MEMOIRE PRESENTEE PAR - Faculté de Médecine et de
Transcription
MEMOIRE PRESENTEE PAR - Faculté de Médecine et de
ROYAUME DU MAROC UNIVERSITE SIDI MOHAMMED BEN ABDDELLAH FACULTE DE MEDECINE ET DE PHARMACIE - FES BOLUS ORAL DE CORTICOÏDE VERSUS INTRAVEINEUX DANS LE TRAITEMENT DE LA PELADE SEVERE ET ACTIVE MEMOIRE PRESENTEE PAR : Docteur BOUYAHYAOUI YOUSSEF POUR L’OBTENTION DU DIPLOME DE SPECIALISTE EN MEDECINE Option : DERMATOLOGIE !"# $ %$ & !" ' ( )"$* + ( ) ! ) ,- # %$ . ( ) ! ) ,- !"( / " !" !"( 0 ( ' $- ( ( *-( 1 (2' ' $ 3 (" ) )( # ! 4 ")! (' $ !"# - ) ") !" ' 5 ' %$ + (" ) ! ) !"# . (" ) ! ) !"# / ' !"( !"6 ! *" 0 !" ' ( 7 %$ 1 8 ) 5 + !"# . # !"# / (" 0 )!5 && # 5 %$ ! !"# & $ " # ("# 5) $ ) "( ! #"! # )"!") ! )"$ <' %$ $ ( <)( ; - (" ) $ - < !-! ' $6 $ ( )$ ! ) 6 ($; 6 ! - "-)(99 <)( ; " #$ ' - )! #" $6 (( 5# @ " 5# ) $ (( ' $ ( 5# (2 * ) "$ ")$ )" "( = (" ! ) ) - $- 2 -" " 6 "$ -$ 9 (()$( # ( $* -2$ $ " " $! $ 9" ) "$ $- $ -$ <' ; -2 D $ #"! ! - +B.?; (" #($#"! "! "( ; 9"6 $! $6 #"! #($ - - $* )' = -2 ! 7 '" - 6 $ # #$(" ! - "! %$ "6" )" %$ (" # (""( ' @+B1>C; $! (" #"!" 5! ,- #"!" !' 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