Publications

Publications
Spyroglou A, Wagner S, Gomez-Sanchez C, Rathkolb B, Wolf E, Manolopoulou J, Reincke M, Bidlingsmaier M,
Hrabé de Angelis M, Beuschlein F: Utilization of a mutagenesis screen to generate mouse models of
hyperaldosteronism. Endocrinology (in press) 2010
Fuchs H, Gailus-Durner V, Adler T, Aguilar-Pimentel JA, Becker L, Cazada-Wack J, Da Silva-Buttkus P, Neff F,
Götz A, Hans W, Hölter SM, Horsch M, Kastenmüller G, Kemter E, Lengger C, Maier H, Matloka M, Möller G,
Naton B, Prehn C, Puk O, Racz I, Rathkolb B, Römisch-Margl W, Rozman J, Wang-Sattler R, Schrewe A, Stöger
C, Tost M, Adamski J, Aigner B, Beckers J, Behrendt H, Busch DH, Esposito I, Graw J, Illig T, Ivandic B,
Klingenspor M, Klopstock T, Kremmer E, Memper M, Neschen S, Ollert M, Schulz H, Suhre K, Wolf E, Wurst W,
Zimmer A, Hrabé de Angelis M: Mouse Phenotyping. Methods (Epub ahead of print) (2010)
Kleinschnitz C, Grund H, Wingler , Armitage ME, Jone E, Mittal M, Barit D, Schwarz T, Geis C, Kraft P, Barthel K,
Schuhmann MK, Herrmann AM, Meuth SG, Stoll G, Meurer S, Schrewe A, Becker L, Gailus-Durner V, Fuchs H,
Klopstock T, Hrabé de Angelis M, Jandeleit-Dahm K, Shah AM, Weissmann N, Schmidt HHHW: Post-Stroke
Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration.
PLoS Biology 8(9) e1000479 (2010)
Wagner S, Calzada-Wack J, Rosemann M, Becker L, Tost M, Silva-Buttlus P, Klein-Rodewald T, Fuchs H, Neff F,
Hrabé de Angelis M, Esposito I: Charakterisierung von ENU-Mausmutanten – Tiermodelle für
menschliche Erkrankungen mittels morphologischer und molekularer Methoden. Pathologe 31 (Suppl
2), (afp)-(alp) (2010)
Yin R, Tian F, Frankenberger B, Hrabé de Angelis M, Stoeger T: Selection and evaluation of stable
housekeeping genes for gene expression normalization in carbon nanoparticle-induced mice acute
pulmonary inflammation. Biochem Biophy Res Commun 399, 531-536 (2010)
Meyer M, Hrabé de Angelis M, Wurst W, Kühn R: Gene targeting by homologous recombination in mouse
zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci USA 107, 15022-15026 (2010)
Bertsch A, Hrabé de Angelis M, Przemeck GKH: A phylogenetic framework for the North American
bumblebee species of the subgenus Bombus sensu stricto (Bombus affinis, B. franklini, B.
moderatus, B. occidentalis & B. terricola) based on mitochondrial DNA markers. Beiträge Entomol 60,
229-242 (2010)
Bertsch A, Hrabé de Angelis M, Przemeck GKH: Phylogenetic relationships of the bumblebees Bombus
moderatus, B. albocinctus, B. burjaeticus, B. florilegus and B. cryptarum based on
mitochondrimitochondrial DNA markers: a complex of closely related taxa with circumpolar
distribution. Beiträge Entomol 60, 13-32 (2010)
Wurst W, Hrabé de Angelis M: Systematic phenotyping of mouse mutants. Nat Biotechnol 28, 684-685
(2010)
Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qui CH,
Londono MB, Ikezawa J, Jedlicka P, Stein B, Schwarzbacher SW, Wolfer DP, Erhardt N, Heuchel R, Nezis I,
Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, Hrabé de Angelis
M, Dikic I: CIN85 regulates dopamine receptor endocytosis and governs behavior in mice. EMBO J 29,
2421-2432 (2010)
Hoesel B, Bhujabal Z, Przemeck GKH, Kurz-Drexler A, Vogt-Weisenhorn DM, Hrabé de Angelis M, Beckers J:
Combination of in silico and in situ hybridisation approaches to identify potential Dll1 associated
miRNAs during mouse embryogenesis. Gene Expr Patterns 10, 265-273 (2010)
Deussing JM, Breu J, Kühne C, Kallnik M, Bunck M, Glasl L, Yen YC, Schmidt MV, Zurmühlen R, Vogl AM, GailusDurner V, Fuchs H, Hölter SM, Wotjak CT, Landgraf R, Hrabé de Angelis M, Holsboer F, Wurst W: Urocortin 3
Modulates Social Discrimination Abilities via Corticotropin-Releasing Hormone Receptor Type 2. J
Neurosci 30, 9103-9166 (2010)
Dror AA, Politi Y, Shahin H, Lenz DR, Dossena S, Nofziger C, Fuchs H, Hrabé de Angelis M, Paulmichl M, Weiner
S, Avraham KB: Calcium Oxalate Stone Formation in the Inner Ear as a Result of an Slc26a4 Mutation.
J Biol Chem 285, 21724-21735 (2010)
Vegiopoulos A, Müller-Decker K, Strzoda D, Schmitt I, Chichelnitskiy E, Ostertag A, Berriel Diaz M, Rozman J,
Hrabé de Angelis M, Nüsing RM, Meyer CW, Wahli W, Klingenspor M, Herzig S: Cyclooxygenase-2 controls
energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 320, 1159-1161
(2010)
Kemter E, Ratkolb B, Bankir L, Schrewe A, Hans W, Landbrecht C, Klaften M, Ivandic BT, Fuchs H, GailusDurner V, Hrabé de Angelis M, Wolf E, Wanke R, Aigner B: Mutation of the Na+-K+-2Cl- cotransporter
NKCC2 in mice is associated with severe polyuria and a urea-selective concentrating defect without
hpyerreninemia. Am J Physiol Renal 298, F1405-1415 (2010).
