Effet de la benzylaminopurine sur des variants somaclonaux de

Transcription

Effet de la benzylaminopurine sur des variants somaclonaux de
PRLQVSRLQWXVTXHFHX[GH)+,$WDQGLV
TXHODSHDXG·,1,9,7HVWYHUWH
/HVSXOSHVGH)+,$HWG·,1,9,7VRQW
GHFRXOHXUFUqPHWDQGLVTXHFHOOHG·,1,9,7
HVWGHFRXOHXURUDQJpH
4XDQW j OD SURGXFWLRQ GH SROOHQ QRXV
SRXYRQV pWDEOLU TX·HOOH HVW VHPEODEOH FKH]
,1,9,7 HW OH FORQH G·RULJLQH )+,$
DYHF XQ SRXUFHQWDJH pOHYp GH JUDLQHV
IHUWLOHV WDQGLV TX·,1,9,7 SURGXLW
XQ IDLEOH QRPEUH GH JUDLQV GH SROOHQ TXL
DSUqV DQDO\VH HQ ODERUDWRLUH Q·pWDLHQW SDV
IHUWLOHV
1RXVUHFRPPDQGRQVGHSRXUVXLYUHO·pWXGH
GHVOLJQpHVG·XQSRLQWGHYXHF\WRJpQpWLTXH
L]RHQ]\PDWLTXH HW PROpFXODLUH HW GH
GpWHUPLQHU OHXU SHUIRUPDQFH DJURQRPLTXH
HQ FKDPS HQ YXH G·XQH pYHQWXHOOH
LQWURGXFWLRQDXSUqVGHVDJULFXOWHXUV
5pIpUHQFHV
'RQLQL3$6RQQLQR,QGXFHGPXWDWLRQLQSODQW
EUHHGLQJ &XUUHQWVWDWXV DQGIXWXUHRXWORRN 3S
LQ6RPDFORQDOYDULDWLRQDQGLQGXFHGPXWDWLRQVLQ
FURS LPSURYHPHQW 60 -DLQ HG .OXZHU $FDGHPLF
3XEOLVKHUV/RQGRQ
+HUQiQGH]$1XHYDYHUVLyQGHODFODVLILFDFLyQGH
ORV VXHORV GH &XED ,QVWLWXWR GH 6XHORV GH &XED /D
+DEDQDSS
,3*5,,1,%$3&,5$' 'HVFULSWHXUV SRXU OH
EDQDQLHU 0XVD VSS ,3*5, 5RPH ,WDOLH ,1,%$3
0RQWSHOOLHU)UDQFH&LUDG0RQWSHOOLHU)UDQFH
,VUDHOL < 2 5HXYHQL ( /DKDY 4XDOLWDWLYH
DVSHFWVRIVRPDFORQDOYDULDWLRQVLQEDQDQDSURSDJDWHG
E\ LQ YLWUR WHFKQLTXHV 6FLHQWLD +RUWLFXOWXUDH /DUNLQ3-6FRZHURIW(\HVSRWGLVHDVHRIVXJDU
FDQH3ODQW3K\VLRORJ\
(IIHWGHODEHQ]\ODPLQRSXULQHVXUGHVYDULDQWV
VRPDFORQDX[GHEDQDQLHUVQDLQV
9DULDWLRQVRPDFORQDOH
.0DWVXPRWR/6W\HU&DOGDVHW<<DPDPRWR
/
D FXOWXUH G·DSH[ D VRXYHQW pWp XWLOLVpH
SRXU HIIHFWXHU OD PLFURSURSDJDWLRQ
G·XQ ODUJH pYHQWDLO GH JpQRW\SHV
GH 0XVD &URQDXHU HW .ULNRULDQ 9X\OVWHNH /HV YLWURSODQWV SURGXLWV
QRQ VHXOHPHQW SRXVVHQW SOXV YLWH PDLV
