Latest project report
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Latest project report
Global Emerging Fungal Infection Registry Initiated in 2003 Report June 2015 Working group of the Under the auspices of Supported by unrestricted grants from Astellas Pharma, Gilead Sciences, Merck, and Pfizer TABLE OF CONTENTS INTRODUCTION 3 CURRENT RESULTS 7 PUBLIC RELATION ACTIVITIES 13 ACHIEVEMENTS AND GOALS 14 PRESENTATIONS 2012 - 2015 PUBLICATIONS AWARDS ACCOMPLISHMENTS GOALS FOR 2015 14 15 16 16 16 CONTACT INFORMATION 17 STUDY COORDINATORS 18 ACTIVE PARTNERS 21 FUNGISCOPE MEMBERS 29 Report June 2015 2 Introduction The incidence of invasive fungal disease (IFD) is increasing in all parts of the world. The etiology for this ongoing epidemiological development is not completely understood. However, major contributing factors are the increasing number of transplantation procedures undertaken around the world (estimated at 500,000 per year), a widening of the indications for intensive chemotherapy, and the growing number of other clinical conditions requiring immunosuppressive treatment. Therapeutic standards have been developed for the most frequent IFD, i.e. candidiasis, aspergillosis and cryptococcosis. However, the so called “emerging fungi” are also a reason for the increased number of IFDs. Thus, clinicians are now facing infections due to a variety of different fungi without any reliable treatment recommendations and therapeutic decision making is not evidencebased. Prevalence of “emerging fungi” is virtually unknown and there is an additional knowledge gap in pathogen biology, since isolates have not been collected systematically. These shortcomings have been described in detail in the recent Clinical Practice Guidelines of the European Fungal Infection Study Group (ESCMID-EFISG) and the European Confederation of Medical Mycology (ECMM). In order to help alleviate the lack of knowledge on epidemiology, clinical course, biology and pathomechanisms, and finally to aid in facilitating an evidence based diagnostic-therapeutic integrated approach of IFD caused by “emerging fungi”, Fungiscope™ - A Global Emerging Fungal Infection Registry has been created in 2003. FungiScope™ uses a web-based electronic case form accessible via www.fungiscope.net. For inclusion into the registry cultural, histopathological, serological or molecular evidence of IFD and associated clinical symptoms and signs are required. The clinical data on underlying disorder and IFD are entered through a web-based interface. Ideally, the pathogen isolated and samples of infected tissue are collected, examined and stored in a bio-bank called FungiThek. The clinical and biological data are subsequently evaluated and analysed. Figure 1a and b present the data / sample flow and overall project structure, respectively. The clinical database and the bio-bank are connected, and anonymized data are easily accessable via a web-based search engine FungiQuest (Figure 2). In the following report we introduce the most current results and achievements. We also discuss future goals and ongoing developments of the project. Report June 2015 3 Figure 1a. Project structure. Report June 2015 4 Isolate FungiThek 1. Shipment to: Prof. Cornely Cologne, GER or 2. Shipment to: Central Lab in your country For < reference analysis: Biopsy & Labor Dr. Wisplinghoff Morphological ID Sequencing & MALDI-TOF Shipment to: Prof. Cornely Cologne, GER Sequencing and Ribosomal RNA FISH Isolate Collection in Cologne Research Morphological ID Sequencing & MALDI-TOF Isolate Collection at central lab Results are documented in the database by the FungiScope.Team Figure 1b. Material flow. Fungal isolates can be send 1.) to Prof. Cornely to Cologne, Germany for formal identification and biobanking in the FungiThek or 2.) to the reference lab in your country (please see in section Study Coordinators below). Bottom: Reference analyses from biopsies will be performed at the Robert Koch Institute in Berlin, Germany. Report June 2015 5 Found a fungus you know nothing about? Go to www.fungiquest.net Type the name of the fungus into the search box Browse through FungiScope cases with the same kind of fungal infection Figure 2. FungiQuest database search engine. Report June 2015 6 Current Results Until now, 444 cases have been documented and considered valid. The most frequently registered pathogens were mucoromycotina (n=201; 45.3%), Fusarium spp. (n=65; 14.6%), yeasts (n=56; 12.6%), and Dematiaceae (n=50; 11.3%) followed by Scedosporium spp. (n=21; 4.7 %) and Penicillium spp./Paecilomyces spp. (n=20; 4.5%) (Figure 3). The contribution of cases by country is shown in Figure 4. A list of major contributors is given in Figure 5, whereby the majority of cases has been documented by central laboratories that have an intermediary function between contributors from their country and FungiScope. The majority of documented patients were Caucasian (71%) followed by Asian (23%) and North/South American Indian origins (2%) (Figure 6). Sites of infection differ among pathogens (Figure 7). In patients with invasive mucormycosis, the lungs were the most commonly involved organs with an incidence of 70.1%. Other involved sites were the paranasal sinuses (21.4%), deep soft tissues (14.9%) and the central nervous system (13.4%). Fusarium spp. infections most frequently presented as blood stream infections (46.2%) or skin infections (46.2%). Other commonly affected sites were lungs (36.9%) and deep soft tissues (21.5%). Infections with Dematiaceae mostly involved the paranasal sinuses, eyes, deep soft tissues, lungs, and skin (range from 12.2% to 28.6%). Yeasts were most often diagnosed from blood cultures (67.9%) followed by pulmonary infections (30.4%). The evaluation of risk factors for the development of IFD revealed differences between individual pathogens shown in Figure 8. The most common risk factors for developing an infection with Mucorales and Fusarium spp. were chemotherapy (55.9% and 56.9%, respectively) or haematopoetic stem cell transplantation (HSCT) (31.6% and 29.2%, respectively) followed by Intensive Care Unit (ICU) stay (26.4% and 20%, respectively) and diabetes mellitus (16% and 17%, respectively). In patients presenting with yeast infections chemotherapy was also the most common risk factor (53.6%). In addition, 37.5% of patients were treated in intensive care units. Other risk factors were haematopoetic stem cell transplantation (21.4%), diabetes mellitus (14.3%), chronic pulmonary disease (12.5%), and solid organ transplantation (8.9%). By contrast, patients with a Dematiaceae infection presented most frequently with diabetes mellitus (42%) and/or chronic renal disease (12%). All-cause-mortality, mortality due to fungal infection and response to treatment differed among individual pathogens and are shown in Figure 9. The highest allcause-mortality was observed in patients with mucoromycosis (56.5%), followed by patients with yeast (55.4%) and Fusarium spp. infections (49.2%). When looking at the mortality due to the fungal infection it was highest in infections caused by Mucorales (43.8%) followed by Fusarium spp. (36.9%) and yeast (38.2%). By contrast, the lowest all-cause-mortality was revealed in patients with Dematiaceae, equaling only 12.2%. Just 4% of these deaths was due to the fungal infection. The highest rates of complete and partial remissions were observed in patients with IFD Report June 2015 7 caused by Dematiaceae and Fusarium spp (74% and 50.8%, respectively). Patients with a Mucorales infection displayed the lowest rate of response to treatment (38.8%) followed by yeast (48.2%). In conclusion, the clinical relevance of invasive fungal infections by emerging fungi is increasing. Over the past 10 years a large number of cases from several countries world-wide could be documented and showed a broad spectrum of pathogens. Further investigators and coordinators are encouraged to contribute to the success of FungiScope™. 