The-effect-of-vaginal-gestrinone-in-Pentravan-with-oral

The effect of vaginal gestrinone in Pentravan® with oral resveratrol and Pinus
pinaster extract on pain score in patients with deep endometriosis
Abstract ID : 1629
Soumis par : Hugo Maia Jr. Le 2016-03-13 14:19:08
Nom de la catégorie : SEUD CONGRESS
Typologie : Communication orale / Oral communication
Statut : validé
Autorisation de diffusion : Yes/Oui
------------------------------------Introduction: Endometriosis is an epigenetic disease of the endometrium in which aromatase p450 is expressed, leading
to increased inflammation and decreased progesterone receptor-B levels. This may result in impaired response to
progestin. The effect of the association of vaginal gestrinone, a 19 nor-testosterone derivative, with oral resveratrol and
Pinus pinaster extract on pain scores was investigated in these patients.
Patients and Methods: Fifty patients with deep endometriosis in whom previous treatment had failed were enrolled for
this study. Sixteen patients also had uterine fibroids and 42 also had adenomyosis. Pain was assessed at baseline and
monthly during treatment. Blood analysis was performed after two months of treatment. Vaginal ultrasonography was
performed at baseline and after three months of treatment. All patients were treated with vaginal gestrinone (5mg/ml) in
Pentravan® thrice weekly with daily oral 30-mg doses of resveratrol and 100 mg of Pinus pinaster.
Results: Vaginal gestrinone in Pentravan®, together with oral resveratrol and Pinus pinaster extract, significantly
decreased the intensity of pain from a mean score of 9 at baseline to 0.4 by the second month of treatment. After three
months, all patients were pain-free and amenorrheic. Uterine volume decreased significantly in patients with fibroids
from 206 cm3 to 138 cm3 (p=0.001) by the third month of treatment and from 146 cm3 to 115 cm3 (p=0.04) in patients
with endometriosis/adenomyosis. Ovarian endometriotic cyst volume also decreased significantly from 36 cm3 to 18 cm3
(p=0.004). Blood levels of estradiol, total testosterone and SHBG decreased significantly after two months (p=0.01).
There was also a significant decrease in triglycerides, HDL cholesterol and glucose. Conversely, total cholesterol levels
and LDL were not significantly affected. Liver enzymes did not increase significantly.
Conclusion: The association of gestrinone with resveratrol, a histone deacetylase inhibitor, and Pinus pinaster, a NFKappa.b blocker, effectively treated endometriosis-related pain in patients who had failed to respond to previous
treatment with progestins.
------------------------------------Mots clefs : endometriosis-related pain; vaginal gestrinone; resveratrol; Pinus pinaster extract.
Auteurs :
Références : , , ,
Auteurs
Hugo Maia Jr. 1, Clarice Haddad 1, Wilson SD Dos Santos Jr. 1,
1. Instituto da Mulher, Itaigara Memorial Day Hospital, Salvador, BRAZIL
Auteurs (raw format)
Maia Jr. Hugo - email : [email protected] Etablissement : Itaigara Memorial Day Hospital Service : Instituto da
Mulher Ville : Salvador Pays : BRAZIL Présentateur : Oui
Haddad Clarice - email : [email protected] Etablissement : Itaigara Memorial Day Hospital Service : Instituto da
Mulher Ville : Salvador Pays : BRAZIL Présentateur : Non
Dos Santos Jr. Wilson SD - email : [email protected] Etablissement : Itaigara Memorial Day Hospital Service : Instituto
da Mulher Ville : Salvador Pays : BRAZIL Présentateur : Non