SHUPHWWHQW GHV UpFROWHV SOXV V\QFKURQLVpHV
HW GHV UHQGHPHQWV VXSpULHXUV DX PDWpULHO
GH SODQWDWLRQ FRQYHQWLRQQHO 'UHZ HW 6PLWK
5RELQVRQHWDOÉOYDUHVHW&DOGDV
3DU FRQWUH FHWWH WHFKQLTXH SHXW
V·DFFRPSDJQHU GH OD SURGXFWLRQ GH YDULDQWV
VRPDFORQDX[ &KH] 0XVD OD SURSRUWLRQ GH
YDULDQWV VRPDFORQDX[ SURGXLW SDU OD FXOWXUH
G·DSH[YDULHGHjPDLVSHXWDWWHLQGUH
FKH] FHUWDLQV FXOWLYDUV GH SODQWDLQ HW
PrPHGDQVGHVFDVH[WUrPHVYRLUOD
UHYXHGHODOLWWpUDWXUHSDU&{WHHWDO
,O HVW LQWpUHVVDQW GH FRQVWDWHU TX·HQYLURQ
GHVYDULDQWVVRPDFORQDX[SURGXLWVVRQW
GHW\SHQDLQ5HXYHQLHW,VUDHOL&·HVW
SRXUFHWWHUDLVRQTXHGHQRPEUHXVHVpWXGHV
RQW SRUWp VXU OD GpWHFWLRQ GH YDULDQWV QDLQV
j GHV VWDGHV GH GpYHORSSHPHQW SUpFRFHV
UpDOLVpHV j O·DLGH G·DFLGH JLEpUHOOLTXH
'DPDVFRHWDO6DQGRYDOHWDO
GX SURILO SRO\IRUPH G·LVR]\PHV &DUYDOKR
HW DO RX GH PDUTXHXUV PROpFXODLUHV
'DPDVFR HW DO *UDMDO0DUWLQ HW
DO &HUWDLQV YDULDQWV VRPDFORQDX[
SURYLHQQHQW GH WLVVXV FKLPpULTXHV H[LVWDQWV
GDQVO·H[SODQWG·RULJLQH&URXFKHWDO
'H IRUWHV FRQFHQWUDWLRQV GH UpJXODWHXUV GH
FURLVVDQFH GDQV OH PLOLHX GH FXOWXUH HW GHV
UHSLTXDJHV VXFFHVVLIV LQGXLVHQW pJDOHPHQW
GHV YDULDWLRQV VRPDFORQDOHV 5HXYHQL HW
,VUDHOL6KHSKHUGHWDO5RGULJXHV
HW DO 6DQWRV HW 5RGULJXHV 3DU FRQWUH FHOD Q·H[SOLTXH SDV OD WUqV IRUWH
SURSRUWLRQGHYDULDQWVQDLQVREWHQXVGDQVOH
FDV GX EDQDQLHU &HWWH IRUWH SURSRUWLRQ SHXW
rWUH GXH GX PRLQV HQ SDUWLH j OD VpOHFWLRQ
LQYRORQWDLUH GH YDULDQWV QDLQV SHQGDQW OD
PLFURSURSDJDWLRQ /H EXW GH FHWWH pWXGH D
pWpGHFRPSDUHUOHVWDX[GHPXOWLSOLFDWLRQLQ
YLWUR GH YDULDQWV QDLQV DYHF FHX[ GH SODQWV
FRQIRUPHV
0DWpULHOVHWPpWKRGHV
/HVFXOWLYDUVXWLOLVpVGDQVFHWWHpWXGHpWDLHQW
¶1DQLFmR· HW ¶*UDQG QDLQH· WRXV OHV GHX[
DSSDUWHQDQW DX VRXVJURXSH &DYHQGLVK
0XVD$$$'DQVOHFDVGXFXOWLYDU¶1DQLFmR·
