(12) International Application Status Report

(12) International Application Status Report
Received at International Bureau: 21 May 2007 (21.05.2007)
Information valid as of: 13 November 2008 (13.11.2008)
Report generated on: 30 September 2016 (30.09.2016)
(10) Publication number:
(43) Publication date:
(26) Publication language:
WO2007/100845
07 September 2007 (07.09.2007)
English (EN)
(21) Application Number:
(22) Filing Date:
(25) Filing language:
PCT/US2007/005142
27 February 2007 (27.02.2007)
English (EN)
(31) Priority number(s):
(31) Priority date(s):
(31) Priority status:
60/777,572 (US)
27 February 2006 (27.02.2006)
60/779,842 (US)
06 March 2006 (06.03.2006)
60/779,841 (US)
06 March 2006 (06.03.2006)
60/779,997 (US)
06 March 2006 (06.03.2006)
60/779,992 (US)
06 March 2006 (06.03.2006)
Priority document received (in compliance
with PCT Rule 17.1)
Priority document received (in compliance
with PCT Rule 17.1)
Priority document received (in compliance
with PCT Rule 17.1)
Priority document received (in compliance
with PCT Rule 17.1)
Priority document received (in compliance
with PCT Rule 17.1)
(51) International Patent Classification:
C12N 5/00 (2006.01)
(71) Applicant(s):
MORAGA BIOTECHNOLOGY CORPORATION [US/US]; 1061 Moraga Drive, Suite 100 Los Angeles, CA 90049 (US) (for all
designated states except US)
YOUNG, Henry [US/US]; 195 Ashton Drive Macon, GA 31207 (US) (for US only)
BLACK, Asa [US/US]; 1061 Moraga Drive, Suite 100 Los Angeles, CA 90049 (US) (for US only)
(72) Inventor(s):
YOUNG, Henry; 195 Ashton Drive Macon, GA 31207 (US)
BLACK, Asa; 1061 Moraga Drive, Suite 100 Los Angeles, CA 90049 (US)
(74) Agent(s):
FESSENMAIER, Martin; Rutan & Tucker, LLP 611 Anton Blvd., Suite 1400 Costa Mesa, CA 92626 (US)
(54) Title (EN): NON-EMBRYONIC TOTIPOTENT BLASTOMERE-LIKE STEM CELLS AND METHODS THEREFOR
(54) Title (FR): Cellules souches totipotentes non embryonnaires DE TYPE blastomères et méthodes
(57) Abstract:
(EN): Human non-embryonic adult totipotent and pluripotent stem cells are isolated in a simplified serum-free and feeder cellfree process. Most remarkably, certain stem cells, and especially BLSCs, are extremely small, fail to exclude trypan blue, but are
nevertheless able to proliferate from even high dilutions. Therefore, so obtained stem cells can be used to prepare true monoclonal
stem cell populations, which are useful in numerous uses, including therapeutic, prophylactic, diagnostic, and research uses.
(FR): L'invention concerne des cellules souches humaines totipotentes et pluripotentes adultes non embryonnaires. Ces dernières
sont isolées au cours d'un processus simplifié sans sérum et sans cellules nourricières. Fait remarquable : certaines cellules souches,
notamment les cellules souches de type blastomères, sont extrêmement petites et ne parviennent pas à rejeter le bleu trypan, mais
peuvent néanmoins proliférer à partir de dilutions élevées. Par conséquent, les cellules souches ainsi obtenues peuvent être utilisées
pour préparer de véritables populations de cellules souches monoclonales, utiles dans de nombreux cas, y compris à des fins
d'utilisation thérapeutique, prophylactique, diagnostique et dans le cadre de recherches.
International search report:
Received at International Bureau: 17 September 2008 (17.09.2008) [US]
International Report on Patentability (IPRP) Chapter II of the PCT:
Not available
(81) Designated States:
AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG,
ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT,
LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD,
SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
European Patent Office (EPO) : AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC,
NL, PL, PT, RO, SE, SI, SK, TR
African Intellectual Property Organization (OAPI) : BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG
African Regional Intellectual Property Organization (ARIPO) : BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM,
ZW
Eurasian Patent Organization (EAPO) : AM, AZ, BY, KG, KZ, MD, RU, TJ, TM