Pham TT, Giesert F, Röthig A, Floss T, Kallnik M, Weindl K, Hölter SM, Ahting U, Prokisch H, Becker L, Klopstock
T, Hrabé de Angelis M, Beyer K, Görner K, Kahle PJ, Vogt-Weisenhorn DM, Wurst W: DJ-1 deficient mice
show less TH-positve neurons in the ventral tegmental area and exhibit non-motoric behavioural
impairments. Genes Brain Behav 9, 305-317 (2010)
Tocchetti A, Ekall Soppo CB, Zani F, Bianchi F, Gagliani MC, Pozzi B, Rozman J, Elvert R, Ehrhardt N, Rathkolb
B, Moerth C, Horsch M, Fuchs H, Gailus-Durner V, Beckers J, Klingenspor M, Wolf E, Hrabé de Angelis M,
Scanziani E, Tacchetti C, Scita G, Di Fiore PP, Offenhäuser N: Loss of the Actin Remodeler Eps8 Causes
Intestinal Defects and Improved Metabolic Status in Mice. PLoS One 5 (3), e9468 (2010)
Van Buerck L, Blutke A, Kautz S, Rathkolb B, Klaften M, Wagner S, Kemter E, Hrabé de Angelis M, Wolf E,
Aigner B, Wanke R, Herbach N: Phenotypic and Pathomorphological Characteristics of a Novel Mutant
Mouse Model for Maturity-Onset Diabetes of the Young Type 2 (MODY 2). Am J Physiol Endocrinol
Metab 298, E512-523 (2010)
Schneider MR, Gratao AA, Dahlhoff M, Boersma A, Hrabé de Angelis M, Hoang-Vu C, Wolf E, Klonisch T: EGFR
ligands exert diverging effects on male reproductive organs. Exp Mol Pathol 88, 216-218 (2010)
Illig T, Gieger C, Zhai G, Römisch-Margl W, Wang-Sattler R, Prehn C, Altmaier E, Kastenmüller G, Kato BS,
Mewes HW, Meitinger T, Hrabé de Angelis M, Kronenberg F, Soranzo N, Wichmann HE, Spector TD, Adamski J,
Suhre K: A genome-wide perspective of genetic variation in human metabolism. Nat Genet 42, 137-141
(2010)
Rosemann M, Ivashkevich A, Favor J, Dalke C, Hölter SM, Becker L, Rácz I, Bolle I, Klempt M, Rathkolb B,
Kalaydjiev S, Adler T, Aguilar A, Hans W, Horsch M, Rozman J, Calzada-Wack J, Kunder S, Naton B, GailusDurner V, Fuchs H, Schulz H, Beckers J, Busch DH, Burbach JP, Smidt MP, Quintanilla-Martinez L, Esposito I,
Klopstock T, Klingenspor M, Ollert M, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M, Atkinson M, Heinzmann
U, Graw J: Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 (416insG) mice. Mamm
Genome 21, 13-27 (2010)
Marklund U, Hansson EM, Sundström E, Hrabé de Angelis M, Przemeck GKH, Lendahl U, Muhr J, Ericson J:
Domain specific control of neurogenesis achieved through patterned regulation of Notch ligand
expression. Development 137, 437-445 (2010)
Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C, Maier H, Melvin D, Meziane
H, Richardson D, Wells, S, White J, Wood J, EUMODIC Consortium, Hrabé de Angelis M, Brown SDM, Hancock
JM, Mallon AM: EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids
Res 38, D577-D585 (2010)
Aguilar-Pimentel JA, Alessandrini F, Huster LM, Jakob T, Schulz H, Behrendt H, Ring J, Hrabé de Angelis M,
Busch DH, Mempel M, Ollert M: Specific CD8 T cells in IgE-mediated allergy correlate with allergen
dose and sllergic phenotype. Am J Respir Crit Care Med 181, 7-16 (2010)
Wilkinson P, Sengerova J, Matteoni R, Chen CK, Soulat G, Ureta-Vidal A, Fessele S, Hagn M, Massimi M,
Pickford K, Butler RH, Marschall S, Mallon AM, Pickard A, Raspa M, Scavizzi F, Fray M, Larrigaldie V, Leyritz J,
Birney E, Tocchini-Valentini GP, Brown S, Herault Y, Montoliu L, Hrabé de Angelis M, Smedley D: EMMA –
mouse mutant resources for the international scientific community. Nucleic Acids Res 38, D570-D576
(2010)
Peters DD, Lepikhov K, Rodenacker K, Marschall S, Boersam A, Hutzler P, Scherb H, Walter J, Hrabé de Angelis
M: Effect of IVF and laser zona dissection on DNA methylation pattern of mouse zygotes. Mamm
Genome 20, 664-673 (2009)
Schofield PN, Bubela T, Weaver T, Portilla L, Brown SD, Hancock JM, Einhorn D, Tocchini-Valentini G, Hrabé de
Angelis M, Rosenthal N, CASIMIR Rome Meeting participants: Post-publication sharing of data and tools.
Nature 461, 171-173 (2009)
Grzmil P, Konietzko J, Boehm D, Hoelter SM, Aguilar A, Javaheri A, Kalaydjiev S, Adler T, Bolle I, Adham I,
Dixkens C, Wolf S, Fuchs H, Gailus-Durner V, Wurst W, Ollert M, Busch D, Schulz H, Hrabé de Angelis M,
Burfeind P: Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE
levels, and impaired lung function. Cytogenet Genome Res 125, 186-200 (2009)
Kemter E, Rathkolb B, Rozman J, Hans W, Schrewe A, Landbrecht C, Klaften M, Ivandic BT, Fuchs H, GailusDurner V, Klingenspor M, Hrabé de Angelis M, Wolf E, Wanke R, Aigner B: Novel Missense Mutation of
Uromodulin in Mice Causes Renal Dysfunction with Alterations in Urea Handling, Energy and Bone
Metabolism. Am J Physiol Renal Physiol 297, F1391-1298 (2009)
Wirth EK, Roth S, Blechschmidt C, Hölter SM, Becker L, Racz I, Zimmer A, Klopstock T, Gailus-Durner V, Fuchs
H, Wurst W, Naumann T, Bräuer A, Hrabé de Angelis M, Köhrle J, Grüters A, Schweizer U: Neuronal 3',3,5triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3
transporter mutated in Allan-Herndon-Dudley syndrome. J Neurosci 29, 9439-9449 (2009)
Rathkolb B, Noyes HA, Brass A, Dark P, Fuchs H, Gailus-Durner V, Gibson J, Hrabé de Angelis M, Ogugo M, Iraqi
F, Kemp SJ, Naessens J, Pope ME, Wolf E, Agaba M: Clinical chemistry of congenic mice with quantitative
trait loci for predicted responses to Trypanosoma congolense infection. Infect Immun 77, 3948-3957
(2009)
Puk O, Dalke C, Calzada-Wack J, Ahmad N, Klaften M, Wagner S, Hrabé de Angelis M, Graw J: Reduced
corneal thickness and enlarged anterior chamber in a novel ColVIIIa2G257D mutant mouse. Invest
Ophthalmol Vis Sci 50, 5653-5661 (2009)
Everett KL, Bunney TD, Yoon Y, Rodriguez-Lima F, Harris R, Driscoll PC, Abe K, Fuchs H, Hrabé de Angelis M, Yu
P, Cho W, Katan M: Characterization of phospholipase C gamma enzymes with gain-of-function
mutations. J Biol Chem 284, 23083-2309-3 (2009)
Rubio-Aliaga I, Przemeck GKH, Fuchs H, Gailus-Durner V, Adler T, Hans W, Horsch M, Rathkolb B, Rozman J,
Schrewe A, Wagner S, Hölter SM, Becker L, Klopstock T, Wurst W, Wolf E, Klingenspor M, Ivandic BT, Busch
DH, Becker J, Hrabé de Angelis M: Dll1 haploinsufficiency in adult mice leads to a complex phenotype
affecting metabolic and immunological processes. PLos One 4, e6054 (2009)
Aigner B, Rathkolb B, Klempt M, Wagner Sibylle, Michel D, Hrabé de Angelis M, Wolf E: N-ethyl-nitrosurea
mutagenesis produced a small number of mice with altered plasma elctrolyte levels. J Biomed Sci
16:53 (2009)
Enard W, Gehre S, Hammerschmidt K, Höler SM, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr
R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J,Dalke
C, Erhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M,
Kling E, Kunder S, Moßbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J,
Ivandic B, Klingenspor M, Klopstock T, Oller M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A,
Fisher SE, Morgenstern R, Arendt T, Hrabé de Angelis M, Fischer J, Schwarz J, Pääbo S: A humanized version
of Foxp2 affects cortico-basal ganglia circuits in mice. Cell 137, 961-971 (2009)
Beckers J, Wurst W, Hrabé de Angelis M: Towards better mouse models: enhanced genotypes, systemic
phenotyping and envirotype modelling. Nat Rev Genet 10, 371-380 (2009)
Schneider M, Förster H, Boersma A, Seiler A, Wehnes H, Sinowatz F, Neumüller C, Deutsch MJ, Walch A, Hrabé
