Final_programme Winter School Are 2012

10
th
EAACI-GA²LEN
Immunology Winter School
BASIC IMMUNOLOGY RESEARCH IN
ALLERGY AND CLINICAL IMMUNOLOGY
12 – 15 February 2012
Åre, Sweden
Scientific Programme and Steering Committee
Cezmi Akdis, Davos, Switzerland (EAACI President)
Christian Virchow, Davos, Switzerland (EAACI Vice President Congress)
Pascal Demoly, Montpellier, France (EAACI Vice President Education & Specialty)
Edward Knol, Utrecht, Netherlands (EAACI Immunology Section Chairperson)
Carsten Schmid-Weber, Munich, Germany (EAACI Immunology Section Secretary)
Gunnar Nilsson, Stockholm, Sweden (EAACI Immunology Section Board Member)
Torsten Zuberbier, Berlin, Germany (GA²LEN Secretary General)
Keynote Speakers
Cezmi Akdis (Davos, Switzerland)
Bart Lambrecht (Ghent, Belgium)
Hans-Gustaf Ljunggren (Stockholm, Sweden)
Claudia Mauri (London, UK)
Juan Rivera ( Maryland, USA)
Maria Grazia Roncarolo (Milan Italy)
Faculty
Edward Knol (Utrecht, The Netherlands)
Carsten Schmid-Weber (Munich, Germany)
Gunnar Nilsson (Stockholm, Sweden)
Claudia Traidl-Hoffmann (Munich, Germany)
Liam O´Mahony (Davos, Switzerland)
Frode Jahnsen (Oslo, Norway)
Francesco Annunziato (Florence, Italy)
Local Organising Committee
Gunnar Nilsson (Stockholm, Sweden)
Edward Knol (Utrecht, The Netherlands)
EAACI Headquarters
Sladjana Scepan (Zurich, Switzerland)
10th EAACI-GA²LEN Immunology Winter School
“Basic Immunology Research in Allergy and Clinical Immunology”
12 – 15 February 2012
Åre, Sweden
Dear colleagues and friends,
Welcome to the 10th EAACI-GA²LEN Immunology Winter School “Basic Immunology Research in Allergy
and Clinical Immunology” in Åre, Sweden.
Since 2001 the Immunology Section of the EAACI has been organizing meetings for young doctoral
and postdoctoral scientists who are active in allergy and clinical immunology research. The aim of
these meetings has always been to increase the impact of basic immunology research in the fields of
allergy and clinical immunology. The previous Immunology Winter Schools have always been a great
success both from its scientific quality, but also from the point of its interactive character. With the
generous support from the EAACI Executive Committee we were are now able to organize the 10th
EAACI-GA²LEN Immunology Winter School in the Hotel Diplomat Åregården in Åre. This is the first
time that the Winter School will be in Scandinavia and not in the Alps. Åre is the biggest winter sport
area in Sweden. The skiing slopes are excellent and appealing with frequent World cup races, but also
many other Winter activities can be experienced in Åre. Moreover, the scenic Scandinavian
surrounding is inspiring for an excellent Winter school.
The meeting includes 5 oral sessions in which selected participants will present their work. These oral
sessions are Immune responses in allergic diseases models, B- and T-cell responses in allergic
diseases, Mast cell and basophil functions, Immune responses in models of allergic inflammation and
New therapeutic developments for allergic diseases.
Directly after the welcome reception and before each session there will be a keynote lecture. The list of
excellent keynote speakers this year includes: Cezmi Akdis, Davos, Switzerland, Hans-Gustaf
Ljunggren, Stockholm, Sweden, Claudia Mauri, London, U.K., Bart Lambrecht, Ghent, Belgium, Juan
Rivera, Bethesda, U.S.A. and Maria Grazia Roncarolo, Milan, Italy. This is the 10th anniversary of the
EAACI Winter Schools and hosts two special keynote speakers. Firstly, Cezmi Akdis who is the initiator
of the EAACI Winter Schools and currently the president of the EAACI. Secondly, Bart Lambrecht who
was one of the young scientists participating at the first Winter School in 2001 and is now a
distinguished researcher in the field.
