View CV - University of Mississippi Medical Center

August 12, 2010
Mazen Kurdi, Ph.D.
Date of Appointment to UMMC: February 1, 2009
Address:
Mazraa, Zreik Street
Joumblat Bldg., 2nd floor
Beirut, Lebanon
UMMC Dept. of Pharmacology and Toxicology
2500 North State Street
Jackson, MS 39216-4505
Phone : + 961-3-303688
601-984-4401
E-mail: [email protected]
[email protected]
32 years, Lebanese, Single
EDUCATION
2004
Ph.D. in Pharmacology
Claude Bernard University, Lyon, France.
2000
Master’s degree in Biochemistry
Claude Bernard University, Lyon, France.
1999
B.Sc. degree in Biochemistry
Lebanese University, Faculty of Sciences, Beirut, Lebanon.
1995
Lebanese Baccalaureate, Experimental Sciences
Saint-Elie Btina School, Beirut, Lebanon.
POST DOCTORAL POSITION
2004-2008
Post-doctoral Research Associate
Texas A&M University Health Science Center, College of Medicine, Cardiovascular
Research Institute, Division of Molecular Cardiology, Temple, Texas, USA.
Mentor: Dr. George W. Booz
PH.D. STUDIES
2000-2004
Ph.D. in Pharmacology
Laboratory of Functional Genomics in Athero-Thrombosis (INSERM U331 and EA
3740), Claude Bernard University, Faculty of Medicine - RTH Laennec, Lyon,
France.
Title: Left ventricular hypertrophy in high blood pressure: Transcriptomic analysis
and candidate genes in rat models.
Directed by: Dr. Giampiero Bricca
Funded by: MIRA fellowship from “La Région Rhône-Alpes”
1999
Master’s degree in Biochemistry
Laboratory of Molecular and Hormonal Pathology (INSERM U329), Claude
Bernard University, Lyon, France.
Title: "Mouse Monoclonal Antibody Production (Anti-Estradiol)"
Directed by: Dr. Claude-Yve Cuilleron.
August 12, 2010
CURRENT POSITIONS
2008-Present
Professor, Lebanese University, Faculty of Sciences, Section I, Department of
Chemistry and Biochemistry, Rafic Hariri Educational Campus, Hadath, Lebanon.
2009- Present
Affiliate Assistant Professor, University of Mississippi Medical Center,
Department of Pharmacology and Toxicology, Jackson, MS.
SCIENTIFIC PUBLICATIONS
Kurdi M., Chidiac R., Hoemann C., Zouein F., Zgheib C., Booz GW. Hydrogels as a Platform for
Stem Cell Delivery to the Heart. Congest Heart Fail. 2010;16:132-135.
Kurdi M. and Booz G.W. JAK Redux - A Second Look at the Regulation and Role of JAKs in the
Heart. Am J Physiol Heart Circ Physiol. 2009;297:H1545-H1556. PMCID# PMC2781365
Chouabe C., Ricci E., Kurdi M., Legrand C., Bricca G., Bonvallet R. Evaluation of remodeling in
left and right ventricular myocytes from heterozygous (mRen2)27 transgenic rats. Gen Physiol
Biophys. 2009;28:24-38.
Kurdi M. and Booz G.W. LIF Coupling to JAK-STAT is Dependent on Cellular Redox Defense:
Implications for IL-6-Type Cytokine Cardioprotective Signaling. submitted.
Kurdi M. and Booz GW. Growing hearts by the bushel. Congest Heart Fail. 2008;14:95-96.
Kurdi M. and Booz G.W. G-CSF-based stem cell therapy for the heart--unresolved issues part B:
Stem cells, engraftment, transdifferentiation, and bioengineering. Congest Heart Fail. 2007;13:34751.
Kurdi M. and Booz G.W. Can the Protective Actions of JAK-STAT in the Heart be Exploited
Therapeutically? Parsing the Regulation of IL-6-Type Cytokine Signaling. J Cardiovasc Pharmacol.
2007;50:126-141.
