Conférence Paul Sabatier

Conférence Paul Sabatier
Pr Ruben Martin
Institute of Chemical Research of Catalonia (ICIQ)
Ni-catalyzed C-O Bond-Cleavage and Reductive
Carboxylation Techniques
Vendredi 30 octobre 2015 à 11h00
Auditorium Fernand Gallais
Campus CNRS 205
205, route de Narbonne, Toulouse
Contact LCC: Dr Eric Manoury, [email protected]
Retrouvez le programme complet des séminaires sur le site web du LCC : http://www.lcc-toulouse.fr/
Ni-catalyzed C-O Bond-Cleavage and Reductive Carboxylation
Techniques
Ruben Martin* ([email protected])
Institute of Chemical Research of Catalonia (ICIQ), Av. Països Catalans 16, 43007, Tarragona, Spain
Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluïs Companys, 23, 08010,
Barcelona, Spain
Activation of inert entities has been and continues to be of extreme interest to any
organic chemist.1 This is especially true with activation of atmospheric molecules such
as CO22 or the activation of relatively inert C- O bonds.3 Certainly, the development of
operationally-simple and practical catalytic methods for the activation of the abovementioned entities would be highly desirable, as many of the current methods involve
the use of stoichiometric amounts or air-sensitive organometallic reagents. In the last
years, our research group has reported some progress directed towards the catalytic
activation of inert molecular bonds, particularly on the field of C-O bond-functionalization
and CO2 fixation (Scheme 1).4 These methods are characterized by their simplicity, wide
substrate scope, including challenging substrate combinations with particularly sensitive
functional groups and a diverse set of substitution patterns.
Scheme 1. Metal-catalyzed functionalization of C-O bonds and CO2 at Martin´s laboratories
(1) Activation of Unreactive Bonds in Organic Synthesis, Springer, Berlin 1999
(2) For reviews: (a) Tsuji, Y.; Fujihara, T. Chem. Commun. 2012, 48, 9956. (b) Cokoja, M.; Bruckmeier, C.;
Rieger, B.; Herrmann, W. A.; Kühn, F. E. Angew. Chem. Int. Ed. 2011, 50, 8510.
(3) For reviews: (a) Rosen, B. M.; Quasdorf, K. W.; Wilson, D. A.; Zhang, N.; Resmerita, A. –M.; Garg, N.
K.; Percec, V. Chem. Rev. 2011, 111, 1346. (b) Cornella, J.; Zarate, C.; Martin, R. Chem. Soc. Rev.
2014, 43, 8081.
(4) Recent examples from our group: (a) Leon, T.; Correa. A.; Martin, R. J. Am. Chem. Soc. 2013, 135,
1221. (b) Cornellà, J.; Gómez-Bengoa, E.; Martín, R. J. Am. Chem. Soc. 2013, 135, 1997. (c) Correa.
A.; Leon, T.; Martin, R. J. Am. Chem. Soc. 2014, 136, 1062. (d) Zarate, C.; Martin, R. J. Am. Chem. Soc.
2014, 136, 2236. (e) Liu, Y.; Cornella, J.; Martin, R. J. Am. Chem. Soc. 2014, 136, 11212. (f) Moragas,
T.; Cornella, J.; Martin, R. J. Am. Chem. Soc. 2014, 136, 17702. (g) Zarate, C.; Manzano, R.; Martin, R.
J. Am. Chem. Soc. 2015, 137, 6754.