Brevet européen: TIP47 as

GUILLAUME BLOT
EXPLOITATION DES RESULTATS ET REALISATIONS
BREVETS, PUBLICATIONS ET COMMUNICATIONS
2 BREVETS INTERNATIONAUX ET 1 BREVET EUROPEEN.
- Brevet européen: TIP47 as the first cellular co-factor required for incorporation of
HIV-1 envelope into HIV-1 virions. Screening of inhibitors of HIV-1 infection,
targeting the incorporation of env into virions and impairing the production of
infectious virions. Déposé par l'INSERM le 19 mai 2003. Inventeurs Benarous. R,
Berlioz-Torrent. C, Blot. G.
- Brevet international: Protein-protein interactions in Human Immunodeficiency
Virus. (WO/2003/046176). Déposé par Hybrigenics, N° priorité US 60/333,346, le
26/11/2001, extension le 26/11/2002. Inventeurs: P. Legrain, J.C. Rain, R. Benarous,
G. Blot, S. Emiliani, C. Berlioz-Torrent.
- Brevet international: Proteins that interact with -trcp. (WO/2002/050261). Déposé
en US provisional le 18/12/2000 et étendu en PCT et en US non provisional le
18/12/2001. Inventeurs: P. Legrain, R. Benarous, G. Blot, I. Lassot.
8 ARTICLES PUBLIES DANS DES REVUES INTERNATIONALES RECONNUES.
- 2008 : Le May N.*, Mansuroglu Z.*, Leger P.*, Josse T., Blot G., Billecocq A., Flick
R., Jacob Y., Bonnefoy E., Bouloy M. A SAP30 complex inhibits IFN- expression in
Rift Valley Fever Virus infected cells. *Co-premier auteurs. PloS pathogens, 4 : e13.
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2007 : Estrabaud E.*, Lassot I.*, Blot G., Le Rouzic E., Tanchou V., Quemeneur E.,
Daviet L., Margottin-Goguet F., Benarous R. RASSF1C, an isoform of the tumor
suppressor RASSF1A, promotes the accumulation of beta-catenin by interacting with
beta-TrCP. *Co-premier auteurs. Cancer. Res, 67 : 1054-1061.
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2006 : Blot G.*, Lopez-Vergès S.*, Treand C., Kubat NJ., Delcroix-Genête D.,
Emiliani S., Benarous R., Berlioz-Torrent C. Luman, a new partner of HIV-1
TMgp41, interferes with Tat-mediated transcription of the HIV-1 LTR. *Co-premier
auteurs. J. Mol. Biol, 364 : 1034-1047.
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2006 : Lopez-Vergès S., Camus G., Blot G., Beauvoir R., Benarous R., BerliozTorrent C. Tail-interacting protein TIP47 is a connector between Gag and Env and is
required for Env incorporation into HIV-1 virions. PNAS, 103 : 14947-14952.
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2005 : Garcia E ., Pion M ., Pelchen-Matthews A., Collinson L., Arrighi JF., Blot G.,
Leuba F., Escola JM., Demaurex N., Marsh M., Piguet V. HIV-1 Trafficking to the
Dendritic Cell-T-Cell Infectious Synapse Uses a Pathway of Tetraspanin Sorting to the
Immunological Synapse. Traffic, 6 : 488-501.
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2003 : Blot G., Janvier K., Le Panse S., Benarous R. and Berlioz-Torrent C. Targeting
of the HIV-1 Envelope to the trans-Golgi Network through Binding to TIP47 is
Required for Env Incorporation into Virions and Infectivity. J. Virol, 77 :6931-6945.
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2002 : Berlioz-Torrent C., Blot G., Benarous R. Contrôle du trafic intracellulaire de la
glycoprotéine d'enveloppe du VIH-1 par le domaine cytoplasmique de la TMgp41.
Virologie, Vol. 6, n° 4, juillet-août 2002.
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2001 : Berlioz-Torrent C.*, Wyss S.*, Boge M., Blot G., Höning S., Benarous R, and
Thali M. The Highly Conserved C-Terminal Dileucine Motif in the Cytosolic Domain
of the Human Immunodeficiency Virus Type-1 Enveloppe Glycoprotein Is Critical for
Its Association with the AP-1 Clathrin Adapter. *Co-premier auteurs. J. Virol,
75 :2982-2992.
6 PRESENTATIONS ORALES A DES CONGRES NATIONAUX ET INTERNATIONAUX.
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Blot., G. Rift Valley Fever Virus NSs protein interacts with and disturbs several
members of the JAK/STAT pathway. Journées départementales de virologie (15 et 16
Octobre 2007), Institut Pasteur, Paris (France).
