Dominique Masset - European Medicines Agency

Curriculum vitae
PERSONAL INFORMATION
Dominique Masset
WORK EXPERIENCE
January 1999–Present
Head of Non-Clinical and Clinical Toxicology Department
ANSM (Agence Nationale de Securite du medicament et des produits de sante), (France)
Management ,coordination and organisation of the non-clinical evaluation of Drugs Marketing
Authorization, and clinical Trials Applications,
-Member of the CHMP/SWP EMA
-CHMP/SWP Representative member to the GTWP involved in Germ line transmission guideline
EMA an ICH and . ICH consideration paper on: General Principles to Address in Preparation for Firstin-Human Gene Therapy Studies (EMEA/CHMP/ICH/705203/2009).
-Expert for EFSA (Genetic Modify Organism)
-WHO Expert (WHO Guidelines on the Nonclinical Evaluation of Vaccine Adjuvants and Adjuvanted
Vaccines)
management and co-ordination of the Committee for innovation for the Non-Clinical Safety Evaluation
of new Medicines or Preclinical innovation working party (PIWP)(OMICS, Nanoscale materials etc…).
January 1992–December 1998
Pharmacist Toxicologist Clinical Toxicology
Centre Antipoison de Marseille Assistance Publique Hopitaux de Marseille, (France)
-Research and evaluation of drugs toxicity mechanism by conformational and molecular modeling and
QSAR
-Drugs Risk/Benefit evaluation for the National Committee of Pharmacovigilance
- management of Analytical Toxicology
-Developpment of new analytical methods for Analytical Toxicology survey
September 1988–December
1991
Intership in pharmacy
Assistance Publique Hopitaux de Marseille, (France)
INSERN U278 Hopital de la Timone Marseille Service du Pr J.P CANO
Drugs monitoring clinical pharmacokinetics
EDUCATION AND TRAINING
September 1987–September
1992
Internship in pharmacy
October 1988–October 1992
PhD
Assistance Publique de Marseille - Hopitaux de Marseille, (France)
University of Aix Marseille, (France)
Development of new in vitro models of intestinal metabolism and transport of drugs
January 1993–December 1993
Medical Toxicology Certification (décret n° 93-696 du 26 mars 1993)
Anti Poison center - Assisantace Publique Hôpitaux de Marseille, (France)
Toxicity Structure Activity Relationship of Trimébutine addiction
September 1987–June 1988
Postgraduate Diploma (DEA Diplome d'étude approfondies)
University of Aix Marseille, (France)
Fondamental and clinical pharmacokinetics
24/10/15
© European Union, 2002-2015 | http://europass.cedefop.europa.eu
Page 1 / 3
Curriculum vitae
October 1982–June 1987
Dominique Masset
Pharm.D
University of Aix Marseilles, (France)
Thesis "Cyclosporin drugs monitoring"
ADDITIONAL INFORMATION
Expertise
Publications
Non Clinical assesmment , Toxicology Pharmacokinetics
1- Rahmani D, Masset D,, Coppens R, Placidi M, Di Marino V, Durand A., Rahmani R. Intestinal
absorption of drugs : digitalis binding and transport by brush-border membrane vesicle from human
duodenum. Eur J Drugs Metab Pharmacokinet 1991 ;3 : 447-455
2- Rahmani D, Masset D, Rolland PH, Garcon D, Rahmani R. Abnormal taurocholate ileal
transepithelial transport in artherosclerotic mini-pigs and effects of ACE inhibitors. Athereosclerosis
1995 ;117 : 285-293
3 -Jourdheuil Rahmani D, Rolland PH, Masset D, Garcon D, Rahmani R. Alterations of methionine
fluxes and incorporation in intestines of miniature pigs fed a diet high in caseinate are restrited by
angiotensin-converting enzyme inhibitor. J.Nutr. 1995 ;125 : 3011-3019
4 - Samperiz S, Millet V, Arditti J, Lacroze V, Masset D, Bourdon H, Jouglard J, Unal D. Value of
toxicological research in newborn infants of addicted mothers by the study of several samples. Arch.
