Final Program THALYS RESEARCH MEETING

THALYS RESEARCH MEETING 2012
Amsterdam – Brussels - Groningen – Leuven – Paris
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21 & 22 December 2012
Auditorium B 1.0004
Faculty of Medicine - Erasme academic Hospital
Université Libre de Bruxelles
Brussels - BELGIUM
Friday 21st December 2012
9:30 – 9:35
Welcome of the participants (Robert Naeije & Laurence Dewachter, from
Université Libre de Bruxelles, Brussels, BE)
1- Pulmonary circulation
Chairs: Christophe Guignabert, Rozenn Quarck and Laurence Dewachter
9:35 - 10:05
Special Lecture: Pulmonary hypertension: What do we learn from the
pathology?
Peter Dorfmuller (U999, Le Plessis Robinson, FR)
Basic science (10’ presentation – 5’ questions)
10:05 - 10:20
Cell alignment of pulmonary endothelial cells of iPAH patients and
controls
Robert Szulcek (VU University Medical Center, Amsterdam, NL)
10:20 - 10:35
Endothelial MIF/CD74 signaling in PAH
Ly Tu (U999, Le Plessis Robinson, FR)
10:35 - 10:50
A proof of concept for exhaled air analysis using Nano Artificial Nose
(NA-NOSE) in PAH
Sylvia Cohen-Kaminsky (U999, Le Plessis Robinson, FR)
10:50 – 11:10
Remaining questions & Discussion
Pause: Coffee Break
11:30 - 11:45
Endothelin-1 and BMPR-2 signaling pathways in PAH
Hidekazu Maruyama (ULB, Brussels, BE)
11:45 – 12:00
Role of leptin in PAH
Alice Huertas (U999, Le Plessis Robinson, FR)
12:00 – 12:15
Effects of leptin on pulmonary and systemic vasoreactivity
Samantha Gomart / Laurence Dewachter (ULB, Brussels, BE)
12:15 – 12:30
Fibroblasts in PAH
Ismail Ben Soussia / Vadim Shlyonsky (ULB, Brussels, BE)
12:30 – 12:45
Glycosaminoglycans disturbance in PAH
Benoit Ranchoux (U999, Le Plessis Robinson, FR)
12:45 – 13:00
Remaining questions & Discussion
Pause: Lunch
Physiological & Clinical Research (10’ presentation – 5’ questions)
Chairs: Barbara Girerd, Gerrina Ruiter and Rebecca Vanderpool
14:00 – 14:15
Pulmonary vascular dynamics in paediatric pulmonary arterial
hypertension
Menno Douwes (University Medical Center Groningen, Groningen, NL)
14:15 – 14:30
Effects of Bosentan on pressure-flow plots in patients with ASD type II
closed after the age of 40
Alexander Van De Bruaene (Clinical Cardiology, KUL, Leuven, BE)
14:30 – 14:45
Diffusion capacity in patients with and without BMPR2 mutation
Pia Trip (VU University Medical Center, Amsterdam, NL)
14:45 – 15:00
Tyrosine kinase inhibitors in PAH
Andrei Seferian/David Montani (U999, Le Plessis Robinson, FR)
15:00 – 15:20
Remaining questions & Discussion
Pause: Coffee Break
2- The integrative biology of CTEPH
Chairs: Marco Vicenzi, Leanda Vengethasamy and Michael Dickinson
15:50 – 16:05
A rabbit model of CTEPH: hemodynamic measurements by telemetry
Alicja Ronisz / Rozenn Quarck (Pneumology, KUL, Leuven, BE)
16:05 – 16:20
Description of a CTEPH model in pigs
Olaf Mercier (U999, Le Plessis Robinson, FR)
16:20 – 16:40
Remaining questions & Discussion
16:40 – 17:00
Conclusion of the day
19:30
Dinner at the BELGA QUEEN Restaurant
Saturday 22nd December 2012
3- Right ventricle
Chairs: Frances de Man, Beatrijs Bartelds and Frédéric Perros
9:00 - 9:30
Special Lecture:
Pathobiology of RV failure: What do we learn
from experimental models?
Harm J. Bogaard (VU University Medical Center, Amsterdam, NL)
Basic science
9:30 – 9:45
Altered right ventricular cardiomyocyte function in PAH patients
Sylvia Rain (VU University Medical Center, Amsterdam, NL)
9:45 – 10:00
Activation of inflammatory processes in RV failure
Céline Dewachter (ULB, Brussels, BE)
10:00 – 10:15
Is the HO-1/CO signaling altered in RV failure on chronic systemic-topulmonary shunting-induced PAH?
Asmae Belhaj (ULB, Brussels, BE)
10:15 – 10:30
A model of RV failure
Reinout Borgdorff (University Medical Center Groningen, Groningen, NL)
10:30 – 10:45
Novel animal model for right heart failure
Stine Andersen / Jacob Schultz (VU University Medical Center, Amsterdam, NL;
Aarhus, DK)
10:45 – 11:00
Remaining questions & Discussion
Pause: Coffee Break
Physiological & Clinical Research
Chairs: David Montani, Marielle van de Veerdonk and Adriana Pavelescu
11:30 - 12:00 Special Lecture:
Left ventricle in pulmonary hypertension
Robert Naeije (ULB, Brussels, BE)
12:00 – 12:15
Altered left ventricular cardiomyocyte function in PAH patients
Emmy Manders (VU University Medical Center, Amsterdam, NL)
12:15 – 12:30
Pressure and volume assessment of the right ventricle during exercise
by magnetic resonance imaging in patients with pulmonary
hypertension
Guido Claessen (Clinical Cardiology, KUL, Leuven, BE)
12:30 – 12:45
Remaining questions & Discussion
12:45 – 13:00
Conclusion of the meeting
Lunch