%&51.#5%4%/5&$%&16A61%/0%&$%7&-EJ-&$%&75.$%7&D&%5&DDM& !& Pour les stades IA j&."0"/&51.#5%4%/5&261#3261.53#1%&/B%75&#/$#@"6M& !& Pour les stades IB&j& 2.7& $%& 51.#5%4%/5& 261#3261.53#1%&o& %/& 2167%/0%& $%& A.05%"17& $%& 4.">.#7& 213/375#0N& 9B#/$#0.5#3/& $B"/%& 08#4#35861.2#%& .$l">./5%& 2%"5& h51%& 6>%/5"%99%4%/5& $#70"56%& $./7& 9%& 0.$1%& $%& 9.& 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IV&j&9.&08#4#35861.2#%&I#/09"./5&9%7&5861.2#%7&0#L96%7N& 7%93/&9%"17&#/$#0.5#3/7K&%75&9%&51.#5%4%/5&$%&16A61%/0%M& &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&& &d &-9.77#A#0.5#3/&^E?&%/&>#C"%"1&$%2"#7&F++G&%5&75.$%7&%/&.//%]%&FM& & ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&Xf&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Résumé des modalités techniques de prise en charge d’un Cancer non à petites cellules selon son stade TNM IA IB II IIIA IIIB IV (3) Chirurgie (exérèse complète) # # # RCP - - Radiothérapie - (1) - (1) - (2) RCP # - Chimiothérapie - RCP #& #& #& #& RCP : Modalité en option, à discuter en RCP selon le malade et sa maladie (1) : La radiothérapie peut être proposée comme une alternative à la chirurgie en cas de non-résécabilité ou non-opérabilité. (2) : Une irradiation peut être discutée en complément de la chirurgie et de la chimiothérapie en cas d’atteinte pariétale ou d’exérèse incomplète. (3) : Stade IV – incluant les cas avec épanchement pleural selon la nouvelle classification TNM. (.& 08#1"1C#%& $"& 0./0%1& $"& 23"43/N& 9.& 1.$#35861.2#%& %5& 9.& 08#4#35861.2#%& $3#>%/5&h51%&16.9#76%7&."&7%#/&$B65.L9#77%4%/57&$#7237./5&$B"/%&."531#7.5#3/& 23"1& 9B.05#>#56& $%& 73#/7& ,&51.#5%4%/5& $"& 0./0%1&:& 7%93/& 9%& $#7237#5#A& $B."531#7.5#3/& $6A#/#& 2.1& 9B.15#09%& WM&cXF*Hfd& $"& 03$%& $%& 9.& 7./56& 2"L9#@"%N& #/09"./5&9%7&01#5`1%7&$6A#/#7&2.1&9BD/75#5"5&E.5#3/.9&$"&-./0%1&fM& 4.4.1. 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$%& 73#/7& #/A#14#%17&U&$34#0#9%KM& (B.00342.C/%4%/5&$B"/&2.5#%/5&%/&A#/&$%&>#%&7%&A.#5&$./7&9%&1%72%05&$%&9.&93#& /v&F++_H*d+&$"& FF&.>1#9&F++_& 1%9.5#>%&."]& $13#57& $%7& 4.9.$%7& %5& U& 9.& A#/& $%& >#%M& ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&*d&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Annexe 1. Liste des participants T/5&2.15#0#26&U&9B69.L31.5#3/&$%&0%&C"#$%&j& Pour l’Institut National du Cancer&j& H& (.%5#5#.