unite de recherche - Faculté de Médecine

Transcription

unite de recherche - Faculté de Médecine
POLE HOSPITALIER
BIOLOGIE
CHEF DE PÔLE : Professeur Bruno LACARELLE
ADRESSE : Hôpital de la Timone - Service de Pharmacocinétique et Toxicologie
264 Rue Saint-Pierre 13385 MARSEILLE Cedex 5
TELEPHONE : 04.91.38.75.65
COURRIEL : [email protected]
RATTACHEMENTS : AP-HM
DISCIPLINES D’APPARTENANCES : Biochimie et Biologie Moléculaire, Hématologie, Immunologie,
génétique, Biologie Cellulaire, Pharmacologie, Toxicologie, Oncologie
SPECIALITÉS : Biochimie et Biologie Moléculaire, Hématologie, Immunologie, Génétique, Biologie
Cellulaire, Pharmacologie, Toxicologie, Oncologie
EFFECTIFS
Enseignants-Chercheurs (PU-PH, MCU-PH, CCA, AHU) : 32,79 ETP
Personnel Hospitalier (PH, Attaché) : 49,04 ETP (PC, Assistant) 2,80 ETP
Personnel Technique (Encadrement) : 14,00 ETP (Techniciens de Laboratoire) : 249,50 ETP
(Ingénieurs) : 31,90 ETP (Aide de Laboratoire – AEQ & Divers) : 36,80 ETP
Personnel Administratif : 44,70 ETP
Internes : 48,60 ETP
Etudiants : 75,00 ETP
PERSONNELS RATTACHÉS A UNE EQUIPE DE RECHERCHE
INSERM UMR 911 CRO2 EQUIPE 4
L Ouafik (PU-PH)
INSERM UMR 911 CRO2
B Lacarelle (PU-PH)
C Solas (MCU-PH)
Suzanne Monjanel (MCU-Attaché)
J Ciccolini (MCU-Attaché)
UMR NORT inserm 1062, inra 1260
Marie-Christine Alessi (PU-PH) PierreEmmanuel Morange (PU-PH) Michel
Fontes (PU-PH)
Henri Portugal (PU-PH)
Marie-Françoise Aillaud (MCU-PH)
Véronique Baccini (MCU-PH)
Alain Margotat (MCU-PH)
Richard Planells (MCU-PH)
Mise à jour : janvier 2015
Pôle hospitalier. Biologie
1/21
Alain Nicolay (MCU-PH)
Marguerite Gastaldi (MCU-PH)
Catherine Defoort (MCU-PH)
Alain Nicolay (MCU-PH)
M Gastaldi (MCU-PH)
A Margotat (MCU-PH)
Charlotte Grosdidier (AHU)
Agathe Henneuse (AHU)
UMR MD2
R Guieu (PU-PH)
PJ Lejeune (MCU-PH)
G Mottola (MCU-PH)
J Fromonot (AHU)
INSERM UMR_S910
Nicolas Lévy (PU-PH)
Catherine Badens (PU-PH)
Christophe Beroud (PU-PH)
Pierre Cau (PU-PH)
Nicole Philip (PU-PH)
Martin Krahn (MCU-PH)
Karine Nguyen (MCU-PH)
Patrice Roll (MCU-PH)
Andrée Robaglia-Schlupp (MCU-PH)
Rafaelle Bernard (PH)
Nathalie Bonello-Palot (PH)
Annachiara De Sandre-Giovanolli (PH)
Sabine Sigaudy (PH)
Elise Kaspi (AHU)
Nathalie Banzet (Ingénieur AP-HM)
Inserm U1076
Nathalie Bardin (MCU-PH)
Inserm U1067/CNRS U7333
Pierre Bongrand (PU-PH)
Philippe Robert (MCU-PH)
Joanna Vitte (MCU-PH)
Cnrs U7286
José Boucraut (MCU-PH)
CNRS U 7259
Sophie Desplat-Jego (MCU-PH)
Inserm U1104/CNRS U7280
Eric Vivier (PU-PH)
Frédéric Vely (MCU-PH)
CRN2M, UMR 7286
Alain Enjalbert (PU-PH)
Anne Barlier (PU-PH)
Amapola Autillo-Touati (PU-PH) JeanLouis Berge Lefranc (MCU-PH)
A Saveanu (MCU-PH)
INSERM 1072
Jean Gabert (PU-PH)
Annie Lévy-Mozziconnacci (MCU-PH)
UMR 1076
Françoise Dignat-George (PU-PH)
Florence Sabatier (PU-PH)
Mise à jour : janvier 2015
Pôle hospitalier. Biologie
2/21
Romaric Lacroix (MCU-PH)
Pascale Paul
Sylvie Cointe
SERVICES HOSPITALIERS
INTITULÉ : Service de Transfert d’Oncologie Biologique
RESPONSABLE : Pr L’Houcine OUAFIK
DISCIPLINE : Oncologie Biologique
INTITULÉ : Département de Génétique Médicale
RESPONSABLE : Pr Nicolas LEVY
DISCIPLINE : Génétique
INTITULÉ : Service de Biologie Cellulaire
RESPONSABLE : Dr Patrice ROLL
DISCIPLINE : Biologie Cellulaire
INTITULÉ : Laboratoire d'Immunologie
RESPONSABLE : Pr Pierre BONGRAND
DISCIPLINE : Immunologie
INTITULÉ : Laboratoire de Biochimie
RESPONSABLE : Pr Henri PORTUGAL
DISCIPLINE : Biochimie
INTITULÉ : Laboratoire de Biochimie et Biologie Moléculaire
RESPONSABLE : Pr Régis GUIEU
DISCIPLINE : Biochimie
INTITULÉ : Biochimie et Biologie Moléculaire.