21 31 20 201 50 Mucorales Fusarium Yeast Dematiaceae Penicillium/Paecilomyces Scedosporium Others 56 65 Figure 3. Distribution of 444 pathogens by major group. Figure 4. FungiScope has collaborators from 63 countries. Report June 2015 8 20% 15% 10% 5% 0% Figure 5. List of major contributors including three central laboratories in the Czech Republic (Z. Racil), India (A. Kindo) and Russia (N. Klimko). 3% 1% 2% 23% 71% Caucasian Asian American Indian or Alaska Native Sub-Saharan African/Afro-American Other Figure 6. Distribution of major ethnic subgroups. Report June 2015 9 Fusarium (n=65) Mucorales (n=201) Lungs 70% Paranasal sinus(es) Deep soft tissues 23% 15% CNS 14% Bones 12% Skin 11% Gastrointestinal tract 11% Blood 46% Skin 46% Lungs Deep soft tissues 22% Paranasal sinus(es) 17% Eyes 17% Dematiaceae (n=50) Yeasts (n=56) Blood 68% Lungs 37% Paranasal sinus(es) 29% Eyes 30% 22% CNS 14% Deep soft tissues 16% Liver 14% Lungs 16% Kidneys Skin 13% 12% Figure 7. Sites of infection for major groups of fungi. (CNS, Central Nervous System) Report June 2015 10 Fusarium (n=65) Mucorales (n=201) Chemotherapy Chemotherapy 56% HSCT HSCT 32% ICU stay Diabetes mellitus 16% Yeasts (n=56) 54% 17% Diabetes mellitus 42% 38% HSCT 21% Diabetes mellitus Chronic pulmonary disease 20% Dematiaceae (n=50) Chemotherapy ICU stay 29% ICU stay 26% Diabetes mellitus 57% Chemotherapy 14% 14% 13% Major surgery 9% Solid organ transplantation 9% Chronic renal disease 12% Solid organ transplantation 12% Figure 8. Most important risk factors for major groups of fungi. (HSCT, Hematopoietic stem cell transplantation; ICU, Intensive Care Unit) Report June 2015 11 74% 57% 55% 51% 49% 48% 44% 37% 39% 38% 12% 4% Mortality Mucorales Mortality due to IFI Fusarium Yeasts Favourable outcome Dematiaceae Figure 9. Mortality rates and outcome for major groups of fungi. Favorable outcome is defined by complete or partial response. Report June 2015 12 Public Relation Activities We were pleased to present FungiScope at ICAAC 2013 in Denver at a booth in the exhibition hall. There we offered information about the project in pamphlets as well as reminders of the activity (Fungiscope pens and post-it pads). Over the 3 days of the convention, an estimated 100 conversations, either brief or more in-depth, were held about the project with interested booth visitors. The majority of visitors, who were mainly clinicians or microbiologists, had never heard of Fungiscope, and many commented that there is a definite need for this registry and were happy to realize that it exists and could be a receptacle for cases from their institution. Approximately 250 flyers were taken, along with 500 pens and 250 post-it pads. Karen Pankraz, TA from our team, was at the booth fulltime to welcome inquiries and distribute information. Additionally, Dr. Wahlers, Dr. Vehreschild and Prof. Cornely were often present to answer specific and in-depth questions about the project. Where appropriate, contact information was collected for future collaboration. Overall, this was a positive experience for our team—many inquiries, much positive feedback. Report June 2015 13 Achievements and Goals Presentations 2012 - 2015 April 25 – 28, 2015 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Kopenhagen, Denmark March 19 – 21, 2015 ESCMID Postgraduate Education Course Diagnosis and Management of Fungal Infections Both in the West and the East, Delhi, India October 13 – 15, 2014 Research for Rare - Translational Science Meeting, Munich, Germany September 5 – 9, 2014 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, USA June 25 – 28, 2014 Kongress für Infektionskrankheiten und Tropenmedizin (KIT), Köln, Germany June 15 – 16, 2014 Symposium on Infections in the immunocompromised hosts, International Immunocompromised Host Society (ICHS), Berlin, Germany May 10 – 13 , 2014 24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Barcelona, Spain January 10 – 12, 2014 10th National Conference of the Society for Indian Human and Animal Mycologists (SIHAM), Coimbatore, Tamil Nadu, India October 11 – 14, 2013 6th Trends in Medical Mycology (TIMM), Copenhagen, Denmark September 22 – 25, 2013 Joint Annual Meeting of the German Society for Hygiene and Microbiology and the German Society for Infectious Diseases (DGI), Rostock, Germany September 9 – 13, 2013 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Denver, CO, USA September 5 – 7, 2013 47th Congress of the German Society for Mycology (DMykG e.V.), Tübingen, Germany April 27 – 30, 2013 23rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Berlin, Germanyhttp://www.orpha.net/consor/cgibin/OC_Exp.php?lng=DE&Expert=431758 Report June 2015 14 Publications November 2013 May 2013 January 2013 October 2011 December 2009 July 2008 Nucci M, Marr K, Vehreschild M, de Souza C, Velasco E, Cappelano P, Carlesse F, Queiroz-Telles F, Sheppard D, Kindo A, Cesaro S, Hamerschlak N, Solza C, Heinz W, Schaller M, Atalla A, Arikan-Akdagli S, Bertz H, Castro Jr C, Herbrecht R, Hoenigl M, Härter G, Hermansen NE, Josting A, Pagano L, Salles M, Mossad SB, Ogunc D, Pasqualotto A, Araujo V, Troke P, Lortholary O, Cornely O, Anaissie E. Improvement in the outcome of invasive fusariosis in the last decade. Clin Microbiol Infect. 2014 Jun; 20(6):580-5. Epub 2013 Nov 18. Pagano L, Cornely O, Caira M, Cesaro S, Gasbarrino C, Girmenia C, Heinz WJ, Herbrecht R, Lass-Flörl C, Nosari A, Potenza L, Racil Z, Rickerts V, Sheppard DC, Simon A, Ullmann AJ, Valentini CG, Vehreschild JJ, Candoni A, Vehreschild MJ. Combined antifungal approach for the treatment of invasive mucormycosis in patients with hematological diseases: a report from the SEIFEM and FUNGISCOPE registries. Haematologica. 2013 Oct; 98(10):e127-30. Epub 2013 May 28. Christopeit M, Lindner A, Surov A, Weber T, Vehreschild MJ, Bialek R, Schmoll HJ. Right flank pain and high fever in a neutropenic patient with acute lymphoblastic leukaemia. Mycoses 2013, Jan; 56(1):90-92 de Hoog GS, Robert V, Lackner M, Vehreschild MJ, Vehreschild JJ, Symoens F, Göttlich-Fligg E, GarciaHermoso D, Harun A, Meyer W, Chen SC, Hamprecht A, Fischer G, Buzina W, Cornely OA, Guarro J, Cano J, Horré R. Making moulds meet. Information retrieval as a basis for understanding Pseudallescheria and Scedosporium. Mycoses. 2011 Oct;54 Suppl 3:1-4 M.J.G.T. Rüping, W.J. Heinz, A.J. Kindo, V. Rickerts, C. Lass-Flörl, C. Beisel, R. Herbrecht, Y. Roth, G. Silling, A.J. Ullmann, K. Borchert, G. Egerer, J. Maertens, G. Maschmeyer, A. Simon, M. Wattad, G. Fischer, J.J. Vehreschild, O.A.Cornely Forty-one Recent Cases of Invasive Zygomycosis from a Global Clinical Registry. J Antimicrob Chemother. 2010 Feb;65(2):296-302 Rüping M.J.G.T., Albermann N., Ebinger F., Burckhard I., Beisel C., Müller C., Vehreschild J.J., Kochanek M., Fätkenheuer G., Bangard C., Ullmann A.J., Herr W., Kolbe K., Hallek M., Cornely O.A. Posaconazole concentrations in Report June 2015 15 the central nervous system. J Antimicrob Chemother. 