OHV DSH[ RQW pWp SUpOHYpV VXU GHV UHMHWV HW
FXOWLYpVVXUXQPLOLHX0XUDVKLJH6NRRJ06
DGGLWLRQQp GH J/ GH VXFURVH PJ/ GH
EHQ]\ODPLQRSXULQH %$ HW RX J/
GH 3K\WDJHO /HV SRXVVHV PXOWLSOHV RQW pWp
UHSLTXpHVVXUOHPrPHPLOLHXWRXVOHVj
MRXUVSHQGDQWDQV/DIRUPDWLRQGHUDFLQHV
D HQVXLWH pWp LQGXLWH VXU XQ PLOLHX 06 DYHF
,QIR0XVD9RO1ƒ-XLQ'pFHPEUH
7HUHVD5DPtUH]3HGUD]D
0LJXHO+HUQiQGH](VWUDGD
/LDQHW*RQ]iOH]'tD]
'DQQH\V$UPDULR$UDJyQ
2VYDOGR7ULDQD$OIUHGRGH
OD1XH](OLpFHU5HLQDOGR
(QD+HUQiQGH]-DLPH6LPy
HW$OH[LV2UWHJDWUDYDLOOHQWj
O·,QVWLWXWRGH,QYHVWLJDFLRQHV
HQ9LDQGDV7URSLFDOHV,1,9,7
$SGR)LQFD7UHV&DUROLQDV
&36DQWR'RPLQJR
9LOOD&ODUD&XED&RXUULHO
WHUHVD#LQLYLWFRFX
PJ/G·DFLGHDFpWLTXH_QDSKWKDOqQLTXH
$$1
3OXVGHSODQWXOHVRQWpWpDFFOLPDWpHV
HW WUDQVSODQWpHV HQ FKDPS 'HX[ DQV
DSUqV OD WUDQVSODQWDWLRQ OD ORQJXHXU GX
SVHXGRWURQF GH OD EDVH GX SVHXGRWURQF j
OD EDVH GX SpGRQFXOH D pWp PHVXUpH /H
FKHYDXFKHPHQW GHV IHXLOOHV D pJDOHPHQW
pWpREVHUYpSRXULGHQWLILHUOHVYDULDQWVQDLQV
3DUPL OHV SODQWV TXL RQW IUXFWLILp pWDLHQWFRQIRUPHVHQPDWLqUHGHWDLOOH
DORUVTXHpWDLHQWQDLQVHW
DYDLHQWGHVFDUDFWpULVWLTXHVLQWHUPpGLDLUHV
7UHL]H GHV SODQWV FRQIRUPHV HW GHV
SODQWVQDLQVRQWpWpVpOHFWLRQQpVDXKDVDUG
&KDTXH SDUHQW D pWp FRQVLGpUp VpSDUpPHQW
SRXU OHV OLJQpHV GH FXOWXUHV LQ YLWUR
VXEVpTXHQWHV'HX[UHMHWVGHFKDTXHSDUHQW
RQWpWpUppWDEOLVLQYLWUR/HVH[SODQWVG·DSH[
RQWpWpFXOWLYpVVXUGXPLOLHX06DGGLWLRQQp
GHJ/GHVXFURVHJ/GH3K\WDJHOHW
PJ/RXPJ/GH%$/HVFXOWXUHVRQWpWp
PDLQWHQXHV VRXV XQH SKRWRSpULRGH GH K
GHOXPLqUHHWKG·REVFXULWpjXQHLQWHQVLWp
OXPLQHXVH GH +PRO P V j (R& HW
UHSLTXpHV j GHV LQWHUYDOOHV G·XQ PRLV VXU
OH PrPH PLOLHX GH FXOWXUH /H QRPEUH GH
SRXVVHV D pWp pYDOXp WURLV PRLV VRLW GHX[
UHSLTXDJHVDSUqVOHGpEXWGHODFXOWXUH
/HPrPHSURFpGpDpWpDSSOLTXpj¶*UDQG