Kurdi M. and Booz G.W. G-CSF-based stem cell therapy for the heart-unresolved issues part A:
paracrine actions, mobilization, and delivery. Congest Heart Fail. 2007;13:221-227.
Kurdi M. and Booz G.W. Evidence that IL-6-type cytokine signaling in cardiomyocytes is
inhibited by oxidative stress: Parthenolide targets JAK1 activation by generating ROS. J Cell
Physiol. 2007;212:424-431.
Kurdi M., Bowers M.C., Dado J., and Booz G.W. Parthenolide induces a distinct pattern of
oxidative stress in cardiac myocytes. Free Radic Biol Med. 2007;42(4):474-481.
Kurdi M. and Booz G.W. Jak inhibition, but not Stat1 knockdown, blocks the synergistic effect of
IFN-gamma on Fas-induced apoptosis of A549 human non-small cell lung cancer cells. J Interferon
Cytokine Res. 2007;27:23-31.
Cerutti C., Kurdi M., Bricca G., Hodroj W., Paultre C., Randon J., Gustin M.P. Transcriptional
alterations in the left ventricle of three hypertensive rat models. Physiol Genomics. 2006;27(3):295308.
Kurdi M., De Mello W.C., Booz G.W. Working outside the system: an update on the
unconventional behavior of the renin-angiotensin system components. Int J Biochem Cell Biol.
2005;37:1357-1367.
Kurdi M., Randon J., Cerutti C., Bricca G. Increased expression of IL-6 and LIF in the
hypertrophied left ventricle of TGR(mRen2)27 and SHR rats. Mol Cell Biochem. 2005;269:95-101.
August 12, 2010
Kurdi M., Cerutti C., Randon J., McGregor L., Bricca G. Macroarray analysis in the hypertrophic
left ventricle of renin-dependent hypertensive rats: identification of target genes for renin. J Renin
Angiotensin Aldosterone Syst. 2004;5:72-78.
Bricca G., Randon J., Paultre C., Legedz L., Kurdi M., Gustin M.P., Cerutti C. Transcriptome
myocardique : une approche de la complexité du remodelage cardiaque. Médecine Thérapeutique
Cardiologie. 2004;3:123-131.
Kurdi M., Dizerens N., Cerutti C., Bricca G., Randon J. Expression des cytokines et de leurs
récepteurs dans le ventricule gauche hypertrophique du rat TGR(mRen2)27. Arch Mal Coeur Vaiss.
2003;96:811-814.
ORAL PRESENTATIONS
2005
Š 1st Annual Cardiovascular Research Institute Retreat of the Texas A&M University
System Health Science Center. Temple, Texas, October 2005.
Parthenolide inhibits IL-6-type cytokine signalling by targeting JAK1 activation: possible
role of reactive oxygen species. Kurdi M., Nickolai J.L., Bowers M., and Booz G.W.
2004
Š Fourteenth European Meeting on Hypertension. Paris, France, June 2004.
1) Transcriptomic analysis of the left ventricular hypertrophy: divergent profiles among
genetic models of hypertension.
2) Transcriptome of left ventricular tissue in genetically hypertensive rats: statistical
aggregation of gene expression levels to identify signatures.
2002
Š XXIIes journées de l’Hypertension Artérielle. Paris, France, Décembre 2002.
Expression des cytokines et de leurs récepteurs dans le ventricule gauche hypertrophique
du rat TGR(mRen2)27.
Š 6ème Congrès Annuel de la Société Française de Pharmacologie. Rennes, France,
Avril 2002.
Transcriptomic analysis of the left ventricular hypertrophy of TGR(mRen2)27 rats.
Š 6ème journée scientifique de l’Ecole Doctorale Interdisciplinaire Sciences-Santé.
Lyon, France, Mars 2002.
Analyse transcriptomique de l’hypertrophie ventriculaire gauche chez le rat transgénique
TGR(mRen2)27.
2001
Š Journées « Méthodes de Classification » Action Informatique Mathématique
Physique pour la Génomique. Paris, France, Juin 2001.