2008 Dec;62 (6):1468-70 Awards Young Investigator Award 2010 (Nachwuchsförderpreis) of the German Society for Mycology (DMykG e.V.) awarded to Dr. M.J.G.T. Vehreschild for her work on FungiScope Accomplishments Booth in exhibit hall of 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Denver, CO, USA (September 9 – 13, 2013) Database restructuring including: o Harmonizing different wording used for documentation o Implementation of new taxonomy o Structural adjustments facilitating data export and analysis o Incorporation of FungiThek into the database Optimization of workflow for centralized reference analysis of fungal isolates New web presence on the Research for Rare website www.research4rare.de New web presence as an Expert center for rare mycosis on the Orphanet - The portal for rare diseases and orphan drugs website www.orpha.net New ethics votum approved by Cologne Ethics committee Goals for 2015 Launch of new CRF with renewed votum of the ethics committee Extending the FungiQuest™ platform (launched in April 2010) o Faster inclusion of new cases o Inclusion of FungiThek / isolate information o Improved search-engine cross linking old and new taxonomy Report June 2015 16 Contact Information Chair Oliver A. Cornely, MD, FACP, FIDSA, FAAM [email protected] Project coordinator Danila Seidel, PhD [email protected] Coordinating physicians Maria J.G.T. Vehreschild (née Rüping), MD [email protected] Kerstin Wahlers, MD [email protected] Reviewing physicians Philipp Köhler, MD [email protected] Blasius Liss, MD [email protected] Luisa Duran Graeff, MD [email protected] Reviewing documentarist Frank Mueller [email protected] Technical advisor, site operator clinicalsurveys.net Jörg J. Vehreschild, MD [email protected] Universität zu Köln Infectious Diseases – Clinical Trials Unit II Herderstrasse 52-54 50931 Köln Germany T +49-221-478-6494 F +49-221-478-3611 www.fungiscope.net Report June 2015 17 Study Coordinators Clinical ID Austria Microbiology Molecular Biology Elisabeth Presterl, MD Allgemeines Krankenhaus Universitätskliniken Wien Währinger Gürtel 18-20 1090 Wien T +43-1-40400-4440 F +43-1-4400-4418 elisabeth.presterl@meduniwie n.ac.at Cornelia Lass-Flörl, MD Institute of Hygiene, Microbiology and Social Medicine Universität Innsbruck Fritz-Pregl-Str. 3 6020 Innsbruck T +43-512-9003-70725 F +43-512-9003-73700 [email protected] Walter Buzina, MD Institut für Hygiene Medizinische Universität Universitätsplatz 4 8010 Graz T +43-316-380-7719 F +43-316-380-9648 [email protected] Iva Kocmanova, MD Dept. of Microbiology University Hospital Brno, Jihlavska 20 62500 Brno T +420 53223 2974 [email protected] Martina Lengerova, MD Dept. of Internal Medicine Hemato-Oncology University Hospital Brno Jihlavska 20 62500 Brno T +420 53223 3642 [email protected] Pharmacology Pathology Ulrich Strasser. MD Institut für Pathologie Medizinische Universität Innsbruck Müllerstr. 44 A-6020 Innsbruck T +43-512-9003-71304 F +43-512-582-088 [email protected] Brazil Marcio Nucci, MD Hospital Universitário Universidade Federal do Rio de Janeiro Av. Brigadeiro Trompovsky 21941-590 Rio de Janeiro T +55-21-2562-2463 [email protected] Czech Republic Zdeněk Ráčil, MD Dept. of Internal Medicine Hemato-Oncology University Hospital Brno Jihlavska 20 62500 Brno T +420-53223-2830/3642 F +420-53223-3603 [email protected] Report June 2015 Mojmir Moulis, MD Dept. of Pathology University Hospital Brno Jihlavska 20 62500 Brno T +420 53223 1111 [email protected] Ludmila Malaskova, MD Dept. of Biochemistery University Hospital Brno Jihlavska 20 62500 Brno T. +420 53223 3073 [email protected] 18 Clinical ID Germany Microbiology Molecular Biology Pharmacology Pathology Oliver A. Cornely, MD, FIDSA, FACP Klinikum der Universität Klinik I für Innere Medizin 50924 Köln T +49 221 478-6494 F +49 221 478-3611 [email protected] Hilmar Wisplinghoff, MD Klinikum der Universität Institut f. Mikrobiologie, Immunologie u. Hygiene Goldenfelsstr. 19-2 50935 Köln T +49 221 478 32023 [email protected] Ralf Bialek, MD MVZ Labor Dr. Krause Steenbeker Weg 25 24106 Kiel T +49-431 388 252 [email protected] Fedja Farowski, Biochemist Klinikum der Universität Institut für Pharmakologie 50924 Köln T +49 221 478 87275 F +49 221 478 3611 [email protected] Birgid Markiefka Klinikum der Universität Institut für Pathologie 50924 Köln [email protected] Volker Rickerts, MD Robert Koch Institute Postbox: 650280 13302 Berlin T +49 30 18754 2862 [email protected] India Anupma Jyoti Kindo, MD Dept. of Microbiology Sri Ramachandra Medical College/Research Institute No.1, Ramachandra Nagar Porur, Chennai, 600 116 T +91 944 523-9196 [email protected] Anuradha Chowdary Department of Medical Mycology Vallabhbhai Patel Chest Institute University of Delhi Delhi 110 007 T +91 11 2766 7560 [email protected] Report June 2015 19 Clinical ID Israel Microbiology Molecular Biology Pharmacology Pathology Maurizio Sanguinetti, MD Istituto di Microbiologia (Roma) Università Cattolica del Sacro Cuore Largo Francesco Vito 1 00168 Roma T +39-06-3015-4964 F +39-06-3051-152 [email protected] Annamaria Tortorano, MD Dip. Sanità PubblicaMicrobiologia-Virologia Milano Università di Milano Via Pascal, 36/38 20133 Milano T +39-2-503-15145 F +39-2-503-15146 [email protected] t Andrea Novelli, MD Dipartimento di Farmacologia Università degli Studi di Firenze Viale Pieraccini, 6 50139 Firenze T +39-055-4271-286 F +39-055-4271-280 [email protected] Gianluigi Vago, MD Department of Clinical Sciences Luigi Sacco Hospital University of Milan Via Pascal, 36/38 20133 Milano T +39 0285994869 F +39 0285994800 [email protected] Morad Wattad, MD Rabin Medical Center Infectious Diseases Unit 39 Jabotinski St. 49100 Petah Tikva T +972-3-937-7377 F +972-3-937-6365 [email protected] Italy Livio Pagano, MD Dipartimento di Ematologia Universita Cattolica del Sacro Cuore (Roma) Largo Francesco Vito 1 00168 Roma T +39-6-355-03953 F +39-630-51343 [email protected] Turkey Sevtap Arikan-Akdagli, MD Mycology Laboratory (Ankara) Hacettepe University 06100 Ankara F +90 (312) 3115250 [email protected] Report June 2015 20 Active Partners Australia Melbourne Royal Melbourne Hospital Royal Melbourne Hospital Infectious Diseases Clinical Centre of Excellence in Infectious Diseases Nenad Macesic Monica Slavin Westmead Westmead Hospital Molecular Mycology Research Laboratory Sharon Chen Department of Internal Medicine, Joint Facilities, Division of Pulmonology Martin Hoenigl Division of Hygiene und Medical Microbiology (HMM) Cornelia Lass- Flörl Klinisches Institut für Hygiene und Medizinische Mikrobiologie Birgit Willinger Austria Graz Medical University of Graz Innsbruck Innsbruck Medical University Wien AKH Wien Belgium Leuven University Hospitals Leuven University Hospitals Leuven University Hospitals Leuven Brazil Curitiba Hospital de Clinicas, Federal University of Paraná Porto Alegre Universidade Federal do Rio Grande do Sul (UFRGS) Universidade Federal do Rio Grande do Sul (UFRGS) Canada Montreal Université de Montréal McGill University Department of Pharmaceutical and Pharmacological Science Laboratory of Clinical Bacteriology and Mycology Department of Haematology Laboratory of Mycology Department of Paediatrics Department Molecular Diagnostic Laboratory CHU Sainte-Justine, Pédiatres infectiologues Department Microbiology and Immunology Isabel Spriet Edith Vermeulen Johan Maertens Flavio de Queiroz Telles Denise Pereira Alessandro Pasqualotto Philipe Ovetchkine Don Sheppard China Beijing Peking University First Hospital Department of Dermatology Jin Yu Peking University of People's Hospital Institute of Hematology Xiao-Dong Mo Affiliated Hospital to Academy of Military Medical Sciences Department of Hematopoietic Stem Cell Transplantation Yongfeng Su Report June 2015 21 Guangzhou Sun Yat-Sen University Hangzhou Zhejiang University Shanghai Huashan Hospital, Fudan University Cuba Habana Instituto de Hematologia e Imunologia Czech Republic Brno University Hospital Brno Department of Dermatology Xi Liyan Pulmonary Department Zhang Jin Department of Infectious Diseases Liping Zhu Alberto Arencibia Núñez Department of Internal Medicine HematoOncology Zdenek Racil Department of Haematology Emil Hermansen Department of Medical Microbiology and Immunology Jarmo Oksi Réanimation Polyvalente Gaëtan Plantefève Denmark Copenhagen Copenhagen Finland Turku Turku University Hospital France Argenteuil Centre Hospitalier d’Argenteuil Rouen Centre Henri Becquerel Centre Henri Becquerel Department of Haematology Department of Haematology Vincent Camus Stephane Lepretre Saint-Mande Fédération de biologie clinique Hôpital d’instruction des armées Bégin Frederic Janvier Hôpital de Hautepierre, Department of Oncology and Hematology Raoul Herbrecht Strasbourg University Hospital of Strasbourg Germany Aachen Uniklinik RWTH Aachen Uniklinik RWTH Aachen Medizinische Klinik IV, Klinik für Onkologie, Hämatologie und Stammzelltransplantation Medizinische Klinik IV, Klinik für Onkologie, Hämatologie und Stammzelltransplantation Joachim Böhm Carolin Becker Berlin Robert Koch Institut Charité - Universitätsmedizin