de Angelis M, Wurst W, Ursini F, Roveri A, Maleszewski M, Maiorino M, Conrad M: Mitochondrial glutathione
peroxidase 4 disruption cause male infertility. FASEB J 23, 3233-3242 (2009)
Puk O, Esposito I, Söker T, Löster J, Budde B, Nürnberg P, Michel-Soewarto D, Fuchs H, Wolf E, Hrabé de
Angelis M, Graw J: A new Fgf10 mutation in the mouse leads to atrophy of the Harderian gland and
slit-eye phenotype in heterozygotes: A novel model for dry-eye disease? Invest Ophthalmol Vis Sci 50,
4311-4318 (2009)
Lewis MA, Quint E, Galzier AM, Fuchs H, Hrabé de Angelis M, Langford C, van Dongen S, Abreu-Goodger C,
Piipari M, Redshaw N, Dalmay T, Moreno-Pelayo MA, Enright AJ, Steel KP: An ENU-induced mutant of mirR96 associated with progressive hearing loss in mice. Nat Genet 41, 614-618 (2009)
Noyes HA, Alimohammadian MH, Agaba M, Brass A, Fuchs H, Gailus-Durner V, Hulme H, Iraqi F, Kemp S,
Rathkolb B, Wolf E, Hrabé de Angelis M, Roshandel D, Naessens J: Mechanisms controlling anaemia in
Trypanosoma congolense infected mice. PLoS One 4(4): e5170 (2009)
Klonisch T, Glogowska A, Gratao AA, Grzech M, Nistor A, Torchia M, Weber E, Hrabé de Angelis M, Rathkolb B,
Hoang-Vu C, Wolf E, Schneider MR: The C-terminal cytoplasmic domain of human proEGF is a negative
modulator of body and organ weights ins transgenic mice. FEBS Lett 583, 1349-1357 (2009)
Ahting U, Floss T, Uez N, Schneider-Lohmar I, Becker L, Kling E, Iuso A, Bender A, Hrabé de Angelis M, GailusDurner V, Fuchs H, Meitinger T, Wurst W, Prokisch H, Klopstock T: Neurological phenotype and reduced
lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial
import. Biochim Biophys Acta 1787, 371-376 (2009)
Bosman EA, Quint E, Fuchs H, Hrabé de Angelis M, Steel KP: Catweasel mice: A novel role for Six1 in
sensory patch development and a model for branchio-oto-renal syndrome. Dev Biol 328, 285-296
(2009)
Isensee J, Meoli L, Zazzu V, Nabzdyk C, Witt H, Soewarto D, Effertz K, Fuchs H, Gailus-Durner V, Busch D,
Adler T, Hrabe de Angelis M, Irgnag M, Otto C, Noppinger PR: Expression Pattern of Gpr30 in LacZ
Reporter Mice. Endocrinology 150, 1722-1730 (2009)
Aigner B, Rathkolb B, Klaften M, Sedlmeier R, Klempt, Wagner S, Micel D, Mayer U, Klopstock T, Hrabé de
Angelis M, Wolf E: Generation of N-ethyl-nitrosurea-induced mouse mutants with deviations in plasma
enzyme activities as novel organ-specific disease models. Exp Physiol 94, 412-421 (2009)
Horsch M, Recktenwald CV, Schädler S, Hrabé de Angelis M, Seliger B, Beckers J: Overexpressed vs mutated
Kras in murine fibroblasts: a molecular phenotyping study. Br J Cancer 100, 656-662 (2009)
Marschall S, Boersma A, Hrabé de Angelis M: Sperm cryopreservation and in vitro fertilization. In: Gene
Knockout Protocols: 2nd Ed., Kühn R, Wurst W (eds.), Methods Mol Biol 530, 407-421 (2009)
Gailus-Durner V, Fuchs H, Adler T, Aguilar Pimentel A, Becker L, Bolle I, Calzada-Wack J, Dalke C, Erhardt N,
Ferwagner B, Hans W , Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Langger C, Mörth
C, Mossbrugger I, Naton B, Prehn C, Puk O, Rathkolb B, Rozman J, Schrewe A, Thiele F, Adamski J, Aigner B,
Behrendt H, Busch DH, Favor J, Graw J, Heldmaier G, Ivandic B, Katus H, Klingenspor M, Elisabeth Kremmer
TK, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Hrabé de Angelis M: Systemic First-Line
Phenotyping. In: Gene Knockout Protocols: 2nd Ed., Kühn R, Wurst W (eds.), Methods Mol Biol 530, 463-510
(2009
Abe K, Klaften M, Narita A, Kimura T, Imai K, Kimura M, Rubio-Aliaga I, Wagner S, Jakob T, Hrabe de Angelis
M: Genome-wide search for genes that modulate inflammatory arthritis caused by Ali18 mutation in
mice. Mamm Genome 20, 152-161 (2009)
Khasawneh J, Schulz MD, Walch A, Rozman J, Hrabe de Angelis M, Klingenspor M, Buck A, Schwaiger M, Saur
D, Schmid RM, Klöppel G, Sipos B, Greten FR, Arkan MC: Inflammation and mitochondrial fatty acid betaoxidation linke obesity to early tumor promotion. Proc Natl Acad Sci USA 106, 3354-3359 (2009)
Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C,
Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A,
Kallnik M, Kling E, Lengger C, Maier H, Mossbrugger I, Mörth C, Naton B, Nöth U, Pasche B, Prehn C, Przemeck
G, Puk O, Racz I, Rathkolb B, Rozman J, Schäble K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F,
Willershäuser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J,
Heldmaier G, Höfler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Müller W,
Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf
E, Wurst W, Zimmer A, Hrabé de Angelis M: The German Mouse Clinic: A Platform for Systemic
Phenotype Analysis of Mouse Models. Curr Pharm Biotechnol 10, 236-243 (2009)
Bazhin AV, Dalke C, Willner N, Abschütz O, Wildberger HGH, Philippov PP, Dummer R, Graw J, Hrabé de Angelis
M, Schadendorf D, Umansky V, Eichmüller SB: Cancer-retina antigens as potential paraneoplastic
antigens in melanoma-associated retinopathy. Int J Cancer 124, 140-149 (2009)
Söker T, Dalke C, Puk O, Floss T, Becker L, Bolle I, Favor J, Hans W, Hölter SM, Horsch M, Kallnik M, Kling E,
Mörth C, Schrewe A, Stigloher C, Topp S, Gailus-Durner V, Naton B, Beckers J, Fichs H, Ivandic B, Klopstock T,
Schulz H, Wolf E, Wurst W, Bally-Cuif L, Hrabé de Angelis M, Graw J: Pleiotropic effects in Eya3 knockout
mice. BMC Dev Biol 8(1):118 (2008)
Gieger C, Geistlinger L, Altmaier E, Hrabé de Angelis M, Kronenberg F, Meitinger T, Mewes HW, Wichmann HE,
Weinberger KM, Adamski J, Illig T, Suhre K: Genetics meets metabolomics: a genome-wide association
study of metabolite profiles in human serum. PLoS Genetics 4(11): e1000282 (2008)
Fröhlich Archangelo L, Greiff PA, Hölzel M, Harasim T, Kremmer, E, Przemeck GKH, Eick D, Deshpande AJ,
Buske C, Hrabé de Angelis M, Ollala Saad ST, Bohlander SK: The CALM and CALM/AF10 interactor CATS is
a marker for proliferation. Mol Oncol 2, 356-367 (2008)
Spiden SL, Bortolozzi M, Di Leva F, Hrabé de Angelis M, Fuchs H, Lim D, Ortolano S, Ingham NJ, Brini M,
Carafoli E, Mammano F, Steel KP: The Novel Mouse Mutation Oblivion Inactivates the PMCA2 Pump and
Causes Progressive Hearing Loss. PLoS Genet 4(10): e1000238 (2008)
Hertzano R, Shalit E, Rzadzinska AK, Dror AA, Song L, Ron U, Tan JZ, Shitrit AS, Fuchs H, Hasson T, Ben-Tal N,
Sweeney HL, Hrabé de Angelis M, Steel KP, Avraham KB: A Myo6 Mutation Destroys Coordination
between the Myosin Heads, Revealing New Functions of Myosin VI in the Stereocilia of Mammalian
Inner Ear Hair Cells. PLoS Genet 4(10): e1000207 (2008)
Uez N, Lickert H, Kohlhase J, Hrabé de Angelis M, Kühn R, Wurst W, Floss T: Sall4 isoforms act during
proximal-distal and anterior-posterior axis formation in the mouse embryo. Genesis 46, 463-477
(2008)
McGowan KE, Li JZ, Park CY, Beaudry V, Tabor HK, Sabnis AJ, Zhang W, Fuchs H, Hrabé de Angelis M, Myers
RM, Attardi, LD, Barsh GS: Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects.
Nat Genet 40, 963-970 (2008)
Bender A, Beckers J, Schneider I, Hölter SM, Haack T, Mader M, Quintanilla-Martinez L, Fuchs H, Gailus-Durner
V, Hrabé de Angelis M, Wurst W, Schmidt J, Klopstock T: Creatine improves health and survival of mice.