RESPONSABLE : Pr Jean GABERT
DISCIPLINE : Biochimie et Biologie Moléculaire
INTITULÉ : laboratoire de Biologie Moléculaire, Hôpital de la Conception
RESPONSABLE : Pr Alain ENJALBERT
DISCIPLINE : Biologie Moléculaire
INTITULÉ : Service d’Hématologie et de Biologie Vasculaire
RESPONSABLE : Pr Françoise DIGNAT - GEORGE
DISCIPLINE : Hématologie, Immunologie, Biologie Vasculaire
INTITULÉ : Pharmacocinétique et toxicologie
RESPONSABLE : Pr Bruno LACARELLE
DISCIPLINE : Pharmacocinétique, Toxicologie
INTITULÉ : Service d’Hématologie Hôpital Nord et Hôpital de la Timone
RESPONSABLE : Pr Pierre-Emmanuel MORANGE
DISCIPLINE : Hématologie
INTITULÉ : Service de Pharmacologie Clinique Hôpital de la Timone et Hôpitaux Sud
RESPONSABLE : Pr Olivier BLIN
DISCIPLINE : Pharmacologie
INTITULÉ : Service Pharmacologie Clinique CAP Hôpitaux Sud
RESPONSABLE : Pr Nicolas SIMON
DISCIPLINE : Pharmacologie
Mise à jour : janvier 2015
Pôle hospitalier. Biologie
3/21
PUBLICATIONS ANNÉE 2013
1
Abaeva AA, Canault M, Kotova YN, Obydennyy SI, Yakimenko AO, Podoplelova NA, Kolyadko VN,
Chambost H, Mazurov AV, Ataullakhanov FI, Nurden AT, Alessi MC, Panteleev MA. Procoagulant
platelets form anα-granule protein-covered 'cap' on their surface that promotes their attachment
to aggregates. J Biol Chem. 2013;288:29621-32 (IF = 4.651)
2
Ambrosi P, Kreitmann B, Cohen W, Habib G, Morange P Anticoagulation with a new oral
anticoagulant in heart transplant recipients.Int J Cardiol. 2013;168:4452-3 (IF = 6.175)
3
Amiot MJ, Romier B, Dao TM, Fanciullino R, Ciccolini J, Burcelin R, Pechere L, Emond C, Savouret
JF, Seree E. Optimization of trans-Resveratrol bioavailability for human therapy. Biochimie. 2013
Jun;95(6):1233-8.
4
André F, Ciccolini J, Spano JP, Penault-Llorca F, Mounier N, Freyer G, Blay JY, Milano G.
Personalized medicine in oncology: where have we come from and where are we going?
Pharmacogenomics. 2013 Jun;14(8):931-9. doi: 10.2217/pgs.13.79.
5
Ayach L, Curti C, Montana M, Pisano P, Vanelle P. Actualités dans le traitement étiologique de la
sclérose latérale amyotrophique. Amyotrophic lateral sclerosis: Update on etiological treatment
Thérapie. Vol. 68, No. 2 (Mars-Avril 2013) : 93
6
Bakour S, Touati A, Sahli F, Ameur AA, Haouchine D, Rolain JM. Antibiotic resistance determinants
of multidrug-resistant Acinetobacter baumannii clinical isolates in Algeria. Diagn Microbiol Infect
Dis. 2013 Aug;76(4):529-31.