Berlin Charité - Universitätsmedizin Berlin Abteilung für Infektionskrankheiten Universitätsklinik für Allgemein-, Viszeral-, Gefäß- und Thoraxchirurgie Universitätsklinik für Allgemein-, Viszeral-, Report June 2015 Volker Rickerts Sebastian Friese Barbara Korinth 22 Charité - Universitätsmedizin Berlin Charité Universitätsmedizin Campus Benjamin Franklin Gefäß- und Thoraxchirurgie Center for Cardiovascular Research (CCR) Medizinische Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie Oskar Wischnewski Stefan Schwartz Dresden University Hospital Dresden Medizinische Klinik und Poliklinik I Nael Alakel Abteilung Pneumologie und Infektiologie Stefanie Später Pädiatrische Stammzelltherapie Roland Meisel Dortmund Klinikum Dortmund Nord Düsseldorf Universitätsklinikum Düsseldorf Erlangen Universitätsklinikum Erlangen Universitätsklinikum Erlangen Universitätsklinikum Erlangen Medizinische Klinik 5 – Hämatologie und Internistische Onkologie Medizinische Klinik 5 – Hämatologie und Internistische Onkologie Medizinische Klinik 5 – Hämatologie und Internistische Onkologie Stefan Kallert Lisa Meintker Vanessa Hofmann Essen Universitätsklinikum Essen Frankfurt am Main Klinikum der Johann Wolfgang Goethe-Universität Klinikum Joh.Wolfg.Goethe-UNI Universitätsklinikum Frankfurt Frankfurt an der Oder Klinikum Frankfurt Oder Freiburg Universitätsklinikum Freiburg Institut für Medizinische Mikrobiologie Jörg Steinmann Zentrum für Kinder- und Jugendmedizin, Klinik III Kinderheilkunde Klinik I Abteilung Infektiologie Thomas Lehrnbecher Adrian Lieb Johanna Kessel Abteilung Unfallchirurgie Dirk Kunzmann Klinik für Innere Medizin I, Abteilung Hämatologie, Onkologie und Stammzelltransplantation Hartmut Bertz Abteilung Hämatologie und Onkologie Silke Neumann Friedrich Loeffler Institut für Medizinische Mikrobiologie Katrin Schulz Göttingen Georg-August-Universität Greifswald Ernst-Moritz-Arndt-Universität Greifswald Halle-Wittenberg Martin-Luther-Universität Halle-Wittenberg Martin-Luther-Universität Halle-Wittenberg Klinik für Innere Medizin IV, Onkologie und Hämatologie Klinik für Innere Medizin IV, Onkologie und Hämatologie Hans-Joachim Schmoll Thomas Weber Hamburg Universitätsklinikum HamburgEppendorf Interdisziplinäre Klinik für Stammzelltransplantation Maximillian Christopeit Heidelberg Report June 2015 23 Ruprecht-Karls-Universität Heidelberg Ruprecht-Karls-Universität Heidelberg Universitätsklinikum Heidelberg Homburg/Saar Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes Jena Universitätsklinikum Jena Universitätsklinikum Jena Universitätsklinikum Jena Medizinische Klinik V, Abt. Hämatologie, Onkologie und Rheumatologie Medizinische Klinik V, Abt. Hämatologie, Onkologie und Rheumatologie ThoraxKlinik Klinik für Pädiatrische Onkologie und Hämatologie Klinik für Kinder- und Jugendmedizin, Sektion Hämatologie, Onkologie, Stammzelltransplantation Klinik, Zentrum für Infektionsmedizin und Krankenhaushygiene Klinik, Zentrum für Infektionsmedizin und Krankenhaushygiene Martina Gronkowski Gerlinde Egerer Maren Schuhmann Arne Simon Bernd Gruhn Stephanie Beier Mathias Pletz Karlsruhe Städtisches Klinikum Karlsruhe Köln Uniklinik Köln, Klinik I Innere Medizin Uniklinik Köln, Klinik I Innere Medizin Uniklinik Köln, Klinik I Innere Medizin Uniklinik Köln, Klinik I Innere Medizin Uniklinik Köln, Klinik I Innere Medizin Magdeburg Städtisches Klinikum Magdeburg München für für für für für Klinikum der Universität München (LMU) Klinikum München Technische Universität München Medizinische Klinik III Klinik I für Medizin Klinik I für Medizin Klinik I für Medizin Klinik I für Medizin Klinik I für Medizin Innere Innere Innere Innere Innere Hämatologie/ Onkologie Medizinische Klinik und Poliklinik IV, Klinische Infektiologie Krankenhaushygiene Klinik und Poliklinik für Orthopädie und Sportorthopädie Jean-Charles Moulin Oliver Cornely Fedja Farowski Maria J.G.T. Vehreschild J. Janne Vehreschild Kerstin Wahlers Kersten Borchert Johannes Bogner Elisabeth Meyer Ingo Banke Münster Universitätsklinikum Münster Universitätsklinikum Münster Klinik für Kinder- und JugendmedizinPädiatrische Hämatologie und Onkologie Klinik für Kinder- und JugendmedizinPädiatrische Hämatologie und Onkologie Report June 2015 Andreas Groll Gerda Silling 24 Postdam Ernst von Bergmann Klinikum Klinik für Hämatologie, Onkologie und Palliativmedizin Georg Maschmeyer Klinik III für Innere Medizin, Sektion Infektiologie und Klinische Immunologie Georg Härter Ulm Uniklinik Ulm Würzburg Universitätsklinikum Würzburg Universitätsklinikum Würzburg Universitätsklinikum Würzburg Universitätsklinikum Würzburg Universitätsklinikum Würzburg Medizinische Klinik und Poliklinik II, Abtl. Leberund Infektionsambulanz Medizinische Klinik und Poliklinik II, Abtl. Leberund Infektionsambulanz Medizinische Klinik und Poliklinik II, Abtl. Leberund Infektionsambulanz Medizinische Klinik und Poliklinik II, Abtl. Leberund Infektionsambulanz Medizinische Klinik und Poliklinik II, Abtl. Leberund Infektionsambulanz Werner Heinz Andrew Ullmann Anna Kuhn Carolin SpielauGleidies Christiane Schneider Greece Athens Attikon University Hospital Attikon University Hospital Department of Emergency and Critical Care Laboratory for Clinical Microbiology Elisabeth Paramythiotou Joseph Meletiadis Hungary Budapest Semmelweis University First Department of Medicine Judit Demeter Szeged University of Szeged University of Szeged University of Szeged Faculty of Science, Department of Microbiology Albert Szent-Györgyi Clinical Centre, Department of Clinical Microbiology Department Of Microbiology Lorant Hatvani László Bereczki Laszlo Kredics India Ahmedabad Infectious Diseases Clinic Chandigarh Government Medical College Hospital (GMCH) Postgraduate Institute of Medical Education & Research Chennai Sri Ramachandra University Medical College, Chennai Vedanta Institute of Medical Sciences Navrangpura Department of Microbiology Department of Medical Microbiology Department of Microbiology Report June 2015 Atul Patel Jagdish Chander Arunaloke Chakrabarti Anupma Jyoti Kindo 25 Lucknow Sanjay Gandhi Postgraduate Institute of Medical Sciences Manipal Kasturba Medical College Shruti Malik Dept. of Microbiology, Centre for Basic Sciences Peralam Yegneswaran Prakash Mumbai Sangmesh Chavanda Hinduja Hospital Sevagram Mahatma Gandhi Institute of Medical Sciences Iran Hamadan Hamadan University of Medical Sciences Israel Holon Edith Wolfson Medical Center Department of Microbiology Dipak Thamke Department of Medical Parasitology & Mycology Seyed Amir Ghiasian Department of Otolaryngology – Head & Neck Surgery Yehudah Roth Jerusalem Hadassah University Medical Center Shaare Zedek Medical Center Petah Tikva Rabin Medical Center Italy Bari University of Bari Aldo Modo Department of Internal Medicine, Infectious Diseases Infectious Disease Unit Maya Korem Eli Ben-Chetrit Infectious Diseases Unit Morad Wattad Department of Biomedical Science and Human Oncology Maria Teresa Montagna Institute of Hematology "Lorenzo e Ariosto Seràgnoli" Marta Stanzani Department of Hematology Chiara Cattaneo Oncoematologia Pediatrica Simone Cesaro Department of Internal Medicine Pasquale Mansueto Istituto di Microbiologia Caira Morena Istituto di Microbiologia Maurizio Sanguinetti Cancer Center Kazunori Nakase Department of Internal Medicine, Division of Infectious Diseases Dong-Gun Lee Bologna Sant'Orsola-Malpighi Hospital University of Bologna Brescia Spedali Civili Padova Policlinico G.B. Rossi Palermo University of Palermo Rome Universita Cattolica del Sacro Cuore Universita Cattolica del Sacro Cuore Japan Edobashi Tsu Mie University Hospital Korea Seoul The Catholic University of Korea Report June 2015 26 Netherlands Nijmegen Canisius-Wilhelmina Ziekenhuis Hospital Utrecht University Medical Center Utrecht Pakistan Rawalpindi National University of Medical Sciences Peru Lima Department of Medical Microbiology Jacques Meis Department of Medical Microbiology Miquel Ekkelenkamp Aamer Ikram Instituto de Medicina Tropical