Neurobiol Aging 29, 1404-1411 (2008)
Schmidt S, Gawlik V, Hölter SM, Augustin R, Scheepers A, Behrens M, Wurst W, Gailus-Durner V, Fuchs H,
Hrabé de Angelis M, Kluge R, Joost HG, Schürmann A: Deletion of GLucose Transporter GLUT8 in Mice
Increases Locomotor Activity. Behav Genet 38, 396-406 (2008)
Puk O, Dalke C, Hrabé de Angelis M, Graw J.: Variation of the response to the optokinetic drum among
various strains of mice. Front Biosci 13, 6269-6275 (2008)
Hölter SM, Dalke C, Kallnik M, Becker L, Horsch M, Schrewe A, Favor J, Klopstock T, Beckers J, Ivandic B,
Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Graw J, Wurst W: “Sighted C3H” mice – a tool for analyzing
the influence of vision on mouse behavior?. Front Biosci 13, 5810-5823 (2008)
Maier H, Lengger C, Simic B, Fuchs H, Gailus-Durner V, Hrabé de Angelis M: MausDB: an open source
application for phenotype data and mouse colony management in large-scale mouse phenotyping
projects. BMC Bioinformatics 9:169 (2008)
Fuchs H, Lisse T, Hans W, Abe K, Thiele F, Gailus-Durner V, Hrabé de Angelis M.: Phenotypic
characterization of mouse models for bone-related diseases in the German Mouse Clinic. J
Musculoskelet Neuronal Interact 8, 13-14 (2008)
Puk O, Löster J, Dalke C, Soewarto D, Fuchs H, Budde B, Nürnberg P, Wolf E, Hrabé de Angelis M, Graw J.:
Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and
causes a variable small-eye phenotype. Invest Ophth Vis Sci 49, 1525-1532 (2008)
Horsch M, Schädler S, Gailus-Durner V, Fuchs H, Meyer H, Hrabé de Angelis M, Beckers J: Systematic gene
expression profiling of mouse model series reveals co-expressed genes. Proteomics 8, 1248-1256
(2008)
Abe K, Wechs S, Kalaydjiev S, Franz TJ, Busch DH, Fuchs H, Soewarto D, Behrendt H, Wagner S, Jakob T,
Hrabe de Angelis M.: Novel lymphocyte-independent mechanisms to initiate inflammatory arthritis via
bone marrow-derived cells of Ali18 mutant mice. Rheumatology 47, 292-300 (2008)
Irmler M, Hartl D, Schmidt T, Schuchhardt J, Lach C, Meyer HE, Hrabé de Angelis M, Klose J, Beckers J: An
approach to handling and interpretation of ambiguous data in transcriptome and proteome
comparisons. Proteomics 8, 1165-1169 (2008)
Hartl D, Irmler M, Römer I, Mader MT, Mao L, Zabel C, Hrabé de Angelis M, Beckers J, Klose J: Transcriptome
and proteome analysis of early embryonic mouse brain development. Proteomics 8, 1257-1265 (2008)
Pawlak CR, Sanchis-Segura C, Soewarto D, Wagner S, Hrabé de Angelis M, Spanagel R: A phenotype-driven
ENU mutagenesis screen for the identification of dominant mutations involved in alcohol
consumption. Mamm Genome 19, 77-84 (2008)
Attia, SM, Badary OA, Hamada FM, Hrabé de Angelis M, Adler ID: The chemotherapeutic agents
nocodazole and amsarcrine cause meiotic delay and non-disjunction in spermatocytes of mice. Mutat
Res 651, 105-113 (2008)
Aigner B, Rathkolb B, Herach N, Hrabé de Angelis M, Wanke R, Wolf E: Diabetes models by screening for
hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. Am J Physiol Endocrinol Metab
294, 292-300 (2008)
Lisse TS, Thiele F, Fuchs H, Hans W, Przemeck GKH, Abe K, Rathkolb B, Quintanilla-Martinez L, Hoelzlwimmer
G, Helfrich M, Wolf E, Ralston SH, Hrabé de Angelis M: ER-stress mediated apoptosis in a new mouse
model of osteogenesis imperfecta. PLoS Genetics 4(2): e7 (2008)
Mayer A, Bulian D, Scherb H, Hrabé de Angelis M, Schmidt J, Mahabir E: Emergency prevention of
extinction of a transgenic allele in a less-fertile transgenic mouse line by crossing with an inbred or
outbred mouse strain coupled with assisted reproductive technologies. Reprod Fert Develop 19, 984994 (2007)
Beckers J, Hrabé de Angelis M: Mausmodelle. Von der funktionellen Genomforschung zur systematischen
Krankheitsanalyse. Biospektrum 05.07, 504-506 (2007)
Hagn M, Marschall S, Hrabé de Angelis M: EMMA - The European mouse mutant archive. Brief Funct
Genomic Proteomic 6, 186-192 (2007)
Magnol L, Chevallier MC, Nalesso V, Retif S, Fuchs H, Klempt M, Pereira P, Riottot M, Andrzejewski S, Doan BT,
Panthier JJ, Puech A, Beloeil JC, Hrabé de Angelis M, Herault Y: KIT is required for hepatic function during
mouse postnatal development. BMC Developmental Biology 7:81 (2007)
Teppner I, Becker S, Hrabé de Angelis M, Gossler A, Beckers J: Compartmentalised expression of Deltalike1 in epithelial somites is required for the formation of invertebral joints. BMC Developmental
Biology 7:68 (2007)
Aigner B, Rathkolb B, Mohr M, Klempt M, Hrabé de Angelis M, Wolf E: Generation of ENU-induced mouse
mutants with hypocholesterolemia: novel tools for dissecting plasma lipoprotein homeostasis. Lipids
42, 731-737 (2007)
Hammel M, Michel G, Hoefer C, Klaften M, Müller-Höcker J, Hrabé de Angelis M, Holzinger, A: Targeted
inactivation of the murine Abca3 gene leads to respiratory failure in newborns with defective
lamellar bodies. Biochem Biophys Res Commun 359, 947-951 (2007)
Hrabé de Angelis M, Michel D, Wagner S, Becker S, Beckers J: Chemical Mutagenesis in Mice. In: The Mouse
in Biomedical Research, 2nd ed. Fox, J., Barthold, S., Davisson, M.T., Newcomer, C., Quimby, F., Smith, A.
(eds.), Elsevier Press (2007)
Hamacher M, Stephan C, Eisenacher M, Lewczuk P, Wiltfang J, Martens L, Vizcaíno JA, Kwon KH, Yoo JS, Park
YM, Beckers J, Horsch M, Hrabé de Angelis M, Cho ZH, Apweiler R, Meyer HE: High Performance Proteomics:
7th HUPO Brain Proteome Project Workshop in Hinxton, UK. Proteomics 7, 2490-2496 (2007)
Tiedemann H, Schneltzer E, Zeiser S, Rubio-Aliaga I, Beckers J, Przemeck GKH, Hrabé de Angelis M: Cellbased simulation of dynamic expression patterns in the presomitic mesoderm. J Theor Biol 248, 120129 (2007)
Seedorf H, Klaften M, Eke F, Fuchs H, Seedorf U, Hrabé de Angelis M: A Mutation in the Enamelin Gene in a
Mouse Model. J Dent Res 86, 764-768 (2007)
Hancock JM, Adams NC, Audinis V, Blake A, Blake JA, Bogue M, Brown SDM, Chesler E, Davidson D, Duran C,
Eppig JT, Gailus-Durner V, Gates H, Gkoutos GV, Greenaway S, Hrabé de Angelis M, Kollia G, Leblanc S, Lee K,
Lengger C, Maier H, Mallon AM, Masuya H, Melvin DB, Müller W, Parkinson H, Proctor G, Reuveni E, Schofield P,
Shukla A, Smith C, Toyoda T, Vasseur L, Wakana S, Walling A, White J, Wood J, Zouberakis M: Integration of
mouse phenome data resources. The Mouse Phenotype Database Integration Consortium. Mamm Genome
18, 157-163 (2007)
Kallnik M, Elvert R, Erhardt N, Kissling D, Mahabir E, Welzl G, Faus-Kessler T, Hrabé de Angelis M, Wurst W,
Schmidt J, Hölter SM: Impact of IVC housing on emotionality and fear learning in male C3HeB/FeJ and
C57BL/6J mice. Mamm Genome 18, 173-186 (2007)
Herbach N, Rathkolb B, Kemter E, Pichl L, Klaften M, Hrabé de Angelis M, Halban PA, Wolf E, Aigner B, Wanke
R: Dominant negative effects of a novel mutated Ins2 allele causes early onset diabetes mellitus and
severe beta cell loss in Munich Ins2C95S mutant mice. Diabetes 56, 1268-1276 (2007)
Aigner B, Rathkolb B, Herbach N, Kemter E, Schessl C, Klaften M, Klempt M, Hrabé de Angelis M, Wanke R,
Wolf E: Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project
reveals kidney disease models. Am J Physiol Renal Physiol 292, F1560-F1567 (2007)
Rubio-Aliaga I, Soewarto D, Wagner S, Klaften M, Fuchs H, Kalaydjiev S, Busch DH, Klempt M, Rathkolb B, Wolf
E, Abe K., Zeiser S, Przemeck GKH, Beckers J, Hrabé de Angelis M: A genetic screen for modifiers of Delta1
dependent Notch signaling function in the mouse. Genetics 175, 1451-1463 (2007)
Vauti F, Goller T, Beine R, Becker L, Klopstock T, Hölter SM, Wurst W, Fuchs H, Gailus-Durner V, Hrabé de
Angelis M, Arnold HH: The mouse Trm1-like gene is expressed in neural tissues and plays a role in
motor coordination and exploratory behaviour. Gene 389, 174-185 (2007)
Meyer CW, Elvert R, Scherag A, Erhardt N, Gailus-Durner V, Fuchs H, Schäfer H, Hrabé de Angelis M, Heldmaier
G, Klingenspor M: Power matters in closing the phenotyping gap. Naturwissenschaften 94, 401-406
(2007)
Mindnich R, Hrabé de Angelis M, Adamski J: Functional genome analysis indicates loss of 17betahydroxysteroid dehydrogenase type 2 enzyme in the zebrafish. J Steroid Biochem Mol Biol 103, 35-43
(2007)
Frey IM, Rubio-Aliaga I, Siewert A, Sailer D, Drobyshev A, Beckers J, Hrabé de Angelis M, Eichinger HM, Daniel,
H: Profiling at mRNA, protein and metabolite level reveals alterations in renal amino acid handling
and glutathione metabolism in kidney tissue of Pept2-/- mice. Physiol Genomics 28, 302-310 (2007)
McGowan KA, Fuchs H, Hrabé de Angelis M, Brash GS: Identification of a Keratin 4 Mutation in a
Chemically Induced Mouse Mutant. J Invest Dermatol 127, 60-64 (2007)
Runkel F, Klaften M, Koch K, Böhnert V, Büssow H, Fuchs H, Franz T, Hrabé de Angelis M: Morphologic and
molecular characterization of two novel Krt71 (Krt2-6g) mutations: Krt71-rco12 and Krt71-rco13.