Obtention et analyse de données du transcriptome : Normalisation des données
expérimentales et agrégation statistique de gènes avec un faible nombre de répétitions
expérimentales.
ABSTRACTS
2007
Š XIX World Congress of the International Society for Heart Research. Bologna, Italy,
Juin 2007.
August 12, 2010
Kurdi M. and Booz G.W. Oxidative stress blocks activation of JAK-STAT signalling in
cardiac myocytes. J Mol Cell Cardiol. 2007.
2006
Š 28th Annual International Society for Heart Research, North American section
meeting. Toronto, Canada, June 2006.
Kurdi M. and Booz G.W. Inhibition of IL-6-type cytokine signaling by oxidative stress in
cardiac myocytes. J Mol Cell Cardiol. 2006;40:883.
2005
Š Heart Failure Society of America, 9th Annual Scientific Meeting, Boca Raton,
Florida, USA, September 2005.
Bowers M., Kurdi M., Nickolai J.L., Booz G.W. Parthenolide induces oxidative stress in
cardiomyocytes: differential activation of mitochondrial and NADPH oxidases. J Cardiac
Failure. 2005;11(Suppl 6):070.
Š 27th Annual International Society for Heart Research, North American section
meeting. New Orleans, Louisiana, USA, May 2005.
Kurdi M., Nickolai J.L., Booz G.W. Anti-inflammatory parthenolide inhibits JAK1
activation in cardiac myocytes but induces oxidative stress. J Mol Cell Cardiol.
2005;38:845.
2004
Š Fourteenth European Meeting on Hypertension. Paris, France, June 2004.
Kurdi M., Cerutti C, Randon J, Bricca G. Transcriptomic analysis of the left ventricular
hypertrophy: divergent profiles among genetic models of hypertension. J Hypertens.
2004;22(Suppl 2): S18.
Cerutti C., Kurdi M., El Feghali R., Randon J., Gustin M.P., Paultre C., Bricca G.
Transcriptome of left ventricular tissue in genetically hypertensive rats: statistical
aggregation of gene expression levels to identify signatures. J Hypertens.
2004;22(Suppl 2):S15.
2003
Š 57th Annual Fall Conference – Council for High Blood Pressure Research.
Washington DC, USA, September 2003.
Kurdi M., Randon J., Cerutti C., Bataillard A., and Bricca G. Differential expression of
cardiac hypertrophic cytokines of the interleukin-6 family in genetic models of
hypertension. Hypertension. 2003;42:405.
Š Thirteenth European Meeting on Hypertension. Milan, Italy, June 2003.
Kurdi M., Dizerens N., Bataillard A., Bricca G., Randon J. Expression of cardiac
cytokines from the interleukin-6 family and their receptors in two models of hypertension.
J Hypertens. 2004;21(Suppl 4):S35-S36.
2002
Š XXIIes journées de l’Hypertension Artérielle. Paris, France, Décembre 2002.
Kurdi M., Dizerens N., Bricca G. et Randon J. Expression des cytokines et de leurs
récepteurs dans le ventricule gauche hypertrophique du rat TGR(mRen2)27. Arch Mal
Cœur Vaiss. 2002;95:16-17.
August 12, 2010
th
Š 7 Annual Meeting of the European Council for Blood Pressure and Cardiovascular
Research. Seeheim, Allemagne, October 2002.
Kurdi M., Randon J., Gauci C., and Bricca G. Involvement of APLP2 and CNTFR genes
in left ventricular hypertrophy. Hypertension. 2002;40:578.
Š 6ème Congrès Annuel de la Société Française de Pharmacologie. Rennes, France,
Avril 2002.
Kurdi M., Randon J., and Bricca G. Transcriptomic analysis of the left ventricular
hypertrophy of TGR(mRen2)27 rats. Fundam Clin Pharmacol. 2002;16:401.
Bricca G., Kurdi M., Chouabe C., Randon J., Timour Q., Ricci E., Bonvallet R. Specific
modification of voltage-gated K+ channel genes expression in the hypertrophic
cardiomyocytes of TGR(mRen2)27. Fundam Clin Pharmacol. 2002;16:377.
