Auteurs

Perinatal exposures and the risk of endometriosis
Abstract ID : 1688
Soumis par : Louis MARCELLIN Le 2016-03-14 21:51:59
Nom de la catégorie : SEUD CONGRESS
Typologie : Communication orale / Oral communication
Statut : validé
Autorisation de diffusion : Yes/Oui
------------------------------------Introduction: Since endometriosis is mostly diagnosed in young women, the early life period may be an important
exposure window for its development. An influence of the perinatal environment has been suggested for several chronic
diseases, but very few data exist regarding endometriosis.
Materials /Patients and methods: E3N is a prospective cohort of French women, insured by a national health scheme
mostly covering teachers and aged 40-65 years at inclusion in 1990. Self-administered questionnaires were sent every
2-3 years during follow-up. Using a nested case-control design, we computed odds-ratios (ORs) and 95% confidence
intervals (CIs) using unconditional logistic regression models.
Results: A total of 2684 endometriosis cases were reported as surgically-ascertained among the 75,918 included
women. Maternal and paternal ages at birth were associated with significantly reduced risks of endometriosis (OR=0.76
for the highest vs. the lowest quartile of maternal or paternal age at birth; Ptrend <0.0001). In age-adjusted models, birth
length was associated with a significantly increased endometriosis risk (OR=1.34, 95% CI=1.08-1.65, for ?52 compared
with <48 cm; Ptrend=0.008), but associations were reduced and no longer statistically significant after full adjustment
(Ptrend=0.05). We found no significant association between endometriosis risk and birth weight, premature birth, fetal
number, exposures to breast milk or to maternal smoking during fetal life, number of siblings, or handedness.
Conclusion: Older maternal and paternal ages at birth are associated with reduced risks of endometriosis. Further
studies are needed to confirm these findings and explore their underlying mechanisms in order to better understand the
influence of the perinatal environment on endometriosis risk.
------------------------------------Mots clefs : Endometriosis, perinatal factor exposure
Auteurs :
Références : , , ,
Auteurs
Louis Marcellin 1, Bruno Borghese 1, G Gusto 2, Charles Chapron 1, A Bijon 2, F Clavel-Chapelon 2, S Mesrine 2, MC
Boutron-Ruault 2, Marina Kvaskoff 2,
1. Service de Chirurgie Gynécologie Obstétrique II et Médecine de la Reproduction, Assistance Publique ? Hôpitaux de
Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Université
Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine,, Paris, FRANCE
2. Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM, Paris, FRANCE
3. Service de Chirurgie Gynécologie Obstétrique II et Médecine de la Reproduction Assistance Publique ? Hôpitaux de
Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Université
Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, FRANCE
Auteurs (raw format)
Marcellin Louis - email : [email protected] Etablissement : Université Paris Descartes, Sorbonne Paris Cité,
Faculté de Médecine, Service : Service de Chirurgie Gynécologie Obstétrique II et Médecine de la Reproduction,
Assistance Publique ? Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier
Universitaire (CHU) Cochin Ville : Paris Pays : FRANCE Présentateur : Oui
Borghese Bruno - email : [email protected] Etablissement : Université Paris Descartes, Sorbonne Paris Cité,
Faculté de Médecine, Service : Service de Chirurgie Gynécologie Obstétrique II et Médecine de la Reproduction,
Assistance Publique ? Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier
Universitaire (CHU) Cochin Ville : Paris Pays : FRANCE Présentateur : Non
Gusto G - email : Etablissement : Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM Service : Ville : Paris
Pays : FRANCE Présentateur : Non
Chapron Charles - email : [email protected] Etablissement : Université Paris Descartes, Sorbonne Paris Cité,
Faculté de Médecine Service : Service de Chirurgie Gynécologie Obstétrique II et Médecine de la Reproduction
Assistance Publique ? Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier
Universitaire (CHU) Cochin Ville : Paris Pays : FRANCE Présentateur : Non
Bijon A - email : Etablissement : Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM Service : Ville : Paris
Pays : FRANCE Présentateur : Non
Clavel-Chapelon F - email : Etablissement : Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM Service :
Ville : Paris Pays : FRANCE Présentateur : Non
Mesrine S - email : Etablissement : Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM Service : Ville :
Paris Pays : FRANCE Présentateur : Non
Boutron-Ruault MC - email : Etablissement : Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM Service :
Ville : Paris Pays : FRANCE Présentateur : Non
Kvaskoff Marina - email : [email protected] Etablissement : Université Paris-Saclay, Univ. ParisSud, UVSQ, CESP, INSERM Service : Ville : Paris Pays : FRANCE Présentateur : Non