&m[W)TEDN&?6$%0#/N&-8%A&$%&213l%5N&)62.15%4%/5&$%7& 1%0344./$.5#3/7& H& m.961#%&?'{['r&|TVE'WN&?6$%0#/N&W%723/7.L9%&$"&$62.15%4%/5& $%7&1%0344./$.5#3/7& H& -935#9$%&<[S('DE&[(H!r[W-;[N&?6583$393C#75%N&)62.15%4%/5&$%7& 1%0344./$.5#3/7& Pour la Haute Autorité de Santé&j& '/$16&?TWDEN&?6$%0#/N&-8%A&$%&J13l%5& & Pour le groupe de travail&j& Q.L1#0%& S'W([<DN& <30#656& $%& 2/%"4393C#%& $%& 9./C"%& A1./R.#7%& I<J(QKN& J/%"43H3/0393C"%N&?.17%#99%& ?#08%9&SW'rE[WN&W.$#393C"%N&<30#656&A1./R.#7%&$%&1.$#393C#%&I<QWKN&J.1#7& '//%H?.1#%&SWT<<'W)N&(#C"%&/.5#3/.9%&03/51%&9%&0./0%1& (."1%/5& -'(<N&T/0393C"%& 46$#0.9N& Q6$61.5#3/& A1./R.#7%& $%7& 3/0393C"%7& 46$#0."]&IQQT?KN&^3"93/& -9.#1%&)'E[(N&J.58393C#75%N&<30#656&A1./R.#7%&$%&2.58393C#%&I<QJKN&J.1#7& n%./H(3"#7& QWTD)[m'(N& ?6$%0#/& C6/61.9#75%N& <30#656& A1./R.#7%& $%& $30"4%/5.5#3/&%5&$%&1%08%108%&%/&46$%0#/%&C6/61.9%&I<Q)W?!KN&'4L`7& J8#9#22%& !DW'r)N& W.$#35861.2%"5%N& <30#656& A1./R.#7%& $%& 1.$#35861.2#%& 3/0393C#@"%&I<QWTKN&J.1#7& m613/#@"%& }TWE?'EN& W67%."& $%7& 4.9.$%7& $%& 9.& (#C"%N&(#C"%& E.5#3/.9%& 03/51%&9%&-./0%1& J8#9#22%&J[W[{N&?6$%0#/&03/7%#9N&-.#77%&E.5#3/.9%&W<D& <5628./#%& <-;W'??N&?6$%0#/& 03/7%#9N& -.#77%& /.5#3/.9%& $B.77"1./0%H 4.9.$#%&$%7&51.>.#99%"17&7.9.1#67& J.70.9& ^;T?'<N& <30#656& A1./R.#7%& $%& 08#1"1C#%& 5831.0#@"%& %5& 0.1$#3>.70"9.#1%&I<Q-^-mKN&-8#1"1C#%/&5831.0#@"%N&?.17%#99%& ?.15#/%& WTr<<['rN& ?6$%0#/& C6/61.9#75%N& W67%."& T/0393C#%& '1C%/5%"#9N&S%e3/7M& ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&*f&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Dans le cadre de la relecture nationale&j& J8#9#22%&'<^Tr(N&J/%"43H3/0393C"%N&?.17%#99%& J#%11%&'^('EN&?6$%0#/&C6/61.9#75%N&E#0%& ;"L%15&S'WWD[r~N&J/%"4393C"%N&'"]%11%& '9.#/&S[WE'W)N&-8#1"1C#%/&^831.0#@"%N&)#l3/& ?.10&SD[Em[ErN&T/0393C"%&46$#0.9N&-8%1L3"1C& n%./&?.1#%&STE[(N&(#C"%&/.5#3/.9%&03/51%&9%&0./0%1& )34#/#@"%&SW[D(;N&J8.14.0#%/N&S31$%."]& !#99%7&-'W)T^N&-8#1"1C#%/&5831.0#@"%N&S3"93C/%H7"1H?%1& T9#>#%1&-'<^[(E'rN&J/%"43H3/0393C"%N&<.#/5H(."1%/5H$"Hm.1& E.58.9#%&-'rE[<N&T/0393C"%&46$#0.9N&^3"93"7%& \9#7.L%58&-;TWWDEN&-'!E'^N&?6$%0#/&C6/61.9#75%N&?./$1%7H9%7HW37%7& S1"/3&-Tr)[W^N&T/0393C"%&46$#0.9N&)#l3/& n%./&)rSW[{N&-8#1"1C#%/&5831.0#@"%N&S.Y3//%& n%./&J."9&)r;'?[(N&J/%"4393C"%N&;.1A9%"1& J#%11%&[44./"%9&Q'(-T{N&-8#1"1C#%/&5831.0#@"%N&<51.7L3"1C& ?.10&Q'W'()DN&W.