QDLQH· &LQT SODQWV FRQIRUPHV HW FLQT SODQWV
QDLQVRQWpWpVpOHFWLRQQpVDXKDVDUGSDUPLOD
SODQWDWLRQGHGHX[DQVUppWDEOLHLQYLWUR/HV
FRQGLWLRQVGHFXOWXUHpWDLHQWOHVPrPHVTXH
SRXU¶1DQLFmR·
5pVXOWDWVHWGLVFXVVLRQ
4XRLTXH SOXV pOHYp OH QRPEUH PR\HQ GH
SRXVVHV SURGXLWHV SDU OHV OLJQpHV QDLQHV
GH ¶1DQLFmR· Q·pWDLW SDV VLJQLILFDWLYHPHQW
GLIIpUHQW GH FHOXL SURGXLW SDU OHV SODQWV
FRQIRUPHV DX[ GHX[ FRQFHQWUDWLRQV GH %$
WDEOHDX'HPrPHOHIDLWG·DXJPHQWHUOD
FRQFHQWUDWLRQ GH %$ Q·D SDV DXJPHQWp GH
IDoRQ VLJQLILFDWLYH OD SURGXFWLRQ GH SRXVVHV
FKH]OHVSODQWVQDLQHVHWFRQIRUPHV
3DU FRQWUH FKH] ¶*UDQGH QDLQH·
O·DXJPHQWDWLRQGHODFRQFHQWUDWLRQGH%$GH
jPJ/DDXJPHQWpGHIDoRQVLJQLILFDWLYH
OH QRPEUH GH SRXVVHV SURGXLWHV SDU OHV
OLJQpHV QDLQHV 'H SOXV OHV OLJQpHV QDLQHV
FXOWLYpHVVXUXQPLOLHXFRQWHQDQWPJ/GH
%$RQWSURGXLWGHSRXVVHVGHSOXVTXH
OHVSODQWVFRQIRUPHVWDEOHDX
5HXYHQLHW,VUDHOLRQWUDSSRUWpTXH
OH WDX[ GH PXOWLSOLFDWLRQ GH SODQWV QDLQV QH
GLIIpUDLW SDV VLJQLILFDWLYHPHQW GH FHOXL GH
SODQWV QRUPDX[ ,OV DYDLHQW XWLOLVp OH FXOWLYDU
¶:LOOLDPV· HW OH PLOLHX 0D HW 6KLL PJ/G·DFLGHLQGROHDFpWLTXH$,$HWPJ
/GHNLQpWLQHRXPJ/GHW\URVLQHPJ/
G·$,$HWPJ/GH%$
'H QRPEUHX[ ODERUDWRLUHV SUDWLTXDQW OD
PLFURSURSDJDWLRQ XWLOLVHQW DXMRXUG·KXL XQ
PLOLHX FRQWHQDQW VHXOHPHQW j PJ/ GH
%$RXGHVFRQFHQWUDWLRQVIDLEOHVG·$,$DYHF
GX %$ YRLU OD UHYXH GH OD OLWWpUDWXUH SDU
0DWVXPRWR HW 6LOYD 1HWR /H PLOLHX
XWLOLVpSDU5HXYHQLHW,VUDHOLDPRQWUp
OD SRVVLELOLWp G·XWLOLVHU OH PLOLHX GH FXOWXUH
FRPPHPR\HQSRXUVWRSSHUODPXOWLSOLFDWLRQ
GHVYDULDQWVQDLQV
6L OHV YDULDQWV VRPDFORQDX[ GH QRWUH
pWXGH DYDLHQW pWp GHV PXWDQWV FKLPpULTXHV
OHXU SURGXFWLRQ DXUDLW pWp UpGXLWH j OD VXLWH
GH UHSLTXDJHV VXFFHVVLIV (Q HIIHW OHV
F\WRFKLPqUHV LQGXLWHV SDU XQ WUDLWHPHQW
j OD FROFKLFLQH RQW pWp UpGXLWHV GH j DSUqV WURLV UHSLTXDJHV DYHF XQH
