Active substance controled release system and preparation process

Active substance controled release
system and preparation process
TECHNICAL DESCRIPTION
Notre référence :
01343-01
Status des brevets
French patent
application FR0705187
filed on july 18, 2007
and entitled "Système à
libération contrôlée
d’un principe actif et
procédé de préparation"
Inventeurs
Michel VERT
Laurent LECLERCQ
Mahfoud BOUSTTA
Status Commercial
Research agreement,
exclusive or non
exclusive licenses.
Laboratoires
Institut des
Biomolécules Max
Mousseron (IBMM,
UMR5247), Montpellier,
France
The invention concerns a biodegradable polymer matrix intended to trap an active
substance and allowing a controled and delayed release of this substance.
The invention is based on the use of a polymer matrix made of PLAGA (poly (lactic-coglycolic acid) trapping the active substance which is combined with a PLCA (poly(L-lysine
citramide)) or a PMLA (poly(malic acid)) polyanion. The association between the active
substance and an acido-sensitive polyelectrolyte makes insoluble the active substance in
aqueous medium. The matrix deterioration leads to the polyelectrolyte complex release
(type PMLA/peptide). The acid nature of the products of the matrix deterioration catalyses
the deterioration.
BENEFITS
Hydrogels are hydrophile polymers networks used in active substance controled release.
Hydrogels models in current development show limits in the level of active substance
retention and the release rate. The matrix/polyanion/peptide system developed in this
invention allows an extended release of the compound up to 18 days.
This technology can be applied to different models of matrix and polyanions and can be
adapted to specific needs.
INDUSTRIAL APPLICATIONS
This system can be used for the controled release of active substances in the
pharmaceutical or cosmetic domains.
Mots clés :
Controled release
system polyelectrolyte
biodegradable polymer
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