7
Barbieri F, Albertelli M, Grillo F, Mohamed A, Saveanu A, Barlier A, Ferone D, Florio T.
Neuroendocrine tumors: insights into innovative therapeutic options andrational development of
targeted therapies. Drug Discov Today. 2013 Oct 27. piiS1359-6446(13)00382-6. doi:
10.1016/j.drudis.2013.10.015. [Epub ahead of print] PubMed PMID: 24171952.
8
Barbolosi D, Ciccolini J, Meille C, Elharrar X, Faivre C, Lacarelle B, André N, Barlesi F. Metronomics
chemotherapy: time for computational decision support. Cancer Chemother Pharmacol. 2014
Sep;74(3):647-52.
9
Barlesi F, Tomasini P, Fina F, Secq V, Greillier L, Nanni-Metellus I, Garcia S, Ouafik L. Regional
molecular genetics centers in thoracic oncology: what and who should be tested?. Bull Cancer.
2013;100:737-41. Ait-Belkacem R, Calligaris D, Sellami L, Villard C, Granjeaud S, Schembri T,
Berenguer C, Ouafik L, Figarella-Branger D, Chinot O, Lafitte D. Tubulin isoforms identified in the
brain by MALDI in-source decay. J Proteomics. 2013;79:172-9.
10
Baujat G, Huber C, El Hokayem J, Caumes R, Do Ngoc Thanh C, David A, Delezoide AL, DieuxCoeslier A, Estournet B, Francannet C, Kayirangwa H, Lacaille F, Le Bourgeois M, Martinovic J,
Salomon R, Sigaudy S, Malan V, Munnich A, Le Merrer M, Le Quan Sang KH, Cormier-Daire
V.Asphyxiating thoracic dysplasia: clinical and molecular review of 39 families. J Med Genet. 2013
Feb;50(2):91-8
11
Baumstarck K, Bonello L, Dignat-George F, Sabatier F.Mobilization of CD34+KDR+ endothelial
progenitor cells predicts target lesion revascularization: a reply to a rebuttal concerning power
and sample size calculation. J Thromb Haemost. 2013 Feb;11(2):398-9.
12
Ben Lassoued A1, Beaufils N, Dales JP, Gabert J. Hypoxia-inducible factor-1α as prognostic
marker. Expert Opin Med Diagn. 2013 Jan;7(1):53-70.
Mise à jour : janvier 2015
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13
Berenguer-Daizé C, Boudouresque F, Bastide C, Tounsi A, Benyahia Z, Acunzo J, Dussault N,
Delfino C, Baeza N, Daniel L, Cayol M, Rossi D, El Battari A, Bertin D, Mabrouk K, Martin PM,
Ouafik L. Adrenomedullin blockade suppresses growth of human hormone-independent prostate
tumor xenograft in mice. Clin Cancer Res. 2013; 19(22):6138-50. Nouguerède E, Berenguer C,
Garcia S, Bennani B, Delfino C, Nanni I, Dahan L, Gasmi M, Seitz J-F, Martin P-M, Ouafik L.
Expression of Adrenomedullin in human colorectal tumors and its role in cell growth and invasion
in vitro and in xenografts growth in vivo. Cancer Medicine. 2013; 2(2):196-207.
14
Bertin D, Grimaud JC, Lesavre N, Benelmouloud C, Desjeux A, Garcia S, et al. Targeting tissular
immune response improves diagnostic performance of anti-Saccharomyces cerevisiae antibodies
(ASCA) in Crohn's disease. PLoS One 2013;8:e80433.
15
Bertin D, Jourde-Chiche N, Bongrand P, Bardin N. Original approach for automated quantification
of antinuclear autoantibodies by indirect immunofluorescence. Clin Dev Immunol
2013;2013:182172.
16
Bertin D, Jourde-Chiche N, Bongrand P, Bardin N. Original approach for automated quantification
of antinuclear autoantibodies by indirect immunofluorescence. Clin Dev Immunol. 2013 ; 2013 :
182 172. doi: 10.1155/2013/182172. Epub 2013 Dec 18.
17
Bertin D, Stephan D, Khrestchatisky M, Desplat-Jégo S. Is TWEAK a Biomarker for
Autoimmune/Chronic Inflammatory Diseases? Front Immunol 2013;4:489.