WHFKQLTXH GH FXOWXUH G·DSH[ HW GH j
DYHF XQH WHFKQLTXH GH FXOWXUH G·DSH[
PXOWLSOHV5RX[HWDO$XOLHXGHFHOD
QRXV DYRQV REVHUYp TXH OD SURSRUWLRQ GH
YDULDQWV QDLQV DXJPHQWDLW DYHF OH QRPEUH
7DEOHDX1RPEUHGHSRXVVHVFRQIRUPHVHWQDLQHVSURGXLWHVDSUqVUHSLTXDJHVGXFXOWLYDU
¶1DQLFmR·FXOWLYpVXUXQPLOLHXGHFXOWXUHFRQWHQDQWGLIIpUHQWHVFRQFHQWUDWLRQVGH
EHQ]\ODPLQRSXULQH%$Q &RQFHQWUDWLRQGH%$
1RPEUHPR\HQ“HW
GHSRXVVHVGDQVOHV
OLJQHVQDLQHV
PJ/
“
PJ/
“
1LYHDXGHVLJQLILFDWLRQSGXWHVWELODWpUDO
1RPEUHPR\HQ“HW
GHSRXVVHVGDQVOHV
OLJQHVFRQIRUPHV
“
“
1LYHDXGH
VLJQLILFDWLRQS
GXWHVWELODWpUDO
HWpFDUWW\SH
7DEOHDX(IIHWGHODIUDJPHQWDWLRQRXGHO·LQFLVLRQG·H[SODQWVGHJpQRW\SHVGHEDQDQLHUVjFXLUHVXU
ODVXUYLHOHWDX[GHPXOWLSOLFDWLRQHWODORQJXHXUGHODSRXVVHTXDWUHVHPDLQHVDSUqVO·LQLWLDWLRQGHOD
FXOWXUHQ &RQFHQWUDWLRQGH%$
1RPEUHPR\HQ“HW
GHSRXVVHVGDQVOHV
OLJQHVQDLQHV
PJ/
“
PJ/
“
1LYHDXGHVLJQLILFDWLRQSGXWHVWELODWpUDO
1RPEUHPR\HQ“HW
GHSRXVVHVGDQVOHV
OLJQHVFRQIRUPHV
“
“
1LYHDXGH
VLJQLILFDWLRQS
GXWHVWELODWpUDO
HWpFDUWW\SH
,QIR0XVD9RO1ƒ-XLQ'pFHPEUH
GH UHSLTXDJHV DWWHLJQDQW GHV SODQWHV
PLFURSURSDJpHV DSUqV DQV HQYLURQ UHSLTXDJHV 5RGULJXHV HW DO RQW
UDSSRUWp O·DXJPHQWDWLRQ GH OD IUpTXHQFH GH
YDULDQWV QDLQV GpILQLV FRPPH D\DQW XQH
LQVHUWLRQ GLIIpUHQWH GH OHXUV IHXLOOHV DSUqV
j UHSLTXDJHV HW 6DQWRV HW 5RGULJXHV
RQWREVHUYpXQHIIHWVHPEODEOHSRXUOH
FXOWLYDU¶3DFRYDQ·-DPEKDOHHWDORQW
pJDOHPHQW REVHUYp GHV UpVXOWDWV VLPLODLUHV
DSUqV j UHSLTXDJHV /·RULJLQH GHV
YDULDQWV QDLQV HVW SOXV YUDLVHPEODEOHPHQW
GXHDX[FRQGLWLRQVGHFXOWXUHLQYLWUR
,ODpWpPRQWUpTXHOHVFRQGLWLRQVGHFXOWXUH
LQ YLWUR SRXYDLHQW SURYRTXHU XQH LQVWDELOLWp
PLWRWLTXH 6KHSKHUG HW GRV 6DQWRV /D PpWK\ODWLRQ GH O·$'1 SHXW pJDOHPHQW
SURYRTXHUXQHFHUWDLQHYDULDWLRQVRPDFORQDOH
-DPHV HW DO &HV REVHUYDWLRQV