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Lopez-Verges S., Camus G., Blot G., Beauvoir R., Benarous R, and Berlioz-Torrent
C. Mechanism of action of TIP47 in HIV-1 envelope incorporation into virions.
Congrès de Cold Spring Harbor sur les Retroviruses (2006). Cold Spring Harbor, New
York (USA).
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Blot G., Janvier K., Le Panse S., Benarous R, and Berlioz-Torrent C. Targeting of the
HIV-1 Envelope to the trans-Golgi Network through Binding to TIP47 is Required for
Env Incorporation into Virions and Infectivity. 2nd IAS Conference on HIV
Pathogenesis and Treatment (2003). Paris, France.
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Blot G., Lopez-Verges S., Benarous R, and Berlioz-Torrent C. Luman, a cyclic AMP
Response Element (CRE)-Binding Protein/Activating Transcription Factor, A New
Partner of the Cytoplasmic Domain of HIV-1 TMgp41. 2nd IAS Conference on HIV
Pathogenesis and Treatment (2003). Paris, France.
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Blot G., Janvier K., Le Panse S., Benarous R, and Berlioz-Torrent C. Targeting of the
HIV-1 Envelope to the trans-Golgi Network through Binding to TIP47 is Required for
Env Incorporation into Virions and Infectivity. Congrès de Cold Spring Harbor sur les
Retroviruses (2003). Cold Spring Harbor, New York (USA).
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Berlioz-Torrent C., Wyss S., Blot G., Boge M., Höning S., Benarous R, and Thali M.
Post-TGN Trafficking of HIV-1 Env : Association of Env with the ClathrinAssociated Protein Complex AP-1. Congrès de Cold Spring Harbor sur les
Retroviruses (1999). Cold Spring Harbor, New York (USA).
8 PRESENTATIONS ECRITES A DES CONGRES NATIONAUX ET INTERNATIONAUX.
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Nikolic DS., Blot G., Garcia E., Piguet V. Analysis of the function of TSG101 and
AP-3 -adaptin in the trafficking of HIV to the dendritic cell-T cell infectious synapse.
Congrès de Cold Spring Harbor sur les Retroviruses (2007). Cold Spring Harbor, New
York (USA).
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Nikolic DS., Garcia E., Blot G., Piguet V. Analysis of the Function of TSG101 and
AP3 -Adaptin in HIV Dendritic Cell – T cell Infectious Synapse. Keystone
Symposia (2007). Whistler (Canada).
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Nikolic DS., Blot G., Garcia E., Piguet V. Analysis of the Function of TSG101 and
AP3 -Adaptin in HIV-1 Dendritic Cell – T cell Infectious Synapse. Journée de
Recherche du Département MIMOL / Université de Genève / Cartigny. (2007).
Genève (Switzerland).
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Nikolic DS1., Blot G1., Garcia E., and Vincent Piguet. Tsg101 Subunit of Human
ESCRT-I Pathway is required for De Novo Production of HIV-1 Infectious Particles
in Primary Human Dendritic Cells. Journée de Recherche Inter-Universités LausanneGenève / Changins (2006). 1 These authors contributed equally to this work. Lausanne
(Switzerland)
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Blot G., Lopez-Verges S., Tréand C., Emiliani S., Benarous R, and Berlioz-Torrent C.
Luman, un cofacteur de la TMgp41, interfere avec la transcription du LTR du VIH-1
régulée par TAT. 1er forum de recherches fondamentales et cliniques sur le VIH : du
patient au laboratoire (2006) – ANRS – Paris (France).
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Lopez-Verges S., Camus G., Blot G., Beauvoir R., Benarous R, and Berlioz-Torrent
C. TIP47: Une protéine essentielle pour l’infectivité du VIH-1. 1er forum de
recherches fondamentales et cliniques sur le VIH : du patient au laboratoire (2006) –
ANRS – Paris (France).
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Blot G., Lopez-Verges S., Tréand C., Emiliani S., Benarous R, and Berlioz-Torrent C.
TMgp41 prevents the inhibition of HIV-1 replication induced by Luman, a
transcription factor regulated by intramembrane proteolysis. Congrès de Cold Spring
Harbor sur les Retroviruses (2005). Cold Spring Harbor, New York (USA).
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Blot G., Benarous R, and Berlioz-Torrent C. The Cytoplasmic Domain of HIV-1
TMgp41 Interacts with Luman, a Cyclic AMP Response Element (CRE)-Binding
Protein/Activating Transcription Factor. Congrès de Cold Spring Harbor sur les
Retroviruses (2002). Cold Spring Harbor, New York (USA).