Alexander von Humboldt Carlos Seas Hamad Medical Corporation Mycology Unit, Division of Microbiology Saad Jaber TajAlden Romania Bucharest Fundeni Clinical Institute Fundeni Clinical Institute Iași BMT Unit Alina Tanase Anca Zgura Universitatea Petre Andrei Department of MycologyMycotoxicology Mihai Mares Infection Control Department Galina Solopova Universidad Peruana Cayetano Heredia Qatar Doha Russia Moscow Federal research center of pediatric hematology, oncology and immunology named after Dmitry Rogachev St. Petersburg St. Petersburg Medical Academy of Postgraduate Education St. Petersburg Medical Academy of Postgraduate Education Serbia Belgrade University of Belgrade Slovakia Bratislava National Cancer Institute Switzerland Zurich University Hospital Zürich Taiwan, Province of China Taipei National Taiwan University Hospital Department of Clinical mycology allergology and immunology Department of Clinical mycology allergology and immunology Institute for Microbiology and Immunology Nikolay Klimko Sofya Khostelidi Valentina Arsic Arsenijevic Lubos Drgona Department of Medicine Nicolas Müller Departments of Laboratory Medicine and Internal Medicine Po-Ren Hsueh Division of Infectious Diseases and Tropical Medicine Ploenchan Chetchotisakd Thailand Khon Kaen Khon Kaen University Report June 2015 27 Bangkok Chulalongkorn University Department of Medicine, Division of Infectious Diseases Tunisia Sousse CHU Farhat Hached of Sousse and the Faculty of Medicine of Sousse Turkey Ankara Hacettepe University Medical School Antalya Akdeniz University Medical Faculty United Kingdom London Imperial College London, Faculty of Medicine USA Boston Massachusetts General Hospital Massachusetts General Hospital Chusana Suankratay Akila Fathallah Department of Medicine, Section of Infectious Diseases and Clinical Microbiology Sevtap Arikan Department of Clinical Microbiology Dilara Ogunc Department of Medicine Darius ArmstrongJames Infectious Diseases Division Infectious Diseases Division Camille Nelson Kotton Vincent Marconi Cleveland Cleveland Clinic Lerner College of Medicine of Case Western University Department of Infectious Diseases, Section of Transplant Infectious Diseases, Medicine Institute and Report June 2015 Sherif Beniameen Mossad 28 FungiScope Members Angola Luanda University of Luanda Department of Microbiology Moises Francisco Argentina Buenos Aires El Centro de Internacion de FUNDALEU Instituto Nacional de Enfermedades Infecciosas „Dr. C.G. Malbran” Rosario Departamento Medico, REMIIN (Registro de Micosis Invasoras) Susana Cordoba Centro de Referencia de Micologia Facultad de Ciencias Bioquimicas Centro de Transplante de Medula Osea de Rosario (CETRAMOR) Universidad Nacional de Rosario University Hospital Rosario Maria Cecilia Dignani Maria Biasoli Jose Anibal Cozzi Australia Melbourne Alfred Health Melbourne Infectious Diseases Unit Victorian Infectious Diseases Service, Department of Microbiology Royal Melbourne Hospital Michelle R Ananda-Rajah Steven Tong Perth Royal Perth Hospital Department of Microbiology and Infectious Diseases Christopher Heath Princess Alexandra Hospital David FM Looke Anästhesiologie und Intensivmedizin Franz Schwameis Abteilung für Innere Medizin Fürstenfeld, Hämato-Onkologie Christina Leitner Abteilung für Innere Medizin Bernd-Lorenz Hartmann Institut für Hygiene, Mikrobiologie und Umweltmedizin Walter Buzina Queensland The University of Queensland Austria Baden Landesklinikum Baden- Mödling Feldbach LKH Feldbach Feldkirch Landeskrankenhaus Feldkirch Graz Medizinische Universität Graz Innsbruck Medizinische Universität Innsbruck Medizinische Universität Innsbruck Medizinische Universität Innsbruck Institut für Hygiene, Mikrobiologie und Sozialmedizin Institut für Hygiene, Mikrobiologie und Sozialmedizin Institut für Pathologie Anna Huppert, Isabella Schalk Ulrich Strasser Klagenfurt Landeskrankenhaus Klagenfurt Krankenhaushygiene Report June 2015 Ulrich Zerlauth 29 Linz Allgemeines Krankenhaus Linz Kinder- Herzzentrum Linz Werner Moosbauer Wagner-Jauregg Nervenklinik Klinik für Anästhesiologie Udo Illievich Zentrum für Krankenhaushygiene und Infektionskontrolle Markus Hell 1. Medizinische Abteilung Petra Pichler Institut für Anästhesie und Intensivmedizin Achim von Goedecke Salzburg Salzburger Universitätsklinikum St. Pölten Landesklinikum St. Pölten Steyr Landeskrankenhaus Steyr Wien Hanusch-Krankenhaus der Wiener Gebietskrankenkasse Hanusch-Krankenhaus der Wiener Gebietskrankenkasse Medizinische Universität Wien Medizinische Universität Wien Medizinische Universität Wien Medizinische Universität Wien Medizinische Universität Wien Wilhelminenspital Wien Institut für Pathologie und Mikrobiologie 3. Medizinische Abteilung, Hämatologisch-Onkologisches Zentrum Universitätsklinik I für Innere Medizin, Infektionen und Tropenmedizin Universitätsklinik I für Innere Medizin, Infektionen und Tropenmedizin Universitätsklinik I für Innere Medizin, Infektionen und Tropenmedizin Universitätsklinik I für Innere Medizin, Infektionen und Tropenmedizin Klinik für Dermatologie, Abteilung für Immundermatologie und Infektiöse Hauterkrankungen Abteilung für Anästhesie, Intensiv- und Schmerzmedizin Universitätsklinik für Krankenhaushygiene und Infektionskontrolle Uwe König Michael Pfeilstöcker Christina Forstner (nee Kratzer) Wolfgang Pöppl Peter Starzengruber Christoph Steininger Katharina GrabmeierPfistershammer Peter Wimmer Elisabeth Presterl Belarus (Republic of) Minsk Republic Research Center for Pediatric Oncology Hematology and Immunolog Sviatlana Kandaurava Faculty of Medicine, Department of Microbiology and Immunology, Laboratory of Clinical Bacteriology and Mycology Katrien Lagrou Unité d’hémato-oncologie Marc Antoine Belgium Leuven KU Leuven Mons CHU Ambroise Paré Report June 2015 30 Brazil Salvador da Bahia Hospital Universitario Professor Edgard Santos – UFBA Hospital Universitario Professor Edgard Santos – UFBA Serviço de Oncohematologia / TMO Serviço de Oncohematologia / TMO Rio de Janeiro Hospital Universitário Clementino Fraga (UFRJ) Hematology and Mycology Laboratory Marcio Nucci Department of Medicine, Section of Infectiuos Diseases Andrew Johnson Jewish General Hospital Department of Microbiology and Infectious Diseases Mark Miller Quebec Laboratoire de santé publique du Quebec Hamilton/Ontario Secteur Mycologie Philippe Dufresne Marco Aurélio Salvino Monica Botura Canada Calgary Peter Lougheed Center Montreal Department of Medicine, Division of Infectious Diseases Department of Medicine, Division of Infectious Diseases Department of Medicine, Division of Medical Microbiology McMaster University McMaster University Hamilton General Hospital Shariq Haider Tracy Reed Debbie Yamamura Vancouver Vancouver General Hospital Microbiology Laboratory Diane Roscoe Clínica Alemana Unidad de Infectología Luis Thompson Moya Clínica Alemana Unidad de Infectología Reinaldo Rosas Clínica Alemana Unidad de Infectología Thomas Weitzel Peking University People's Hospital Institute of Hematology Feng-Rong Wang Yanda International Hospital Dao-pei Blood Cancer Center Yanyan An Department of Hematology Respiratory and critical care medicine Department Southern Medical University in pediatrics Xin Du Chile Santiago de Chile China Beijing Guangzhou Guangdong General Hospital Nanfang hospital Nanfang hospital The First Affiliated Hospital of Sun Yat-sen Su Jin Min Yuyi Ronghai Deng Hangzhou Zhejiang University School of Medicine Shanghai The First Affiliated Hospital, Bone Marrow Transplant Center He Huang Changhai Hospital Department of Hematology Jian-Min Yang Fudan University, Huashan Hospital Report June 2015 Zhang Qiangqiang 31 Fudan University, Huashan Hospital Department of Infectious Diseases Hongzhou Lu Respiratory Disease department Long Xiang Institute of Hematology & Hospital of Blood Diseases Mingzhe Han Shenzhen Peking University Shenzhen Hospital Tianjin Chinese Academy of Medical Sciences & Peking Union Medical College Columbia Medellin Conjunto Residencial Montevideo