18
Bessoles S, Angelov GS, Back J, Leclercq G, Vivier E, Held W. Education of murine NK cells
requires both cis and trans recognition of MHC class I molecules. J Immunol 2013;191:5044-51.
19
Biroccio A, Cherfils-Vicini J, Augereau A, Pinte S, Bauwens S, Ye J, et al. TRF2 inhibits a cellextrinsic pathway through which natural killer cells eliminate cancer cells. Nat Cell Biol
2013;15:818-28.
20
Blons H, Rouleau E, Charrier N, Chatellier G, Côté JF, Pages JC, de Fraipont F, Boyer JC, Merlio JP,
Morel A, Gorisse MC, de Cremoux P, Leroy K, Milano G, Ouafik L, Merlin JL, Le Corre D,
Aucouturier P, Sabourin JC, Nowak F, Frebourg T, Emile JF, Durand-Zaleski I, Laurent-Puig P;
MOKAECM Collaborative Group. Performance and cost efficiency of KRAS mutation testing for
metastatic colorectal cancer in routine diagnosis: the MOKAECM study, a nationwide experience.
PLoS One. 2013;8(7):e68945.
21
Bonello L, Frère C, Paganelli F, Laine M. The impact of the environment on diseases and drugs. J
Am Coll Cardiol. 2013 Aug 6;62(6):513-5.
22
Bonello L, Laine M, Baumstarck K, Fernandez J, Maillard L, Peyrol M, Bessereau J, Aradi D,
Camilleri E, Roubille F, Piot C, Paganelli F, Camoin-Jau L, Dignat-George F. A randomized trial of
platelet reactivity monitoring-adjusted clopidogrel therapy versus prasugrel therapy to reduce
high on-treatment platelet reactivity. Int J Cardiol. 2013 Oct 9;168(4):4244-8.
23
Bonello L, Laine M, Kipson N, Mancini J, Helal O, Fromonot J, Gariboldi V, Condo J, Thuny F, Frere
C, Camoin-Jau L, Paganelli F, Dignat-George F, Guieu R. Ticagrelor increases adenosine plasma
concentration in patients with an acute coronary syndrome. J Am Coll Cardiol. 2014 Mar
11;63(9):872-7. doi: 10.1016/j.jacc.2013.09.067. Epub 2013 Nov 27. PubMed PMID: 24291273.
24
Bonello L, Paganelli F, Laine M. Pharmacological interactions: the next frontier ? JACC Cardiovasc
Interv. 2013 Feb;6(2):180-1.
25
Bordignon B, Chiron J, Fontés M. Ascorbic acid derivatives as a new class of antiproliferative
molecules.Cancer Lett. 2013;338:317-27 (IF = 4.258)
26
Bordignon B, Mones S, Rahman F, Chiron J, Peiretti F, Vidal N, Fontes M. A derivative of ascorbic
acid modulates cAMP production. Biochem Biophys Res Commun. 2013;439:137-41 (IF = 2.406)
27
Boubred F, Saint-Faust M, Buffat C, Ligi I, Grandvuillemin I, Simeoni U. Developmental Origins of
Chronic Renal Disease: An Integrative Hypothesis. Int J Nephrol. 2013;2013:346067. Epub 2013
Aug 29.
Mise à jour : janvier 2015
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28
Bourgeois C, Douplat M, Guieu R, Pradel V, Fromonot J, Bonnet JL, Alazia M. [Interest of the
combination of high-sensitivity troponine and copeptin in diagnosis of non ST elevation myocardial
infarction]. Ann Biol Clin (Paris). 2013 Sep-Oct;71(5):545-54.
29
Bricaire L, Odou MF, Cardot-Bauters C, Delemer B, North MO, Salenave S, Vezzosi D, Kuhn JM,
Murat A, Caron P, Sadoul JL, Silve C, Chanson P, Barlier A, Clauser E, Porchet N, Groussin L; GTE
Group. Frequent large germline HRPT2deletions in a French National cohort of patients with
primaryhyperparathyroidism. J Clin Endocrinol Metab. 2013 Feb;98(2):E403-8. doi:
10.1210/jc.2012-2789. Epub 2013 Jan 4. Erratum in: J Clin Endocrinol Metab. 2013
Apr;98(4):1766. PubMed PMID: 23293331.
30
Brodovitch A, Bongrand P, Pierres A. T lymphocytes sense antigens within seconds and make a
decision within one minute. J Immunol 2013;191:2064-71.