SRXUUDLHQW H[SOLTXHU OHV SURSRUWLRQV IDLEOHV
GH YDULDQWV PDLV SDV OHV IUpTXHQFHV
VXSpULHXUHV j /DQH HW /RRQH\ RQW PRQWUp TX·XQ QLYHDX pOHYp GH %$ +0 GDQV OH PLOLHX GH FXOWXUH VpOHFWLRQQH
GHV PXWDQWV QDLQV FKH] OH SRPPLHU 1RXV
VXJJpURQVTXHO·LQFLGHQFHpOHYpHGHYDULDQWV
QDLQVGDQVODPLFURSURSDJDWLRQGHEDQDQLHUV
SHXW V·H[SOLTXHU HQ SDUWLH SDU OHXU FDSDFLWp
VXSpULHXUH j SURGXLUH GHV SRXVVHV SHQGDQW
OD PLFURSURSDJDWLRQ GH IDoRQ j FH TX·LOV
UHSUpVHQWHQW XQ SRXUFHQWDJH UHODWLYHPHQW
SOXVpOHYpGHODSRSXODWLRQWRWDOHjODVXLWH
GHUHSLTXDJHVVXFFHVVLIV
5pIpUHQFHV
ÉOYDUHV 0 GR & /6 &DOGDV &UHVFLPHQWR
SURGXomR H YDULDomR VRPDFORQDO HP EDQDQHLUDV
PLFURSURSDJDGDV 3HVTXLVD $JURSHFXiULD %UDVLOHLUD
&DUYDOKR 079 ( 'HUE\VKLUH 03 0DUWLQV&RUGHU
%0- 0HQGHV $ 7XOPDQQ 1HWR ,VR]\PH
DQGGLVVRFLDWHGSURWHLQSURILOHVRIQRUPDOSODQWVDQG
VRPDFORQDO YDULDQWV RI EDQDQD REWDLQHG E\ LQ YLWUR
FXOWXUH$FWD+RUW
&{WH);-$6DQGRYDO30DULH($XERLURQ
3KHQRW\SLF YDULDWLRQ LQ PLFURSURSDJDWHG EDQDQDV
DQGSODQWDLQV&RUEDQD
&URQDXHU 66 $' .ULNRULDQ 0XOWLSOLFDWLRQ
SRWHQWLDO RI 0XVD IURP H[FLVHG VWHP WLSV$QQDOV RI
%RWDQ\
&URXFK-+'9X\OVWHNH52UWL]3HUVSHFWLYHV
RQ WKH DSSOLFDWLRQ RI ELRWHFKQRORJ\ WR DVVLVW WKH
JHQHWLF HQKDQFHPHQW RI SODQWDLQ DQG EDQDQD
0XVD VSS (OHFWURQLF -RXUQDO RI %LRWHFKQRORJ\
8QLYHUVLGDG&DWyOLFDGH9DOSDUDtVR&KLOHLVVXH
RI$SULO
'DPDVFR236:$GNLQV,'*RGZLQ0.6PLWK
8VH RI 6&$5EDVHG PDUNHU IRU WKH HDUO\
GHWHFWLRQ RI GZDUI RIIW\SHV LQ PLFURSURSDJDWHG
&DYHQGLVKEDQDQDV$FWD+RUW
'DPDVFR23,'*RGZLQ0.6PLWK6:$GNLQV
*LEEHUHOOLFDFLGGHWHFWLRQRIGZDUIRIIW\SHVLQ
PLFURSURSDJDWHG &DYHQGLVK EDQDQDV $XVWUDOLDQ -
([SHU$JUL
'UHZ5$0.6PLWK)LHOGHYDOXDWLRQRIWLVVXH
FXOWXUHG EDQDQDV LQ VRXWKHDVWHUQ 4XHHQVODQG
$XVWUDO-([SW$JU
*UDMDO0DUWLQ 0- * 6LYHULR*ULOOR $ 0DUUHUR