Mamm Genome 17, 1172-1182 (2006)
Ohnesorg T, Keller B, Hrabé de Angelis M, Adamski J: Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis. J
Mol Endocrinol 37, 185-197 (2006)
Puk O, Dalke C, Favor J, Hrabé de Angelis M, Graw J: Variations of eye size parameters among different
strains of mice. Mamm Genome 17, 851-857 (2006)
Abe K, Fuchs H, Lisse T, Hans W, Hrabé de Angelis M: New ENU-induced semidominant mutation, ALI18,
causes inflammatory arthritis, dermatitis, and osteoporosis in the mouse. Mamm Genome 17, 915-926
(2006)
Becker S, Hrabé de Angelis M, Beckers J: Use of chemical mutagenesis in mouse embryonic stem cells.
Methods Mol Biol 329:397-407 (2006)
Kleine-Ostmann T, Jördens C, Baaske K, Weimann T, Hrabé de Angelis M, Koch M: Conductivity of singlestranded and double-stranded deoxyribose nucleic acid under ambient conditions: The dominance of
water. Appl Phys Lett 88, 102102 (2006)
Schneider I, Tirsch WS, Faus-Keßler T, Becker L, Kling E, Austin Bussi RL, Bender A, Feddersen B, Tritschler J,
Fuchs H, Gailus-Durner V, Englmeier KH, Hrabé de Angelis M, Klopstock T: Systematic, standardized and
comprehensive neurological phenotyping of inbred mice strains in the German Mouse Clinic. J
Neurosci Meth 157, 82-90 (2006)
Noguchi Y, Kurima K, Makishima T, Hrabé de Angelis M, Fuchs H, Frolenkov G, Kitamura K, Griffith AJ: Multiple
quantitative trait loci modify cochlear hair cell degeneration in the Beethoven (Tmc1Bth) mouse
model of progressive hearing loss DFNA36. Genetics 173, 2111-2119 (2006)
McGowan KA, Aradadhya S, Fuchs H, Hrabé de Angelis M, Barsh GS: A Mouse Keratin1 Mutation Causes
Dark Skin and Epidermolytic Hyperkeratosis. J Invest Dermatol 126, 1013-1016 (2006)
Zeiser S, Liebscher HV, Tiedemann H, Rubio-Aliaga I, Przemeck GKH, Hrabé de Angelis M, Winkler G: Number
of Active Transcription Factor Binding Sites Is Essential for Hes7 Oscillator. Theor Biol Med Model 3:11
(2006)
Del Barco Barrantes I, Montero-Pedrazuela A, Gudano-Ferraz A, Obregon MJ, Martinez de Mena R, GailusDurner V, Fuchs H, Franz TJ, Kalaydjiev S, Klempt M, Hölter S, Rathkolb B, Reinhard C, Morreale de Escobar G,
Bernal J, Busch DH, Wurst W, Wolf E, Schulz H, Shtrom S, Greiner E, Hrabé de Angelis M, Westphal H, Niehrs
C: Generation and Characterization of Dickkopf3 Mutant Mice. Mol Cell Biol 26, 2317-2326 (2006)
Klempt M, Rathkolb B, Fuchs E, Hrabé de Angelis M, Wolf E, Aigner B: Genotype-specific environmental
impact on the variance of blood values in inbred and F1 hybrid mice. Mamm Genome 17, 93-102 (2006)
Hrabé de Angelis M, Chambon P, Brown S (eds): Standards of Mouse Model Phenotyping. John Wiley &
Sons Ltd. (2006)
Fuchs H, Lisse T, Abe K, Hrabé de Angelis M: Screening for bone-and cartilage phenotypes in mice. In:
Phenotyping of the Laboratory Mouse. (eds.: Hrabé de Angelis M, Chambon P and Browns S) Wiley-VCH,
Weinheim, 35-86 (2006)
Prehn C, Ströhle F, Haller F, Keller B, Hrabé de Angelis M, Adamski J, Mindnich R: A Comparison of Methods
for Assays of Steroidogenic Enzymes: New GC/MS Versus HPLC and TLC. In: Enzymology and Molecular
Biology of Carbonyl Metabolism (eds.: Weiner H, Plapp B, Lindhal R, Maser E ), Purdue University Press, West
Lafayette, Indiana, USA (2006)
Peters DD, Marschall S, Mahabir E, Boersma A, Heinzmann U, Schmidt J, Hrabé de Angelis M: Risk
assessment of mouse hepatitis virus infection via in vitro fertilization and embryo transfer by the
use of zona-intact and laser-microdissected oocytes. Biol Reprod 74, 246-252 (2006)
Mindnich R, Haller F, Halbach F, Moeller G, Hrabé de Angelis M, Adamski J: Androgen metabolism via
17beta-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates:
comparison of the human and the zebrafish enzyme. J Mol Endocrinol 35, 305-316 (2005)
Graw J, Löster J, Puk O, Münster D, Haubst N, Soewarto D, Fuchs H, Meyer B, Nürnberg P, Pretsch W, Selby P,
Favor J, Wolf E, Hrabé de Angelis M: Three novel Pax6 alleles in the mouse leading to the same smalleye phenotype caused by different consequences at target promoters. Invest Ophthalmol Vis Sci 46,
4671-4683 (2005)
Brown SDM, Chambon P, Hrabé de Angelis,M. (Eumorphia consortium): EMPReSS: standardized phenotype
screens for functional annotation of the mouse genome. Nature Genetics 37, 1155 (2005)
Hawker K, Fuchs H, Hrabé de Angelis M, Steel KP: Two new mouse mutants with vestibular defects that
map to the highly mutable locus on chromosome 4. Int J Audiol 44, 171-177 (2005)
Pasche B, Kalaydjiev S, Franz T, Kremmer E, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Lengeling A, Busch
DH: Sex-Dependent Susceptibilty to Listeria monocytogenes Infection Is Mediated by Differential
Interleukin-10 Production. Infect Immun 73, 5952-5960 (2005)
Machka C, Kersten B, Zobawa M, Harder A, Horsch M, Halder T, Lottspeich F, Hrabé de Angelis M, Beckers J:
Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential
expression profiling. Gene Expr Patterns 6, 94-101 (2005)
Mijalski T, Harder A, Halder T, Kersten M, Horsch M, Strom TM, Liebscher HV, Lottspeich F, Hrabé de Angelis M,
Beckers J: Identification of coexpressed gene clusters in a comparative analysis of transcriptome and
proteome in mouse tissues. Proc Natl Acad Sci USA 102, 8621–8626 (2005)
Maier H, Döhr S, Grote K, O'Keefe S, Werner T, Hrabé de Angelis M, Schneider R: LitMiner and WikiGene:
identifying problem-related key players of gene regulation using publication abstracts. Nucleic Acids
Res 33, W779-W782 (2005)
Klaften M, Hrabé de Angelis M: ARTS: A web-based tool for the setup of high-throughput genome wide
mapping panels for the SNP genotyping of mouse mutants. Nucleic Acids Res 33, W496-W500 (2005)
Attia SM, Badary OA, Hamada FM, Hrabé de Angelis M, Adler ID: Orthovanadate increased the frequency
of aneuploid mouse sperm without micronucelus induction in mouse bone marrwo erythrocytes at
the same dose level. Mutat Res 583, 158-167 (2005)
Gailus-Durner V, Fuchs H, Becker L, Bolle I, Bielmeier M, Calzada-Wack J, Elvert, R, Erhardt N, Dalke C, Franz
TJ, Grundner-Culemann E, Hammelbacher S, Hölter S, Hölzlwimmer G, Horsch M, Javaheri, A, Kalaydjiev S,
Klempt M, Kling E, Kunder S, Lengger C, Lisse T, Mijalski T, Naton B, Pedersen V, Prehn C, Przemeck G, Racz I,
Reinhard C, Reitmeir P, Schneider I, Schrewe A, Steinkamp R, Zybill C, Adamski J, Beckers J, Behrendt H,
Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Kirchhof P, Klingenspor M, Klopstock T, Lengeling A,
Müller W, Ohl F, Ollert M, Quintanilla-Martinez L, Schmidt J, Schulz H, Wolf E, Wurst W, Zimmer A, Busch DH,
Hrabé de Angelis M: Introducing the German Mouse Clinic: Open access platform for standardized
phenotyping. Nat Methods 2, 403-404 (2005)
Yu P, Constien R, Dear N, Katan M, Hanke P, Bunney TD, Kunder S, Quintanilla-Martinez L, Huffstadt U,
Schröder A, Peters T, Fuchs H, Hrabé de Angelis M, Nehls M, Grosse J, Wabnitz P, Meyer TPH, Yasuda K,
Schneider-Fresenius C, Jagla W, Russ A, Popp A, Laufs J, Schmittwolf C, Wagner H, Pfeffer K, Mudde GC:
Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase Cγ2 that
specifically increase external Ca2+ entry. Immunity 22, 451-465 (2005)
Döhr S, Klingenhoff A, Maier H, Hrabé de Aneglis M, Werner T, Schneider R: Linking disease-associated
genes to regulatory networks via promoter organization. Nucleic Acids Res 33, 864-872 (2005)
Rathkolb B, Tuyen VT, Klempt M, Hrabé de Angelis M, Wanke R, Wolf E, Aigner B: Large scale albuminuria
screen for Nephropathy models in chemically induced mouse mutants. Experimental Nephrology 100,
143-149 (2005)
Jakupoglu C, Przemeck GKH, Schneider M, Moreno SG, Mayr N, Hatzopoulus AK, Hrabé de Angelis M, Wurst W,
Bornkamm GW, Brielmeier M, Conrad M: Cytoplasmic Thioredoxin Reductase is Essential for
Embryogenesis but dispensable for Cardiac Development. Mol Cell Biol 25, 1980-1988 (2005)
Reinhard C, Meyer B, Fuchs H, Stoeger T, Eder G, Rüschendorf F, Heyder J, Nürnberg P, Hrabé de Angelis M,
Schulz H: Genomewide linkage analysis identifies novel genetic loci for lung function in mice. Am J
Resp Crit Care Med 171, 880-888 (2005)
Seltmann M, Horsch M, Drobyshev A, Chen Y, Hrabé de Angelis M, Beckers J: Assessment of a systematic
expression profiling approach. In: ENU-induced mouse mutant lines. Mammalian Genome 16, 1-10
(2005)
Beckers J, Herrmann F, Rieger S, Drobyshev AL, Horsch M, Hrabé de Angelis M, Seliger B: Identification and
validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis. Int J Cancer
114, 590-597 (2005)
Pau H, Fuchs H, Hrabé de Angelis M, Steel KP: Hush puppy: a new mouse mutant wih pinna, ossicle, and
inner ear defects. Laryngoscope 115, 116-124 (2005)
Mahabir E, Mayer A, Marschall S, Hrabé de Angelis M, Schmidt J: Importance of embryo transfers in
transgenic mouse facilities. Reprod Fert Develop 16, 211-212 (2004)
Runkel F, Marquardt A, Stoeger C, Kochmann E, Simon D, Kohnke B, Korthaus D, Wattler F, Fuchs H, Hrabé de
Angelis M, Stumm G, Nehls M, Wattler S, Franz T, Augustin M: The dominant alopecia phenotypes
Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3. Genomics 84,
824-835 (2004)
Mohr M, Klempt M, Rathkolb B, Hrabé de Angelis M, Wolf E, Aigner B: Hypercholesterolemia in ENUinduced mouse mutants. J Lipid Res. 45, 2132-2137 (2004)
Rhodes CR, Hertzano R, Fuchs H, Bell RE, Hrabé de Angelis M, Steel KP, Avraham KB: A Myo7a mutation
cosegregtaes with stereocilia defects and low-frequency hearing impairment. Mamm Genome 15, 686697 (2004)
Willer T, Belén P, Falcón-Pérez JM, Renner-Müller I, Przemeck GKH, Lommel M, Coloma A, Valero MC, Hrabé de
Angelis M., Tanner W, Wolf E, Strahl S, Cruces J: Targeted disruption of the Walker-Warburg syndrome
gene Pomt1 in mouse results in embryonic lethality. Proc Natl Acad Sci USA 101, 14126-14131 (2004)
Pau H, Hawker K, Fuchs H, Hrabé de Angelis M, Steel KP: Characterization of a New Mouse Mutant,
Flouncer, with a Blance Defect and Inner Ear Malformation. Otol Neurotol. 25 , 707-713 (2004)
Van Raamsdonk CD, Fitch KR, Fuchs H, Hrabé de Angelis M, Barsh GS: Effects of G-protein mutations on
skin color. Nat Genet 36, 961-968 (2004)
Auwerx J, Avner P, Baldock R, Ballabio A, Balling R, Barbacid M, Berns A, Bradley A, Brown S, Carmeliet P,
Chambon P, Cox R, Davidson D, Davies K, Duboule D, Forejt J, Granucci F, Hastie N, Hrabé de Angelis M,
Jackson J, Kioussis D, Kollias G, Lathrop M, Lendahl U, Malumbres M, von Melchner H, Müller W, Partanen J,
Ricciardi-Castagnoli P, Rigby P, Rosen B, Rosenthal N, Skarnes B, Stewart AF, Thornton J, Tocchini-Valentini G,
Wagner E, Wahli W, Wurst W: The European dimension for the mouse genome mutagenesis programm.