31
Broucqsault N1, Morere J, Gaillard MC, Dumonceaux J, Torrents J, Salort-Campana E, Maues De
Paula A, Bartoli M, Fernandez C, Chesnais AL, Ferreboeuf M, Sarda L, Dufour H, Desnuelle C,
Attarian S, Levy N, Nguyen K, Magdinier F, Roche S.Dysregulation of 4q35- and muscle-specific
genes in fetuses with a short D4Z4 array linked to facio-scapulo-humeral dystrophy.Hum Mol
Genet. 2013 Oct 15;22(20):4206-14.
32
Busa T, Chabrol B, Perret O, Longy M, Philip N. Novel PTEN germline mutation in a family with
mild phenotype: difficulties in genetic counseling. Gene. 2013 Jan 10;512(2):194-7. doi:
10.1016/j.gene.2012.09.134. Epub 2012 Nov 2. PubMed PMID: 23124040.
33
Cacciagli P, Sutera-Sardo J, Borges-Correia A, Roux JC, Dorboz I, Desvignes JP, Badens C,
Delepine M, Lathrop M, Cau P, Lévy N, Girard N, Sarda P, Boespflug-Tanguy O, Villard L.
Mutations in BCAP31 cause a severe X-linked phenotype with deafness, dystonia, and central
hypomyelination and disorganize the Golgi apparatus. Am J Hum Genet. 2013 Sep 5;93(3):57986.
34
Calfee MW, Rose LJ, Morse S, Mattorano D, Clayton M, Touati A, Griffin-Gatchalian N, Slone C,
McSweeney N. Comparative evaluation of vacuum-based surface sampling methods for collection
of Bacillus spores. J Microbiol Methods. 2013 Dec;95(3):389-96.
35
Callier P, Aral B, Hanna N, Lambert S, Dindy H, Ragon C, Payet M, Collod-Beroud G, Carmignac V,
Delrue M, Goizet C, Philip N, Busa T, Dulac Y, Missotte I, Sznajer Y, Toutain A, Francannet C,
Megarbane A, Julia S, Edouard T, Sarda P, Amiel J, Lyonnet S, Cormier-Daire V, Gilbert B,
Jacquette A, Heron D, Collignon P, Lacombe D, Morice-Picard F, Jouk P, Cusin V, Willems M,
Sarrazin E, Amarof K, Coubes C, Addor M, Journel H, Colin E, Khau Van Kien P, Baumann C,
Leheup B, Martin-Coignard D, Doco-Fenzy M, Goldenberg A, Plessis G, Thevenon J, Pasquier L,
Odent S, Vabres P, Huet F, Marle N, Mosca-Boidron A, Mugneret F, Gauthier S, Binquet C,
Thauvin-Robinet C, Jondeau G, Boileau C, Faivre L. Systematic molecular and cytogenetic
screening of 100 patients with marfanoid syndromes and intellectual disability. Clin Genet. 2013
Mar 18. doi: 10.1111/cge.12094. [Epub ahead of print] PubMed PMID: 23506379.
36
Carrieri MP, Lions C, Sogni P, Winnock M, Roux P, Mora M, Bonnard P, Salmon D, Dabis F, Spire B;
ANRS CO13 HEPAVIH Study Group. Association between elevated coffee consumption and daily
chocolate intake with normal liver enzymes in HIV-HCV infected individuals: results from the
ANRS CO13 HEPAVIH cohort study. J Hepatol. 2014 Jan;60(1):46-53. doi:
10.1016/j.jhep.2013.08.014. Epub 2013 Aug 24.
37
Cayla G, Cuisset T, Silvain J, O'Connor SA, Kerneis M, Castelli C, Quilici J, Bonnet JL, Alessi MC,
Morange PE, Collet JP, Montalescot G. Prasugrel monitoring and bleeding in real world patients.
Am J Cardiol. 2013;11138-44. (IF = 3.425)
38
Cayla G, Morange PE, Chambost H, Schved JF. Management of cardiovascular disease in
haemophilia.Thromb Res. 2013;132:8-14 (IF = 2.372)
39
Chabbert-Buffet N, Guigues B, Trillot N, Biron C, Morange P, Pernod G, Scheffler M, Brugere S,
Hedon B. [DVT and combined oral contraceptives: update of the pluridisciplinary CNGOF-FNCGMGEHT-SFMV group].J Gynecol Obstet Biol Reprod (Paris). 2013;42:309-15 (IF = 0.448)
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40
Chassaing N1, Causse A, Vigouroux A, Delahaye A, Alessandri JL, Boespflug-Tanguy O, BouteBenejean O, Dollfus H, Duban-Bedu B, Gilbert-Dussardier B, Giuliano F, Gonzales M, HolderEspinasse M, Isidor B, Jacquemont ML, Lacombe D, Martin-Coignard D, Mathieu-Dramard M,
Odent S, Picone O, Pinson L, Quelin C, Sigaudy S, Toutain A, Thauvin-Robinet C, Kaplan J, Calvas
P. Molecular findings and clinical data in a cohort of 150 patients with
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41
Ciccolini J, Fanciullino R, Milano G. Predicting survival of gastric cancer patients treated with 5fluorouracil-based regimen: falling again on TP53 Pharmacogenomics 07/2013; 14(10):11371138.