Angela Restrepo Conjunto Residencial Montevideo Angela Tobón Croatia Slavonski Brod Institute of Public Health of BrodPosavina County Department of Microbiology Maja Tomić Paradžik Zagreb University Hospital Centre Division of Internal Medicine Nemet Damir Zagreb University Hospital Centre Division of Internal Medicine Radovan Vrohvac Faculty of Medicine, Department of Microbiology Petr Hamal Deptartment of Hematology Department of HematologyGranulocyte Research Lab. Jannik Helweg-Larsen Andreas Birkedal Glenthøj Microbiology Department Sherif Zaki Zagreb Czech Republic Olomouc Palacky University Denmark Copenhagen Copenhagen University Hospital Rigshospitalet Egypt Cairo Ain Shams University France Bordeaux Laboratoire de Microbiologie Fondamentale et Pathogénicité Laboratoire de Microbiologie Fondamentale et Pathogénicité Université de Bordeaux Université de Bordeaux Isabelle Accoceberry Frederic Gabriel Montpellier Service de soins intensifs en hématologie Nantes Patrice Ceballos CHU Hematology Pierre Peterlin Paris Hospital Saint-Louis Département d'Hématologie Emmanuel Raffoux Hospital Saint-Louis Département d'Hématologie Patricia Ribaud Service de Pneumologie Sandrine Hirschi Strasbourg Hôpitaux Universitaires de Strasbourg Report June 2015 32 Germany Aachen Medizinisches Zentrum Städteregion Aachen Augsburg Klinik für Orthopädie Rolf Sobottke Klinikum Augsburg II. Medizinische Klinik, Einheit für Stammzelltransplantation Christoph Schmid Bad Kreuznach Sana Rheumazentrum RheinlandPfalz AG Berlin Rheumatologische Ambulanz Eckhard Weber Klinik für Hämatologie und Onkologie Klinik für Hämatologie und Onkologie Vivantes Krankenhaus Vivantes Krankenhaus DRK Kliniken Berlin Jörg Beyer Markus Müller Olaf Süss Medizinische Klinik und Poliklinik II Center für Muskuloskeletale Chirurgie Abteilung für Infektionskrankheiten Klinik für Neurologie Charité-Universitätsmedizin Berlin Charité-Universitätsmedizin Berlin Robert Koch Institut Helios-Klinikum Berlin-Buch Markus Ruhnke Andrej Trampuz Michael Seibold Franz- Josef Dieste Bielefeld Städtische Kliniken Bielefeld gem.GmbH Bochum Klinikum der Ruhr-Universität Bochum Klinik für Hämatologie, Onkologie & Palliativmedizin Martin Görner St. Josef Hospital, Gastroenterologie und Infektiologie Renate Schlottmann Bonn Universitätsklinikum zu Bonn Klinik für Neonatologie Medizinische Klinik und Poliklinik III Medizinische Klinik und Poliklinik III Universitätsklinikum zu Bonn Universitätsklinikum zu Bonn Cornelia Graef Axel Kaeferstein Dominik Wolf Borstel Medical Clinic Research Center Borstel, Division of Clinical Infectious Diseases Christoph Lange Medizinische Klinik I Henrike Thomssen Bremen Klinikum Bremen-Mitte Dortmund Abteilung Pneumologie/Infektiologie Abteilung Pneumologie/Infektiologie Klinikum Dortmund Nord Klinikum Dortmund Nord Bernhard Schaaf Greta Ullrich Dresden Krankenhaus Dresden-Friedrichstadt Medizinische Klinik und Poliklinik I Dermatologie Krankenhaus Dresden-Friedrichstadt Mykologisches Labor University Hospital Dresden Report June 2015 Ulrich Schuler Gesina Hansel Irina Vennewald 33 Düsseldorf Universitätsklinikum Düsseldorf HNO-Klinik Katrin Gollner Universitätsklinikum Düsseldorf HNO-Klinik Klinik für Hämatologie, Onkologie und klinische Immunologie Kathrin Scheckenbach Universitätsklinikum Düsseldorf Thomas Schröder Erlangen Medizinische Hämatologie Onkologie Medizinische Hämatologie Onkologie Uniklinik Erlangen Uniklinik Erlangen Klinik 5 – und Internistische Stefan Krause Klinik 5 – und Internistische Wolf Rösler Essen Klinik für Knochenmarktransplantation Universitätsklinikum Essen Universitätsklinikum Essen Klinik für Nephrologie Klinik für Hämatologie/ Internistische Onkologie und Stammzelltransplantation Kliniken Essen Süd Rudolf Trenschel Oliver Witzke Mohammed Wattad Frankfurt am Main Infektiologikum Frankfurt Gaby Knecht Onkologikum Frankfurt Angelika Böhme Zentrum für Innere Medizin, Medizinische Klinik II – Hämatologie, Onkologie, Rheumatologie, Infektiologie Klinikum der Johann Wolfgang Goethe-Universität AGAPLESION Markus-Krankenhaus Klinik für Palliativmedizin Frankfurt an der Oder Klinikum Frankfurt Oder Anjali Dubey Sabine Mousset Abteilung für Innere Medizin, Hämatologie und Onkologie Michael Kiehl Hämatologie und Onkologie Werner Neubauer Freiburg Universitätsklinikum Freiburg Universitätsklinikum Freiburg Helmut Lang Zentrum für Infektiologie und Reisemedizin Zentrum für Infektiologie und Reisemedizin Universitätsklinikum Freiburg Universitätsklinikum Freiburg Dirk Wagner Insa Joost Geesthacht Medizinischen Versorgungszentrum Dr. Kramer und Kollegen Göttingen LADR GmbH Ralf Bialek Universitätskliniken Göttingen Institut für Medizinische Mikrobiologie Uwe Groß Klinik und Poliklinik für Innere Medizin C, Hämatologie und OnkologieTransplantationszentrum William Krüger Greifswald Universitätsklinikum der Ernst-MoritzArndt-Universität Greifswald Halle (Saale) Universitätsklinikum Halle (Saale) Claudia Wickenhauser Report June 2015 34 Halle-Wittenberg Martin-Luther-Universität HalleWittenberg Hannover Klinik für Innere Medizin IV, Onkologie und Hämatologie Hans- Heinrich Wolf Medizinische Hochschule Hannover Abteilung für Pneumologie Tobias Welte Institut für Infektiologie M. Sabranski Hamburg Asklepios Klinik St. Georg Heidelberg Medizinische Klinik V, Abt. Hämatologie, Onkologie und Rheumatologie Medizinische Klinik V, Abt. Hämatologie, Onkologie und Rheumatologie Medizinische Klinik V, Abt. Hämatologie, Onkologie und Rheumatologie Abteilung für Infektiologie, Sektion Krankenhaushygiene Medizinische Universitätsklinik V Universitätsklinikum Heidelberg Universitätsklinikum Heidelberg Universitätsklinikum Heidelberg Universität Heidelberg Zelluläre Immuntherapie Johann-Wilhelm Schmier Gerlinde Egerer Nicola Lehners Alexandra Heininger Michal Schmitt Homburg/Saar Universitätskliniken des Saarlandes Innere Medizin I Jörg Bittenbring Jena Hans-Knoell-Institute Oliver Kurzai Karlsruhe Städtisches Klinikum Karlsruhe Medizinische Klinik III Jean-Charles Moulin Kiel Universitätsklinikum SchleswigHolstein Köln Medizinische Klinik und Poliklinik II Heinz-A. Horst Kliniken der Stadt Köln Krankenhaus Merheim, Institut für Hygiene Frauke Mattner Klinik für Anästhesiologie und Operative Intensivmedizin Wolfgang Krüger Medizinische Klinik IV – Allgemeine Innere Medizin, Infektiologie, Pneumologie, Osteologie Stefan Reuter Institut für Medizinische Mikrobiologie und Hygiene Jan Rupp Konstanz Klinikum Konstanz Leverkusen Klinikum Leverkusen Lübeck Universität Lübeck Mainz Johannes-Gutenberg-Universität Universitätsmedizin Mainz III. Medizinische Klinik und Poliklinik, Hämatologie, internistische Onkologie, Pneumologie I. Medizinische Klinik und Poliklinik, Innere Medizin Ralf Georg Meyer Martin Sprinzl Mannheim Universitätsklinikum Mannheim III. Medizinische Klinik Report June 2015 Anne Dietz 35 Mönchengladbach Laboratoriumsmedizin, Mikrobiologie, Infektionsepidemiologie MVZ Stein und Kollegen Roman Schwarz München Ludwig- Maximilians-Universität München Klinikum Harlaching Klinikum Harlaching Klinikum der Großhadern Klinikum der Großhadern Klinikum der Großhadern Klinikum der Großhadern Münster Universität MünchenUniversität MünchenUniversität MünchenUniversität München- Uniklinik Münster Medizinische Klinik und Poliklinik IV, Abteilung für Infektions- und Tropenmedizin Städtisches Klinikum München GmbH, Klinik für HämatoOnkologie Städtisches Klinikum München GmbH, Klinik für HämatoOnkologie Kinderkardiologie und Pädiatrische Intensivmedizin Klinik für Hals-, Nasen- und Ohrenheilkunde Thomas Löscher Meinolf Karthaus Xaver Schiel Markus Loeff Robert Guerkov Medizinische Klinik III Helmut Ostermann Medizinische Klinik III Lisa Peterson Medizinische Klinik A Felix Rosenow Stauferklinik, Hämatologie/Onkologie/Immun ologie/Rheumatologie Holger Hebart Klinik und Poliklinik für Innere Medizin, Abteilung für Hämatologie, Onkologie, Palliativmedizin Brigitte Kragl Medizinische Klinik I, Hämatologie und Onkologie, Stefan Neuburger