Pediatr. 1996 ; 3 : 440-444
5- Arditti J, Masset D, Samperiz S, Bourdon H, Millet V, Unal D, Jouglard J. Mise au point et validation
de méthodes de recherche et d'identification de toxiques dans les cheveux et le méconium de
nouveau-nés de mère toxicomane. Toxicorama 1994 ; 4 : 11-17
6 - Arditti J, Bourdon H, Jean PH, Landi H, Masset D, Jouglard J, Thirion X, Deviation d'utilisation de
la buprénorphine dans une série de 50 toxicomanes hospitalisés au CHR de Marseille. Thérapie 1992
; 47 : 561-2
7- Masset D, Bourdon JH, Arditti J, Jouglard J. Impact of delta-9-tetrahydrocannabinol and
métabolites on the immune system Acta Clin Belg Suppl. 1999;1:39-43
8 Masset D. Contribution of statistical analytic Tools to risk assessmentAnn Pharm Fr. 2007
Sep;65(5):303-7
9 -Arnich N, Canivenc-Lavier MC, Kolf-Clauw M, Coffigny H, Cravedi JP, Grob K, Macherey AC,
Masset D, Maximilien R, Narbonne JF, Nesslany F, Stadler J, Tulliez J. Conclusion of the French
Food Safety Agency on Toxicity of Bisphenol A. Int.J.Hyg.Environ Health 2011 jun 214(3) 271-75
Projects
Memberships
COMMUNICATIONS
XI International Symposium on drugs affecting lipid metabolism 7 février 1992 Liège.
Effect of ACE inhibitors on taurocholate ileal transepithelial transport in atherosclerotic minipigs" D
Masset, PH Rolland and R Rahmani
I er congrès de la Société Française de Toxicologie Analytique. Strasbourg 9/12/93
Recherche de stupéfiant dans les cheveux et dans le méconium de nouveau-né de mères supposées
toxicomanes. D.Masset, S. Samperiz, J.Arditti, H. Bourdon. V. Millet, J. Jouglard. D. Unal.
Les pièges de l'analyse Toxicologique de Routine J.Arditti, H. Bourdon. D. Masse t, P.Brouant. J.
Jouglard., J. Barbe
XXXIe congrès de la Société de TOXICOLOGIE Clinique Nancy 16 et 17 septembre 1993.
§Approche analytique des pharmacodépendances et des usagers de drogues. H. Bourdon,
D.Masset, J. Arditti. M. Spadari, J. Jouglard,
Traitement antidotique par alcoolisation et 4 methyl-pyrazole d'une intoxication grave par l'ethylene
glycol. M. Hayek-lanthois, H. Bourdon, D. Masse t, C. Mullanu. A. Puget, J. Arditti. J. Jouglard. M.
24/10/15
© European Union, 2002-2015 | http://europass.cedefop.europa.eu
Page 2 / 3
Curriculum vitae
Dominique Masset
Gainnier, Ph. Blanc. J. M Sainty.
XVII International Congress of the European Association of Poisons Centres and Clinical
Toxicologists (EAPCCT) Marseille le Juin 1996
Interest of the Structure-Activity relationships studies in misuse and abuse of pharmaceutical. Masset
D., Arditti J., Bourdon H., Jouglard J..
Interest of study of irregular prescriptions in the screening and the following of misuse and abuse of
pharmaceutical. Obedia E. Masset D., Jouglard J., European congres of 1996
Utility of actived charcoal before gastric lavage : interests and limits. Bourdon H. Masset D; Jouglard
J.,
Journées scientifiques 2 éme Forum des Innovations Technologiques du Laboratoire Forum
Labo 2-5 avril 1996 CNIT PARIS la Défense.
§Intérêt dans l'aide au diagnostic du dépistage des drogues dans les cheveux de nouveau-nés de
mères toxicomanes. D. Masset.
Journées Société Française de Toxicologie Analytique. 26 novembre 1996 Paris. 1996
Matrices alternatives et immunochimie recherche de toxiques dans le méconium. D. Masset, J. Arditti,
H. Bourdon J. Jouglard .
Congrès de la SFT 13 et 14 octobre 2005 Brest
Médicaments et Allergies : Retours d’expérience D.Masset
Congrès de la SFT 25 et 26 octobre 2007 Montpellier
La sécurité des excipients : Etudes de cas D.Masset
XII Congrès Eurotox 19 et 23 juillet 2010
EMEA’s position in the use of X‐Omics in regulatory studies
Dominique Masset,
Congrès ETP nanomed 25 décembre 2010 Milan
Report on French « support to innovation » programme : focus on nanomedecines
Other Relevant Information
24/10/15
© European Union, 2002-2015 | http://europass.cedefop.europa.eu
Page 3 / 3