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Ciccolini J, Peters GJ, Giovannetti E. Gender, cytidine deaminase, and 5-aza/decitabine--letter.
Clin Cancer Res. 2013 Jun 1;19(11):3105.
43
Colson P, Bregigeon S, Tourres C, Solas C, Poizot-Martin I, Tamalet C. Relapse of hepatitis C virus
after 14 months of sustained virological response following pegylated-interferon alpha plus
ribavirin therapy in a human immunodeficiency virus type 1 infected patient. J Clin Virol. 2013
Sep;58(1):309-14.
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Cordier C, Taris N, De Pauw A, Sobol H, Philip N, Voelckel MA. French professionals in genetic
counselor careers. J Genet Couns. 2013 Dec;22(6):844-8. doi: 10.1007/s10897-013-9599-x.
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Cottereau E, Mortemousque I, Moizard MP, Bürglen L, Lacombe D, Gilbert-Dussardier B, Sigaudy
S, Boute O, David A, Faivre L, Amiel J, Robertson R, Viana Ramos F, Bieth E, Odent S, Demeer B,
Mathieu M, Gaillard D, Van Maldergem L, Baujat G, Maystadt I, Héron D, Verloes A, Philip N,
Cormier-Daire V, Frouté MF, Pinson L, Blanchet P, Sarda P, Willems M, Jacquinet A, Ratbi I, Van
Den Ende J, Lackmy-Port Lis M, Goldenberg A, Bonneau D, Rossignol S, Toutain A..Phenotypic
spectrum of Simpson-Golabi-Behmel syndrome in a series of 42 cases with a mutation in GPC3
and review of the literature. Am J Med Genet C Semin Med Genet. 2013 May;163C(2):92-105
46
Courcet JB, Faivre L, Michot C, Burguet A, Perez-Martin S, Alix E, Amiel J, Baumann C, Cordier
MP, Cormier-Daire V, Delrue MA, Gilbert-Dussardier B, Goldenberg A, Jacquemont ML, Jaquette A,
Kayirangwa H, Lacombe D, Le Merrer M, Toutain A, Odent S, Moncla A, Pelet A, Philip N, Pinson L,
Poisson S, Kim-Han le QS, Roume J, Sanchez E, Willems M, Till M, Vincent-Delorme C, Mousson
C, Vinault S, Binquet C, Huet F, Sarda P, Salomon R, Lyonnet S, Sanlaville D, Geneviève D.
Clinical and molecular spectrum of renal malformations in Kabuki syndrome. J Pediatr. 2013
Sep;163(3):742-6. doi: 10.1016/j.jpeds.2013.02.032. Epub 2013 Mar 25. PubMed PMID:
23535010.
47
Cristofaro B, Shi Y, Faria M, Suchting S, Leroyer AS, Trindade A, Duarte A, Zovein AC, IruelaArispe ML, Nih LR, Kubis N, Henrion D, Loufrani L, Todiras M, Schleifenbaum J, Gollasch M,
Zhuang ZW, Simons M, Eichmann A, le Noble F. Dll4-Notch signaling determines the formation of
native arterial collateral networks and arterial function in mouse ischemia models. Development.