'RPtQJXH] 7KH XVH RI UDQGRPO\ DPSOLILHG
SRO\PRUSKLF '1$ 5$3' IRU WKH VWXG\ RI JHQHWLF
GLYHUVLW\DQGVRPDFORQDOYDULDWLRQLQ0XVD$FWD+RUW
-DPEKDOH 1' 6& 3DWLO $6 -DGKDY 69 3DZDU
%' :DJKPRGH (IIHW GX QRPEUH GH
UHSLTXDJHV VXU PXOWLSOLFDWLRQ LQ YLWUR GH TXDWUH
YDULpWpVGHEDQDQLHUV,1)2086$
-DPHV$&63HUD]D(FKHYHUULD9+HUUHUD9DOHQFLD
2 0DUWLQH] $SSOLFDWLRQ RI WKH DPSOLILHG
IUDJPHQW OHQJWK SRO\PRUSKLVP $)/3 DQG WKH
PHWK\ODWLRQVHQVLWLYH DPSOLILFDWLRQ SRO\PRUSKLVP
06$3 WHFKQLTXHV IRU WKH GHWHFWLRQ RI '1$
SRO\PRUSKLVPV DQG FKDQJHV LQ '1$ PHWK\ODWLRQ LQ
PLFURSURSDJDWHG EDQDQDV 3S LQ %DQDQD
,PSURYHPHQW &HOOXODU 0ROHFXODU %LRORJ\ DQG
,QGXFHG 0XWDWLRQV 60 -DLQ 5 6ZHQQHQ HGV
6FLHQFH3XEOLVKHUV,QF(QILHOG86$
/DQH :' 1( /RRQH\ $ VHOHFWLYH WLVVXH
FXOWXUHPHGLXPIRUJURZWKRIFRPSDFWGZDUIPXWDQWV
RIDSSOH7KHRU$SSO*HQHW
0D 66 &7 6KLL ,Q YLWUR IRUPDWLRQ RI
DGYHQWLWLRXV EXGV LQ EDQDQD VKRRW DSH[ IROORZLQJ
GHFDSLWDWLRQ -RXU &KLQHVH 6RF +RUW 6FL 0DWVXPRWR.636LOYD1HWR0LFURSURSDJDWLRQ
RI EDQDQDV 3S LQ 0LFURSURSDJDWLRQ RI
:RRG\ 7UHH DQG )UXLWV 60 -DLQ . ,VKLL HGV
.OXZHU$FDGHPLF3XEOLVKHUV'RUGUHFKW3D\V%DV
5HXYHQL 2 < ,VUDHOL 0HDVXUHV WR UHGXFH
VRPDFORQDOYDULDWLRQLQLQYLWURSURSDJDWHGEDQDQDV
$FWD+RUW
5RELQVRQ -& & )UDVHU . (FNVWHLQ $ ILHOG
FRPSDULVRQ RI FRQYHQWLRQDO VXFNHUV ZLWK WLVVXH
FXOWXUH EDQDQD SODQWLQJ PDWHULDO RYHU WKUHH FURS
F\FOHV-+RUW6FL
5RGULJXHV 3+9 $ 7XOPDQQ 1HWR 3 &DVVLHUL 1HWR
%0- 0HQGHV ,QIOXHQFH RI WKH QXPEHU RI
VXEFXOWXUHV RQ WKH VRPDFORQDO YDULDWLRQ RI EDQDQD
SODQWOHWV FY 1DQLFmR LQ 9DOH GR 5LEHLUD 63 5HY
EUDV)UXWLF&UX]GDV$OPDV
5RX[ 1 - 'ROH]HO 5 6ZHQQHQ )- =DSDWD$ULDV
(IIHFWLYHQHVV RI WKUHH PLFURSURSDJDWLRQ
WHFKQLTXHV WR GLVVRFLDWH F\WRFKLPHUDV LQ 0XVD VSS
3ODQW&HOO7LVVXHDQG2UJDQ&XOWXUH
6DQGRYDO -$ ) &{WH 3 'RXPDV ,Q YLWUR
