3 (_ _3`557)

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3 (_ _3`557)
Vl I_D No. 441 [§102a]
CARLSON,
0 14 pupil
V.R.
Pupil dilatation has been frequently reported after
LSD and special studies have been made, e.g. by FREEMAN,
LSD No. 485.
#,
• "0.,[J.
_3 (_ _3'557)
NKT/Dr.Bs/Dr.Spi/pz
1058
Effects of IZD and other drugs on the pupil
CARLSON, V.R. (Lab.of Psychol.,
Bethesda, Md)
:
l
Nat.lnst.of
Mental
_
Health,
Individua I pupillary reactions to cert_j_ contrally
drugs in man.
J.Pharmacol.Exper.Therap.
!21,
501-506
acting
(1957)!:!
In lO normal subjects ISD caused pupillary dilatation,
the effect of lO0 _g by mouth being greater than t_t of
50 _g. LSD had a significantly greater effect on the
constricted pupil than on the dilated pupil.
!
l
Chlcrpromazine
produced pupillary constriction,
the
effect of a high dose being greater than that of a low dose.
Meperidine
had little effect.
Secobarbital
had no effect.
The degree of probability that the individual] variations
in pupillary response were not accidental agreed exactly
with the descending order of potency on the pupil: LSD,
chlorpromazine,
meperidine
and secobarbital.
!
Subjects exhibiting a great effect after LSD tended
to show relatively little effect after chlorpromazine,
and
vice versa.
114If/13
!
Wirkumgen yon LSD und anderen Pharmaka auf die
Pupille
CARLSON, V.R.
Bethesda, Md)
(Lab.of Psychol.,
Individual pupillary
drugs in man.
(Individuelle
mit zentraler
reactions
Nat.lnst.of
to certain
Reaktion der Pupillenweite
Wirkung beim Menschen).
J.Pharmacol.Exper.Therap.
Mental
centrally
acting
auf gewisse Mittel
!21, 501-506
Bei i0 normalen Versuchspersonen
Health,
(1957).
verursachte LSD Er-
weiterung der Pupille, wobei die Wirku_g von lO0_g oral
starker war als die yon 50 _g oral. Die LSD-Wirknng war bei
enger Pupille signifikant st/rker als bei welter.
Chlorpromazin bewirkte Pupillenverengerung. Die Wirkung einer hohen Dosis war grSsser als die einer kleinen.
Meperidin war wenig und Secobarbital gar nicht wirksam.
Der Grad der Wahrscheinlichkeit, dass die bei den einzelnen Versuchspersonen unter Pharmakoneinfluss beobachteten
Pupillen/nde_Ingen nicht zufallsbedingt waren, nahm genau
entsprechend der Pupillenwirksamkeit der _Littel ab: LSD
Chlorpromazin _ _leperidin _ Secobarbital.
Personen, die auf LSD stark reagierten, waren gegenGber
Chlorpromazin verh_ltnism_ssig wenig empfindlich und umgekehrt.
D
ll4 II/13
n _D _o.441[§i02_
3
0 14pupil
CARLSON,V.R.
!
Pupil dilatation has been frequently reported after
LSD and special studies have been made, e.g. by FREEMAN,
LSD No. 485.
w3 (EK 13'557)
l
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Effets du LSD et d'autres
CARLSON, V.R.
Bethesda, Md)
Indivi_2_
(Lab.of Psychol.,
pupillaryreactions
agents sur la pupille
Nat.Inst.of
to certain
Mental Health,
centrally
acting
d_mgs in m_n.
(R_actions pupillaires individuelles
effet central chez l'homme)
J.Pharmacol.Exper.Therap.
_ certains
agents
1__2_,501-506
(1957).
Chez lO sujets sains, LSD provoque une dilatation de
la pupille, l'effet de lO0 2g per os 6rant plus prononc6
que celui de 50 _g per os. Si la pupille est en myosis,
l'effet du LSD est nettement plus prononc_ que si elle
est en mydriase.
Chlorpromazine
provoque unmyosis,
l'effet d'une dose
_lev6e @rant plus prononc6 que celui d'une dose faible.
[email protected]@ridine
n'ag±t
que peu, [email protected]
pas du tout.
Le [email protected] de la probabilit_ que les variations individuelles des r6actions pupillaires ne soient pas accidentelles correspond exactemeut _ l'ordre suivant de la diminution de l'e£fet pupillaire:
ridine _ s_cobarbital.
LSD _ [email protected]
Les sujets r_agissant fortement au LSD sont relativement peu sensibles _ la chlorpromazine, et vice versa.
F
114 II/13
w mD _o.441[_lO2g
o 14pupil
!
CARLSON,
V.R.
Pupil dilatation has been frequently reported after
ISD and special studies have been made, e.g. by FREEMAN,
LSD No. 485.
!
w3 (EK13'557)
NK_/Dr.Bs/Dr.Spi/pz
1058