2013 Apr;140(8):1720-9.
48
Cuisset T, Grosdidier C, Loundou AD, Quilici J, Loosveld M, Camoin L, Pankert M, Beguin S,
Lambert M, Morange PE, Bonnet JL, Alessi MC. Clinical Implications of Very Low On-Treatment
platelet reactivity in patients treated with thienopyridine: The POBA study (Predictor of bleedings
with antiplatelet drugs).JACC Cardiovasc Interv. 2013;6:854-63 (IF = 6.552)
49
Cuisset T, Quilici J, Morange PE, Bonnet JL, Alessi MC. Predictors of long-term high on-treatment
platelet reactivity in clopidogrel-treated patients undergoing coronary stenting for acute coronary
syndrome.Int J Cardiol. 2013 ;168:1565-6. (IF = 6.175)
50
Cuisset T,Cayla G, Quilici J, Pankert M, Deharo P, Bonnet G, Grosdidier C, Beguin S, Morange P,
Bonnet JL, Alessi MC.Off-label use of prasugrel in stable coronary artery disease is associated with
greater degree of platelet inhibition compared with use after acute coronary syndrome. Int J
Cardiol. 2013 ;168:2988-9 (IF = 6.175)
51
Cuny T, Barlier A. The significance of MEN1 mutations in pituitary carcinomas. Biomark Med. 2013
Aug;7(4):567-9. doi: 10.2217/bmm.13.69. PubMed PMID: 23905891.
Mise à jour : janvier 2015
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52
Cuny T, Pertuit M, Sahnoun-Fathallah M, Daly A, Occhi G, Odou MF, Tabarin A, Nunes ML,
Delemer B, Rohmer V, Desailloud R, Kerlan V, Chabre O, Sadoul JL, Cogne M, Caron P, CortetRudelli C, Lienhardt A, Raingeard I, Guedj AM, Brue T, BeckersA, Weryha G, Enjalbert A, Barlier A.
Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don't
forget MEN1 genetic analysis. Eur J Endocrinol. 2013 Mar 15;168(4):533-41. doi: 10.1530/EJE12-0763. Print 2013Apr. PubMed PMID: 23321498.
53
D. Barbolosi A. Benabdallah S. Benzekry J. Ciccolini C. Faivre F. Hubert F. Verga B. You A
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CONTRATS ANNÉE 2013
S. ATTARIAN – « Outils pour l’évaluation thérapeutique dans la maladie de Charcot-Marie-Tooth de type
IA : critères de jugement et biomarqueurs » - AP-HM – PHRC Inter régional 2013
P. ROLL : « Matrice nucléaire et Cancers : analyses génomique par puces à ADN et protéique des cellules
obtenues par ponction pleurale », ARARD (2009-2013)
P. ROLL : « Microparticules, vecteurs d’information génétique au cours de l’infection par le VIH ? », Projet
de recherche ANRS (2012-2013)
L. NEE : Effets de la caféine dans le FA post opératoire – AORCA. HAUTIER « RECHERCHE DE BIOMARQUEURS INNOVANTS : EXPRESSION DE HIF-1α ET DE SES
ISOFORMES DANS LE SANG ET LES TISSUS CUTANES DES GRANDS BRULES » - AORC Investigateurs associés : Amin BEN LASSOUED et Pr Jean GABERT. Références CPP : 2012-23 /
Référence du Comité : 12 49 / Numéro d'identification : 2012-A00644
A. BARLIER/ A. SAVEANU/ A. ENJALBERT : Nouveaux déterminants moléculaires des déficits
hypophysaires - ANR 2008-2013
V. GEROLAMI : Essai thérapeutique TICAGRELOR 2012-2013
V. GEROLAMI : Hémochromatose de type 4 - Ministère santé PHRC -2010-2013
A. BARLIER . H. ZATTARA : Séquencage du gène VHL dans les hémangioblastomes, impact
psychologique lors de la reconvocation des patients - AORC 2013 - 2013-2014
N. LEVY: Neuromics - CEE FP7-305121 -Nov 2012
N. LEVY: MNH-DECRYPT : Genomics, pathophysiology and therapeutic approaches in a panel of rare
genetics diseases mainly affecting muscle, heart and nervous system – AFM- Juin 2010
Mise à jour : janvier 2015
Pôle hospitalier. Biologie
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J. CICCOLINI - « Pharmacocinétique du bévacizumab » Subvention Cancéropôle 2013
J. CICCOLINI - Recherche des effets séquernces anti-angiogéniques/cytotoxiques » Contrat Roche 2013
J. CICCOLINI - « Développement des ANC »Subvention Gefluc 2013
C. DUBOIS -« Rôles des microparticules dans l’initiation et la régulation des processus de thromboses et
de métastases » MiniRev – ANR -2009 2013
C. DUBOIS -« Rôle des plaquettes sanguines dans le développement d’une tumeur et la formation de
métastases dans un modèle murin du cancer du pancréas » - ARC-2012 2013