Š 6ème journée scientifique de l’Ecole Doctorale Interdisciplinaire Sciences-Santé.
Lyon, France, Mars 2002.
Kurdi M., Randon J., Bricca G. Analyse transcriptomique de l’hypertrophie ventriculaire
gauche chez le rat transgénique TGR(mRen2)27. (www.ibcp.fr/ediss).
2001
Š Journées « Méthodes de Classification » Action Informatique Mathématique
Physique pour la Génomique. Paris, France, Juin 2001.
Bricca G., Mc Gregor L., Kurdi M., Roussoulières A., Thiéblemont C., Chettab K.,
Randon J., Mc Gregor J.L. Obtention et analyse de données du transcriptome:
Normalisation des données expérimentales et agrégation statistique de gènes avec un
faible nombre de répétitions expérimentales.
Š 3rd meeting of the Federation of the European Pharmacological Societies (EPHAR).
Lyon, France, Juillet 2001.
Chouabe C., Randon J., Kurdi M., Bricca G., Bonvallet R. Electrophysiological
characterization of isolated ventricular myocytes from the transgenic rat TGR(mRen2)27.
Fundam Clin Pharmacol. 2001;15:90.
GRANT AND RESEARCH SUPPORT
7/15/2010-31/12/2011 The Academy of Sciences for the Developing World (TWAS) and the
OIC Standing Committee on Scientific and Technological Cooperation
(COMSTECH)
Expression and Regulation of IL-6 type Cytokine Signaling in Coronary Endothelial Cells
Principal Investigator: Mazen Kurdi
Total Direct Costs: $ 14,000
12/1/2009-12/1/2011 Lebanese National Council for Scientific Research (CNRS)
Regulation of IL-6 type Cytokine Signaling in Coronary Endothelial Cells
Principal Investigator: Mazen Kurdi
Co-Investigators: Iman Saad
Total Direct Costs: LBP 24 000 000
7/1/2008-6/30/2013 National Heart, Lung, and Blood Institute
August 12, 2010
Regulation of IL-6-Type Cytokine Cardioprotective Signaling in the Ischemic Heart.
Principal Investigator: George Booz
Co-Investigators: Roy Duhé, Mazen Kurdi
Total Direct Costs: $1,225,676
10/1/2008-9/30/2010 ProStem Biotech Inc.
Improving the Therapeutic Potential of Umbilical Cord Blood Stem Cells for Cardiac Repair.
Principal Investigator: George Booz
Co-Investigator: Mazen Kurdi
Total Direct Costs: $240,000
May 2009 – May 2011 Lebanese University
Mesure des cytokines de la famille de l’interleukine-6 chez les patients libanais atteints d’une
maladie cardiovasculaire : Identification des facteurs pronostiques lors du développement d’une
insuffisance cardiaque.
Principal Investigator: Iman Saad
Co-Investigator: Mazen Kurdi
Total Direct Costs: LBP 8 000 000
5/6/2008-5/5/2010 Lebanese University
Interaction entre les cytokines de la famille de l’interleukine-6 et le système rénine angiotensine
lors du remodelage cardiovasculaire.
Principal Investigator: Mazen Kurdi
Co-Investigator: Iman Saad
Total Direct Costs: LBP 17 000 000
2/1/2007-1/31/2008 S&W Research Foundation Grant
Role of SOCS3 in Determining the Nature of IL-6-Type Cytokine Signaling in the Heart.
Principal Investigator: Mazen Kurdi
Co-Investigators: Mohamad Nawaz
Total Direct Costs: $40,000
PROFESSIONAL MEMBERSHIP
2006 -
Member of “International Society for Heart Research”, North American section.
2005 -
Member of “American Heart Association”, Council on High Blood Pressure
Research. Interdisciplinary working group on Functional Genomics and
Translational Biology, USA.
2005 -
Member of “Heart Failure Society of America”, USA.