Mutlangen Klinikum Schwäbisch Gmünd Rostock Universitätsklinikum Rostock Sindelfingen Kliniken Sindelfingen Tübingen Universität Tübingen Universität Tübingen Klinik für Dermatologie Institut für Medizinische Mikrobiologie und Hygiene Sybille Schmidt Matthias Willmann Witten Marienhospital Witten Universität Witten/Herdecke Abteilung für Kinder- und Jugendmedizin Medizinische Klinik 5Hämatologie und Internistische Onkologie Bahman Gharavi Stefan Sauerland Würzburg Universität Würzburg Universität Würzburg Universität Würzburg Medizinische Klinik und Poliklinik für Innere Medizin II Medizinische Klinik und Poliklinik für Innere Medizin II Institut für Hygiene und Mikrobiologie Report June 2015 Jürgen Löffler Hartwig Klinker Bhanu Sinha 36 Greece Athens 1st Department of Propaedeutic Medicine Cystic Fibrosis Department Infectious Diseases and Antimicrobial Chemotherapy Research Laboratory Athens University Aghia Sophia Children´s Hospital Athens University General University Hospital ATTIKON Anna Skiada Stavros Doudounakis George L. Petrikkos Maria Stamouli Hungary Budapest Military Hospital Saint Laszlo Hospital, National Center for Infectious Diseases Szent László Hospital Laszlo Rokusz Department of Infectious Diseases Department of Bone Marrow Transplantation Botond Lakatos Janos Sinkó India Bangalore Narayana Health Bangalor Ramaiah Curie Centre of Oncology Anil Kumar Mazumdar Shaw Hospital Center Narayana Health Sunil Bhat Chandigarh Postgraduate Institute of Medical Education & Research Chennai Department of Pulmonary Medicine Ritesh Agarwal Global Hospital and Health City Department of Infectious Diseases Subramanian Swaminathan Apollo Hospitals Purnima Parthasarathy Kolkata Tata Medical Center Mammen Chandy Lucknow Sanjay Gandhi Post Graduate Institute of Medical Sciences Mumbai Grant Medical College and Sir J.J. Group of Hospitals Jaslok Hospital Department of Neuro-Surgery Amit Goyal Department of Microbiology Sarala Menon Department of Infectious Diseases Om Shrivastav Dhanashree KelkarGalwankar Global Hospitals New Delhi Institute Rotary Cancer Hospital Sameer Bakhshi Institute Rotary Cancer Hospital Lalit Kumar Deen Dayal Upadhyayaa Hospital Neelam Sood University of Delhi Rajan Babu Institute of Pulmonary Medicine and Tuberculosis Pune Jehangir Hospital Department of Medical Mycology Vallabhbhai Patel Chest Institute Department of Chest and Tuberculosis Incharge Carciac Recovery Unit Report June 2015 Anuradha Chowdhary Kshitij Agarwal C.S. Sharma 37 Tiruchirapalli Institute of Ophthalmology Philip A. Thomas Indonesia Jakarta University of Indonesia, Department of Internal Medicine Division of Mycology, Department of Parasitology, Faculty of Medicine Mangunkusumo Hospital Ospedale San Martino Erni Juwita Nelwan Retno Wahyuningsih Ireland Dublin Dublin Saint James Hospital Trinity College, Department of Microbiology Thomas Rogers Infection Disease Unit Anat Shteren Israel Haifa Rambam Medical Center Petah Tikva Rabin Medical Center Schneider Childrens Medical Center Department of Infectious Disease Infectious Diseases Unit Jihad Bishara Itzhak Levy Tel Aviv Department of Clinical Microbiology Infectious Diseases Unit Sheba Medical Center Israel Tel Aviv Sourasky Medical Center Tel Aviv Sourasky Medical Center Infectious Diseases Unit Department of Otolaryngology, Head and Neck Surgery and Maxillofacial Surgery Tel Aviv Sourasky Medical Center Nathan Keller Ronen Ben-Ami Michal Dekel Dan M. Fliss Italy Bari University of Bari Aldo Moro Bologna Alma Mater Studiorum Università di Bologna Department of Biomedical Science and Human OncologyHygiene Section Russell Edward Lewis Dipartimento di Scienze Mediche e Chirurgiche Russell Edward Lewis Dipartimento di Farmacologia Andrea Novelli Divisione di Ematologia e Trapianto di Midollo Osseo Andrea Bacigalupo Firenze Università degli Studi di Firenze Genova Ospedale San Martino Milan University of Milan University of Milan Laboratorio di Micologia Medica, Sezione Sanità Pubblica Luigi Sacco Hospital, Pathology Unit Humanitas Clinical Institute Anna Maria Tortorano Gianluigi Vago Concetta De Luca Report June 2015 38 Modena Section of Haematology, Department of Oncology, Haematology and Respiratory Diseases Mario Luppi Universita Cattolica del Sacro Cuore Dipartimento di Ematologia Livio Pagano San Camillo-Forlanini Hospital Hematology Unit Mariagrazia Garzia Department of Infectious Diseases Enrico Maria Trecarichi University of Modena and Reggio Emilia Rome Palermo Policlinico Gemelli Japan Chiba Medical Mycology Research Center (MMRC), Division of Clinical Research Medical Mycology Research Center (MMRC), Division of Clinical Research Chiba University Hospital Chiba University Hospital Katsuhiko Kamei, Akira Watanabe Nagasaki Nagasaki University Hospital Department of Molecular Microbiology and Immunology Shigeru Kohno Division of Infectious Diseases Shinichiro Morioka Shizuoka Shizuoka Cancer Center Korea Seoul Center for Specific Organs Cancer Sungkyunkwan University Sungkyunkwan University Soon Chun Hyang University Hospital Research Institute and Hospital, National Cancer Center, Hematology-Oncology Clinic, Hematopoietic Stem Cell Transplantation Center Department of Medicine, Division of Infectious Diseases Department of Medicine, Center for Intensive Care Department of Internal Medicine, Division of Infectious Diseases Hyeon Seok Eom Kyong Ran Peck Gee Young Suh Tae Hyong Kim Suwon Ajou University School of Medicine Department of HematologyOncology Joon Seong Park Faculty of Medicine, Department of Microbiology Eiman Mokaddas Department of Medicine, Division of Infectious Disease Souha Kanj-Sharara Kuwait Kuwait City Kuweit University Lebanon Beirut American University of Beirut Medical Center Report June 2015 39 Lithuania Vilnius Santariskiu Klinikos, Nephrology Centre, Department of Nephrology, Kidney Transplantation and Dialysis Santariskiu Klinikos, Department of Hematology Vilnius University Hospital Vilnius University Hospital Marius Miglinas Indre Klimiene Macedonia Skopje University Sts Cyril and Methodius Medical Faculty, Institute for Microbiology and Parasitology Gordana Mirchevska Haematology Department Chang Kian Meng Malaysia Ampang Hospital Ampang Kuala Lumpur Department of Parasitology, Faculty of Medicine Building Department of Medicine University of Malaya Universiti Kebangsaan Malaysia Suresh Kumar Adawiyah Jamil Sungai Buloh Department of Medicine Hospital Sungai Buloh Christopher Lee Fray Antonio Alcalde, Instituto de Patología Infecciosa y Experimental Eduardo RodriguezNoriega Mexico Guadalajara Hospital Civil de Guadalajara Mexico City Ixtlamatia Clinical Research S.A. de C.V Instituto Nacional de Cancerología Miguel Ángel Reséndiz Departamento de Infectología Patricia Cornejo-Juárez Departamento de Otorrinolaringología Salomón Waizel-Haiat Santa Fe Hospital de Especialidades del Centro Médico Nacional Siglo XXI Sinaloa Hospital General de Culiacán Ramón Rivas Llamas Veracruz Universidad Veracruzana Jalapa Facultad de Bioanálisis Sandra Gómez Netherlands Groningen University Medical Center Groningen Jan P. Arends Utrecht New Zealand Wellington Aotea Pathology Microbiology Department Hongtao Liu College of Medicine Rita Oladele Nigeria Lagos University of Lagos Report June 2015 40 North Ireland Belfast Belfast City Hospital Department of Bacteriology John E. Moore Department of Infection Raisa Hannula Hematology/ BMT Department Eduardo FernandezVertiz Infectious Disease Unit Raul Castillo Philippine General Hospital Agata Szymańska Norway Trondheim Medisinsk Klinikk - St. Olav Hospital HF Peru Lima Hospital Nacional Edgardo Rebagliati Martins Hospital Almenara Philippines Manila University of the Philippines Poland Gdansk Medical University Gdánsk Agata Szymańska Lodz Medical University of Lodz Department of Pediatrics, Oncology, Hematology and Diabetics Filip Pierlejewski Hematologii i Onkologii Dziecięcej Magdalena Bartnik Oncology, Hematology and Diabetics Jaroslaw Dybko Warsaw Klinika Pediatrii Wroclaw