UHFRJQLWLRQ RI KLJK VWDWXUH VRPDFORQDO YDULDQWV LQ
EDQDQDFY¶*UDQG1DLQH·0XVD$$$5HVSRQVHWR
D*$WUHDWPHQW&RUEDQD
6DQWRV &&& 3+9 5RGULJXHV 9DULDomR
VRPDFORQDO HP PXGDV PLFURSURSDJDGDV GH
EDQDQHLUD FXOWLYDU 3DFRYDQ %UDJDQWLD 6KHSKHUG.-$'RV6DQWRV0LWRWLFLQVWDELOLW\
LQEDQDQDYDULHWLHV,3ODQWVIURPFDOOXVDQGVKRRWWLS
FXOWXUHV)UXLWV
6KHSKHUG . )9' 6RX]D .0 6LOYD 0LWRWLF
LQVWDELOLW\LQEDQDQDYDULHWLHV,9%$3FRQFHQWUDWLRQ
DQG HIIHFWV RI QXPEHU RI VXEFXOWXUHV )UXLWV 9X\OVWHNH '5 6KRRWWLS FXOWXUH IRU WKH
SURSDJDWLRQ FRQVHUYDWLRQ DQG GLVWULEXWLRQ RI
0XVD JHUPSODVP ,QWHUQDWLRQDO ,QVWLWXWH RI 7URSLFDO
$JULFXOWXUH,EDGDQ1LJHULDSS
,QIR0XVD9RO1ƒ-XLQ'pFHPEUH
.D]XPLWVX0DWVXPRWR
WUDYDLOOHjO·(PEUDSD*HQHWLF
5HVRXUFHVDQG%LRWHFKQRORJ\
%UDVLOLD')%UpVLO/LQGD6W\HU
&DOGDVjO·XQLYHUVLWpGX%UpVLOj
%UDVLOLD')%UpVLOHW<RVKLWDND
<DPDPRWRj12085$%5$6
$UD[D0*%UpVLO$XWHXUSRXU
ODFRUUHVSRQGDQFH.D]XPLWVX
0DWVXPRWR&RXUULHOND]XPRWR
#FHQDJUHQHPEUDSDEU

Documents pareils

Power drive - JFMusic Sono Audio Pro

Power drive - JFMusic Sono Audio Pro 2QFHSRZHUHGXSWKHKXEORFNVLWV VLJQDORQWRWKHVSHDNHUVVRDOOWKDW·V OHIWWRGRLVSOXJWKHKXELQWR\RXU FKRVHQVRXUFHDQGDVWKHVD\LQJJRHV %RE·V\RXUPRWKHU·VEURWKHU

Plus en détail

La myélopathie cervico arthrosique

La myélopathie cervico arthrosique 6XUWRXWOHVKRPPHVGHSOXVGHDQV 0DODGLHpYROXWLYHjGpEXWLQVLGLHX[SRXYDQWDERXWLUjXQHLPSRWHQFHVpYqUH &RQMRQFWLRQGHGHX[IDFWHXUV  &DQDOFHUYLFDOpWURLWFRQJpQLWDO 'pYHORSSHPHQWGHO...

Plus en détail

ce week-end, le combat des paysans de l`aubrac

ce week-end, le combat des paysans de l`aubrac GHUpVLVWHUjODOHQWHGpFRPSRVLWLRQGHVFDPSDJQHVTXLWUDYDLOOHQWHWV DUUDFKHQWSRXUSUpVHUYHU XQHFHUWDLQHLGpHGHODYLHjODFDPSDJQHHWGXUDSSRUWDX[DQLPDX[/DSURMHFWLRQDOLHXVDPHGL ...

Plus en détail