2000 - 2002
Member of “la Socièté Francaise de Pharmacologie”, France.
FELLOWSHIPS AND AWARDS
2005
Young Investigator Best Oral Presentation, 1st Annual Cardiovascular Research
Institute Retreat of the Texas A&M University System Health Science Center.
Temple, Texas, USA.
2001 - 2002
MIRA Ph.D. Fellowship by “La Région Rhone-Alpes”, Lyon, France.
August 12, 2010
2003 - 2004
MIRA Ph.D. Fellowship by “La Région Rhone-Alpes”, Lyon, France.
CERTIFICATIONS
A - Radiation Safety
2004 -
Certification on General Radiation Safety. Central Texas Veterans Health Care
System, Temple, Texas, USA.
B - Animal Experimentation
2004
Certification on Animal Experimentation. Scott and White Hospital, Temple,
Texas, USA.
University Certification on animal and biological experimentation
Claude Bernard University and Veterinary National School. Lyon, France.
2002
TEACHING ACTIVITIES
2009 –
Professor, Lebanese University, Faculty of Sciences, Department of Chemistry
and Biochemistry, Beirut, Lebanon.
2008 – 2009
Associate Professor, Lebanese University, Faculty of Sciences, Department of
Chemistry and Biochemistry, Beirut, Lebanon.
Cellular Biochemistry, Enzymology, Metabolic Biochemistry.
2007 – 2008
Assistant Professor, Holy Spirit University of Kaslik, Faculty of Sciences and
Computer Engineering, Department of Chemistry and Life Sciences, Kaslik,
Lebanon.
General and structural Biochemistry, Metabolic Biochemistry, Enzymology, Cell
signaling, Cellular Biochemistry, General Pharmacology and Cosmetology.
2007 – 2008
Coordinator of the Master’s degree in Cosmetology and Pharmacology, Holy
Spirit University of Kaslik, Kaslik, Lebanon.
Fall 2005
Lecturer for Cell Signaling Course at University of Mary Hardin-Baylor, Belton,
Texas, USA.
2002-2003
High School teacher, Biology and Life Science courses and practical works, Jean
Paul Sartre High School, Bron, France.
2002
Advisor of Master’s degree students. Laboratory of Functional Genomics in
Athero-Thrombosis (INSERM U331 and EA 3740), Claude Bernard University,
Faculty of Medicine - RTH Laennec, Lyon, France.
PUBLIC AND PROFESSIONAL SERVICE
A- Journal Reviewer
2005
B- Committees
Reviewer for Leukemia and Lymphoma; JCMM .
August 12, 2010
2005 - 2008
Human Studies Subcommittee. Alternate member of the Human Studies
Subcommittee (IRB), The Central Texas Veterans Health Care System
(CTVHCS).
2005 - 2008
Subcommittee on Research Safety. Alternate member of the Human
Studies Subcommittee (IRB), The Central Texas Veterans Health Care
System (CTVHCS).
C- Chair
2005-2006
Chair of the Heart and Lung Focus Group meeting (1st and 3rd Tuesday of
each month). Texas A&M University, Cardiovascular Research Institute,
Division of Molecular Cardiology, Temple, Texas, USA.
GRADUATE STUDENTS
Master’s students:
2007/2008
Marita Faddoul, Master Student, Holy Spirit University of Kaslik, Lebanon
2007/2008
Youssef Bou Assy, Master Student, Holy Spirit University of Kaslik, Lebanon
2007/2009
Carlos Zgheib Master Student, Holy Spirit University of Kaslik, Lebanon
2008/2010
Rony Chidiac, Master Student, Holy Spirit University of Kaslik, Lebanon
Ph.D. students:
2009Carlos Zgheib, Ph.D. student, The Mississippi Medical Center, Department of
Pharmacology and Toxicology, Jackson, USA.
COMPLEMENTARY INFORMATION
Languages
English, French, Arabic (written / spoken)
Informatics
MS-Word, Excel, Powerpoint.
Hobbies
Music, volley-ball, working out, …