We have received a large number of outstanding abstracts which were reviewed by an international
panel of 7 experts. Based on the scientific quality of the submitted abstract, 70 participants were
selected and invited. 25 abstracts will be presented as oral presentations. In addition, two poster
sessions with dessert and drinks will be arranged in which participants have the opportunity to discuss
their data with the keynote lecturers, EAACI Immunology board members and with each other. During
the day, there will be time for winter sports, other activities or sightseeing in beautiful Åre.
The goal of the meeting is to create a warm scientific environment in which allergy and asthma-related
immunological concepts can be covered with ample time for discussions and in which young scientists
have the opportunity to directly interact with well-known excellent researchers in the field. All keynote
speakers and the faculty will stay during the entire meeting for further discussions - let it be on the ski
slopes or other afternoon activities, during lunch or dinner or in the evenings at the poster session.
Remember, the meeting is a great opportunity to make friends with young scientists from all over the
world!
The organisers are looking forward to a successful meeting.
On behalf of the Organising Committee
Gunnar Nilsson
Edward Knol
10th EAACI-GA²LEN Immunology Winter School
“Basic Immunology Research in Allergy and Clinical Immunology”
12 – 15 February 2012
Åre, Sweden
PROGRAMME
Sunday, 12 February 2012
18:00
Welcome reception
18:45
Opening
Gunnar Nilsson (Stockholm, Sweden)
Edward Knol (Utrecht, The Netherlands)
19:00
Introductory KEYNOTE lecture:
Chairperson: Edward Knol (Utrecht, The Netherlands)
Mechanisms of allergy immune therapy
Cezmi Akdis (Davos, Switzerland)
20:00
Dinner
Monday, 13 February 2012
08:00 – 11:00
Session I
Chairpersons:
Hans-Gustaf Ljunggren (Stockholm, Sweden)
Liam O´Mahony (Davos, Switzerland)
08:00 – 09:00
KEYNOTE Lecture:
New features of natural killer cells - no longer just a cell that kills
Hans-Gustaf Ljunggren (Stockholm, Sweden)
09:00 – 09:20
Break
09:20 – 11:00
Immune responses in allergic diseases models (oral presentations)
1. Sphingosine 1 phosphate homeostasis affects intestinal allergen uptake and oral sensitization in a
mouse food allergy model
Susanne Diesner (Vienna, Austria)
2. Barrier functions of epidermal toll-like receptor 2 (TLR2) and its relevance for atopic dermatitis
I-Hsin Kuo (Rochester, USA)
3. The role of IL-33 in virus-induced exacerbations in a house dust mite mouse model of asthma
Suzanne Bal (Amsterdam, The Netherlands)
4. Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in allergic asthma
Roel Klein Wolterink (Rotterdam, The Netherlands)
5. Does IL-4 receptor alpha signalling through CD4+ T cells play a role in ovalbumin-induced allergic
airway disease?
Jaisubash Jayakumar (Cape Town, South Africa)
11:00 – 16:30
Break
16:30 – 19:30
Session II:
Chairpersons:
Claudia Mauri (London, UK)
Carsten Schmidt-Weber (Munich, Germany)
16:30 – 17:30
KEYNOTE Lecture:
Functions of regulatory B cells
Claudia Mauri (London, UK)
17:30 – 17:50
Break
17:50 – 19:30
B- and T-cell responses in allergic diseases (oral presentations)