U. SIMEONI F. SABATIER - « Encéphalopathie anoxo-ischémique néonatale : étude de la tolérance et de
la faisabilité d’un traitement curatif par les cellules souches du sang du cordon ombilical »- PHRC- 2010
2013
B.GRANEL N. BARDIN - « Sclérodermie et marqueurs vasculaires » - AORC Sénior- 2013
J.R. HARLE F. DIGNAT-GEORGE - « Etude de la lésion endothéliale dans la Drépanocytose »- AORC Sénior
– 2011 2013
P. PAUL - « Evaluation de la réaction humorale et cellulaire anti-endothéliale dans la survenue du rejet de
greffe cardiaque » - AAP 2010 Recherche Clinique Translationnelle -2010 2013
F. DIGNAT-GEORGE - « CD 146 nouvelle cible dans les pathologies vasculaires » -FONDATION DE
FRANCE – 2012 2014
C.DUBOIS - « Etude du pouvoir antitumoral du Clopidrogrel dans un modèle murin du cancer du
pancréas » - FORMATION RECHERCHE TRANSLATIONNELLE EN CANCEROLOGIE-2009 2013
C.DUBOIS - « Study of the antitumoral effect of Clopidogrel in a mouse model of pancreatic cancer » GFTC – 2012 2013
F. DIGNAT-GEORGE - Exploratory assessment of biomarkers in female patients suffering from chronic
venous leg ulcer versus control subjects free of leg ulcer - Laboratoire SERVIER- 2013
M.CANAULT /M.C.ALESSI - Bases cellulaires et moléculaires du risque thrombotique dans l'insulino
résistance : étude dans la plaquette - Fondation de France – 2012 2013
M.C. ALESSI - Rôle de la molécule de costimulation CD28 dans le développement de l'état inflammatoire
et de la résistance à l'insuline associés à l'obésité - Société Fancophone de Diabète- 2012 2013
M.C. ALESSI - Subvention Annuelle – FRM- 2013
BREVETS ANNÉE 2013
Method for assessing the ability of a patient to respond to or be safely treated by a nucleoside analog
based-chemotherapy. Inventeurs : Ciccolini, Mercier, Dahan, Iliadis, Seitz, Ouafik. N° dépôt : US
20130011392 A1. Année de dépôt :2009. Année de publication : 10 janvier 2013. Déposant AMU, codéposant : AP-HM.
Method for assessing the ability of a patient to respond to or be safely treated by a nucleoside analog
based-chemotherapy Brevet - États-Unis US 20130011392 A1 Publié le 10 janvier 2013
Développement d’un système de lecture automatisé. Bertin D, Bongrand P, Bardin N. European patent n°
1000191432. 2013. AP-HM.
Mise à jour : janvier 2015
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THESES DE DOCTORAT ANNÉE 2013
Mathey-Turba Camille –« « JAK2 et syndromes myeloproliferatifs : comparaison de méthodes
diagnostiques » - 18 janvier 2013.
Franceschi Frédéric « Contribution à l’étude du système adénosinergique en pathologie cardiovasculaire »
- 22 Février 2013
Bennis Youssef . L'érythropoïétine, agent d'optimisation de la thérapie cellulaire par progéniteurs
endothéliaux dans l'AVC ischémique et l'ischémie aigüe des membres inférieurs. Mars 2013
Taulelle Jean-Marie – « Quantification de la mutation JAK2 V617 F : Que faire des patients faiblement
positifs ? Etude de 165 patients JAK2 V617F positifs entre 2008 et 2010 à l’AP-HM » - 21 juin 2013.
Bonello Nathalie. Conséquences des laminopathies dans l’endothélium vasculaire. Septembre 2013
Favier Marie. Pathologies plaquettaires héréditaires : caractérisation d’une nouvelle mutation. Septembre
2013
Gravier Gilles « Cinétique des réponses cardiorespiratoires et métaboliques lors d’un exercice
incrémentiel maximal chez l’homme » – 18 novembre 2013.
Gondouin Bertrand. Les toxines urémiques provoquent un phénotype procoagulant de l’endothélium par
la voie du facteur de transcription AHR. Novembre 2013
Darbousset Roxane. Rôle des polynucléaires neutrophiles dans la formation d'un thrombus in vivo dans un
modèle murin après blessure au rayon laser. Décembre 2013
Amira Mohamed. Nouvelles molécules thérapeutiques en développement pour les Tumeurs
Neuroendocrines d’origine gastroentéropancréatiques et hypophysaires: Preuves de concept in vitro dec
2013
Mise à jour : janvier 2015
Pôle hospitalier. Biologie
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