Plan de Cochin

Pr. John D. Scott
Howard Hughes Medical Institute.
Department of Pharmacology.
University of Washington. School of Medicine, Seattle, WA
Guiding signals through anchored enzyme complexes
Lundi 29 Septembre 2014
à 14h – Hôpital Cochin - Amphithéâtre Jean Dausset, Rez-de-Jardin du bâtiment Jean Dausset
(27 Rue du Faubourg St-Jacques) - 75014 PARIS.
(RER B station Port-Royal, Metro ligne 6 (Saint Jacques) ou Bus 38, 83,91)
John Scott is interested in the specificity of signal transduction events that are controlled by anchoring
proteins, which facilitate rapid signal transduction by optimally positioning protein kinases and
phosphatases in the vicinity of their activating signals and close to their substrates.
His research program focuses on defining the intracellular communication networks that promote
specificity in signal transduction events. His laboratory identified a family of A-kinase–anchoring
proteins (AKAPs) that target the cAMP-dependent protein kinase (PKA) and other signaling enzymes
to specific subcellular sites. AKAPs influence the regulation of physiological processes by bringing
enzymes close to their appropriate effectors and substrates at precisely the right moment. His group
made progress on establishing the AKAP model, the functional consequences of PKA anchoring, and
the bigger role of AKAP signaling networks in the coordinate regulation of cellular signaling.
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Amphithéâtre Jean Dausset
Rez-de-Jardin
Bâtiment Jean Dausset
27 Rue du Faubourg St-Jacques
75014 PARIS
é
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