6. Reduced B cell IL-10 in response to LPS in Allergic Asthma patients: an impaired Breg function?
Luciën van der Vlugt (Leiden, The Netherlands)
7. Human allergen-specific T cell clones show high heterogeneity and plasticity within the Th2 lineage
Nora Zulehner (Vienna, Austria)
8. Characterization of IL-22 producing T cells from human palatine tonsils
Marcin Wawrzyniak (Davos, Switzerland)
9. Der P 1 induces FOXP3+GATA-3+ T cells in allergic individuals
Lieke Reubsaet (Utrecht, The Netherlands)
10. Activin-A is a novel inducer of human regulatory T cells that suppress allergen-driven T helper
responses
Sofia Tousa (Athens, Greece)
19:30
Dinner
21:00
Poster session I
Chairpersons:
Bart Lambrecht (Ghent, Belgium)
Juan Rivera (Bethesda, USA)
Claudia Mauri (London, UK)
Liam O´Mahony (Davos, Switzerland)
Mouse models
11. Mice deficient in an asthma candidate gene have increased epithelial denudation, remodeling and
airway hyperresponsiveness in a model of airway epithelial damage
Simon G Royce (Parkville, Australia)
12. Naso-ocular interaction in a mouse model of rhinoconjunctivitis
Ina Callebaut (Leuven, Belgium)
13. Defective anti-bacterial immunity in the allergic lung
Maryam Habibzay (London, UK)
14. Combined nasal exposure to hypochlorite and ovalbumin induces airway hyperreactivity in mice
through activation of the TRPA1 channel and mast cells
Valerie Hox (Leuven, Belgium)
15. The role of placental growth factor in allergic asthma
Sonja Bobic (Leuven, Belgium)
16. Impact of cutaneous exposure in the development of IgE-mediated allergy to cow's milk
Sophie Wavrin (Paris, France)
17. Application of small dose of Hsp70 is able to prevent manifestation of allergic airway inflammation
in an animal model of asthma
Ekaterina Servuli (Moscow, Russia)
Food allergy
18. Influence of the Maillard reaction on immunogenicity and allergenicity of food allergens
Monika Heilmann (Langen, Germany)
19. Pru p 3 is transported intact across gastrointestinal epithelia-An essential step towards the
induction of food allergy?
Leticia Tordesillas Villuendas (Madrid, Spain)
20. Validation of a murine cow’s milk allergy model to assess the potential allergenicity of cow’s milk
based infant hydrolysates – first results of a ring trial
Prescilla Jeurink (Utrecht, The Netherlands)
21. IgE cross-reactivity between Bet v 1 and the mung bean proteins cytokinin-specific binding protein
and Vig r 1 in patients with birch pollen-associated allergy to mung bean sprouts Eva Elisabeth Guhsl
(Vienna, Austria)
Mast cells and basophils
22. Effects of IL-4 and IgE on the surface expression of FcepsilonRI on peripheral blood-derived human
mast cells
Inge Kortekaas Krohn (Copenhagen, Denmark)
23. Can respiratory infections recruit mast cell progenitors, and if so, does this contribute to the
common exacerbations of allergic asthma seen after respiratory infections?
Cecilia Söderberg (Uppsala, Sweden)
24. Induction of IL-4 by active Def f 1 in bone marrow-derived basophils
Myung-hee Yi (Seoul, Korea)
Immune responses
25. Comparison of complement activation and regulatory protein levels in asthmatic and COPD sputa
Zsoka Weiszhar (Budapest, Hungary)
26. Immune response of human leukocytes to the xenogenic molecule Neu5Gc
Remo Frei (Davos, Switzerland)
27. Investigation of the interaction between c-type lectin receptors and arabinogalactans
Patrick Guidato (Bochum, Germany)
28. The activity and expression of the immunomodulatory enzyme, Indoleamine 2,3 dioxygenase, in
asthma, allergic rhinitis and chronic rhinosinusitis
Annika Luukkainen (Tampere, Finland)
29. Cytosolic phospholipase A2 group IVA is activated by hyaluronan in murine macrophages and in