Wroclaw Medical University Portugal Coimbra Coimbra University Hospital Rui Tome Porto Institute of Molecular Pathology and Immunology University of Porto Hospital São João Rita Caramalho Ana Carneiro Hospital São João Laboratorio de Microbiologia Maria Dolores Pinheiro Russia Krasnodar City Regional Children Hospital Tatiana Askretova Moscow Russian Cancer Research Centre Anton Ivanov Vishnevsky Institute of Surgery Federal research center of pediatric hematology, oncology and immunology named after Dmitry Rogachev St. Petersburg Andrey Chizhov Infection Control Department I Pavlov State Medical University Galina Solopova Vladimir Vavilov Report June 2015 41 Saudi Arabia Riyadh King Fahad Medical City Department of Medicine Musa Garbati King Fahad Medical City King Faisal Specialist Hospital and Research Center Department of Medicine Jameela Edathodu Section of Infectious Diseases Hail Mater Al-Abdely PSMMC Section of Infectious Diseases Fatehi Elzein Clinical Centre of Serbia Ava Vidovic Serbia Belgrade Clinic of hematology Novi Sad Clinical center of Vojvodina Ivanka Savic-Tatic Singapore Mount Elizabeth Medical Centre Infectious Diseases Care National University Health System (NUHS), Division of Infectious Diseases Department of Pediatrics Infectious Diseases University Medicine Center National University Hospital Asok Kurup Chai Louis Yi Ann Si Min Chan South Africa Cape Town Groote Schuur Hospital University of Cape Town, Department of Orthopaedic Surgery Robert Dunn Nelson R. Mandela School of Medicine, Department of Infection Prevention and Control Teke Apalata Department of Medicine Mervyn Mer Pediatric Infectious Diseases and Immunodeficiencies Unit Pediatric Infectious Diseases and Immunodeficiencies Unit Pere Soler- Palacín Durban University of KwaZulu-Natal Johannesburg Hospital and University of Witwatersrand Spain Barcelona Hospital Universitari Vall d'Hebron Hospital Universitari Vall d'Hebron Belén Hernández Cadiz Puerta del Mar University Hospital Clinical Microbiology Laboratory Manuel RodriguezIglesias Servicio de Laboratorio Clínico Jesús García Martínez Grupo Andaluz de Leucemias Agudas GALA Eusebio Martín Chacón Fuenlabrada Hospital Universitario de Fuenlabrada Huelva Hospital Juan Ramon Jimenez-Huelva Madrid Hospital de la Princesa Hospital la Paz Servicio de Hematología de la Unidad de Consejo y Cuidado Oncológico de Sanitas Department of Hematology Report June 2015 Rafael de la Cámara Pilar Gomez Pietro 42 Hospital Infantil Universitario Niño Jesús Murcia Hospital Morales Meseguer Sección de Microbiología Maria Jose Gonzalez Abad Hematology and Medical Oncology Service Pastora Iniesta LopezMatencio Oviedo Asturias Central University Hospital María del Pilar Palmo Palma de Mallorca University Hospital Son Espases Antonia Sampol Santander Hospital Universitario Marqués De Valdecilla Sevilla Department of Hematology Lucrecia Yanez San Segundo University Hospital Virgen des Rocio/CSIC/University of Seville Clinical Unit of Infectious Disease, Microbiology and Preventative Medicine Martin-Pena Almudena Hospital Universitario La Fe Servicio de Microbiología Javier Peman University Hospital La Fe Fundación Instituto Valenciano de Oncología Department of Hematology Rebeca Rodriguez-Veiga Servicio de Microbiología Tomás García Lozano Clinical Microbiological Laboratory Peter Cettner Department of Infectious Diseases Gisela Otto Valencia Schweden Luleå Sunderby Hospital Lund Skane University Hospital Switzerland Basel Abteilung für Infektiologie und Spitalhygiene Abteilung für Infektiologie und Spitalhygiene Division of Infectious Diseases & Hospital Epidemiology Medizin I Abteilung für Hämatologie Universitätsspital Basel Universitätsspital Basel University Hospital Basel Universitätsspital Basel Andreas Widmer Ursula Flueckiger Maja Weisser Alois Gratwohl Bern Universitätsklinik für Infektiologie Klinik für Pneumologie Inselspital Inselspital Stefan Zimmerli Sebastian Ott Taiwan, Province of China Taipei Far Eastern Memorial Hospital National Taiwan University Hospital National Taiwan University Hospital Department of Internal Medicine, Division of Infectious Diseases Tai-Chen Stem Cell Therapy Center Department of Internal Medicine, Division of Infectious Diseases Report June 2015 Chia- Ying Liu Jih-Luh Tang Yee-Chun Chen 43 Turkey Ankara Hacettepe University Medical School Hacettepe University Medical School Baskent University Gazi University Gazi University Department of Medicine, Section of Infectious Diseases Department of Medicine, Section of Infectious Diseases Faculty of Medicine, Department of Internal Medicine, Division of Hematology Pediatric Hematology and Oncology Pediatric Hematology and Oncology Murat Akova Ömrün Uzun Can Boga Ertan Sal Funda Tekkesīn Gölköy/Bolu Department of Otorhinolaryngology, Bolu Izzet Baysal Faculty of Medicine Abant Izzet Baysal University Istanbul Beyoglu Eye Training and Research Hospital Capa University Serhat Imamoglu Zeynep Memis Department of Infectious Diseases and Clinical Microbiology Department of Microbiology and Clinical Microbiology Marmara University Cerrahpasa Medical Faculty Ahmet Emre Süslü Volkan Korten Tiraje Celkan Izmir Faculty of Medicine, Division of Hematology Faculty of Medicine, Division of Hematology Dokuz Eylül University Dokuz Eylül University Fatih Demirkan Ömür Gökmen Sevindik Kayseri Faculty of Medicine, Department of Pediatrics Division of Pediatric Hematology and Oncology Erciyes University Ekrem Unal Ukraine Kiev National Cancer Institute Kateryna Filonenko Ukranian National Children Hospital Centre of pediatric hematology and BMT Iulia Bazaluk Department of Microbiology Nitish Khanna Department of Microbiology Abhijit Bal United Kingdom Glasgow Southern General Hospital Kilmarnock University Hospital Crosshouse Kingsgate ID Consultancy Peter F. Troke London St Guys and St. Thomas NHS Trust Report June 2015 Jon Lambourne 44 Orpington South London Healthcare NHS Trust Princess Royal University Hospital M. Mansour Ceesay Department of Microbiology Nidhika Berry Department of Internal Medicine, Division of Infectious Diseases Marisa Miceli Swansea Singleton Hospital USA Ann Arbor Taubman Center Report June 2015 45 Baltimore Johns Hopkins University School of Medicine Cleveland Case Western Reserve University School of Medicine Department of Pathology, Division of Microbiology Sean Zhang Metrohealth Medical Center, Department of Dermatology Stephen Somach Detroit Transplantation Infectious Diseases Infectious Disease Henry Ford Medical Center Henry Ford Medical Center Mayur Ramesh Pamela Hartman Denver University of Colorado Department of Pathology Diane Hutchinson Downingtown TranScrip Partners (USA) LLC Glenn S Tillotson Duarte City of Hope National Medical Center Division of Infectious Diseases Sanjeet Singh Dadwal Indianapolis MiraVista Diagnostics and MiraBella Technologies Iowa City Patricia Connolly College of Medicine, Department of Pathology, Medical Microbiology Division, Linda Boyken St. Jude Children's Research Hospital Department of Surgery John A. Sandoval St. Jude Children's Research Hospital Infectious Diseases Elisabeth Adderson Department of Medicine Anne-Marie Leuck Department of Dermatology Marc E. Grossman University of Iowa Memphis Minneapolis University of Minnesota New York Columbia University Park Ridge St. James School of Medicine Harish Gugnani Pittsburgh University of Pittsburgh Rochester Mayo Clinic College of Medicine, Rochester San Antonio University of Texas Health Science Center University of Texas Health Science Center Temple Scott & White Healthcare/Texas A&M Health Science Center College of Medicine Washington University of Washington Department of Medicine Hong Nguyen Department of Medicine and Division of Infectious Diseases Zelalem Temesgen Department of Medicine Gregory Anstead Health Science Center Nathan Wiederhold A&M Health Science Center College of Medicine Mohanram Narayanan Division of Infectious Diseases Philip Coffin Report June 2015 46 Report June 2015 47