Nat Genet 36, 925-927 (2004)
Seedorf H, Springer IN, Grundner-Culemann E, Albers HK, Reis A, Fuchs H, Hrabé de Angelis M, Acil Y:
Amelogenesis imperfecta in a new animal model – a mutation in chromosome 5 (human 4q21). J
Dent Res 83, 608-612 (2004)
Adler ID, Gonda H, Hrabé de Angelis M, Jentsch I, Otten IS, Speicher MR: Heritable translocations induced
by dermal exposure of male mice to acrylamide. Cytogenet Genome Res 104, 271-276 (2004)
Ahituv N, Erven A, Fuchs H, Guy K, Ashery-Padan R, Williams T, Hrabé de Angelis M, Avraham KB, Steel KP: An
ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. Mamm
Genome 15, 424-432 (2004)
Hansdottir AG, Palsdottir K, Favor J, Neuhäuser-Klaus A, Fuchs H, Hrabé de Angelis M, Steingrimsson E: The
novel microphthalmia mutations Mitf(mi-enu5) andMitf(mi-bcc2) produce dominant negative Mitf
proteins. Genomics 83, 932-935 (2004)
Meyer CWE, Korthaus D, Jagla W, Cornali E, Grosse J, Fuchs H, Klingenspor M, Roemheld S, Tschöp M,
Heldmaier G, Hrabé de Angelis M, Nehls M: A Novel Missense Mutation in the Mouse Growth Hormone
Gene Causes Semidominant Dwarfism, Hyperghrelinemia and Obesity. Endocrinology 145: 2531-2541
(2004)
Dalke C, Löster J, Fuchs H, Gailus-Durner V, Soewarto D, Favor J, Neuhäuser-Klaus A, Pretsch W, Gekeler F,
Shinoda K, Zrenner E, Meitinger T, Hrabé de Angelis M, Graw J: Electroretinography as a Screening
Methods for Mutations Causing Retinal Dysfunction in Mice. Invest Ophtalmol Vis Sci 45, 601-609 (2004)
Hrabé de Angelis M, Adler A, Beckers J, Soewarto D, Wagner S, Gailus-Durner V, Imai K: ENU mutagenesis.
In: The Laboratory Mouse. (eds.: Hedrich HH, Bullock G) Academic Press, Chapter 4, 47-85 (2004)
Reinhard C, Eder G, Fuchs H, Ziesenis A, Meyer B, Rueschendorf F, Hrabé de Angelis M, Heyder J, Schulz H:
Differences in lung function among mouse inbred strains are genetically determined. In: INIS
Monographs, Effects of air contaminants on the respiratory tract - Interpretations from molecular to meta
analysis. 9. International Inhalation Symposium, Heinrich U, Stuttgart; Fraunhofer IRB Verlag, 435-444 (2004)
Peters T, Sedlmeier R, Büssow H, Runkel F, Lüers GH, Korthaus D, Fuchs H, Hrabé de Angelis M, Stumm G,
Russ AP, Porter RM, Augustin M, Franz T: Alopecia in a Novel Mouse Model RCO3 Is Caused by mK6irs1
Deficiency. J Invest Dermatol 121, 674-680 (2003)
Pfister S, Przemeck GKH, Gerber JK, Beckers J, Adamski J, Hrabé de Angelis M: Interaction of the MAGUK
Family Member Acvrinp1 and the Cytoplasmic Domain of the Notch Ligand Delta1. J Mol Biol 333, 229235 (2003)
Drobyshev AL, Hrabé de Angelis M, Beckers J: Artefacts and Reliability of DNA Microarray Expression
Profiling Data. Curr Genomics 4, 615-621 (2003)
Drobyshev AL, Machka C, Horsch M, Seltmann M, Liebscher V, Hrabe de Angelis M, Beckers J: Specificity
assessment from fractionation experiments (SAFE): a novel method to evaluate microarray probe
specificity based on hybridisation stringencies. Nucleic Acids Res 31, 2-10 (2003)
Hafezparast M, Klocke R, Ruhrberg C, Marquardt A, Ahmad-Annuar A, Bowen S, Lalli G, Witherden AS,
Hummerich H, Nicholson S, Morgan PJ, Oozageer R, Priestly JV, Averill S, King VR, Ball S, Peters J, Toda T,
Yamamoto A, Hiraoka Y, Augustin M, Korthaus D, Wattler S, Wabnitz P, Dickneite C, Lampel S, Boehme F,
Peraus G, Popp A, Rudelius M, Schlegel J, Fuchs H, Hrabé de Angelis M, Shciavo G, Shima DT, Russ AP, Stumm
G, Martin JE, Fisher EMC: Mutations in Dynein link motor neuron degeneration to defects in retrograde
transport. Science 300, 808-812 (2003)
Fitch KR, McGowan KA, Van Raamsdonk CD, Fuchs H, Lee D, Puech A, Herault Y, Threadgill DW, Hrabé de
Angelis M, Barsh GS: Genetics of dark skin in mice. Genes Dev 17 (2), 214-228 (2003)
Grandbarbe L, Bouissac J, Rand M, Hrabé de Angelis M, Artavanis-Tsakonas S, Mohier E: Delta-Notch
signaling controls the generation of neurons/glia from neural stem cells in a stepwise process.
Development 130 (7), 1391-1402 (2003)
Przemeck GKH, Heinzmann U, Beckers J, Hrabé de Angelis M: Node and midline defects are associated
with left-right development in Delta1 mutant embryos. Development 130 (1), 3-13 (2003)
Marschall S, Hrabé de Angelis M: In vitro fertilization/cryopreservation. Methods Mol Biol 209, 35-50
(2003)
Soewarto D, Blanquet V, Hrabé de Angelis M: Random ENU mutagenesis. Methods Mol Biol 209, 249-66
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Beckers J, Hoheisl J, Mewes W, Vingron M, Hrabé de Angelis M: Molecular Phenotyping of Mouse Mutant
Resources by RNA Expression Profiling. Current Genomics 3, 121-129 (2002)
Graw J, Löster J, Soewarto D, Fuchs H, Reis A, Wolf E, Balling R, Hrabé de Angelis M: V76D mutation in a
conserved gD-crystallin region leads to dominant cataracts in mice. Mamm Genome 13 (8), 452-455
(2002)
Yun K, Fischman S, Johnson J, Hrabé de Angelis M, Weinmaster G, Rubenstein JL: Modulation of the Notch
signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor
cell types in the subcortical telencephalon. Development 129 (21), 5029-5040 (2002)
Reinhard C, Eder G, Fuchs H, Ziesenis A, Heyder J, Schulz H: Inbred strain variation in lung function.
Mamm Genome 13 (8), 429-437 (2002)
Vreugde S, Erven A, Kros CJ, Marcotti W, Fuchs H, Kurima K, Wilcox ER, Friedmann TB, Griffith AJ, Balling R,
Hrabé de Angelis M, Avraham KB, Steel KP: Beethoven, a mouse model for dominant, progressive
hearing loss DFNA36. Nat Genet 30 (3), 257-258 (2002)
Beckers J, Hrabé de Angelis M: Large-scale mutational analysis for the annotation of the mouse
genome. Curr Opin Chem Biol 6 (1), 17-23 (2002)
Graw J, Löster J, Soewarto D, Fuchs H, Meyer B, Reis A, Wolf E, Balling R, Hrabé de Angelis M:
Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a
dominant cataract. Exp Eye Res 73, 867-876 (2001)
Nadeau JH, Balling R, Barsh G, Beier D, Brown SD, Bucan M, Camper S, Carlson G, Copeland N, Eppig J,
Fletcher C, Frankel WN, Ganten D, Goldowitz D, Goodnow C, Guenet JL, Hicks G, Hrabé de Angelis M, Jackson I,
Jacob HJ, Jenkins N, Johnson D, Justice M, Kay S, Kingsley D, Lehrach H, Magnuson T, Meisler M, Poustka A,
Rinchik EM, Rossant J, Russel LB, Schimenti J, Shiroishi T, Skarnes WC, Soriano P, Stanford W, Takahashi JS,
Wurst W, Zimmer A: Sequence interpretation. Functional annotation of mouse genome sequences.
Science 291, 1251-1255 (2001)
Kiernan AE, Ahituv N, Fuchs H, Balling R, Avraham KB, Steel KP, Hrabé de Angelis M: The Notch ligand
Jagged1 is required for inner ear sensory development. Proc Natl Acad Sci USA 98, 3873-3878 (2001)
Hrabé de Angelis M, Strievens M: Large-scale production of mouse phenotypes. The search for animal
models for inherited diseases in humans. Brief Bioinform 2, 170-180 (2001)
Graw J, Klopp N, Löster J, Soewarto D, Fuchs H, Becker-Follmann J, Reis A, Wolf E, Balling R, Hrabé de Angelis
M: Ethylnitrosourea-induced mutation in mice leads to the expression o a novel protein in the eye
and to dominant cataracts. Genetics 157, 1313-1320 (2001)
Graw J, Löster J, Soewarto D, Fuchs H, Reis A, Wolf E, Balling R, Hrabé de Angelis M: Aey2, a new mutation
in the betaB2-crystallin-encoding gene. Invest Ophtalmol Vis Sci 42, 1574-1580 (2001)
Graw J, Löster J, Soewarto D, Fuchs H, Meyer B, Reis A, Wolf E, Balling R, Hrabé de Angelis M:
Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene.