$#35861.2%"5%N&-342#`C/%& J.70.9&QTr-;[WN&J/%"4393C"%N&)#l3/& '//%&![E[mTD<N&W.$#393C"%N&W3"%/& ^8#%11Y&![W?'DEN&W.$#35861.2%"5%N&J3#5#%17& Q1./R3#7&('ETr[N&&-8#1"1C#%/&5831.0#@"%&%5&>.70"9.#1%N&(.&W6"/#3/& <6L.75#%/&('WDm[N&J/%"4393C"%N&?b03/& -60#9%&([&J[-;Tr~N&W.$#35861.2%"5%N&m#99%l"#A& S%1/.1$&([)r-N&T/0393C"%&46$#0.9N&S1#>%& J8#9#22%&?TW['r)N&?6$%0#/&C6/61.9#75%N&J%77.0& '$%9&E''?[[N&-8#1"1C#%/&5831.0#@"%N&-9%143/5HQ%11./$& ?#08`9%&JDW'ST^N&J/%"43H3/0393C"%N&?.17%#99%& ;%/1#&JTW^[N&-8#1"1C#%/&5831.0#@"%N&(#99%& J#%11%&WD-;'r)N&W.$#35861.2%"5%N&S31$%."]& )34#/#@"%&WTr~N&J/%"43H3/0393C"%N&'4L%15& -9."$%&<'DE^&rJ[WVN&(#C"%&/.5#3/.9%&03/51%&9%&0./0%1& S1"/3&^'mDT^N&J/%"43H3/0393C"%N&-8.93/H7"1H<.t/%& Q1./R3#7%&^;DmT([^HS[nrDN&J.58393C#75%N&&(Y3/& ^8#%11Y&rWS'EN&J/%"4393C"%N&'/C%17& W%"L%/&m[[W'J[EN&-8#1"1C#%/&5831.0#@"%&%5&>.70"9.#1%N&(.&W6"/#3/& n%./H?.10&m[WE[nTr~N&J/%"4393C"%N&S31$%."]& ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&*G&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Annexe 2. Classifications Classification TNM des cancers du poumon non à petites cellules (7e révision 12) Stades ! ! 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3"&2167%/0%&$B"/&/3$"9%&5"431.9&$#75#/05&$./7&"/&."51%&93L%&$"&23"43/&.55%#/5& NX :&9%7&C./C9#3/7&/%&2%">%/5&2.7&h51%&6>.9"67& N0 :&2.7&$%&465.75.7%&C./C9#3//.#1%&9Y428.5#@"%&16C#3/.9%& N1 :& 465.75.7%& $./7& 9%7& C./C9#3/7& 9Y428.5#@"%7& #/51.2"943/.#1%7N& 261#L13/08#@"%7& %5=3"& 8#9.#1%7#9.561."]N&Y&03421#7&2.1&%/>.8#77%4%/5&$#1%05& N2&j& 465.75.7%& $./7& 9%7& C./C9#3/7& 9Y428.5#@"%7& 46$#.75#/."]& #27#9.561."]& %5=3"& 73"7H 0.1#/.#1%7& N3&j& 465.75.7%& $./7& 9%7& C./C9#3/7& 9Y428.5#@"%7& 46$#.75#/."]& 03/5139.561."]N& 8#9.#1%7& 03/5139.561."]N&70.9`/%7&3"&73"7H09.>#0"9.#1%7#9.561."]&3"&03/5139.561."]& MX :&9%7&465.75.7%7&U&$#75./0%&/B3/5&2.7&2"&h51%&6>.9"6%7& M0 :&.L7%/0%&$%&465.75.7%&U&$#75./0%& M1 :&465.75.7%&U&$#75./0%& M1a :& E3$"9%I7K& 5"431.9& $#75#/05& $./7& "/& 93L%& 03/5139.561.9&o& 5"4%"1& .>%0& /3$"9%7& 29%"1."]& 3"&62./08%4%/5&29%"1.9&I3"&261#0.1$#@"%K&4.9#/& M1b :&465.75.7%&U&$#75./0%& & &&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&&& &XF &D/5%1/.5#3/.9&'7730#.5#3/&A31&58%&<5"$Y&3A&("/C&-./0%1N&!39$751.O&JN&-13O9%Y&nN&-8./7ZY&}N& !#13"]& )nN& !1334%& J', et al.& ^8%& D'<(-& ("/C& -./0%1& <5.C#/C& J13l%05&j& 213237.97& A31& 58%& 1%>#7#3/& 3A& 58%& ^E?