primary human monocytes
Milena Sokolowska (Bethesda, USA)
30. Role of Treg in allergic inflammation by Aspergillus fumigatus
Claudio Henríquez (Valdivia, Chile)
31. NetMHCcons: a consensus method for the major histocompatibility complex class I predictions
Edita Karosiene (Kgs. Lyngby, Denmark)
Skin inflammations
32. Impact of proteasome inhibitor treatment on allergen induced atopic eczema mice
Kiran Kumar Mudnakudu (Berlin, Germany)
33. Patients with chronic mucocutaneous candidiasis are characterized by gain-of-function STAT1
mutations
Julia Hiller (Munich, Germany)
Tuesday, 14 February 2012
08:00 – 11:00
Session III
Chairpersons:
Bart Lambrecht (Ghent, Belgium)
Claudia Traidl-Hoffmann (Munich, Germany)
08:00 – 09:00
KEYNOTE Lecture:
Dendritic cells and epithelial cells as regulators of allergic airway
inflammation
Bart Lambrecht (Ghent, Belgium)
09:00 – 09:20
Break
09:20 – 11:00
Immune responses in models of allergic inflammation (oral
presentations)
34. Regulation of Bronchial Epithelium Integrity and Tight Junctions by Regulatory T cells in allergic
airway disease
Kerstin Wanke (Davos, Switzerland)
35. Mast cell-engraftment of the peripheral lung increases airway hyperresponsiveness in an asthma
model
Lisa Sjöberg (Stockholm, Sweden)
36. CD11c+ cells are required for mast cell progenitor recruitment to lung in a mouse model of allergic
airway inflammation
Joakim Dahlin (Uppsala, Sweden)
37. Alternative activation of macrophages during allergic airway inflammation alters their antigen
presenting capacities
Carla Winkler (Hannover, Germany)
38. Signaling at the level of dendritic cells upon specific recognition of the major birch pollen allergen
Bet v 1 indicates different response mechanisms in allergic and healthy individuals
Ursula Smole (Vienna, Austria)
11:00 – 16:30
Break
16:30 – 19:30
Session IV:
Chairpersons:
Juan Rivera (Bethesda, USA)
Gunnar Nilsson (Stockholm, Sweden)
16:30 – 17:30
KEYNOTE Lecture:
Regulatory and effector functions of mast cells
Juan Rivera (Bethesda, USA)
17:30 – 17:50
Break
17:50 – 19:30
Mast cell and basophil functions (oral presentations)
39. Single cell dynamics of Mast cell-CD4+/CD25+ regulatory T cell interaction
Federica D'Incà (Udine, Italy)
40. Human mast cell responses to injured airway epithelial cells - implications for chronic airway
inflammation
Mattias Enoksson (Stockholm, Sweden)
41. Increased mast cell numbers in alveolar parenchyma in infants with respiratory viral infections
Cecilia Andersson (Lund, Sweden)
42. Human basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1
Claudia Kitzmueller (Vienna, Austria)
43. Human basophils produce IL-5 and IL-9 by IgE-independent mechanisms
Britta Poulsen (Copenhagen, Denmark)
19:30
Dinner
21:00
Poster session II
Chairpersons:
Hans-Gustaf Ljunggren (Stockholm, Sweden)
Francesco Annunziato (Florence, Italy)
Cezmi Akdis (Davos, Switzerland)
Frode Jahnsen (Oslo, Norway)
Allergens
44. Adjuvant activity of low molecular-weight, non-protein fraction of aqueous birch pollen extracts an in vivo analysis
Stefanie Gilles (Munich, Germany)
45. Structural and immunological characterization of Phl p 4, a major pollen allergen
Domen Zafred (Graz, Austria)
46. Analysis of the complement activating ability of different types of allergens
Dorottya Csuka (Budapest, Hungary)
47. Grafting of Bet v 1 epitopes onto its celery homologue Api g 1 reveals patient-specific IgE
recognition profiles
Barbara Gepp (Vienna, Austria)
48. Defining the significance of IgE epitopes on the surface of the major birch pollen allergen Bet v 1
using scFv antibodies
Daniela Ackerbauer (Vienna, Austria)