Invest Ophthalmol Vis Sci 42, 2909-2915 (2001)
Berti L, Mittler G, Przemeck GKH, Stelzer G, Gunzler B, Amati F, Conti E, Dallapiccola B, Hrabé de Angelis M,
Novelli G, Meisterernst M: Isolation and characterization of a novel gene from the DiGeorge
chromosomal region that encodes for a mediator subunit. Genomics 74, 320-332 (2001)
Alessandrini F, Jakob T, Wolf A, Wolf E, Balling R, Hrabé de Angelis M, Ring J, Behrendt H: ENU mouse
mutagenesis: generation of mouse mutants with aberrant plasma IgE levels. Int Arch Allergy Immunol
124, 25-28 (2001)
Soewarto D, Fella C, Teubner A, Rathkolb B, Pargent W, Heffner S, Marschall S, Wolf E, Balling R, Hrabé de
Angelis M: The large-scale Munich ENU-mouse-mutagenesis screen. Mamm Genome 11(7), 507-510
(2000)
Schindewolf C, Lobenwein K, Trinczek K, Gomolka M, Soewarto D, Fella C, Pargent W, Singh N, Jung T, Hrabé
de Angelis M: Comet assay as a tool to screen for mouse models with inherited radiation sensitivity.
Mamm Genome 11(7), 552-554 (2000)
Rolinski B, Arnecke R, Dame T, Kreischer J, Olgemöller B, Wolf E, Balling R, Hrabé de Angelis M, Roscher AA:
The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project: determination of
amino acids and acylcarnitines by tandem mass spectrometry. Mamm Genome 11(7), 547-551 (2000)
Rathkolb B, Fuchs E, Kolb HJ, Renner-Müller I, Krebs O, Balling R, Hrabé de Angelis M, Wolf E: Large Scale Nethyl-N-nitrosourea mutagenesis of mice – from phneotypes to genes. Exp Physiol 85, 1-10 (2000)
Rathkolb B, Decker T, Fuchs E, Soewarto D, Fella C, Heffner S, Pargent W, Wanke R, Balling R, Hrabé de
Angelis M, Kolb HJ, Wolf E: The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project:
screening for clinically relevant phenotypes. Mamm Genome 11(7), 543-546 (2000)
Pargent W, Heffner S, Schäble K, Soewarto D, Fuchs H, Hrabé de Angelis M: MouseNet database: digital
management of a large-scale mutagenesis project. Mamm Genome 11(7), 590-593 (2000)
Nacke S, Schäfer R, Hrabé de Angelis M, Mundlos S: Mouse mutant "rib-vertebrae" (rv): A defect in
somite polarity. Dev Dyn 219(2), 192-200 (2000)
Leimeister C, Dale K, Fischer A, Klamt B, Hrabé de Angelis M, Radtke F, McGrew MJ, Pourquie O, Gessler M:
Oscillating expression of c-hey2 in the presomitic mesoderm suggests that the segmentation clock
may use combinatorial signaling through multiple interacting bHLH factors. Dev Biol 227, 91-103
(2000)
Justice MJ, Carpenter DA, Favor J, Neuhäuser-Klaus A, Hrabé de Angelis M, Soewarto D, Moser A, Cordes S,
Miller D, Chapman V, Weber JS, Rinchik EM, Hunsicker PR, Russell WL, Bode VC: Effects of ENU dosage on
mouse strains. Mamm Genome 11, 484-488 (2000)
Hrabé de Angelis M, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W,
Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K,
Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F,
Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R:
Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet 25, 444-447
(2000)
Fuchs H, Schughart K, Wolf E, Balling R, Hrabé de Angelis M: Screening for dysmorphological
abnormalities -- a powerful tool to isolate new mouse mutants. Mamm Genome 11, 528-530 (2000)
Flaswinkel H, Alessandrini F, Rathkolb B, Decker T, Kremmer E, Servatius A, Jakob T, Soewarto D, Marschall S,
Fella C, Behrendt H, Ring J, Wolf E, Balling R, Hrabé de Angelis M, Pfeffer K: Identification of immunological
relevant phenotypes in ENU mutagenized mice. Mamm Genome 11, 526-527 (2000)
Beckers J, Caron A, Hrabé de Angelis M, Hans S, Campos-Ortega JA, Gossler A: Distinct regulatory elements
direct delta1 expression in the nervous system and paraxial mesoderm of transgenic mice. Mech
Develop 95(1-2), 23-34 (2000)
Balling R, Hrabé de Angelis M: From developmental biology to developmental toxicology. Ann N Y Acad
Sci 919, 239-245 (2000)
Kiernan AE, Zalzman M, Fuchs H, Hrabé de Angelis M, Balling R, Steel KP, Avraham KB: Tailchaser (Tlc): a
new mouse mutation affecting hair bundle differentiation and hair cell survival. J Neurocytol 28, 969985 (1999)
Morrison A, Hodgetts C, Gossler A, Hrabé de Angelis M, Lewis J: Expression of Delta1 and Serrate1
(Jagged1) in the mouse inner ear. Mech Develop 84, 169-172 (1999)
Marschall S, Hrabé de Angelis M: Cryopreservation of mouse spermatozoa - double your mouse space.
Trends Genet 15, 128-131 (1999)
Graw J, Löster J, Klopp N, Soewarto D, Fella C, Fuchs H, Reis A, Wolf E, Balling R, Hrabé de Angelis M:
Mutation in the bA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse.
Genomics 62, 67-73 (1999)
Beckers J, Clark A, Wünsch K, Hrabé de Angelis M, Gossler A: Expression of the mouse Delta1 gene during
organogenesis and fetal development. Mech Develop 84, 165-168 (1999)
Barrantes IB, Elia A, Wünsch K, Hrabé de Angelis M, Mak T, Rossant J, Conlon R, Gossler A, de la Pompa J:
Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the
mouse. Curr Biol 6, 470-480 (1999)
Apelqvist A, Li H, Sommer L, Anderson D, Honjo T, Hrabé de Angelis M, Lendahl U, Edlund H: Notchsignalling controls pancreatic cell differentiation. Nature 400, 877-881 (1999)
Marschall S, Huffstadt U, Balling R, Hrabé de Angelis M: Reliable recovery of inbred mouse lines using
cryopreserved spermatozoa. Mech Dev 10, 773-776 (1999)
Hrabé de Angelis M, Balling R: Large scale ENU screens in the mouse: genetics meets genomics. Mutat
Res 400, 25-32 (1998)
Gossler A, Hrabé de Angelis M: Somitogenesis. Curr Top Dev Biol 38, 225-287 (1998)
Hrabe de Angelis M, McIntyre J 2nd, Gossler A: Maintenance of somite borders requires the Delta
homologue Dll1. Nature 386, 771-721 (1997)
Hrabé de Angelis M, Gründker C, Herrmann BG, Kispert A, Kirchner C: Promotion of gastrulation by
maternal growth factor in cultured rabbit blastocysts. Cell Tissue Res 292, 147-154 (1995)
Bettenhausen B, Hrabé de Angelis M, Simon D, Guenet JL, Gossler A: Transient and restricted expression
during mouse embryogensis of Dll1, a murine gene closely related to Drosophila Delta. Development
121, 2407-2418 (1995)
Viehbahn C, Mayer B, Hrabé de Angelis M: Signs of the principle body axes prior to primitive streak
formation in the rabbit embryo. Anat Embryol 192, 159-169 (1995)
Gründker C, Hrabé de Angelis M, Krichner C: Chorionic gonadotropin-like proteins in the obplacental
giant cells of the rabbit. Cell Tissue Res 278, 573-578 (1994)
Hrabé de Angelis M, Dannhorn DR, Hänel H, Kirchner C: Effects of rilopirox on rabbit blastocysts in a
protein-free in vitro culture under different culture conditions. Arzneimittelforschung 44, 674-678
(1994)
Gründker C, Hrabé de Angelis M, Kirchner C: Placental lactogen-like proteins in the rabbit placenta. Anat
Embryol 188, 395-399 (1993)
Hrabé de Angelis M, Kirchner C: Fibroblast growth factor induces primitive streak formation in rabbit
pre-implantation embryos in vitro. Anat Embryol 187, 269-273 (1993)