3 (_ _3`557)
Transcription
3 (_ _3`557)
Vl I_D No. 441 [§102a] CARLSON, 0 14 pupil V.R. Pupil dilatation has been frequently reported after LSD and special studies have been made, e.g. by FREEMAN, LSD No. 485. #, • "0.,[J. _3 (_ _3'557) NKT/Dr.Bs/Dr.Spi/pz 1058 Effects of IZD and other drugs on the pupil CARLSON, V.R. (Lab.of Psychol., Bethesda, Md) : l Nat.lnst.of Mental _ Health, Individua I pupillary reactions to cert_j_ contrally drugs in man. J.Pharmacol.Exper.Therap. !21, 501-506 acting (1957)!:! In lO normal subjects ISD caused pupillary dilatation, the effect of lO0 _g by mouth being greater than t_t of 50 _g. LSD had a significantly greater effect on the constricted pupil than on the dilated pupil. ! l Chlcrpromazine produced pupillary constriction, the effect of a high dose being greater than that of a low dose. Meperidine had little effect. Secobarbital had no effect. The degree of probability that the individual] variations in pupillary response were not accidental agreed exactly with the descending order of potency on the pupil: LSD, chlorpromazine, meperidine and secobarbital. ! Subjects exhibiting a great effect after LSD tended to show relatively little effect after chlorpromazine, and vice versa. 114If/13 ! Wirkumgen yon LSD und anderen Pharmaka auf die Pupille CARLSON, V.R. Bethesda, Md) (Lab.of Psychol., Individual pupillary drugs in man. (Individuelle mit zentraler reactions Nat.lnst.of to certain Reaktion der Pupillenweite Wirkung beim Menschen). J.Pharmacol.Exper.Therap. Mental centrally acting auf gewisse Mittel !21, 501-506 Bei i0 normalen Versuchspersonen Health, (1957). verursachte LSD Er- weiterung der Pupille, wobei die Wirku_g von lO0_g oral starker war als die yon 50 _g oral. Die LSD-Wirknng war bei enger Pupille signifikant st/rker als bei welter. Chlorpromazin bewirkte Pupillenverengerung. Die Wirkung einer hohen Dosis war grSsser als die einer kleinen. Meperidin war wenig und Secobarbital gar nicht wirksam. Der Grad der Wahrscheinlichkeit, dass die bei den einzelnen Versuchspersonen unter Pharmakoneinfluss beobachteten Pupillen/nde_Ingen nicht zufallsbedingt waren, nahm genau entsprechend der Pupillenwirksamkeit der _Littel ab: LSD Chlorpromazin _ _leperidin _ Secobarbital. Personen, die auf LSD stark reagierten, waren gegenGber Chlorpromazin verh_ltnism_ssig wenig empfindlich und umgekehrt. D ll4 II/13 n _D _o.441[§i02_ 3 0 14pupil CARLSON,V.R. ! Pupil dilatation has been frequently reported after LSD and special studies have been made, e.g. by FREEMAN, LSD No. 485. w3 (EK 13'557) l NKT/Dr. Bs/Dr. Spi/pz 1058 Effets du LSD et d'autres CARLSON, V.R. Bethesda, Md) Indivi_2_ (Lab.of Psychol., pupillaryreactions agents sur la pupille Nat.Inst.of to certain Mental Health, centrally acting d_mgs in m_n. (R_actions pupillaires individuelles effet central chez l'homme) J.Pharmacol.Exper.Therap. _ certains agents 1__2_,501-506 (1957). Chez lO sujets sains, LSD provoque une dilatation de la pupille, l'effet de lO0 2g per os 6rant plus prononc6 que celui de 50 _g per os. Si la pupille est en myosis, l'effet du LSD est nettement plus prononc_ que si elle est en mydriase. Chlorpromazine provoque unmyosis, l'effet d'une dose _lev6e @rant plus prononc6 que celui d'une dose faible. M@p@ridine n'ag±t que peu, s@cobarbital pas du tout. Le degr@ de la probabilit_ que les variations individuelles des r6actions pupillaires ne soient pas accidentelles correspond exactemeut _ l'ordre suivant de la diminution de l'e£fet pupillaire: ridine _ s_cobarbital. LSD _ chlorpromazine_m_p@- Les sujets r_agissant fortement au LSD sont relativement peu sensibles _ la chlorpromazine, et vice versa. F 114 II/13 w mD _o.441[_lO2g o 14pupil ! CARLSON, V.R. Pupil dilatation has been frequently reported after ISD and special studies have been made, e.g. by FREEMAN, LSD No. 485. ! w3 (EK13'557) NK_/Dr.Bs/Dr.Spi/pz 1058