& 75.C%& C13"2#/C7& #/& 58%& A3158034#/C& I7%>%/58K& %$#5#3/& 3A& 58%& ^E?& -9.77#A#0.5#3/&3A&4.9#C/./5&5"43"17M&n&^831.0&T/039&F++d&o&F&IfK&j&d+cHXPM& & ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&P+&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Classification par stades Cancer occulte Stade 0 Stade IA Stade IB Stage IIA Stade IIB Stade IIIA Stade IIIB Stade IV ^~& ^#7& ^X.N&L& ^F.& ^X.N&L& ^F.& ^FL& ^FL& ^*& ^XN&^F& ^*& ^P& ^P& ^3"5&^& ^3"5&^& E+& E+& E+& E+& EX& EX& E+& EX& E+& EF& EXN&EF& E+N&EX& EF& E*& ^3"5&E& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?+& ?X& ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&PX&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Classification des cancers du poumon à petites cellules Maladie localisée (atteinte accessible à un seul champ d’irradiation) !& ^"4%"1&53"08%&"/&7%"9&23"43/& !& !./C9#3/7&8#9.#1%7&%5&46$#.75#/."]& 83439.561."]&%5&03/5139.561."]N& 7"709.>#0"9.#1%&83439.561."]& Maladie étendue !& ^"4%"1&L#9.561.9%& !& '55%#/5%&$"&261#0.1$%N&29%"167#%& 0.10#/34.5%"7%& !& !./C9#3/7&L#9.561."]& !& ?65.75.7%7&%/&$%8317&$"&5831.]& Classification des tumeurs pleurales – TNM IMIG T1 T1a T1b T2 T3 T4 ^"4%"1&9#4#56%&U&9.&29`>1%&2.1#65.9%&83439.561.9%&•&46$#.75#/.9%& •&$#.281.C4.5#@"%& '55%#/5%&$%&9.&29`>1%&>#7061.9%&83439.561.9%&i&r/&62./08%4%/5& %75&%/&1`C9%&2167%/5& ^"4%"1&$%&9.&29`>1%&2.1#65.9%N&46$#.75#/.9%N&$#.281.C4.5#@"%N&%5& 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%]5%/7#3/&$#1%05%&."]&31C./%7&46$#.75#/."]N&."&1.08#7N&U&9.& A.0%&#/5%1/%&$"&261#0.1$%N&."&4Y30.1$%& ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&PF&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Score de performance (PS) de l’OMS +& X& F& '05#>#56&28Y7#@"%&#/5.05%&i&[AA3157&2377#L9%7&7./7&9#4#5.5#3/& W6$"05#3/&$%7&%AA3157&i&'"53/34#%&03429`5%& *& J%173//%&$62%/$./5%&i&(%>%1&2377#L9%&4.#7&/%&A.#5&2.7&7.&53#9%55%&7%"9%& )62%/$./0%&535.9%&i&\5.5&@".7#&C1.L.5.#1%& P& J%173//%& %/031%& ."53/34%& i&<%& A.5#C"%& A.0#9%4%/5& i&E60%77#56& $%& 7%& 1%237%1&29"7&$%&c&8%"1%7&2.1&l3"1& & ;'<=<%1>#0%&?.9.$#%7&0813/#@"%7&%5&$#7237#5#A7&$B.00342.C/%4%/5&$%7&4.9.$%7&=& DE-.=)62.15%4%/5&$%7&1%0344./$.5#3/7&23"1&9%7&213A%77#3//%97&$%&7./56& & ?.#&F++G& H&P*&H& !"#$%&'()&*+&i&-./0%1&$"&23"43/&%5&46735869#34%&29%"1.9& Annexe 3. 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