49. Crystal structure of the first allergenic lipid-transfer protein from pollen: Artv3 as role model to
resolve conformational epitopes relevant for LTP-allergic patients
Eva Vejvar (Salzburg, Austria)
50. Characterization of Red Kidney Bean (Phaseolus vulgaris L.) Allergens and Their Allergenic
Potential Using BALB/c Mice and Allergic Patients
Sandeep Kumar (Lucknow, India)
51. Dog saliva – a source of allergens
Konrad Wadén (Stockholm, Sweden)
Immunotheraphy
52. Pru p 3 mutants exhibit low IgE- binding capacity: a good strategy for specific peach
immunotherapy
Cristina Gómez-Casado (Madrid, Spain)
53. Generation of a hybrid protein as a novel therapeutic for Fagales immunotherapy
Ulrike Pichler (Salzburg, Austria)
54. Diversity of epitope recognition of IgG4 antibodies induced by birch-pollen specific immunotherapy
Brinda Subbarayal (Vienna, Austria)
55. Evaluation of Immunogenicity and safety aspects of Adeno-associated virus-like particles (AAVLPs)
as carriers for B-cell vaccines in an OVA-allergy model
Josef Singer (Vienna, Austria)
56. Treatment with synthetic β-lactoglobulin peptides can prevent clinical symptoms in a mouse model
for cow’s milk allergy
Laura Meulenbroek (Utrecht, The Netherlands)
57. Predictions of conformational B-cell epitopes using 3 dimensional protein structures
Jens Kringelum (Copenhagen, Denmark)
58. Anti-inflammatory effects of a polyglycerolsulfate on allergic type I and type IV reactions in mice
Julia Trosien (Berlin, Germany)
Diagnostics and monitoring
59. The role of alpha-Gal in systemic allergic reactions to meat
Dagmar Kollmann (Vienna, Austria)
60. Detection of auto-reactive IgE in young children using a high-throughput screening assay
Tanja Seher (Munich, Germany)
61. Short-time cold dry air exposure represents a useful diagnostic tool for nasal hyperresponsiveness,
and is associated with mast cell degranulation in AR patients.
Laura Van Gerven (Leuven, Belgium)
62. High basophil allergen sensitivity (CD-sens) is associated with severe allergic asthma in children
Jon Konradsen (Stockholm, Sweden)
63. IgA2 in saliva correlates with reduced severity of clinical symptoms to house dust mite allergens
Gerco den Hartog (Wageningen, The Netherlands)
64. Study of cAMP changes during specific IgE desensitization
Ibon Eguíluz (Madrid, Spain)
65. High β-defensin levels in colostrum are associated with the emergence of allergy in children
Emma Savilahti (Helsinki, Finland)
Wednesday, 15 February 2012
08:00 – 11:00
Session V
Chairpersons:
Maria Grazia Roncarolo (Milan, Italy)
Francesco Annunziato (Florence, Italy)
08:00 – 09:00
KEYNOTE Lecture:
Regulatory T cell immunotherapy
Maria Grazia Roncarolo (Milan, Italy)
09:00 – 09:20
Break
09:20 – 11:00
New therapeutic developments for allergic diseases (oral presentations)
66. Effects of vitamin D deficiency during early life on the development of neonatal house dust mite
induced allergic airways disease
Jessica Vasiliou (London, UK)
67. A high fat diet prevents oral tolerance induction and enhances allergic symptoms in a mouse
model for cow’s milk allergy
Lieke van den Elsen (Utrecht, The Netherlands)
68. Recombinant Modified Vaccinia Virus Ankara as an Allergy Vaccine Candidate
Christof Bohnen (Langen, Germany)
69. Transcutaneous immunisation with the TLR 7 ligand R848 combined with birch pollen allergen Bet
v 1 prophylactically suppressed allergen-specific IgE production by induction of predominant TH1
responses
Susanne Siebeneicher (Langen, Germany)
70. Exosomes loaded with alpha-galactosylceramide amplify innate and adaptive immunity via iNKT
cells
Stefanie Hiltbrunner (Stockholm, Sweden)
11:00 – 11:30
Wrap up and Farewell